{"id":"https://openalex.org/W7225618922","doi":"https://doi.org/10.1007/s44313-026-00189-4","title":"Real-world outcomes of CHASE therapy as salvage or bridging treatment for relapsed or refractory non-Hodgkin lymphoma","display_name":"Real-world outcomes of CHASE therapy as salvage or bridging treatment for relapsed or refractory non-Hodgkin lymphoma","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225618922","doi":"https://doi.org/10.1007/s44313-026-00189-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002332"},"language":"en","primary_location":{"id":"doi:10.1007/s44313-026-00189-4","doi":"https://doi.org/10.1007/s44313-026-00189-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44313-026-00189-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44313-026-00189-4.pdf","source":{"id":"https://openalex.org/S2764367232","display_name":"Blood Research","issn_l":"2287-979X","issn":["2287-979X","2288-0011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","oarl","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s44313-026-00189-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045637944","display_name":"Ryutaro Tominaga","orcid":"https://orcid.org/0000-0003-2113-7631","observed_orcids":["https://orcid.org/0000-0003-2113-7631"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryutaro Tominaga","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2113-7631","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064956018","display_name":"Kento Umino","orcid":"https://orcid.org/0000-0001-6791-0007","observed_orcids":["https://orcid.org/0000-0001-6791-0007"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kento Umino","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6791-0007","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161331086","display_name":"Tomonori Honda","orcid":"https://orcid.org/0009-0001-4198-7679","observed_orcids":["https://orcid.org/0009-0001-4198-7679"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Honda","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0009-0001-4198-7679","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036723936","display_name":"Yoshika Saito","orcid":"https://orcid.org/0009-0003-5971-2256","observed_orcids":["https://orcid.org/0009-0003-5971-2256"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshika Saito","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0009-0003-5971-2256","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051210056","display_name":"Seina Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seina Honda","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051832482","display_name":"Daizo Yokoyama","orcid":"https://orcid.org/0009-0004-1500-2292","observed_orcids":["https://orcid.org/0009-0004-1500-2292"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daizo Yokoyama","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0009-0004-1500-2292","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045972058","display_name":"Atsuto Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuto Noguchi","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061965156","display_name":"Shuka Furuki","orcid":"https://orcid.org/0009-0008-6495-2699","observed_orcids":["https://orcid.org/0009-0008-6495-2699"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuka Furuki","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0009-0008-6495-2699","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023554299","display_name":"Shunsuke Koyama","orcid":"https://orcid.org/0009-0001-4397-0643","observed_orcids":["https://orcid.org/0009-0001-4397-0643"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Koyama","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0009-0001-4397-0643","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016528603","display_name":"Rui Murahashi","orcid":"https://orcid.org/0009-0000-1479-0101","observed_orcids":["https://orcid.org/0009-0000-1479-0101"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rui Murahashi","raw_affiliation_strings":["Division of Cell Transplantation and Transfusion, Jichi Medical University, Jichi Medical University, 3311-1 Yakushiji, Tochigi, 329-0498, Japan","Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0009-0000-1479-0101","affiliations":[{"raw_affiliation_string":"Division of Cell Transplantation and Transfusion, Jichi Medical University, Jichi Medical University, 3311-1 Yakushiji, Tochigi, 329-0498, Japan","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013660885","display_name":"Hirotomo Nakashima","orcid":"https://orcid.org/0000-0003-2262-6699","observed_orcids":["https://orcid.org/0000-0003-2262-6699"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotomo Nakashima","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2262-6699","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158910210","display_name":"Kazuki Hyodo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Hyodo","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039784657","display_name":"Yumiko Toda","orcid":"https://orcid.org/0000-0001-6770-0579","observed_orcids":["https://orcid.org/0000-0001-6770-0579"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Toda","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067697483","display_name":"Daisuke Minakata","orcid":"https://orcid.org/0000-0001-7529-5585","observed_orcids":["https://orcid.org/0000-0001-7529-5585","https://orcid.org/0000-0002-0217-8107"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Minakata","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7529-5585","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113603442","display_name":"Masahiro Ashizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Ashizawa","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079581197","display_name":"Chihiro Yamamoto","orcid":"https://orcid.org/0000-0002-5333-8414","observed_orcids":["https://orcid.org/0000-0002-5333-8414"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chihiro Yamamoto","raw_affiliation_strings":["Division of Cell Transplantation and Transfusion, Jichi Medical University, Jichi Medical University, 3311-1 Yakushiji, Tochigi, 329-0498, Japan","Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5333-8414","affiliations":[{"raw_affiliation_string":"Division of Cell Transplantation and Transfusion, Jichi Medical University, Jichi Medical University, 3311-1 Yakushiji, Tochigi, 329-0498, Japan","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021720893","display_name":"Kaoru Hatano","orcid":"https://orcid.org/0000-0001-9159-3398","observed_orcids":["https://orcid.org/0000-0001-9159-3398"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Hatano","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9159-3398","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089194366","display_name":"Kazuya Sato","orcid":"https://orcid.org/0000-0003-2876-4224","observed_orcids":["https://orcid.org/0000-0003-2876-4224"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Sato","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2876-4224","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012157148","display_name":"Ken Ohmine","orcid":"https://orcid.org/0000-0001-6847-3056","observed_orcids":["https://orcid.org/0000-0001-6847-3056"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Ohmine","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013574242","display_name":"Shin\u2010ichiro Fujiwara","orcid":"https://orcid.org/0000-0002-4523-2994","observed_orcids":["https://orcid.org/0000-0002-4523-2994"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210153031","display_name":"Jichi Medical University Hospital","ror":"https://ror.org/04at0zw32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichiro Fujiwara","raw_affiliation_strings":["Division of Cell Transplantation and Transfusion, Jichi Medical University, Jichi Medical University, 3311-1 Yakushiji, Tochigi, 329-0498, Japan","Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4523-2994","affiliations":[{"raw_affiliation_string":"Division of Cell Transplantation and Transfusion, Jichi Medical University, Jichi Medical University, 3311-1 Yakushiji, Tochigi, 329-0498, Japan","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210153031"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009975594","display_name":"Yoshinobu Kanda","orcid":"https://orcid.org/0000-0002-4866-9307","observed_orcids":["https://orcid.org/0000-0002-4866-9307"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshinobu Kanda","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. ycanda-tky@umin.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-4866-9307","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. ycanda-tky@umin.ac.jp","institution_ids":["https://openalex.org/I146500386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009975594"],"corresponding_institution_ids":["https://openalex.org/I146500386"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsed-or-refractory-non-hodgkin-lymphoma","display_name":"relapsed or refractory non-Hodgkin lymphoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bridging-therapy","display_name":"bridging therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6579999923706055},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9575999975204468},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.8223999738693237},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7724999785423279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6230000257492065},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.486299991607666},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4821999967098236},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4726000130176544},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45899999141693115},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4519999921321869},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.41929998993873596},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.39070001244544983},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.350600004196167},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3402000069618225},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C3018657049","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Complete remission","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.2540999948978424},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s44313-026-00189-4","doi":"https://doi.org/10.1007/s44313-026-00189-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44313-026-00189-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44313-026-00189-4.pdf","source":{"id":"https://openalex.org/S2764367232","display_name":"Blood Research","issn_l":"2287-979X","issn":["2287-979X","2288-0011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","oarl","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Research","raw_type":"journal-article"},{"id":"pmid:43002332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s44313-026-00189-4","doi":"https://doi.org/10.1007/s44313-026-00189-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s44313-026-00189-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s44313-026-00189-4.pdf","source":{"id":"https://openalex.org/S2764367232","display_name":"Blood Research","issn_l":"2287-979X","issn":["2287-979X","2288-0011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","kci-registered","oarl","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225618922.pdf","grobid_xml":"https://content.openalex.org/works/W7225618922.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W180728216","https://openalex.org/W1940892707","https://openalex.org/W2021484315","https://openalex.org/W2054714021","https://openalex.org/W2069071811","https://openalex.org/W2086108274","https://openalex.org/W2119147717","https://openalex.org/W2121960517","https://openalex.org/W2131395115","https://openalex.org/W2133345449","https://openalex.org/W2137348614","https://openalex.org/W2150587745","https://openalex.org/W2744261860","https://openalex.org/W3186874033","https://openalex.org/W4283023614","https://openalex.org/W4285492548","https://openalex.org/W4403508472","https://openalex.org/W4413885244","https://openalex.org/W7134817291"],"related_works":["https://openalex.org/W2069071811","https://openalex.org/W2054714021","https://openalex.org/W2968223450","https://openalex.org/W2346252839","https://openalex.org/W3027036348","https://openalex.org/W2082670418","https://openalex.org/W7214287163","https://openalex.org/W2327027751","https://openalex.org/W1982093470","https://openalex.org/W7220205475"],"abstract_inverted_index":{"PURPOSE:":[0],"CHASE":[1,24,60,162,199],"(cyclophosphamide,":[2],"high-dose":[3],"cytarabine,":[4],"dexamethasone,":[5],"and":[6,11,21,43,68,80,92,101,107,131,180],"etoposide)":[7],"is":[8],"an":[9],"anthracycline-":[10,79],"platinum-free":[12],"salvage":[13,37],"regimen.":[14],"This":[15],"study":[16],"evaluated":[17],"the":[18,168],"real-world":[19],"efficacy":[20],"safety":[22],"of":[23],"in":[25,174,182,210],"relapsed":[26,54,214],"or":[27,38,55,166,215],"refractory":[28,56,152,216],"non-Hodgkin":[29],"lymphoma":[30],"(NHL),":[31],"focusing":[32],"on":[33],"its":[34],"role":[35],"as":[36,75,163],"bridging":[39],"therapy":[40,45,165,179],"before":[41,205],"transplantation":[42],"cellular":[44],"(TCT).":[46],"METHODS:":[47],"We":[48],"retrospectively":[49],"analyzed":[50],"53":[51],"patients":[52,112,142,150,159,212],"with":[53,137,143,151,161,184,213],"NHL":[57],"who":[58],"received":[59],"at":[61],"Jichi":[62],"Medical":[63],"University":[64],"Hospital":[65],"between":[66],"2014":[67],"2026.":[69],"Double-refractory":[70],"(DR)":[71],"disease":[72,133,145,153,203],"was":[73,125],"defined":[74],"refractoriness":[76],"to":[77,120,155,177,207],"both":[78],"platinum-based":[81],"regimens.":[82],"Progression-free":[83],"survival":[84,87],"(PFS),":[85],"overall":[86,99],"(OS),":[88],"response,":[89,148],"TCT":[90,209],"completion,":[91],"adverse":[93],"events":[94],"were":[95,105,134,172,190,196],"assessed.":[96],"RESULTS:":[97],"The":[98,122],"response":[100,103],"complete":[102,147],"rates":[104,171],"47.2%":[106],"32.1%,":[108],"respectively.":[109],"Among":[110,158],"43":[111],"considered":[113],"eligible":[114],"for":[115],"TCT,":[116],"36":[117],"(83.7%)":[118],"proceeded":[119,154],"TCT.":[121,157],"median":[123],"PFS":[124],"138":[126],"days.":[127],"Poor":[128],"performance":[129],"status":[130],"DR":[132,144],"independently":[135],"associated":[136],"shorter":[138],"PFS.":[139],"Although":[140],"no":[141],"achieved":[146],"selected":[149,211],"subsequent":[156],"treated":[160],"third-line":[164],"later,":[167],"3-year":[169],"OS":[170],"54.8%":[173],"those":[175,183],"unresponsive":[176],"prior":[178],"54.3%":[181],"platinum-refractory":[185],"disease.":[186],"Severe":[187],"hematologic":[188],"toxicities":[189,195],"frequent,":[191],"whereas":[192],"severe":[193],"nonhematologic":[194],"infrequent.":[197],"CONCLUSION:":[198],"may":[200],"provide":[201],"temporary":[202],"control":[204],"transition":[206],"appropriate":[208],"NHL.":[217]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}