{"id":"https://openalex.org/W7225614649","doi":"https://doi.org/10.3390/biomedicines14112570","title":"Urinary 8-Hydroxy-2\u2032-Deoxyguanosine, Oxidative DNA Damage and Health-Related Quality of Life in Albanian Patients with Cancer: A Case\u2013Control Study","display_name":"Urinary 8-Hydroxy-2\u2032-Deoxyguanosine, Oxidative DNA Damage and Health-Related Quality of Life in Albanian Patients with Cancer: A Case\u2013Control Study","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614649","doi":"https://doi.org/10.3390/biomedicines14112570"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines14112570","doi":"https://doi.org/10.3390/biomedicines14112570","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112570","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines14112570","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069991310","display_name":"Elisa Domi","orcid":"https://orcid.org/0009-0006-7125-8940","observed_orcids":["https://orcid.org/0009-0006-7125-8940"]},"institutions":[{"id":"https://openalex.org/I4210110342","display_name":"Catholic University Our Lady of Good Counsel","ror":"https://ror.org/01qgdf403","country_code":"AL","type":"education","lineage":["https://openalex.org/I4210110342"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Elisa Domi","raw_affiliation_strings":["Department of the Chemical-Toxicological and Pharmacologic Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of the Chemical-Toxicological and Pharmacologic Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I4210110342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091372468","display_name":"Bledi Kreka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800414091","display_name":"Mother Teresa Hospital","ror":"https://ror.org/027x3m696","country_code":"AL","type":"healthcare","lineage":["https://openalex.org/I2800414091"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Bledi Kreka","raw_affiliation_strings":["Chemotherapy Unit, Oncology Service, UHC \u201cMother Teresa\u201d, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemotherapy Unit, Oncology Service, UHC \u201cMother Teresa\u201d, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I2800414091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055090690","display_name":"Domenico Tricarico","orcid":"https://orcid.org/0000-0003-2726-0462","observed_orcids":["https://orcid.org/0000-0003-2726-0462"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Domenico Tricarico","raw_affiliation_strings":["Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2726-0462","affiliations":[{"raw_affiliation_string":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034774605","display_name":"Arben Boshnjaku","orcid":"https://orcid.org/0000-0003-4343-9366","observed_orcids":["https://orcid.org/0000-0003-4343-9366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arben Boshnjaku","raw_affiliation_strings":["Faculty of Technical Medical Sciences, Alma Mater Europea Campus College Rezonanca, 10000 Prishtina, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Technical Medical Sciences, Alma Mater Europea Campus College Rezonanca, 10000 Prishtina, Kosovo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069581778","display_name":"Michele Denora","orcid":"https://orcid.org/0000-0001-7218-1953","observed_orcids":["https://orcid.org/0000-0001-7218-1953","https://orcid.org/0009-0005-0495-6274"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Denora","raw_affiliation_strings":["Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"],"raw_orcid":"https://orcid.org/0009-0005-0495-6274","affiliations":[{"raw_affiliation_string":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000243950","display_name":"Mariagrazia Abbasciano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131270","display_name":"Institute of Sciences of Food Production","ror":"https://ror.org/03x7xkr71","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210131270","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariagrazia Abbasciano","raw_affiliation_strings":["Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy","Institute of Sciences of Food Production (ISPA), National Research Council (CNR), 70126 Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Institute of Sciences of Food Production (ISPA), National Research Council (CNR), 70126 Bari, Italy","institution_ids":["https://openalex.org/I4210131270","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002249685","display_name":"Annamaria Di Turi","orcid":"https://orcid.org/0009-0007-1718-4319","observed_orcids":["https://orcid.org/0009-0007-1718-4319"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annamaria Di Turi","raw_affiliation_strings":["Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy"],"raw_orcid":"https://orcid.org/0009-0007-1718-4319","affiliations":[{"raw_affiliation_string":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari \u201cAldo Moro\u201d, 70121 Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006527223","display_name":"\u0412\u0438\u0441\u0430\u0440 \u041c\u0430\u043b\u0430\u0458","orcid":"https://orcid.org/0000-0002-3439-2642","observed_orcids":["https://orcid.org/0000-0002-3439-2642"]},"institutions":[{"id":"https://openalex.org/I68784830","display_name":"University of Tirana","ror":"https://ror.org/03g9v2404","country_code":"AL","type":"education","lineage":["https://openalex.org/I68784830"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Visar Malaj","raw_affiliation_strings":["Department of Economics, University of Tirana, Rruga Arben Broci, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Economics, University of Tirana, Rruga Arben Broci, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I68784830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087621785","display_name":"Adela Perolla","orcid":"https://orcid.org/0000-0002-5777-0845","observed_orcids":["https://orcid.org/0000-0002-5777-0845"]},"institutions":[{"id":"https://openalex.org/I1283489935","display_name":"University of Medicine Tirana","ror":"https://ror.org/03y2x8717","country_code":"AL","type":"education","lineage":["https://openalex.org/I1283489935"]},{"id":"https://openalex.org/I2800414091","display_name":"Mother Teresa Hospital","ror":"https://ror.org/027x3m696","country_code":"AL","type":"healthcare","lineage":["https://openalex.org/I2800414091"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Adela Perolla","raw_affiliation_strings":["Department of Internal Medicine, Service of Hematology, University of Medicine Tirana/UHC \u201cMother Teresa\u201d, 1005 Tirana, Albania"],"raw_orcid":"https://orcid.org/0000-0002-5777-0845","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Service of Hematology, University of Medicine Tirana/UHC \u201cMother Teresa\u201d, 1005 Tirana, Albania","institution_ids":["https://openalex.org/I1283489935","https://openalex.org/I2800414091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161318556","display_name":"Valbona \u00c7eka Shahinaj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valbona \u00c7eka Shahinaj","raw_affiliation_strings":["Health Centre Nr 2, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Centre Nr 2, 1001 Tirana, Albania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003498157","display_name":"Bruno Zappacosta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110342","display_name":"Catholic University Our Lady of Good Counsel","ror":"https://ror.org/01qgdf403","country_code":"AL","type":"education","lineage":["https://openalex.org/I4210110342"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Bruno Zappacosta","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I4210110342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122780553","display_name":"Artejana Marku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110342","display_name":"Catholic University Our Lady of Good Counsel","ror":"https://ror.org/01qgdf403","country_code":"AL","type":"education","lineage":["https://openalex.org/I4210110342"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Artejana Marku","raw_affiliation_strings":["Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I4210110342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122818752","display_name":"Xhoana Tahiraj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110342","display_name":"Catholic University Our Lady of Good Counsel","ror":"https://ror.org/01qgdf403","country_code":"AL","type":"education","lineage":["https://openalex.org/I4210110342"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Xhoana Tahiraj","raw_affiliation_strings":["Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I4210110342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041415128","display_name":"Malvina Hoxha","orcid":"https://orcid.org/0000-0002-1688-116X","observed_orcids":["https://orcid.org/0000-0002-1688-116X"]},"institutions":[{"id":"https://openalex.org/I4210110342","display_name":"Catholic University Our Lady of Good Counsel","ror":"https://ror.org/01qgdf403","country_code":"AL","type":"education","lineage":["https://openalex.org/I4210110342"]}],"countries":["AL"],"is_corresponding":false,"raw_author_name":"Malvina Hoxha","raw_affiliation_strings":["Department of the Chemical-Toxicological and Pharmacologic Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania"],"raw_orcid":"https://orcid.org/0000-0002-1688-116X","affiliations":[{"raw_affiliation_string":"Department of the Chemical-Toxicological and Pharmacologic Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1001 Tirana, Albania","institution_ids":["https://openalex.org/I4210110342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5055090690"],"corresponding_institution_ids":["https://openalex.org/I5561750"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"11","first_page":"2570","last_page":"2570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8740000128746033},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.9179999828338623},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.906000018119812},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.8619999885559082},{"id":"https://openalex.org/keywords/symptom-burden","display_name":"symptom burden","score":0.6669999957084656},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.8324000239372253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8220999836921692},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6694999933242798},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6265000104904175},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6229000091552734},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5692999958992004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5393999814987183},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4772999882698059},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3573000133037567},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.33230000734329224},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3285999894142151},{"id":"https://openalex.org/C2781119792","wikidata":"https://www.wikidata.org/wiki/Q5205759","display_name":"DNA oxidation","level":4,"score":0.3248000144958496},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.31150001287460327},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.29739999771118164},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.2840999960899353},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.26260000467300415}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biomedicines14112570","doi":"https://doi.org/10.3390/biomedicines14112570","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112570","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines14112570","doi":"https://doi.org/10.3390/biomedicines14112570","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112570","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1940886528","https://openalex.org/W1968967017","https://openalex.org/W1972130246","https://openalex.org/W1991030758","https://openalex.org/W2020383780","https://openalex.org/W2044433401","https://openalex.org/W2045920795","https://openalex.org/W2062565730","https://openalex.org/W2062869760","https://openalex.org/W2112784018","https://openalex.org/W2155208388","https://openalex.org/W2471605942","https://openalex.org/W2785091318","https://openalex.org/W2888698858","https://openalex.org/W2960149587","https://openalex.org/W3023781031","https://openalex.org/W3028638182","https://openalex.org/W3110284831","https://openalex.org/W3111102104","https://openalex.org/W3208087436","https://openalex.org/W4306939094","https://openalex.org/W4307906178","https://openalex.org/W4308871765","https://openalex.org/W4310946789","https://openalex.org/W4318318928","https://openalex.org/W4386832864","https://openalex.org/W4388629509","https://openalex.org/W4389101086","https://openalex.org/W4400882958","https://openalex.org/W4413992750"],"related_works":["https://openalex.org/W2062023515","https://openalex.org/W2078239734","https://openalex.org/W2978477511","https://openalex.org/W1940886528","https://openalex.org/W2051203350","https://openalex.org/W1999067101","https://openalex.org/W2073397738","https://openalex.org/W2033633290","https://openalex.org/W2515215532","https://openalex.org/W2003729348"],"abstract_inverted_index":{"Background/Objectives:":[0],"Oxidative":[1],"DNA":[2,206],"damage":[3,207],"contributes":[4],"to":[5,65,130,235],"cancer":[6,49,243],"development":[7],"and":[8,29,50,63,77,94,102,162,165,188,214,228,247],"progression,":[9,244],"but":[10],"its":[11],"relationship":[12,31],"with":[13,32,37,46,134,153,177,202,210],"health-related":[14],"quality":[15],"of":[16,79,82,239],"life":[17],"(HRQoL)":[18],"remains":[19],"insufficiently":[20],"explored.":[21],"This":[22,40],"study":[23,42],"evaluated":[24,98],"urinary":[25,66,91,172],"8-hydroxy-2\u2032-deoxyguanosine":[26],"(8-OHdG)":[27],"levels":[28,93,109,137],"their":[30],"HRQoL":[33,68,95],"in":[34,113,242],"Albanian":[35,200],"patients":[36,45,114,201],"cancer.":[38],"Methods:":[39],"case\u2013control":[41],"included":[43],"106":[44],"histologically":[47],"confirmed":[48],"35":[51],"healthy":[52],"controls.":[53],"Urinary":[54,107,217],"8-OHdG":[55,92,108,149,173,218],"was":[56,69,208],"measured":[57],"by":[58],"enzyme-linked":[59],"immunosorbent":[60],"assay":[61],"(ELISA)":[62],"normalized":[64],"creatinine.":[67],"assessed":[70],"using":[71,99],"the":[72,135,140,237],"European":[73],"Organization":[74],"for":[75,183],"Research":[76],"Treatment":[78],"Cancer":[80],"Quality":[81],"Life":[83],"Questionnaire":[84],"Core":[85],"30":[86],"(EORTC":[87],"QLQ-C30).":[88],"Associations":[89],"between":[90],"domains":[96],"were":[97,110,151],"correlation":[100],"analyses":[101],"multivariable":[103,170],"linear":[104],"regression.":[105],"Results:":[106],"significantly":[111,128],"higher":[112],"than":[115],"controls":[116],"(median":[117],"21.04":[118],"vs.":[119],"5.65":[120],"ng/mg":[121],"creatinine;":[122],"p":[123,195],"<":[124,146,196],"0.001).":[125,147,197],"Levels":[126],"differed":[127],"according":[129],"time":[131,189],"since":[132,190],"diagnosis,":[133],"highest":[136],"observed":[138],"within":[139],"first":[141],"year":[142],"after":[143,181],"diagnosis":[144,191],"(p":[145],"Higher":[148],"concentrations":[150],"associated":[152,176,209],"poorer":[154,215],"global":[155],"health":[156],"status,":[157,187],"reduced":[158],"physical,":[159],"emotional,":[160],"cognitive,":[161],"social":[163],"functioning,":[164],"increased":[166,204],"symptom":[167],"burden.":[168],"In":[169],"analysis,":[171],"remained":[174],"independently":[175],"lower":[178],"physical":[179],"functioning":[180],"adjustment":[182],"age,":[184],"sex,":[185],"smoking":[186],"(\u03b2":[192],"=":[193],"\u22121.032,":[194],"Conclusions:":[198],"Among":[199],"cancer,":[203],"oxidative":[205,240],"impaired":[211],"functional":[212],"status":[213],"HRQoL.":[216],"may":[219],"represent":[220],"a":[221],"useful":[222],"non-invasive":[223],"biomarker":[224],"reflecting":[225],"disease-related":[226],"burden":[227],"patient":[229],"well-being.":[230],"Longitudinal":[231],"studies":[232],"are":[233],"needed":[234],"clarify":[236],"role":[238],"stress":[241],"treatment":[245],"effects,":[246],"quality-of-life":[248],"outcomes.":[249]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}