{"id":"https://openalex.org/W7225614463","doi":"https://doi.org/10.5281/zenodo.24068094","title":"The Role of Cannabidiol (CBD) in Parkinson's Disease Treatment - Mechanisms, Therapeutic Potential, and Implications for Motor and Non-Motor Symptoms","display_name":"The Role of Cannabidiol (CBD) in Parkinson's Disease Treatment - Mechanisms, Therapeutic Potential, and Implications for Motor and Non-Motor Symptoms","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614463","doi":"https://doi.org/10.5281/zenodo.24068094"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24068094","doi":"https://doi.org/10.5281/zenodo.24068094","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24068094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24068094","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123757889","display_name":"Paul Michael Hallelujah","orcid":"https://orcid.org/0009-0006-8143-555X","observed_orcids":["https://orcid.org/0009-0006-8143-555X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hallelujah, Paul","raw_affiliation_strings":["Vaxx Research Incorporated"],"raw_orcid":"https://orcid.org/0009-0006-8143-555X","affiliations":[{"raw_affiliation_string":"Vaxx Research Incorporated","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5123757889"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.19349999725818634,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.9609000086784363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6306999921798706},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5914000272750854},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5231999754905701},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5146999955177307},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5022000074386597},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.486299991607666},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.44679999351501465},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.43630000948905945},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.43160000443458557},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.42260000109672546},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.3725999891757965},{"id":"https://openalex.org/C2778258207","wikidata":"https://www.wikidata.org/wiki/Q600203","display_name":"Dopamine agonist","level":4,"score":0.35190001130104065},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.350600004196167},{"id":"https://openalex.org/C2779989193","wikidata":"https://www.wikidata.org/wiki/Q421304","display_name":"Pramipexole","level":4,"score":0.3292999863624573},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.3206999897956848},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C2776286997","wikidata":"https://www.wikidata.org/wiki/Q2880966","display_name":"Dopaminergic pathways","level":4,"score":0.26030001044273376},{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.2558000087738037}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24068094","doi":"https://doi.org/10.5281/zenodo.24068094","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24068094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.24068095","doi":"https://doi.org/10.5281/zenodo.24068095","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24068095","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24068094","doi":"https://doi.org/10.5281/zenodo.24068094","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24068094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"This":[0],"preprint":[1],"presents":[2],"a":[3,26,68,147,179,221,228],"comprehensive":[4],"review":[5,77],"of":[6,10,35,83,129,162,170,183],"the":[7,19,33,81,110,125,207,215,250],"therapeutic":[8,172],"potential":[9],"Cannabidiol":[11,66,84,95,135,176,213],"for":[12],"treating":[13],"Parkinson's":[14,23],"disease,":[15],"as":[16,60,178,220,246],"detailed":[17],"in":[18,39,102,109,150,165,206],"document":[20],"CBD_Parkinsons_Treatment_Report":[21],"(1).pdf.":[22],"disease":[24],"is":[25,67,254],"progressive":[27],"neurodegenerative":[28,90],"condition":[29],"primarily":[30],"caused":[31],"by":[32,198,218],"loss":[34],"dopaminergic":[36],"neurons,":[37],"resulting":[38],"debilitating":[40],"motor":[41,127,142],"and":[42,54,88,99,101,156,160,188,202,209,237,259],"non-motor":[43,132],"symptoms.":[44],"Standard":[45],"treatments":[46],"like":[47],"Levodopa":[48],"often":[49],"lose":[50],"efficacy":[51],"over":[52],"time":[53],"cause":[55],"severe":[56],"side":[57],"effects":[58],"such":[59],"Levodopa-induced":[61,121],"dyskinesia.":[62],"Unlike":[63],"conventional":[64],"treatments,":[65],"non-intoxicating":[69],"compound":[70],"with":[71,120],"an":[72,238,247],"excellent":[73],"safety":[74],"profile.":[75],"The":[76,167],"surveys":[78],"evidence":[79],"regarding":[80],"impact":[82],"on":[85],"various":[86],"symptoms":[87,139],"its":[89,257],"pathway":[91],"mechanisms.":[92],"Evidence":[93],"suggests":[94],"modestly":[96],"improves":[97,157],"rigidity":[98],"bradykinesia,":[100],"preclinical":[103],"models,":[104],"it":[105,244],"prevents":[106],"dopamine":[107],"depletion":[108],"striatum.":[111],"It":[112,144,193],"also":[113,145],"significantly":[114,136],"reduces":[115,137],"abnormal":[116],"involuntary":[117],"movements":[118],"associated":[119],"dyskinesia":[122],"without":[123,140],"diminishing":[124],"primary":[126],"benefits":[128],"Levodopa.":[130],"For":[131],"symptoms,":[133],"oral":[134],"psychotic":[138],"worsening":[141],"function.":[143],"causes":[146],"prompt":[148],"reduction":[149],"REM":[151],"sleep":[152],"behavior":[153],"disorder":[154],"events":[155],"overall":[158],"well-being":[159],"quality":[161],"life":[163],"scores":[164],"patients.":[166],"underlying":[168],"mechanisms":[169],"these":[171],"actions":[173],"are":[174],"multifaceted.":[175],"acts":[177,245],"potent":[180],"antioxidant":[181],"capable":[182],"neutralizing":[184],"reactive":[185],"oxygen":[186],"species":[187],"restoring":[189],"mitochondrial":[190],"membrane":[191],"potential.":[192],"exhibits":[194],"robust":[195],"anti-inflammatory":[196],"properties":[197],"downregulating":[199],"pro-inflammatory":[200],"cytokines":[201],"preventing":[203],"microglial":[204],"activation":[205],"striatum":[208],"substantia":[210],"nigra.":[211],"Additionally,":[212],"modulates":[214],"endocannabinoid":[216,267],"system":[217],"acting":[219],"negative":[222],"allosteric":[223],"modulator":[224],"at":[225,234,240,249],"CB1":[226],"receptors,":[227,236],"partial":[229],"agonist":[230,233,248],"or":[231],"inverse":[232],"CB2":[235],"antagonist":[239],"GPR55":[241],"receptors.":[242],"Finally,":[243],"serotonin":[251],"receptor,":[252],"which":[253],"critical":[255],"to":[256],"anxiolytic":[258],"anti-dyskinetic":[260],"effects.":[261],"Keywords:":[262],"Cannabidiol,":[263],"neuroprotection,":[264],"dyskinesia,":[265],"psychosis,":[266]},"counts_by_year":[],"updated_date":"2026-11-10T13:44:29.811591","created_date":"2026-11-10T00:00:00"}