{"id":"https://openalex.org/W7225619904","doi":"https://doi.org/10.21203/rs.3.rs-11368075/v1","title":"Proteomic profiling reveals a distinct inflammatory microenvironment in trigger finger","display_name":"Proteomic profiling reveals a distinct inflammatory microenvironment in trigger finger","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225619904","doi":"https://doi.org/10.21203/rs.3.rs-11368075/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11368075/v1","doi":"https://doi.org/10.21203/rs.3.rs-11368075/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11368075/v1","pdf_url":"https://www.researchsquare.com/article/rs-11368075/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11368075/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095656868","display_name":"Utkan Aydin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Utkan Aydin","raw_affiliation_strings":["Uppsala University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161352527","display_name":"Bj\u00f6rn G. Holm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn G. Holm","raw_affiliation_strings":["Uppsala University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108811512","display_name":"Monica E. Wiig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Monica Wiig","raw_affiliation_strings":["Uppsala University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084884436","display_name":"Bijar Ghafouri","orcid":"https://orcid.org/0000-0002-6396-5104","observed_orcids":["https://orcid.org/0000-0002-6396-5104"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bijar Ghafouri","raw_affiliation_strings":["Link\u00f6ping University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Link\u00f6ping University","institution_ids":["https://openalex.org/I102134673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10630","display_name":"Orthopedic Surgery and Rehabilitation","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10630","display_name":"Orthopedic Surgery and Rehabilitation","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trigger-finger","display_name":"trigger finger","score":1.0},{"id":"https://openalex.org/keywords/a1-pulley","display_name":"A1 pulley","score":0.8669999837875366},{"id":"https://openalex.org/keywords/flexor-tendons","display_name":"flexor tendons","score":0.765999972820282},{"id":"https://openalex.org/keywords/inflammatory-microenvironment","display_name":"inflammatory microenvironment","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9940000176429749},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.925000011920929},{"id":"https://openalex.org/keywords/atopic-inflammation","display_name":"atopic inflammation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.9869999885559082},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5708000063896179},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.569100022315979},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4957999885082245},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.47119998931884766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45329999923706055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44200000166893005},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.427700012922287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40139999985694885},{"id":"https://openalex.org/C171937826","wikidata":"https://www.wikidata.org/wiki/Q48378","display_name":"Pulley","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36039999127388},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36039999127388},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35929998755455017},{"id":"https://openalex.org/C2775899180","wikidata":"https://www.wikidata.org/wiki/Q2093127","display_name":"Trigger finger","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C133702464","wikidata":"https://www.wikidata.org/wiki/Q3487083","display_name":"Actinin","level":4,"score":0.3181999921798706},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2630999982357025},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2623000144958496}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11368075/v1","doi":"https://doi.org/10.21203/rs.3.rs-11368075/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11368075/v1","pdf_url":"https://www.researchsquare.com/article/rs-11368075/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11368075/v1","doi":"https://doi.org/10.21203/rs.3.rs-11368075/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11368075/v1","pdf_url":"https://www.researchsquare.com/article/rs-11368075/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323305","display_name":"Akademiska Sjukhuset","ror":"https://ror.org/01apvbh93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225619904.pdf","grobid_xml":"https://content.openalex.org/works/W7225619904.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W819018147","https://openalex.org/W1826265218","https://openalex.org/W1892560055","https://openalex.org/W1968567718","https://openalex.org/W1989027880","https://openalex.org/W1997375946","https://openalex.org/W2026644297","https://openalex.org/W2077592814","https://openalex.org/W2079159632","https://openalex.org/W2098041022","https://openalex.org/W2125551265","https://openalex.org/W2127826659","https://openalex.org/W2136688582","https://openalex.org/W2152611039","https://openalex.org/W3127903636","https://openalex.org/W4303684410","https://openalex.org/W4387798746","https://openalex.org/W4390982916","https://openalex.org/W4402474154","https://openalex.org/W4406325836","https://openalex.org/W4411402195","https://openalex.org/W4415361152"],"related_works":["https://openalex.org/W4226153358","https://openalex.org/W2161842274","https://openalex.org/W2127826659","https://openalex.org/W1545012654","https://openalex.org/W1892560055","https://openalex.org/W2613964915","https://openalex.org/W2072659131","https://openalex.org/W2125551265","https://openalex.org/W1916446578","https://openalex.org/W2316481230"],"abstract_inverted_index":{"Abstract":[0],"Trigger":[1],"finger":[2],"is":[3],"a":[4,71,84,140,169],"common":[5],"hand":[6],"disorder,":[7],"but":[8],"the":[9,22,27,50,104,145],"contribution":[10],"of":[11,26,56,74,100,106,148,177],"local":[12],"inflammation":[13],"to":[14,38,114,161],"its":[15],"pathophysiology":[16],"remains":[17],"unclear.":[18],"This":[19,164],"study":[20],"investigated":[21],"inflammatory":[23,86,142],"protein":[24,87],"profile":[25,88],"tendon\u2013pulley":[28],"apparatus":[29],"in":[30,62,89,134,144],"patients":[31],"with":[32,35,41,96,121],"trigger":[33,93,109,149],"finger,":[34],"particular":[36],"attention":[37],"mediators":[39,119],"associated":[40,120],"atopic":[42,126],"inflammation.":[43,127],"Biopsies":[44],"were":[45,68],"obtained":[46],"during":[47],"surgery":[48],"from":[49,92],"A1":[51,90,146],"pulley":[52,147],"and":[53,58,78,110,125,151,156,175],"flexor":[54],"tendon":[55,135],"affected":[57],"adjacent":[59],"asymptomatic":[60],"fingers":[61,94,150],"16":[63],"patients.":[64],"Sixty-two":[65],"tissue":[66],"samples":[67],"analyzed":[69],"using":[70],"multiplex":[72],"panel":[73],"71":[75],"cytokines,":[76],"chemokines,":[77],"growth":[79],"factors.":[80],"Multivariate":[81],"analysis":[82],"demonstrated":[83],"distinct":[85],"pulleys":[91,112],"compared":[95],"controls.":[97],"The":[98],"levels":[99],"eleven":[101],"cytokines":[102],"had":[103],"capacity":[105],"discriminating":[107],"between":[108],"control":[111],"according":[113],"multivariate":[115,130],"analysis,":[116],"including":[117],"several":[118],"leukocyte":[122],"recruitment,":[123],"fibrosis,":[124],"No":[128],"significant":[129],"separation":[131],"was":[132],"observed":[133],"samples.":[136],"These":[137],"findings":[138],"demonstrate":[139],"localized":[141],"microenvironment":[143],"suggest":[152],"that":[153],"inflammatory,":[154],"fibrotic,":[155],"atopy-associated":[157],"pathways":[158],"may":[159,167],"contribute":[160],"disease":[162],"pathophysiology.":[163],"molecular":[165,173],"characterization":[166],"provide":[168],"basis":[170],"for":[171],"further":[172],"studies":[174],"development":[176],"targeted":[178],"therapeutic":[179],"approaches.":[180]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}