{"id":"https://openalex.org/W7225614528","doi":"https://doi.org/10.1021/acs.est.6c09761","title":"Multiomics: TBPH Enhances Thyroid Hormone Synthesis via PIS-LPI-ERK-EGR1 Pathway","display_name":"Multiomics: TBPH Enhances Thyroid Hormone Synthesis via PIS-LPI-ERK-EGR1 Pathway","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614528","doi":"https://doi.org/10.1021/acs.est.6c09761"},"language":"en","primary_location":{"id":"doi:10.1021/acs.est.6c09761","doi":"https://doi.org/10.1021/acs.est.6c09761","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.est.6c09761","pdf_url":null,"source":{"id":"https://openalex.org/S13479253","display_name":"Environmental Science & Technology","issn_l":"0013-936X","issn":["0013-936X","1520-5851"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","fnege-4","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science &amp; Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161330468","display_name":"Jiawei Yang","orcid":"https://orcid.org/0009-0007-2333-1522","observed_orcids":["https://orcid.org/0009-0007-2333-1522"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Yang","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":"https://orcid.org/0009-0007-2333-1522","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161337910","display_name":"Qiong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Zhang","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125391293","display_name":"Haichen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haichen Zhang","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125394219","display_name":"Tao Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhou","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161315281","display_name":"Xiaohe Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohe Li","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091266496","display_name":"Qianqian Xiao","orcid":"https://orcid.org/0009-0006-5982-9368","observed_orcids":["https://orcid.org/0009-0006-5982-9368"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Xiao","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059127672","display_name":"Qinghe Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghe Meng","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146498194","display_name":"Jianjun Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Jiang","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033144951","display_name":"Weidong Hao","orcid":"https://orcid.org/0000-0001-5879-450X","observed_orcids":["https://orcid.org/0000-0001-5879-450X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Hao","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025658739","display_name":"Xuetao Wei","orcid":"https://orcid.org/0000-0001-5902-9973","observed_orcids":["https://orcid.org/0000-0001-5902-9973","https://orcid.org/0000-0002-7355-9759"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuetao Wei","raw_affiliation_strings":["Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","Peking University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7355-9759","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety , ,","institution_ids":[]},{"raw_affiliation_string":"Peking University , , ,","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025658739"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.23720000684261322,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brominated-flame-retardants","display_name":"brominated flame retardants","score":0.9509999752044678},{"id":"https://openalex.org/keywords/thyroid-hormone-synthesis","display_name":"thyroid hormone synthesis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/phosphatidylinositol-synthase","display_name":"phosphatidylinositol synthase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/lysophosphatidylinositol","display_name":"lysophosphatidylinositol","score":0.9309999942779541},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/thyroid-peroxidase","display_name":"thyroid peroxidase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycerophospholipid-metabolism","display_name":"glycerophospholipid metabolism","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.9509999752044678},{"id":"https://openalex.org/keywords/thyroid-follicular-cells","display_name":"thyroid follicular cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.878000020980835},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":1.0}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6952000260353088},{"id":"https://openalex.org/C180650514","wikidata":"https://www.wikidata.org/wiki/Q419502","display_name":"Thyroid peroxidase","level":3,"score":0.656499981880188},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6021999716758728},{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.5723999738693237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5346999764442444},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5253999829292297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5248000025749207},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.517300009727478},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.5091000199317932},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.49709999561309814},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.3874000012874603},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3797000050544739},{"id":"https://openalex.org/C2777886399","wikidata":"https://www.wikidata.org/wiki/Q211544","display_name":"Thyroid-stimulating hormone","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34220001101493835},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3190000057220459},{"id":"https://openalex.org/C182203180","wikidata":"https://www.wikidata.org/wiki/Q324663","display_name":"Endocrine gland","level":3,"score":0.31619998812675476},{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.313400000333786},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C149574134","wikidata":"https://www.wikidata.org/wiki/Q18031987","display_name":"Thyroid hormone receptor beta","level":5,"score":0.26669999957084656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.est.6c09761","doi":"https://doi.org/10.1021/acs.est.6c09761","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.est.6c09761","pdf_url":null,"source":{"id":"https://openalex.org/S13479253","display_name":"Environmental Science & Technology","issn_l":"0013-936X","issn":["0013-936X","1520-5851"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","fnege-4","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science &amp; Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1893536585","https://openalex.org/W1966824338","https://openalex.org/W1971954175","https://openalex.org/W1973617509","https://openalex.org/W2038675142","https://openalex.org/W2046159411","https://openalex.org/W2075623565","https://openalex.org/W2093805097","https://openalex.org/W2119821900","https://openalex.org/W2144679863","https://openalex.org/W2158173168","https://openalex.org/W2235086696","https://openalex.org/W2320813981","https://openalex.org/W2509032209","https://openalex.org/W2523326658","https://openalex.org/W2583351051","https://openalex.org/W2585303886","https://openalex.org/W2603959463","https://openalex.org/W2766501219","https://openalex.org/W2767759374","https://openalex.org/W2891261166","https://openalex.org/W2895048594","https://openalex.org/W2899915536","https://openalex.org/W2919635040","https://openalex.org/W2944932350","https://openalex.org/W2945883683","https://openalex.org/W2981311142","https://openalex.org/W2998667353","https://openalex.org/W3096828292","https://openalex.org/W3169187054","https://openalex.org/W3174703292","https://openalex.org/W3194440396","https://openalex.org/W4206043197","https://openalex.org/W4225121881","https://openalex.org/W4229007623","https://openalex.org/W4307034884","https://openalex.org/W4379377066","https://openalex.org/W4384401175","https://openalex.org/W4386134072","https://openalex.org/W4386569764","https://openalex.org/W4387849370","https://openalex.org/W4388591871","https://openalex.org/W4390014327","https://openalex.org/W4399802334","https://openalex.org/W4400271626","https://openalex.org/W4402638912","https://openalex.org/W4404644284","https://openalex.org/W4405949380","https://openalex.org/W4410840349","https://openalex.org/W4412158259","https://openalex.org/W7116793373"],"related_works":["https://openalex.org/W7212180288","https://openalex.org/W4390014327","https://openalex.org/W4410840349","https://openalex.org/W4400271626","https://openalex.org/W7202193432","https://openalex.org/W2093805097","https://openalex.org/W2078861858","https://openalex.org/W7160252580","https://openalex.org/W3080399002","https://openalex.org/W4386569764"],"abstract_inverted_index":{"Abstract":[0],"Bis(2-ethylhexyl)-tetrabromophthalate":[1],"(TBPH),":[2],"a":[3,123,136,145],"high-production-volume":[4],"novel":[5],"brominated":[6],"flame":[7],"retardant":[8],"(NBFR),":[9],"has":[10],"been":[11],"shown":[12],"to":[13,82],"perturb":[14],"thyroid":[15,43,58,63,132],"hormone":[16,133],"synthesis,":[17,134],"yet":[18],"the":[19,88,98,150],"underlying":[20],"molecular":[21],"mechanism":[22,139],"remains":[23],"poorly":[24],"understood.":[25],"Using":[26],"transcriptomics,":[27],"phosphoproteomics,":[28],"and":[29,41,57,64,69,102,143],"metabolomics":[30],"as":[31],"discovery":[32],"tools,":[33],"combined":[34],"with":[35],"validation":[36],"in":[37,61],"Sprague\u2013Dawley":[38],"(SD)":[39],"rats":[40],"human":[42],"follicular":[44],"epithelial":[45],"cells":[46],"(Nthy-ori":[47],"3\u20131),":[48],"we":[49],"investigated":[50],"this":[51],"mechanism.":[52],"TBPH":[53,77,130],"increased":[54],"thyroglobulin":[55],"(TG)":[56],"peroxidase":[59],"(TPO)":[60],"rat":[62],"elevated":[65],"circulating":[66],"triiodothyronine":[67],"(T3)":[68],"thyroxine":[70],"(T4)":[71],"levels.":[72],"In":[73],"Nthy-ori":[74],"3\u20131":[75],"cells,":[76],"remodeled":[78],"glycerophospholipid":[79],"metabolism,":[80],"leading":[81],"phosphatidylinositol":[83],"synthase":[84],"(PIS)-dependent":[85],"accumulation":[86],"of":[87,107,114,140,153],"signaling":[89,100],"lipid":[90,137],"lysophosphatidylinositol":[91],"18:1":[92,95],"(LPI_18:1).":[93],"LPI":[94],"selectively":[96],"activated":[97],"ERK-EGR1":[99],"axis":[101],"drove":[103],"TG/TPO":[104,118],"upregulation.":[105],"Knockdown":[106],"PIS":[108],"or":[109,111],"EGR1,":[110],"pharmacological":[112],"inhibition":[113],"ERK,":[115],"abolished":[116],"TBPH-induced":[117],"expression.":[119],"These":[120],"findings":[121],"reveal":[122],"previously":[124],"unrecognized":[125],"PIS-LPI-ERK-EGR1":[126],"pathway":[127],"through":[128],"which":[129],"enhances":[131],"highlighting":[135],"metabolism-driven":[138],"endocrine":[141],"disruption":[142],"providing":[144],"mechanistic":[146],"basis":[147],"for":[148],"reassessing":[149],"health":[151],"risks":[152],"NBFRs.":[154]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
