{"id":"https://openalex.org/W7225619997","doi":"https://doi.org/10.5281/zenodo.24079660","title":"Entropy of ATLAS AACF Susceptibility Profiles across Cancer Cell Lines: Dependence on Model, Normalization Scale, and Checkpoint Aggregation","display_name":"Entropy of ATLAS AACF Susceptibility Profiles across Cancer Cell Lines: Dependence on Model, Normalization Scale, and Checkpoint Aggregation","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225619997","doi":"https://doi.org/10.5281/zenodo.24079660"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24079660","doi":"https://doi.org/10.5281/zenodo.24079660","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24079660","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24079660","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010700333","display_name":"Vasil Tsanov","orcid":"https://orcid.org/0000-0002-5695-1601","observed_orcids":["https://orcid.org/0000-0002-5695-1601"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tsanov, Vasil","raw_affiliation_strings":["Ministry of Interior"],"raw_orcid":"https://orcid.org/0000-0002-5695-1601","affiliations":[{"raw_affiliation_string":"Ministry of Interior","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010700333"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.6980000138282776},{"id":"https://openalex.org/keywords/shannon-entropy","display_name":"Shannon entropy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/fair-assessment","display_name":"fair assessment","score":0.6060000061988831},{"id":"https://openalex.org/keywords/reproducibility-audit","display_name":"reproducibility audit","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5680999755859375},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.44830000400543213},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.42899999022483826},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4180999994277954},{"id":"https://openalex.org/C9679016","wikidata":"https://www.wikidata.org/wiki/Q1417473","display_name":"Principle of maximum entropy","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.35350000858306885},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.305400013923645},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30169999599456787},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.287200003862381},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2599000036716461},{"id":"https://openalex.org/C171752962","wikidata":"https://www.wikidata.org/wiki/Q255166","display_name":"Kullback\u2013Leibler divergence","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24079660","doi":"https://doi.org/10.5281/zenodo.24079660","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24079660","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.24079661","doi":"https://doi.org/10.5281/zenodo.24079661","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24079661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24079660","doi":"https://doi.org/10.5281/zenodo.24079660","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24079660","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7213613088","https://openalex.org/W7212517374","https://openalex.org/W7225617967","https://openalex.org/W7224535241","https://openalex.org/W7167411038","https://openalex.org/W6969319582","https://openalex.org/W3022964047","https://openalex.org/W7167837864","https://openalex.org/W7212375597","https://openalex.org/W2144384671"],"abstract_inverted_index":{"This":[0,291],"record":[1],"accompanies":[2],"Working":[3,260],"Paper":[4],"No.":[5],"9":[6],"of":[7,13,19,41,105,111,141,319,347],"the":[8,14,39,103,139,145,158,184,216,246,287,299,348],"Independent":[9],"FAIR":[10],"Evaluation":[11],"Series":[12],"ATLAS":[15,20,259,349],"Framework,":[16],"entitled":[17],"Entropy":[18],"AACF":[21,43,76],"Susceptibility":[22],"Profiles":[23],"across":[24,58,125],"Cancer":[25],"Cell":[26],"Lines:":[27],"Dependence":[28],"on":[29],"Model,":[30],"Normalization":[31,193],"Scale,":[32],"and":[33,50,93,123,155,178,194,200,226,233,238,240,253,267,278,296,343],"Checkpoint":[34],"Aggregation.":[35],"The":[36,97,211,270,311,337],"study":[37],"examines":[38],"concentration":[40,198],"computational":[42,209,213,320],"susceptibility":[44],"profiles":[45,119,182,188],"derived":[46],"from":[47,138,258],"frozen":[48,222],"PaccMann":[49,154],"DRPreter":[51,127,159],"predictions":[52],"for":[53,153,157],"95":[54,112],"unique":[55,113],"registered":[56,108],"configurations":[57],"970":[59],"matched":[60],"cancer":[61],"cell-line":[62,171],"profiles.":[63],"Scores":[64],"are":[65],"transformed":[66],"into":[67],"normalized":[68,88,149],"weights":[69],"using":[70],"a":[71,316],"softmax":[72],"transformation":[73],"favouring":[74],"lower":[75],"indices,":[77],"with":[78,166],"fixed":[79],"model-specific":[80],"reference":[81,146],"scales.":[82],"Profile":[83],"characterization":[84],"includes":[85],"Shannon":[86],"entropy,":[87,89],"effective":[90],"configuration":[91,95,225],"counts,":[92],"leading":[94],"weights.":[96],"evaluation":[98,346],"addresses":[99],"five":[100],"normalization-scale":[101],"multipliers,":[102],"effect":[104],"retaining":[106],"97":[107,185],"labels":[109],"instead":[110],"configurations,":[114],"lineage":[115],"comparisons":[116],"covering":[117],"953":[118],"in":[120,170,286],"21":[121],"groups,":[122],"variability":[124],"ten":[126],"checkpoints.":[128],"It":[129],"also":[130],"distinguishes":[131],"entropy":[132,150,172,204,314],"calculated":[133],"after":[134],"median":[135,140,148,160],"index":[136],"aggregation":[137,196],"checkpoint-wise":[142],"entropies.":[143],"At":[144],"scales,":[147],"was":[151],"0.9346":[152],"0.9528":[156],"consensus.":[161],"These":[162],"aggregate":[163],"differences":[164],"coexisted":[165],"weak":[167],"cross-model":[168],"agreement":[169],"rankings":[173],"(Spearman":[174],"\u03c1":[175],"=":[176],"\u22120.0788)":[177],"only":[179],"six":[180],"shared":[181],"among":[183],"most":[186],"concentrated":[187],"identified":[189],"by":[190],"each":[191],"model.":[192],"checkpoint":[195],"affected":[197],"summaries":[199],"rankings,":[201],"demonstrating":[202],"that":[203],"requires":[205],"an":[206],"explicitly":[207],"specified":[208],"representation.":[210],"accompanying":[212],"materials":[214,338],"document":[215],"six-stage":[217],"workflow":[218],"through":[219],"analysis":[220,289],"scripts,":[221],"input":[223],"resources,":[224],"profile":[227,321],"mappings,":[228],"normalization":[229],"policies,":[230],"numerical":[231],"tables":[232],"arrays,":[234],"saved":[235],"bootstrap":[236],"draws,":[237],"provenance":[239],"validation":[241],"records.":[242],"A":[243],"README":[244],"explains":[245],"directory":[247],"structure,":[248],"principal":[249],"outputs,":[250],"reproduction":[251],"workflow,":[252],"interpretation":[254],"limits.":[255],"Resources":[256],"inherited":[257],"Papers":[261],"06\u201308":[262],"retain":[263],"their":[264],"upstream":[265],"licensing":[266],"attribution":[268],"requirements.":[269],"final":[271],"technical":[272,294],"audit":[273,292],"recorded":[274],"2,363":[275],"passed":[276],"checks":[277],"no":[279],"failed":[280],"checks,":[281],"reviewing":[282],"206":[283],"distinct":[284],"files":[285],"selected":[288],"chain.":[290],"supports":[293],"consistency":[295],"traceability":[297],"within":[298],"implemented":[300],"checks;":[301],"it":[302],"does":[303],"not":[304,325],"constitute":[305],"independent":[306],"experimental":[307],"or":[308,334],"clinical":[309],"validation.":[310],"results":[312],"establish":[313,326],"as":[315],"conditional":[317],"descriptor":[318],"concentration.":[322],"They":[323],"do":[324],"therapeutic":[327],"efficacy,":[328],"measured":[329],"mixture":[330],"responses,":[331],"biological":[332],"mechanisms,":[333],"malignant-versus-normal":[335],"selectivity.":[336],"support":[339],"transparent":[340],"inspection,":[341],"reanalysis,":[342],"further":[344],"methodological":[345],"framework.":[350]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}