{"id":"https://openalex.org/W7225619738","doi":"https://doi.org/10.1080/03007995.2026.2758492","title":"Perceptions and preferences of self-injectable therapies among adults living with immunoglobulin A nephropathy in the United States: a mixed-methods study","display_name":"Perceptions and preferences of self-injectable therapies among adults living with immunoglobulin A nephropathy in the United States: a mixed-methods study","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225619738","doi":"https://doi.org/10.1080/03007995.2026.2758492","pmid":"https://pubmed.ncbi.nlm.nih.gov/43001846"},"language":"en","primary_location":{"id":"doi:10.1080/03007995.2026.2758492","doi":"https://doi.org/10.1080/03007995.2026.2758492","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2026.2758492","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2026.2758492?needAccess=true","source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2026.2758492?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019394563","display_name":"Joel Iff","orcid":"https://orcid.org/0000-0002-1102-0651","observed_orcids":["https://orcid.org/0000-0002-1102-0651"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel Iff","raw_affiliation_strings":["Vertex Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081590689","display_name":"Rajeshwari Nair","orcid":"https://orcid.org/0000-0002-9406-7841","observed_orcids":["https://orcid.org/0000-0002-9406-7841"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeshwari Nair","raw_affiliation_strings":["Vertex Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056815944","display_name":"Richard Mellor","orcid":"https://orcid.org/0000-0002-7603-5256","observed_orcids":["https://orcid.org/0000-0002-7603-5256"]},"institutions":[{"id":"https://openalex.org/I4210120329","display_name":"RTI Health Solutions","ror":"https://ror.org/032nh7f71","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670","https://openalex.org/I4210120329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Mellor","raw_affiliation_strings":["RTI Health Solutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008641121","display_name":"Manish R. Maski","orcid":"https://orcid.org/0000-0003-3010-2844","observed_orcids":["https://orcid.org/0000-0003-3010-2844"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manish Maski","raw_affiliation_strings":["Vertex Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143947186","display_name":"Wei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Lin","raw_affiliation_strings":["Vertex Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157901230","display_name":"Jiaxuan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxuan Liu","raw_affiliation_strings":["Vertex Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108153840","display_name":"Ching-Heng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120329","display_name":"RTI Health Solutions","ror":"https://ror.org/032nh7f71","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670","https://openalex.org/I4210120329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching-Heng Wu","raw_affiliation_strings":["RTI Health Solutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011194026","display_name":"Christine M. Poulos","orcid":"https://orcid.org/0000-0001-7810-3411","observed_orcids":["https://orcid.org/0000-0001-7810-3411"]},"institutions":[{"id":"https://openalex.org/I4210120329","display_name":"RTI Health Solutions","ror":"https://ror.org/032nh7f71","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670","https://openalex.org/I4210120329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Poulos","raw_affiliation_strings":["RTI Health Solutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108620199","display_name":"Beth Barber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Barber","raw_affiliation_strings":["Vertex Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals","institution_ids":["https://openalex.org/I61970326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019394563"],"corresponding_institution_ids":["https://openalex.org/I61970326"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.3264000117778778,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.3264000117778778,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-a-nephropathy","display_name":"immunoglobulin A nephropathy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/patient-preferences","display_name":"patient preferences","score":0.7739999890327454},{"id":"https://openalex.org/keywords/autoinjector","display_name":"autoinjector","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prefilled-syringes","display_name":"prefilled syringes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dosing-frequency","display_name":"dosing frequency","score":0.8840000033378601},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.9909999966621399},{"id":"https://openalex.org/keywords/injection-pain","display_name":"injection pain","score":0.7850000262260437},{"id":"https://openalex.org/keywords/psychological-burden","display_name":"psychological burden","score":0.8130000233650208},{"id":"https://openalex.org/keywords/shared-decision-making","display_name":"shared decision-making","score":0.9129999876022339},{"id":"https://openalex.org/keywords/device-preference","display_name":"device preference","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9750000238418579},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8439000248908997},{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.689300000667572},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.6043999791145325},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.602400004863739},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4625999927520752},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.3864000141620636},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.36059999465942383},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35850000381469727},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.31470000743865967},{"id":"https://openalex.org/C2781249084","wikidata":"https://www.wikidata.org/wiki/Q908656","display_name":"Preference","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3086000084877014},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2849000096321106},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.26820001006126404}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/03007995.2026.2758492","doi":"https://doi.org/10.1080/03007995.2026.2758492","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2026.2758492","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2026.2758492?needAccess=true","source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:43001846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43001846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/03007995.2026.2758492","doi":"https://doi.org/10.1080/03007995.2026.2758492","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2026.2758492","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2026.2758492?needAccess=true","source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312517","display_name":"Vertex Pharmaceuticals","ror":"https://ror.org/00anb1726"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225619738.pdf","grobid_xml":"https://content.openalex.org/works/W7225619738.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W2017534125","https://openalex.org/W2142225512","https://openalex.org/W2142507445","https://openalex.org/W2235318197","https://openalex.org/W2763510211","https://openalex.org/W2792037535","https://openalex.org/W2804599232","https://openalex.org/W2904268507","https://openalex.org/W2923029572","https://openalex.org/W3161072778","https://openalex.org/W3179656935","https://openalex.org/W3208645186","https://openalex.org/W4200006144","https://openalex.org/W4280650127","https://openalex.org/W4286504500","https://openalex.org/W4293798101","https://openalex.org/W4310350886","https://openalex.org/W4387308366","https://openalex.org/W4389199403","https://openalex.org/W4401656772","https://openalex.org/W4401715856","https://openalex.org/W4403637579","https://openalex.org/W4408230252","https://openalex.org/W4414335273","https://openalex.org/W7119081531","https://openalex.org/W7140799249"],"related_works":["https://openalex.org/W7224761593","https://openalex.org/W2915689952","https://openalex.org/W2158353417","https://openalex.org/W2014389606","https://openalex.org/W4313385420","https://openalex.org/W2892069777","https://openalex.org/W3153303568","https://openalex.org/W4414241838","https://openalex.org/W4401428163","https://openalex.org/W4386117106"],"abstract_inverted_index":{"Background":[0],"and":[1,24,32,65,71,86,98,147,214,222],"objective":[2],"Self-injectable":[3],"therapies":[4,37],"are":[5],"available":[6],"as":[7,200],"newer":[8],"treatment":[9,234],"options":[10],"for":[11,21,34,129],"Immunoglobulin":[12],"A":[13],"nephropathy":[14],"(IgAN),":[15],"but":[16,188],"evidence":[17],"on":[18],"patients\u2019":[19],"preferences":[20,33,224],"dosing,":[22],"administration,":[23],"tolerability":[25],"is":[26],"lacking.":[27],"This":[28],"study":[29],"explored":[30],"perceptions":[31],"self-administered":[35],"injectable":[36,233],"among":[38],"adults":[39],"with":[40,47,208,228,236,240],"IgAN":[41,48,76,209,241],"in":[42,53,75],"the":[43,69,108,111,130,201,212,217],"United":[44],"States.Methods":[45],"Adults":[46,207],"(n":[49],"=":[50],"25)":[51],"participated":[52],"semi-structured":[54],"virtual":[55],"interviews":[56],"lasting":[57],"up":[58],"to":[59,181,183],"60":[60],"min.":[61],"After":[62],"viewing":[63],"images":[64],"short":[66],"videos":[67],"of":[68],"autoinjector":[70,109,131,213],"prefilled":[72,112,126],"syringe":[73,113],"used":[74],"treatment,":[77],"participants":[78,106,166],"discussed":[79],"device":[80,221],"preferences,":[81],"dosing":[82,171,223],"frequency,":[83],"injection":[84,87],"volume":[85],"site":[88],"reactions":[89],"(ISRs)":[90],"using":[91,100],"a":[92,160,191,245],"discussion":[93],"guide.":[94],"Responses":[95],"were":[96],"audio-recorded":[97],"analyzed":[99],"directed":[101],"content":[102],"analysis.Results":[103],"Nearly":[104],"all":[105,120],"preferred":[107,167,211,216],"over":[110,169],"(96.0%":[114],"[24/25]":[115],"vs":[116,174],"4.0%":[117],"[1/25]),":[118],"including":[119],"four":[121],"currently":[122],"receiving":[123],"sibeprenlimab":[124],"via":[125],"syringe.":[127],"Preference":[128],"was":[132,197],"driven":[133],"by":[134],"perceived":[135],"or":[136],"expected":[137],"reduced":[138,141],"psychological":[139],"burden,":[140],"pain,":[142],"safer":[143],"handling,":[144],"increased":[145],"confidence,":[146],"user-friendliness":[148],"(e.g.":[149,177],"\u201c[\u2026]":[150,178],"not":[151,179],"seeing":[152],"it":[153,159],"[the":[154],"needle]":[155],"[\u2026]":[156],"just":[157],"makes":[158],"lot":[161],"easier.":[162],"Less":[163],"anxiety.\u201d).":[164],"Most":[165],"every-4-week":[168,218],"every-week":[170],"(80.0%":[172],"[20/25]":[173],"20.0%":[175],"[5/25])":[176],"having":[180],"remember":[182],"do":[184],"something":[185],"every":[186],"week,":[187],"instead":[189],"once":[190],"month":[192],"would":[193],"be":[194],"nice\u201d).":[195],"Pain":[196],"frequently":[198],"cited":[199],"most":[202],"bothersome":[203],"ISR":[204],"(64.0%":[205],"[16/25]).Conclusion":[206],"overwhelmingly":[210],"strongly":[215],"dosing.":[219],"Incorporating":[220],"into":[225],"shared":[226],"decision-making":[227],"nephrologists":[229],"may":[230],"better":[231],"align":[232],"choices":[235],"factors":[237],"that":[238],"patients":[239],"value":[242],"when":[243],"choosing":[244],"therapy.":[246]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}