{"id":"https://openalex.org/W7225614399","doi":"https://doi.org/10.21203/rs.3.rs-11300970/v1","title":"Efficacy and safety of 3-month versus 1-month depot leuprolide acetate in children with central precocious puberty: a systematic review and meta-analysis","display_name":"Efficacy and safety of 3-month versus 1-month depot leuprolide acetate in children with central precocious puberty: a systematic review and meta-analysis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614399","doi":"https://doi.org/10.21203/rs.3.rs-11300970/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11300970/v1","doi":"https://doi.org/10.21203/rs.3.rs-11300970/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11300970/v1","pdf_url":"https://www.researchsquare.com/article/rs-11300970/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11300970/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100393725","display_name":"Qiao Li","orcid":"https://orcid.org/0009-0008-0252-7988","observed_orcids":["https://orcid.org/0009-0008-0252-7988"]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaoling Li","raw_affiliation_strings":["Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147508122","display_name":"Maochang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maochang Liu","raw_affiliation_strings":["Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008154818","display_name":"\u5f6d\u9759","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Peng","raw_affiliation_strings":["Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114204246","display_name":"Linhui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linhui Liu","raw_affiliation_strings":["Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161318650","display_name":"Hui Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Peng","raw_affiliation_strings":["Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101672286","display_name":"Lifang Feng","orcid":"https://orcid.org/0000-0002-0618-175X","observed_orcids":["https://orcid.org/0000-0002-0618-175X"]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifang Feng","raw_affiliation_strings":["Endocrinology\uff0cWuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology\uff0cWuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5139449907","display_name":"Xiaoqian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqian Chen","raw_affiliation_strings":["Endocrinology\uff0cWuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology\uff0cWuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital, Huazhong University of Science & Technology","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leuprolide-acetate","display_name":"leuprolide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/depot-formulation","display_name":"depot formulation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/central-precocious-puberty","display_name":"central precocious puberty","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pediatric-endocrinology","display_name":"pediatric endocrinology","score":0.6850000023841858},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.5640000104904175},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.5389999747276306},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8870000243186951},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bone-age","display_name":"bone age","score":0.7910000085830688},{"id":"https://openalex.org/keywords/growth-rate","display_name":"growth rate","score":0.6570000052452087},{"id":"https://openalex.org/keywords/predicted-adult-height","display_name":"predicted adult height","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ovarian-volume","display_name":"ovarian volume","score":0.5590000152587891},{"id":"https://openalex.org/keywords/uterine-volume","display_name":"uterine volume","score":0.8040000200271606},{"id":"https://openalex.org/keywords/injection-burden","display_name":"injection burden","score":0.5640000104904175},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2776561332","wikidata":"https://www.wikidata.org/wiki/Q5554853","display_name":"Depot","level":2,"score":0.9154999852180481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.816100001335144},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7297000288963318},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4108000099658966},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.40709999203681946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3864000141620636},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3483999967575073},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3271999955177307},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.31839999556541443},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.31779998540878296},{"id":"https://openalex.org/C2779093440","wikidata":"https://www.wikidata.org/wiki/Q907160","display_name":"Leuprorelin","level":5,"score":0.31630000472068787},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C2776306185","wikidata":"https://www.wikidata.org/wiki/Q2823834","display_name":"Medroxyprogesterone acetate","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C2777886879","wikidata":"https://www.wikidata.org/wiki/Q16875676","display_name":"Hormone antagonist","level":4,"score":0.2711000144481659},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C2778367240","wikidata":"https://www.wikidata.org/wiki/Q224513","display_name":"Precocious puberty","level":3,"score":0.25850000977516174}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11300970/v1","doi":"https://doi.org/10.21203/rs.3.rs-11300970/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11300970/v1","pdf_url":"https://www.researchsquare.com/article/rs-11300970/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11300970/v1","doi":"https://doi.org/10.21203/rs.3.rs-11300970/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11300970/v1","pdf_url":"https://www.researchsquare.com/article/rs-11300970/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225614399.pdf","grobid_xml":"https://content.openalex.org/works/W7225614399.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1563792799","https://openalex.org/W1994008949","https://openalex.org/W2013966547","https://openalex.org/W2020875068","https://openalex.org/W2056219466","https://openalex.org/W2078052604","https://openalex.org/W2156436919","https://openalex.org/W2963789970","https://openalex.org/W3004842774","https://openalex.org/W3032526316","https://openalex.org/W3092256325","https://openalex.org/W3118615836","https://openalex.org/W3128921735","https://openalex.org/W3160099561","https://openalex.org/W3183894179","https://openalex.org/W3186038933","https://openalex.org/W4200199132","https://openalex.org/W4312190852","https://openalex.org/W4324128958","https://openalex.org/W4388328042","https://openalex.org/W4388455936","https://openalex.org/W4395684971","https://openalex.org/W4410895456","https://openalex.org/W4411219771","https://openalex.org/W7117572517","https://openalex.org/W7164754925"],"related_works":["https://openalex.org/W4411219771","https://openalex.org/W2056219466","https://openalex.org/W2004112891","https://openalex.org/W4312190852","https://openalex.org/W4379052662","https://openalex.org/W2078052604","https://openalex.org/W4403153618","https://openalex.org/W2156436919","https://openalex.org/W7126152801","https://openalex.org/W2020875068"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"To":[2],"systematically":[3],"compare":[4],"the":[5,39,245],"efficacy":[6,241],"and":[7,42,56,117,135,212,228,242,267],"safety":[8,243],"of":[9,37],"leuprolide":[10,60],"acetate":[11,61],"3-month":[12,62,181,237,255],"versus":[13],"1-month":[14,70,150,200,246],"depot":[15,63,71,182,201,238],"formulations":[16],"in":[17,80,146,149,159,225,232],"children":[18,81,273],"with":[19,69,82],"central":[20],"precocious":[21],"puberty":[22],"(CPP).":[23],"Methods":[24],"A":[25],"comprehensive":[26],"literature":[27],"search":[28],"was":[29],"conducted":[30],"across":[31],"CNKI,":[32],"Wanfang,":[33],"VIP,":[34],"PubMed,":[35],"Web":[36],"Science,":[38],"Cochrane":[40],"Library,":[41],"Embase":[43],"databases":[44],"from":[45],"inception":[46],"to":[47,196,244],"July":[48],"10,":[49],"2026.":[50],"Randomized":[51],"controlled":[52],"trials":[53],"(RCTs),":[54],"prospective,":[55],"retrospective":[57,197],"studies":[58,142],"comparing":[59],"(11.25":[64],"mg":[65,73,76],"every":[66,77],"12":[67],"weeks)":[68,79],"(3.75":[72],"or":[74,121,174],"7.5":[75],"4":[78],"CPP":[83,276],"were":[84,124,138,152,157],"included.":[85,153],"Primary":[86],"outcomes":[87],"included":[88],"hormonal":[89,249],"parameters":[90,110],"(\u0394basal/peak":[91],"LH,":[92,161],"\u0394basal/peak":[93],"FSH,":[94,163],"\u0394estradiol),":[95],"pelvic":[96,164],"ultrasound":[97],"metrics":[98],"(\u0394ovarian/uterine":[99],"volume,":[100],"\u0394uterine":[101],"diameter),":[102],"bone":[103,166],"age":[104,167],"indices":[105],"(\u0394BA/CA":[106],"ratio,":[107],"\u0394BA),":[108],"growth":[109,169],"(\u0394growth":[111],"velocity,":[112,170],"predicted":[113,171],"adult":[114,172],"height":[115],"(\u0394PAH)),":[116],"adverse":[118,175],"events.":[119],"Random-effects":[120],"fixed-effects":[122],"models":[123],"applied":[125],"based":[126],"on":[127],"heterogeneity.":[128],"Subgroup":[129],"analyses":[130,137],"stratified":[131],"by":[132],"study":[133],"design":[134],"sensitivity":[136,233],"performed.":[139],"Results":[140],"Thirteen":[141],"(1,051":[143],"participants;":[144],"470":[145],"3-month,":[147],"581":[148],"group)":[151],"No":[154],"significant":[155],"differences":[156],"observed":[158],"\u0394peak":[160,185],"\u0394basal":[162,204],"metrics,":[165],"advancement,":[168],"height,":[173],"events":[176],"(P":[177],">":[178],"0.05).":[179],"The":[180,199,236,254],"showed":[183],"greater":[184,203],"FSH":[186],"reduction":[187,214],"(MD":[188,206,215],"=":[189,193,207,210,216,219],"\u2212":[190],"0.51,":[191],"P":[192,209,218],"0.01),":[194],"confined":[195],"studies.":[198],"demonstrated":[202],"LH":[205],"0.34,":[208],"0.02)":[211],"\u0394estradiol":[213],"4.65,":[217],"0.04),":[220],"but":[221],"neither":[222],"reached":[223],"significance":[224],"subgroup":[226],"analyses,":[227],"estradiol":[229],"lacked":[230,251],"robustness":[231],"analysis.":[234],"Conclusions":[235],"provides":[239],"comparable":[240],"formulation.":[247],"Minor":[248],"divergences":[250],"clinical":[252],"robustness.":[253],"regimen":[256],"offers":[257],"a":[258],"practical":[259],"option":[260],"that":[261],"reduces":[262],"injection":[263],"burden,":[264],"improves":[265],"adherence,":[266],"optimizes":[268],"healthcare":[269],"resource":[270],"utilization":[271],"for":[272],"requiring":[274],"prolonged":[275],"therapy.":[277]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}