{"id":"https://openalex.org/W7225614378","doi":"https://doi.org/10.64898/2026.11.04.764298","title":"Psychoneuroimmunology of Viral Hepatitis and Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis","display_name":"Psychoneuroimmunology of Viral Hepatitis and Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614378","doi":"https://doi.org/10.64898/2026.11.04.764298"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764298","doi":"https://doi.org/10.64898/2026.11.04.764298","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764298","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.04.764298","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111170169","display_name":"Adriel Leal N\u00f3bile","orcid":"https://orcid.org/0009-0009-7252-777X","observed_orcids":["https://orcid.org/0009-0009-7252-777X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Adriel Leal Nobile","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;"],"raw_orcid":"https://orcid.org/0009-0008-3745-5806","affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024792080","display_name":"Roseane Galdioli Nava","orcid":"https://orcid.org/0000-0001-7415-2136","observed_orcids":["https://orcid.org/0000-0001-7415-2136"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roseane Galdioli Nava","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, SP,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, SP,;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646986","display_name":"Ronaldy Santana Santos","orcid":"https://orcid.org/0000-0002-4928-7802","observed_orcids":["https://orcid.org/0000-0002-4928-7802"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ronaldy Santana Santos","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000132521","display_name":"Fernando Yuri Nery do Vale","orcid":"https://orcid.org/0000-0003-1763-343X","observed_orcids":["https://orcid.org/0000-0003-1763-343X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Yuri Nery do Vale","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073358441","display_name":"J\u00falia Nakanishi Usuda","orcid":"https://orcid.org/0000-0002-1516-162X","observed_orcids":["https://orcid.org/0000-0002-1516-162X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Julia Nakanishi Usuda","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092795426","display_name":"Anny Silva Adri","orcid":"https://orcid.org/0009-0007-0275-6126","observed_orcids":["https://orcid.org/0009-0007-0275-6126"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anny Silva Adri","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097848327","display_name":"Yohan Lucas Gon\u00e7alves Corr\u00eaa","orcid":"https://orcid.org/0009-0005-1024-2454","observed_orcids":["https://orcid.org/0009-0005-1024-2454"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Yohan Lucas Goncalves Correa","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161326333","display_name":"Amanda Rodriguez Valera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amanda Rodriguez Valera","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Institute of Biomedical Sciences of the University of Sao Paulo (USP);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Institute of Biomedical Sciences of the University of Sao Paulo (USP);","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067961877","display_name":"Luciana Bezerra de Souza Gianasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I3129508524","display_name":"Universidade Federal do Sul e Sudeste do Par\u00e1","ror":"https://ror.org/01737f379","country_code":"BR","type":"education","lineage":["https://openalex.org/I3129508524"]},{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana Bezerra de Souza Gianasi","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Brazil.; Universidade Federal do Sul e Sudeste do Para;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Brazil.; Universidade Federal do Sul e Sudeste do Para;","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I3129508524","https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076684237","display_name":"Gustavo Cabral\u2010Miranda","orcid":"https://orcid.org/0000-0001-8351-4880","observed_orcids":["https://orcid.org/0000-0001-8351-4880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gustavo Cabral-Miranda","raw_affiliation_strings":["Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine of the USP (FMUSP);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine of the USP (FMUSP);","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113185481","display_name":"Lena Marques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lena F Schimke Marques","raw_affiliation_strings":["Department of Medicine, Division of Molecular Medicine, Laboratory of Medical Investigation, University of Sao Paulo (USP) School of Medicine, Sao Paulo, SP, Brazil.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Molecular Medicine, Laboratory of Medical Investigation, University of Sao Paulo (USP) School of Medicine, Sao Paulo, SP, Brazil.;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012140349","display_name":"Rodrigo Juliani Siqueira Dalmolin","orcid":"https://orcid.org/0000-0002-1688-6155","observed_orcids":["https://orcid.org/0000-0002-1688-6155"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo J S Dalmolin","raw_affiliation_strings":["Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Brazil.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Brazil.;","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007167001","display_name":"Rohini Sharma","orcid":"https://orcid.org/0000-0003-2441-549X","observed_orcids":["https://orcid.org/0000-0003-2441-549X"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rohini Sharma","raw_affiliation_strings":["Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK;","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161337050","display_name":"Hans Dieter Ochs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Dieter Ochs","raw_affiliation_strings":["Center for Immunity and Immunotherapies, Seattle Children's Research Institute, University of Washington, Seattle, Wash;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies, Seattle Children's Research Institute, University of Washington, Seattle, Wash;","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042234356","display_name":"Igor Salerno Filgueiras","orcid":"https://orcid.org/0000-0002-3493-4464","observed_orcids":["https://orcid.org/0000-0002-3493-4464","https://orcid.org/0000-0002-0515-6990"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Igor Salerno Filgueiras","raw_affiliation_strings":["Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil; DO'R Institute for Research, Sao Paulo, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil; DO'R Institute for Research, Sao Paulo, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108321785","display_name":"Haroldo Dutra Dias","orcid":"https://orcid.org/0009-0001-1884-5373","observed_orcids":["https://orcid.org/0009-0001-1884-5373"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haroldo Dutra Dias","raw_affiliation_strings":["Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006650480","display_name":"Ot\u00e1vio Cabral-Marques","orcid":"https://orcid.org/0000-0002-3183-6236","observed_orcids":["https://orcid.org/0000-0002-3183-6236","https://orcid.org/0000-0003-0649-8279"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Otavio Cabral-Marques","raw_affiliation_strings":["Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil; Int"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Psychoneuroimmunology, Selye Lab, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil; Int","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5111170169"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C38042653","wikidata":"https://www.wikidata.org/wiki/Q1500332","display_name":"Psychoneuroimmunology","level":3,"score":0.8881000280380249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6316999793052673},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.6276999711990356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5490999817848206},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5436999797821045},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47369998693466187},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.45840001106262207},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.447299987077713},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.4392000138759613},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3953999876976013},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3831999897956848},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34139999747276306},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.33889999985694885},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.30230000615119934},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.28690001368522644},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764298","doi":"https://doi.org/10.64898/2026.11.04.764298","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764298","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764298","doi":"https://doi.org/10.64898/2026.11.04.764298","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764298","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"and":[3,26,49,68,72,90,118,164,177,190,192,198],"viral":[4],"hepatitis":[5],"(VH)":[6],"are":[7],"recognized":[8],"primarily":[9],"as":[10],"hepatic":[11],"diseases,":[12],"yet":[13],"they":[14],"impose":[15],"a":[16,45,76,103,119,140,165],"substantial":[17],"neuropsychiatric":[18,96],"disorders":[19],"(NPDs)":[20],"encompassing":[21],"depression,":[22],"anxiety,":[23],"cognitive":[24],"impairment,":[25],"fatigue.":[27],"Whether":[28],"these":[29,99],"manifestations":[30],"reflect":[31],"psychological":[32],"reactions":[33],"or":[34],"biologically":[35],"grounded":[36],"psychoneuroimmune":[37],"dysfunction":[38],"remains":[39,159],"poorly":[40],"understood.":[41],"Here,":[42],"we":[43],"present":[44],"pre-registered":[46],"systematic":[47],"review":[48],"meta-analysis":[50],"(PROSPERO":[51],"2026":[52],"CRD420251081757)":[53],"synthesizing":[54],"evidence":[55],"from":[56],"24":[57],"studies":[58],"combining":[59],"psychosocial":[60,178],"outcomes":[61,115],"with":[62,148],"immune":[63],"dysregulation":[64,93],"markers":[65],"across":[66],"HCC":[67,117,189],"VH":[69,146,191],"populations.":[70],"Bibliometric":[71],"network":[73],"analyses":[74],"identified":[75],"growing":[77],"psychoneuroimmunology":[78],"research":[79,197],"hub":[80],"linking":[81],"cytokine":[82],"signaling,":[83],"microglial":[84],"activation,":[85],"blood-brain":[86],"barrier":[87],"(BBB)":[88],"disruption,":[89],"gut-liver-brain":[91],"axis":[92],"to":[94,130],"the":[95,184],"phenotype":[97],"of":[98,108,122,167,188],"diseases.":[100],"Meta-analysis":[101],"revealed":[102],"pooled":[104,120],"hazard":[105],"ratio":[106],"(HR)":[107],"1.92":[109],"(95%":[110,124],"CI:":[111,125],"1.09-3.39)":[112],"for":[113,127,182],"adverse":[114],"in":[116,133,145],"HR":[121],"2.28":[123],"1.48-3.52)":[126],"depression":[128],"associated":[129],"genetic":[131],"variants":[132],"VH.":[134],"TNF-a,":[135],"but":[136],"not":[137],"IL-6,":[138],"showed":[139],"tendency":[141],"toward":[142],"lower":[143],"levels":[144],"patients":[147],"versus":[149],"without":[150],"NPDs,":[151],"suggesting":[152],"differential":[153],"inflammatory":[154],"roles.":[155],"The":[156],"literature,":[157],"however,":[158],"fragmented":[160],"by":[161],"heterogeneous":[162],"designs":[163],"paucity":[166],"longitudinal":[168],"data.":[169],"A":[170],"psychoneuroimmunological":[171],"approach,":[172],"integrating":[173],"immune,":[174],"endocrine,":[175],"neural,":[176],"dimensions,":[179],"is":[180],"essential":[181],"capturing":[183],"full":[185],"systemic":[186],"impact":[187],"should":[193],"inform":[194],"future":[195],"mechanistic":[196],"multidisciplinary":[199],"clinical":[200],"strategies.":[201]},"counts_by_year":[],"updated_date":"2026-11-10T13:44:29.811591","created_date":"2026-11-10T00:00:00"}