{"id":"https://openalex.org/W7225619263","doi":"https://doi.org/10.53941/jmnp.2026.100023","title":"Cardioprotective Effects of the Aqueous Leaf Extract of Asystasia vogeliana via Modulation of VCAM-1 and p53 in Anemia-Induced Rats","display_name":"Cardioprotective Effects of the Aqueous Leaf Extract of Asystasia vogeliana via Modulation of VCAM-1 and p53 in Anemia-Induced Rats","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225619263","doi":"https://doi.org/10.53941/jmnp.2026.100023"},"language":"en","primary_location":{"id":"doi:10.53941/jmnp.2026.100023","doi":"https://doi.org/10.53941/jmnp.2026.100023","is_oa":true,"landing_page_url":"https://doi.org/10.53941/jmnp.2026.100023","pdf_url":"https://media.sciltp.com/articles/2610005446/2610005446.pdf","source":{"id":"https://openalex.org/S5407040498","display_name":"Journal of Medicinal Natural Products","issn_l":"2982-1975","issn":["2982-1975"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://media.sciltp.com/articles/2610005446/2610005446.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014705912","display_name":"Basiru Olaitan Ajiboye","orcid":"https://orcid.org/0000-0001-5982-2322","observed_orcids":["https://orcid.org/0000-0001-5982-2322"]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Basiru Olaitan Ajiboye","raw_affiliation_strings":["Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017783787","display_name":"Olawale Razaq Ajuwon","orcid":"https://orcid.org/0000-0003-3958-1685","observed_orcids":["https://orcid.org/0000-0003-3958-1685"]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olawale Razaq Ajuwon","raw_affiliation_strings":["Redox Biology and Phytomedicine Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redox Biology and Phytomedicine Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161317108","display_name":"Abdullateef Olamide Babalola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Abdullateef Olamide Babalola","raw_affiliation_strings":["Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161361108","display_name":"Damilare Emmanuel Bamigboye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Damilare Emmanuel Bamigboye","raw_affiliation_strings":["Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161316369","display_name":"Olumide Adebola Alonge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olumide Adebola Alonge","raw_affiliation_strings":["Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161345406","display_name":"Oluwatosin Aliu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Oluwatosin Aliu","raw_affiliation_strings":["Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161361405","display_name":"Raimot Olabisi Ojedokun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123698207","display_name":"Fountain University","ror":"https://ror.org/00ah3j950","country_code":"NG","type":"education","lineage":["https://openalex.org/I123698207"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Raimot Olabisi Ojedokun","raw_affiliation_strings":["Nutritional Biochemistry Unit, Department of Chemical Sciences, Fountain University Osogbo, Osogbo 230284 Osun State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Biochemistry Unit, Department of Chemical Sciences, Fountain University Osogbo, Osogbo 230284 Osun State, Nigeria","institution_ids":["https://openalex.org/I123698207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161335610","display_name":"Sunday Abimbade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Sunday Abimbade","raw_affiliation_strings":["Natural Product Laboratory, Department of Chemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Laboratory, Department of Chemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161347917","display_name":"Mary Abiola Okesola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259080","display_name":"Augustine University, Ilara","ror":"https://ror.org/01q2py144","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405259080"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Mary Abiola Okesola","raw_affiliation_strings":["Biochemistry Unit, Department of Chemical Sciences, Augustine University, 106103 Ilara-Epe, Lagos, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Unit, Department of Chemical Sciences, Augustine University, 106103 Ilara-Epe, Lagos, Nigeria","institution_ids":["https://openalex.org/I4405259080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036093704","display_name":"Precious Eseose Agboinghale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Precious Eseose Agboinghale","raw_affiliation_strings":["Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092602513","display_name":"Ajoke Fehintola Idayat Akindele","orcid":"https://orcid.org/0000-0002-0559-8131","observed_orcids":["https://orcid.org/0000-0002-0559-8131"]},"institutions":[{"id":"https://openalex.org/I4387155186","display_name":"University of Medical Sciences, Ondo","ror":"https://ror.org/00q898q52","country_code":"NG","type":"education","lineage":["https://openalex.org/I4387155186"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ajoke Fehintola Idayat Akindele","raw_affiliation_strings":["Environmental Management and Toxicology Unit, Department of Biosciences and Biotechnology, Faculty of Sciences, University of Medical Sciences, Ondo City 351104, Ondo State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Management and Toxicology Unit, Department of Biosciences and Biotechnology, Faculty of Sciences, University of Medical Sciences, Ondo City 351104, Ondo State, Nigeria","institution_ids":["https://openalex.org/I4387155186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089070522","display_name":"Oluwafemi Adeleke Ojo","orcid":"https://orcid.org/0000-0001-9331-396X","observed_orcids":["https://orcid.org/0000-0001-9331-396X"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Oluwafemi Adeleke Ojo","raw_affiliation_strings":["Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0001-9331-396X","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029887767","display_name":"Babatunji Emmanuel Oyinloye","orcid":"https://orcid.org/0000-0003-2165-7936","observed_orcids":["https://orcid.org/0000-0003-2165-7936"]},"institutions":[{"id":"https://openalex.org/I43427933","display_name":"Federal University Oye Ekiti","ror":"https://ror.org/02q5h6807","country_code":"NG","type":"education","lineage":["https://openalex.org/I43427933"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Babatunji Emmanuel Oyinloye","raw_affiliation_strings":["Phytomedicine and Molecular Drug Discovery Laboratory (PMDDL), Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytomedicine and Molecular Drug Discovery Laboratory (PMDDL), Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 371104, Ekiti State, Nigeria","institution_ids":["https://openalex.org/I43427933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130724820","display_name":"Gamal Moustafa Mahmoud Abdelfattah","orcid":"https://orcid.org/0009-0002-7639-7684","observed_orcids":["https://orcid.org/0009-0002-7639-7684"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210156025","display_name":"Czech Academy of Sciences, Institute of Experimental Botany","ror":"https://ror.org/057br4398","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210156025"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Gamal Moustafa Mahmoud Abdelfattah","raw_affiliation_strings":["0 Laboratory of Growth Regulators, Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences, \u0160lechtitel\u016f 27, 78371 Olomouc, Czech Republic"],"raw_orcid":"https://orcid.org/0009-0002-7639-7684","affiliations":[{"raw_affiliation_string":"0 Laboratory of Growth Regulators, Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences, \u0160lechtitel\u016f 27, 78371 Olomouc, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210156025","https://openalex.org/I70703428"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.859000027179718},{"id":"https://openalex.org/keywords/2-4-dinitrophenylhydrazine","display_name":"2,4-dinitrophenylhydrazine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9919999837875366},{"id":"https://openalex.org/keywords/aqueous-leaf-extract","display_name":"aqueous leaf extract","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cardiac-injury","display_name":"cardiac injury","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.746999979019165},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.6080999970436096},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43950000405311584},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4207000136375427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4154999852180481},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40059998631477356},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.38370001316070557},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.37770000100135803},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C2776985958","wikidata":"https://www.wikidata.org/wiki/Q14901827","display_name":"VCAM-1","level":4,"score":0.35260000824928284},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3043999969959259},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2924000024795532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2922999858856201},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.53941/jmnp.2026.100023","doi":"https://doi.org/10.53941/jmnp.2026.100023","is_oa":true,"landing_page_url":"https://doi.org/10.53941/jmnp.2026.100023","pdf_url":"https://media.sciltp.com/articles/2610005446/2610005446.pdf","source":{"id":"https://openalex.org/S5407040498","display_name":"Journal of Medicinal Natural Products","issn_l":"2982-1975","issn":["2982-1975"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Natural Products","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.53941/jmnp.2026.100023","doi":"https://doi.org/10.53941/jmnp.2026.100023","is_oa":true,"landing_page_url":"https://doi.org/10.53941/jmnp.2026.100023","pdf_url":"https://media.sciltp.com/articles/2610005446/2610005446.pdf","source":{"id":"https://openalex.org/S5407040498","display_name":"Journal of Medicinal Natural Products","issn_l":"2982-1975","issn":["2982-1975"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Natural Products","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225619263.pdf","grobid_xml":"https://content.openalex.org/works/W7225619263.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1632163793","https://openalex.org/W1963479676","https://openalex.org/W1964719993","https://openalex.org/W1984547206","https://openalex.org/W1984829261","https://openalex.org/W2012469800","https://openalex.org/W2013673770","https://openalex.org/W2015230474","https://openalex.org/W2029076251","https://openalex.org/W2085458630","https://openalex.org/W2086446995","https://openalex.org/W2116291727","https://openalex.org/W2126807214","https://openalex.org/W2144473676","https://openalex.org/W2154673914","https://openalex.org/W2164089346","https://openalex.org/W2259977388","https://openalex.org/W2794944537","https://openalex.org/W2925546141","https://openalex.org/W2981325095","https://openalex.org/W3021628257","https://openalex.org/W3111901330","https://openalex.org/W3119318888","https://openalex.org/W4200308452","https://openalex.org/W4243483386","https://openalex.org/W4308591127","https://openalex.org/W4313025390","https://openalex.org/W4392857949"],"related_works":["https://openalex.org/W4281485359","https://openalex.org/W3011742071","https://openalex.org/W4401177286","https://openalex.org/W2890845017","https://openalex.org/W4386876516","https://openalex.org/W1230627018","https://openalex.org/W2372430272","https://openalex.org/W7163447565","https://openalex.org/W3189244280","https://openalex.org/W4415654964"],"abstract_inverted_index":{"This":[0],"study":[1],"evaluates":[2],"the":[3,14,23,29,91,94,96],"therapeutic":[4,194],"potential":[5],"of":[6,16,32,77,93,117,141],"Asystasia":[7],"vogeliana":[8,171],"(AV)":[9],"aqueous":[10,172],"leaf":[11],"extract":[12,61,173],"on":[13],"expression":[15,115,145],"vascular":[17],"cell":[18],"adhesion":[19],"molecule":[20],"(VCAM)":[21],"and":[22,64,69,100,108,114,119,137,143,177,193],"tumor":[24],"suppressor":[25],"protein":[26],"p53":[27,120,144],"in":[28,134,157,180],"cardiac":[30,162,182],"tissue":[31],"rats":[33,40,130,150],"rendered":[34],"anemic":[35,129,149],"with":[36,74,161],"2,4-dinitrophenylhydrazine":[37],"(DNPH).":[38],"Forty":[39],"were":[41,98,104,122],"randomly":[42],"assigned":[43],"to":[44,147,188],"five":[45],"groups:":[46],"a":[47,51,70,81,138,155],"normal":[48],"control":[49],"group,":[50],"DNPH-induced":[52,57,71],"group":[53,72],"without":[54],"treatment,":[55],"two":[56],"groups":[58],"receiving":[59],"AV":[60],"at":[62],"200":[63,75],"400":[65],"mg/kg":[66,76],"body":[67],"weight,":[68],"treated":[73],"vitamin":[78],"B12":[79],"as":[80],"standard":[82],"reference.":[83],"All":[84],"treatments":[85],"lasted":[86],"for":[87,106],"29":[88],"days.":[89],"At":[90],"conclusion":[92],"study,":[95],"animals":[97],"sacrificed,":[99],"their":[101],"heart":[102],"tissues":[103],"harvested":[105],"biochemical":[107],"molecular":[109],"assessments.":[110],"Serum":[111],"lipid":[112,135],"profiles":[113],"levels":[116],"VCAM":[118,142],"proteins":[121],"assessed.":[123],"The":[124],"results":[125],"showed":[126],"that":[127,169],"AV-treated":[128],"exhibited":[131],"significant":[132],"improvements":[133],"parameters":[136],"marked":[139],"downregulation":[140],"compared":[146],"untreated":[148],"(p":[151],"<":[152],"0.05).":[153],"Additionally,":[154],"reduction":[156],"pro-inflammatory":[158],"cytokines":[159],"associated":[160],"injury":[163],"was":[164],"observed.":[165],"These":[166],"findings":[167],"suggest":[168],"A.":[170],"may":[174],"have":[175],"cardioprotective":[176],"anti-inflammatory":[178],"effects":[179],"anemia-induced":[181],"damage.":[183],"Further":[184],"investigations":[185],"are":[186],"warranted":[187],"fully":[189],"elucidate":[190],"its":[191],"mechanisms":[192],"potential.":[195]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}