{"id":"https://openalex.org/W7225617629","doi":"https://doi.org/10.3390/brainsci16111225","title":"BioEdge-Rx: From Regenerative Control States to Biologically Compilable Therapeutic Policies for Optic Nerve Repair","display_name":"BioEdge-Rx: From Regenerative Control States to Biologically Compilable Therapeutic Policies for Optic Nerve Repair","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225617629","doi":"https://doi.org/10.3390/brainsci16111225"},"language":"en","primary_location":{"id":"doi:10.3390/brainsci16111225","doi":"https://doi.org/10.3390/brainsci16111225","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci16111225","pdf_url":null,"source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/brainsci16111225","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160582891","display_name":"Razvan Buga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122748864","display_name":"\"Dunarea de Jos\" University of Galati","ror":"https://ror.org/052sta926","country_code":"RO","type":"education","lineage":["https://openalex.org/I3122748864"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"R\u0103zvan Buga","raw_affiliation_strings":["Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","institution_ids":[]},{"raw_affiliation_string":"Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania","institution_ids":["https://openalex.org/I3122748864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035422569","display_name":"C\u0103lin Gheorghe Buzea","orcid":"https://orcid.org/0000-0003-2791-3400","observed_orcids":["https://orcid.org/0000-0003-2791-3400"]},"institutions":[{"id":"https://openalex.org/I4210158639","display_name":"National Institute of Research and Development for Technical Physics","ror":"https://ror.org/05dv4bz40","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210158639"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"C\u0103lin Gheorghe Buzea","raw_affiliation_strings":["Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","National Institute of Research and Development for Technical Physics, IFT Ia\u0219i, 700050 Ia\u0219i, Romania"],"raw_orcid":"https://orcid.org/0000-0003-2791-3400","affiliations":[{"raw_affiliation_string":"Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Research and Development for Technical Physics, IFT Ia\u0219i, 700050 Ia\u0219i, Romania","institution_ids":["https://openalex.org/I4210158639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026798837","display_name":"Florin Nedeff","orcid":"https://orcid.org/0000-0003-3863-6904","observed_orcids":["https://orcid.org/0000-0003-3863-6904"]},"institutions":[{"id":"https://openalex.org/I4210142575","display_name":"University of Bac\u0103u","ror":"https://ror.org/03x3axr33","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210142575"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Florin Nedeff","raw_affiliation_strings":["Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania"],"raw_orcid":"https://orcid.org/0000-0003-3863-6904","affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania","institution_ids":["https://openalex.org/I4210142575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020304445","display_name":"Valentin Nedeff","orcid":"https://orcid.org/0000-0003-4408-2688","observed_orcids":["https://orcid.org/0000-0003-4408-2688"]},"institutions":[{"id":"https://openalex.org/I4210142575","display_name":"University of Bac\u0103u","ror":"https://ror.org/03x3axr33","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210142575"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Valentin Nedeff","raw_affiliation_strings":["Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania","institution_ids":["https://openalex.org/I4210142575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023025134","display_name":"Diana Miril\u0103","orcid":"https://orcid.org/0000-0002-0922-740X","observed_orcids":["https://orcid.org/0000-0002-0922-740X"]},"institutions":[{"id":"https://openalex.org/I4210142575","display_name":"University of Bac\u0103u","ror":"https://ror.org/03x3axr33","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210142575"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Diana Miril\u0103","raw_affiliation_strings":["Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania"],"raw_orcid":"https://orcid.org/0000-0002-0922-740X","affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania","institution_ids":["https://openalex.org/I4210142575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075070779","display_name":"Mirela Panainte-Leh\u0103du\u0219","orcid":"https://orcid.org/0000-0002-8582-1988","observed_orcids":["https://orcid.org/0000-0002-8582-1988"]},"institutions":[{"id":"https://openalex.org/I4210142575","display_name":"University of Bac\u0103u","ror":"https://ror.org/03x3axr33","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210142575"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mirela Panainte-Leh\u0103du\u0219","raw_affiliation_strings":["Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania"],"raw_orcid":"https://orcid.org/0000-0002-8582-1988","affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania","institution_ids":["https://openalex.org/I4210142575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001789544","display_name":"Maricel Agop","orcid":"https://orcid.org/0000-0003-2293-5803","observed_orcids":["https://orcid.org/0000-0003-2293-5803"]},"institutions":[{"id":"https://openalex.org/I4210142575","display_name":"University of Bac\u0103u","ror":"https://ror.org/03x3axr33","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210142575"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Maricel Agop","raw_affiliation_strings":["Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, Mechanical Engineering and Agritourism, Faculty of Engineering, \u201cVasile Alecsandri\u201d University of Bac\u0103u, 600115 Bac\u0103u, Romania","institution_ids":["https://openalex.org/I4210142575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117651711","display_name":"Leti\u021bia Doina Duceac","orcid":"https://orcid.org/0000-0002-1652-2618","observed_orcids":["https://orcid.org/0000-0002-1652-2618"]},"institutions":[{"id":"https://openalex.org/I3122748864","display_name":"\"Dunarea de Jos\" University of Galati","ror":"https://ror.org/052sta926","country_code":"RO","type":"education","lineage":["https://openalex.org/I3122748864"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Leti\u021bia Doina Duceac","raw_affiliation_strings":["Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"],"raw_orcid":"https://orcid.org/0000-0002-1652-2618","affiliations":[{"raw_affiliation_string":"Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","institution_ids":[]},{"raw_affiliation_string":"Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania","institution_ids":["https://openalex.org/I3122748864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073617988","display_name":"Ioana \u0218tirban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122748864","display_name":"\"Dunarea de Jos\" University of Galati","ror":"https://ror.org/052sta926","country_code":"RO","type":"education","lineage":["https://openalex.org/I3122748864"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ioana \u0218tirban","raw_affiliation_strings":["Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","institution_ids":[]},{"raw_affiliation_string":"Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania","institution_ids":["https://openalex.org/I3122748864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110531681","display_name":"Lucian Eva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122748864","display_name":"\"Dunarea de Jos\" University of Galati","ror":"https://ror.org/052sta926","country_code":"RO","type":"education","lineage":["https://openalex.org/I3122748864"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Lucian Eva","raw_affiliation_strings":["Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Emergency Hospital \u201cProf. Dr. Nicolae Oblu\u201d Ia\u0219i, 700309 Ia\u0219i, Romania","institution_ids":[]},{"raw_affiliation_string":"Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania","institution_ids":["https://openalex.org/I3122748864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023025134","https://openalex.org/A5117651711"],"corresponding_institution_ids":["https://openalex.org/I3122748864","https://openalex.org/I4210142575"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"1225","last_page":"1225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optic-nerve-injury","display_name":"optic nerve injury","score":0.7559999823570251},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.4819999933242798},{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"model predictive control","score":0.8519999980926514},{"id":"https://openalex.org/keywords/out-of-distribution-generalization","display_name":"out-of-distribution generalization","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4300000071525574},{"id":"https://openalex.org/keywords/engineering-simulator","display_name":"engineering simulator","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.708299994468689},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.597100019454956},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5001000165939331},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.48159998655319214},{"id":"https://openalex.org/C45340560","wikidata":"https://www.wikidata.org/wiki/Q215382","display_name":"Disjoint sets","level":2,"score":0.4717999994754791},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40939998626708984},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3797999918460846},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37279999256134033},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.35089999437332153},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.29490000009536743},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C2778067643","wikidata":"https://www.wikidata.org/wiki/Q166507","display_name":"Interval (graph theory)","level":2,"score":0.2854999899864197},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.2833000123500824},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27549999952316284},{"id":"https://openalex.org/C84525736","wikidata":"https://www.wikidata.org/wiki/Q831366","display_name":"Decision tree","level":2,"score":0.25920000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/brainsci16111225","doi":"https://doi.org/10.3390/brainsci16111225","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci16111225","pdf_url":null,"source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/brainsci16111225","doi":"https://doi.org/10.3390/brainsci16111225","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci16111225","pdf_url":null,"source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7205707860","https://openalex.org/W2991550077","https://openalex.org/W2761999424","https://openalex.org/W2757058492","https://openalex.org/W1487518386","https://openalex.org/W2892237362","https://openalex.org/W2116899091","https://openalex.org/W6992395667","https://openalex.org/W7099524187","https://openalex.org/W2081397000"],"abstract_inverted_index":{"Background/Objectives:":[0],"Distinct":[1],"responses":[2],"to":[3,57,152,166],"optic-nerve":[4],"injury":[5],"motivate":[6],"multidimensional,":[7],"state-dependent":[8,188],"control":[9,149],"rather":[10],"than":[11,156],"a":[12,59,187],"universal":[13],"regeneration":[14],"score.":[15],"We":[16],"tested":[17],"whether":[18],"public":[19,33],"perturbational":[20],"transcriptomes":[21],"could":[22],"define":[23],"interpretable":[24],"states":[25],"and":[26,62,97,109,120,129,169],"support":[27],"computational":[28,184],"policy":[29,189],"compression.":[30],"Methods:":[31],"Five":[32],"mouse":[34],"datasets":[35],"were":[36,77],"analyzed":[37],"using":[38],"six":[39,105],"prespecified":[40],"biological":[41,201],"modules.":[42],"Zero-preserving":[43],"transformed":[44],"treatment\u2013control":[45],"effects":[46],"defined":[47],"nine":[48],"perturbation":[49],"anchors.":[50],"A":[51,89,100],"16-region":[52],"engineering":[53,171],"simulator":[54],"was":[55],"used":[56],"retrain":[58],"gradient-boosting":[60],"student":[61,92],"select":[63],"an":[64,191],"explicit":[65],"decision":[66],"tree":[67,102],"in":[68,116],"disjoint":[69],"simulated":[70],"episode":[71,167],"cohorts.":[72],"Results:":[73],"Longitudinal":[74],"treatment-response":[75],"correlations":[76],"0.177\u20130.406,":[78],"while":[79],"same-time":[80],"PTEN-derived":[81],"interventions":[82],"remained":[83],"non-identical":[84],"(pairwise":[85],"Spearman":[86],"rho":[87],"0.670\u20130.787).":[88],"newly":[90],"trained":[91],"attained":[93],"85.67%":[94],"action-label":[95],"accuracy":[96],"macro-F1":[98],"0.598.":[99],"depth-3":[101],"(eight":[103],"leaves,":[104],"features)":[106],"retained":[107],"98.59%":[108],"98.62%":[110],"of":[111,127,176,186,207],"the":[112,138,143,157,174,177],"recalibrated":[113],"MPC":[114],"objective":[115],"120":[117,121],"independent":[118],"Standard":[119,139],"OOD":[122,162],"episodes,":[123],"with":[124],"failure-rate":[125],"differences":[126],"+3.33":[128],"+0.83":[130],"percentage":[131],"points.":[132],"The":[133],"95%":[134],"bootstrap":[135],"interval":[136],"for":[137],"failure":[140],"increase":[141],"exceeded":[142],"five-percentage-point":[144],"selection":[145],"limit.":[146],"Greedy":[147],"one-step":[148],"performed":[150],"similarly":[151],"or":[153,205],"slightly":[154],"better":[155],"approximate":[158],"MPC.":[159],"Additional":[160],"post-review":[161],"simulations":[163],"revealed":[164],"sensitivity":[165],"sampling":[168],"alternative":[170],"dynamics,":[172],"limiting":[173],"generalizability":[175],"initial":[178],"benchmark":[179],"estimates.":[180],"Conclusions:":[181],"BioEdge-Rx":[182],"demonstrates":[183],"compression":[185],"within":[190],"assumed":[192],"simulator.":[193],"It":[194],"does":[195],"not":[196],"establish":[197],"causal":[198],"treatment":[199],"transitions,":[200],"efficacy,":[202],"sensor-level":[203],"realizability,":[204],"superiority":[206],"multistep":[208],"planning.":[209]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
