{"id":"https://openalex.org/W7225619657","doi":"https://doi.org/10.3390/cimb48111182","title":"Integrative Identification of Comorbid Genes Linking ANCA-Associated Vasculitis and Bladder Cancer Using Single-Cell Transcriptomics and Mendelian Randomisation","display_name":"Integrative Identification of Comorbid Genes Linking ANCA-Associated Vasculitis and Bladder Cancer Using Single-Cell Transcriptomics and Mendelian Randomisation","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225619657","doi":"https://doi.org/10.3390/cimb48111182"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48111182","doi":"https://doi.org/10.3390/cimb48111182","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111182","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb48111182","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147750737","display_name":"Desheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Desheng Zhang","raw_affiliation_strings":["Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147795679","display_name":"Yunjin Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjin Bai","raw_affiliation_strings":["Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161326973","display_name":"Ping Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Han","raw_affiliation_strings":["Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5161326973"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"11","first_page":"1182","last_page":"1182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.17149999737739563,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anca-associated-vasculitis","display_name":"ANCA-associated vasculitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8539999723434448},{"id":"https://openalex.org/keywords/shared-genetic-risk","display_name":"shared genetic risk","score":0.8100000023841858},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.875},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.597000002861023},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/anca-associated-glomerulonephritis","display_name":"ANCA-associated glomerulonephritis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pseudotime-trajectory","display_name":"pseudotime trajectory","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7652000188827515},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6840000152587891},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5892000198364258},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.5486000180244446},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5180000066757202},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4763000011444092},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.4571000039577484},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.45669999718666077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42289999127388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4205999970436096},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4108000099658966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4081999957561493},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.39469999074935913},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3828999996185303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35359999537467957},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C2777374719","wikidata":"https://www.wikidata.org/wiki/Q7663822","display_name":"Systemic vasculitis","level":4,"score":0.3093999922275543},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C97669555","wikidata":"https://www.wikidata.org/wiki/Q4118435","display_name":"Molecular epidemiology","level":4,"score":0.2851000130176544},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C177860879","wikidata":"https://www.wikidata.org/wiki/Q5532897","display_name":"Genetic epidemiology","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/cimb48111182","doi":"https://doi.org/10.3390/cimb48111182","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111182","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/cimb48111182","doi":"https://doi.org/10.3390/cimb48111182","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111182","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326670","display_name":"Chengdu Science and Technology Bureau","ror":"https://ror.org/00xfea068"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W137802152","https://openalex.org/W1769783081","https://openalex.org/W1905058580","https://openalex.org/W1976587845","https://openalex.org/W1990353372","https://openalex.org/W2019732936","https://openalex.org/W2029562600","https://openalex.org/W2035618305","https://openalex.org/W2069089843","https://openalex.org/W2077243151","https://openalex.org/W2110065044","https://openalex.org/W2113699335","https://openalex.org/W2121637463","https://openalex.org/W2279785978","https://openalex.org/W2324862792","https://openalex.org/W2582033455","https://openalex.org/W2613603864","https://openalex.org/W2746848409","https://openalex.org/W2769218683","https://openalex.org/W2777019574","https://openalex.org/W2794480084","https://openalex.org/W2805983714","https://openalex.org/W3185102435","https://openalex.org/W3189664645","https://openalex.org/W3208830425","https://openalex.org/W4220819727","https://openalex.org/W4229004121","https://openalex.org/W4283211728","https://openalex.org/W4307432965","https://openalex.org/W4327568817","https://openalex.org/W4376645144","https://openalex.org/W4386547373","https://openalex.org/W4394824397","https://openalex.org/W4404330325","https://openalex.org/W4407034910","https://openalex.org/W4413805435","https://openalex.org/W4414085380","https://openalex.org/W4414853246","https://openalex.org/W4416185980","https://openalex.org/W7203889151"],"related_works":["https://openalex.org/W7133509666","https://openalex.org/W4414850895","https://openalex.org/W4396499158","https://openalex.org/W4405603420","https://openalex.org/W4413362071","https://openalex.org/W4407100520","https://openalex.org/W4388180245","https://openalex.org/W4414652279","https://openalex.org/W4360982817","https://openalex.org/W4415101578"],"abstract_inverted_index":{"Background:":[0],"Anti-neutrophil":[1],"cytoplasmic":[2],"antibody":[3],"(ANCA)-associated":[4],"vasculitis":[5],"(AAV)":[6],"is":[7,15],"an":[8],"immune-mediated":[9],"inflammatory":[10],"disorder,":[11],"and":[12,54,70,99,101,117,126,134,162,167,172,184,199,224,255,270],"bladder":[13,31,71,135,165],"cancer":[14,32,72,136,239,266],"a":[16,26,181,186,246],"common":[17],"urologic":[18],"malignancy.":[19],"Epidemiological":[20],"evidence":[21],"shows":[22],"AAV":[23,133,161],"patients":[24],"have":[25],"markedly":[27],"higher":[28],"risk":[29,187],"of":[30,44,213,264],"(OR":[33],"=":[34],"3.84;":[35],"95%":[36],"CI:":[37],"2.72\u20135.42).":[38],"However,":[39],"the":[40,77,132,141,261],"shared":[41,175,230],"genetic":[42],"basis":[43,263],"this":[45],"comorbidity":[46],"remains":[47],"unclear.":[48],"Here,":[49],"we":[50],"integrate":[51],"single-cell":[52],"transcriptomics":[53],"Mendelian":[55,87],"randomisation":[56,88],"to":[57,237,275],"explore":[58],"its":[59],"molecular":[60],"architecture.":[61],"Methods:":[62],"Single-cell":[63],"RNA-seq":[64],"data":[65],"for":[66,189],"ANCA-associated":[67],"glomerulonephritis":[68],"(GSE303481)":[69],"(GSE222315)":[73],"were":[74,129],"obtained":[75],"from":[76],"GEO.":[78],"We":[79],"identified":[80,153,170],"overlapping":[81,148],"monocyte":[82,217],"DEGs":[83],"after":[84],"Seurat":[85],"preprocessing.":[86],"was":[89],"conducted":[90],"using":[91],"five":[92],"complementary":[93],"methods":[94],"(IVW,":[95],"MR-Egger,":[96],"weighted":[97,102],"median,":[98],"simple":[100],"mode)":[103],"with":[104,156,178],"comprehensive":[105],"sensitivity":[106],"tests.":[107],"Further":[108,268],"analyses":[109],"covered":[110],"functional":[111],"enrichment,":[112],"gene":[113],"networks,":[114],"miRNA":[115],"prediction,":[116],"pseudotime":[118],"trajectories.":[119],"Results:":[120],"After":[121],"stringent":[122],"quality":[123],"control,":[124],"138,457":[125],"96,017":[127],"cells":[128],"retained":[130],"in":[131,195,219],"datasets,":[137],"respectively.":[138],"Monocytes":[139],"displayed":[140],"most":[142],"pronounced":[143],"transcriptional":[144,196,248],"alterations,":[145],"yielding":[146],"3288":[147],"candidate":[149,176],"genes.":[150],"MR":[151],"analysis":[152,169,206],"94":[154],"genes":[155,193,215],"putative":[157],"causal":[158],"effects":[159],"on":[160,164],"80":[163],"cancer,":[166],"intersection":[168],"SP1":[171,179],"GET4":[173,185,225],"as":[174],"genes,":[177],"showing":[180],"protective":[182],"association":[183,188],"both":[190,214,220],"diseases.":[191],"Both":[192],"participated":[194],"regulatory":[197,203,253],"programmes":[198],"exhibited":[200],"extensive":[201],"miRNA-mediated":[202],"interactions.":[204],"Pseudotime":[205],"further":[207],"revealed":[208],"disease-specific":[209,252],"dynamic":[210],"expression":[211],"trajectories":[212],"during":[216],"differentiation":[218],"disease":[221],"contexts.":[222],"Conclusions:SP1":[223],"may":[226,235,259],"represent":[227],"genetically":[228],"supported":[229],"susceptibility":[231],"factors":[232],"whose":[233],"dysregulation":[234],"contribute":[236],"AAV\u2013bladder":[238,265],"comorbidity.":[240,267],"Our":[241],"findings":[242],"provide":[243],"insights":[244],"into":[245],"monocyte-centric":[247],"programme":[249],"characterised":[250],"by":[251],"dynamics":[254],"immunoinflammatory":[256],"crosstalk":[257],"that":[258],"underlie":[260],"pathophysiological":[262],"experimental":[269],"independent":[271],"studies":[272],"are":[273],"warranted":[274],"validate":[276],"these":[277],"findings.":[278]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}