{"id":"https://openalex.org/W7225618732","doi":"https://doi.org/10.1021/acs.nanolett.6c03677","title":"Atomically Precise Au14V1 Clusters Selectively Block the Neutrophil Elastase-NETosis Axis","display_name":"Atomically Precise Au14V1 Clusters Selectively Block the Neutrophil Elastase-NETosis Axis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225618732","doi":"https://doi.org/10.1021/acs.nanolett.6c03677"},"language":"en","primary_location":{"id":"doi:10.1021/acs.nanolett.6c03677","doi":"https://doi.org/10.1021/acs.nanolett.6c03677","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.6c03677","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102640097","display_name":"Sufei Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sufei Zhou","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076409839","display_name":"Yili Wang","orcid":"https://orcid.org/0009-0004-2637-565X","observed_orcids":["https://orcid.org/0009-0004-2637-565X"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yili Wang","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161339450","display_name":"Guo Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo Li","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104105571","display_name":"Hongli Yu","orcid":"https://orcid.org/0009-0000-0502-4384","observed_orcids":["https://orcid.org/0009-0000-0502-4384"]},"institutions":[{"id":"https://openalex.org/I2800200322","display_name":"Tianjin First Center Hospital","ror":"https://ror.org/02ch1zb66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800200322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongli Yu","raw_affiliation_strings":["Tianjin First Central Hospital , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin First Central Hospital , , ,","institution_ids":["https://openalex.org/I2800200322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140880013","display_name":"Chenxi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenxi Li","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101522401","display_name":"Si Sun","orcid":"https://orcid.org/0009-0000-9880-8929","observed_orcids":["https://orcid.org/0009-0000-9880-8929"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si Sun","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101832789","display_name":"Xin Qi","orcid":"https://orcid.org/0009-0007-4351-9186","observed_orcids":["https://orcid.org/0009-0007-4351-9186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Xin","raw_affiliation_strings":["Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases , , ,"],"raw_orcid":"https://orcid.org/0009-0007-4351-9186","affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101943345","display_name":"Nan Song","orcid":"https://orcid.org/0000-0001-6542-1488","observed_orcids":["https://orcid.org/0000-0001-6542-1488"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Song","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161342623","display_name":"Di Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Liu","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077277862","display_name":"Xiaodong Zhang","orcid":"https://orcid.org/0000-0002-7212-0138","observed_orcids":["https://orcid.org/0000-0002-7212-0138"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Dong Zhang","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7212-0138","affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101601481","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0002-2882-9596","observed_orcids":["https://orcid.org/0000-0002-2882-9596","https://orcid.org/0000-0001-9990-2714"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Tianjin University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2882-9596","affiliations":[{"raw_affiliation_string":"Tianjin University , , ,","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077277862","https://openalex.org/A5101601481"],"corresponding_institution_ids":["https://openalex.org/I162868743"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12149","display_name":"Nanocluster Synthesis and Applications","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12149","display_name":"Nanocluster Synthesis and Applications","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/netosis","display_name":"NETosis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/gold-clusters","display_name":"gold clusters","score":0.7670000195503235},{"id":"https://openalex.org/keywords/vanadium-doping","display_name":"vanadium doping","score":0.7239999771118164},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neutrophilic-inflammation","display_name":"neutrophilic inflammation","score":0.722000002861023},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.6679999828338623},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6442999839782715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5601999759674072},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5533999800682068},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4869000017642975},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.4602999985218048},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.4323999881744385},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43130001425743103},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4081999957561493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3928999900817871},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.37940001487731934},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3131999969482422},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28929999470710754},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.26829999685287476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.nanolett.6c03677","doi":"https://doi.org/10.1021/acs.nanolett.6c03677","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.6c03677","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null},{"id":"https://openalex.org/F4320336125","display_name":"National Science Fund for Distinguished Young Scholars","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W3111332991","https://openalex.org/W3118586537","https://openalex.org/W3130881036","https://openalex.org/W3161028058","https://openalex.org/W3197109059","https://openalex.org/W3202236753","https://openalex.org/W4200262752","https://openalex.org/W4308549696","https://openalex.org/W4308766980","https://openalex.org/W4309046889","https://openalex.org/W4309825881","https://openalex.org/W4318753541","https://openalex.org/W4320920463","https://openalex.org/W4366086045","https://openalex.org/W4377691296","https://openalex.org/W4379880075","https://openalex.org/W4385253281","https://openalex.org/W4385481117","https://openalex.org/W4386498961","https://openalex.org/W4387768734","https://openalex.org/W4387949078","https://openalex.org/W4392044449","https://openalex.org/W4392302538","https://openalex.org/W4395013110","https://openalex.org/W4399465424","https://openalex.org/W4399866645","https://openalex.org/W4400441634","https://openalex.org/W4401422774","https://openalex.org/W4401574918","https://openalex.org/W4401814345","https://openalex.org/W4402630519","https://openalex.org/W4402844802","https://openalex.org/W4404054116","https://openalex.org/W4405003160","https://openalex.org/W4406525837","https://openalex.org/W4408569336","https://openalex.org/W4409665417","https://openalex.org/W4410807894","https://openalex.org/W4412016161","https://openalex.org/W4412521966","https://openalex.org/W4413110604","https://openalex.org/W4414023672","https://openalex.org/W4414280026","https://openalex.org/W4415512638","https://openalex.org/W4417290815","https://openalex.org/W7116739527","https://openalex.org/W7117303828","https://openalex.org/W7122448237","https://openalex.org/W7123354191","https://openalex.org/W7123831670","https://openalex.org/W7129059681"],"related_works":["https://openalex.org/W3211088703","https://openalex.org/W3030687589","https://openalex.org/W4404831866","https://openalex.org/W4379467234","https://openalex.org/W1956031789","https://openalex.org/W1999645527","https://openalex.org/W7201852036","https://openalex.org/W2088888142","https://openalex.org/W4224314904","https://openalex.org/W2624871753"],"abstract_inverted_index":{"Abstract":[0],"Neutrophil":[1],"elastase":[2],"(NE)":[3],"is":[4],"a":[5,50,79,134],"key":[6],"driver":[7],"of":[8,60,88],"neutrophil-mediated":[9],"inflammation":[10,32],"and":[11,33,53,106,116,122,128,143],"tissue":[12,126],"injury":[13,110],"across":[14],"diverse":[15],"diseases.":[16],"However,":[17],"current":[18],"NE":[19,55,67,77,114],"inhibitors":[20],"often":[21],"lack":[22],"sufficient":[23],"target":[24],"selectivity,":[25],"limiting":[26],"their":[27],"therapeutic":[28],"efficacy":[29],"in":[30],"suppressing":[31],"promoting":[34],"organ":[35],"repair.":[36],"Here,":[37],"we":[38],"report":[39],"that":[40,74],"single-atom":[41,135],"V":[42],"doping":[43],"programs":[44],"atomically":[45],"precise":[46,144],"Au15":[47],"clusters":[48],"into":[49],"relatively":[51],"selective":[52,63,140],"potent":[54],"inhibitor.":[56],"The":[57],"ultrasmall":[58],"size":[59],"Au14V1":[61,75,112],"enables":[62],"accommodation":[64],"within":[65],"the":[66,147],"binding":[68],"pocket.":[69],"Multiscale":[70],"mechanistic":[71],"analyses":[72],"demonstrated":[73],"inhibits":[76],"through":[78],"reversible":[80],"mixed":[81],"inhibition":[82,86,101],"mechanism":[83],"with":[84],"an":[85],"rate":[87],"87.6%,":[89],"while":[90],"exhibiting":[91],"minimal":[92],"activity":[93,115],"toward":[94,102],"closely":[95],"related":[96],"proteases,":[97],"highlighting":[98],"its":[99],"preferential":[100],"NE.":[103],"In":[104],"LPS-":[105],"CLP-induced":[107],"systemic":[108],"inflammatory":[109,123],"models,":[111],"reduced":[113],"NET":[117],"formation,":[118],"alleviated":[119],"oxidative":[120],"stress":[121],"responses,":[124],"mitigated":[125],"injury,":[127],"improved":[129],"survival.":[130],"These":[131],"findings":[132],"establish":[133],"engineering":[136],"strategy":[137],"for":[138],"developing":[139],"enzyme":[141],"modulators":[142],"therapy":[145],"targeting":[146],"NE-NETosis":[148],"axis.":[149]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}