{"id":"https://openalex.org/W7225614270","doi":"https://doi.org/10.17630/sta/1767","title":"Self/nonself recognition in bivalves","display_name":"Self/nonself recognition in bivalves","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614270","doi":"https://doi.org/10.17630/sta/1767"},"language":"en","primary_location":{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/33799","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/33799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10023/33799","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161344928","display_name":"Mollie Rose Stefanek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefanek, Mollie Rose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161344928"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11088","display_name":"Marine Bivalve and Aquaculture Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allorecognition","display_name":"allorecognition","score":0.8500000238418579},{"id":"https://openalex.org/keywords/self-nonself-recognition","display_name":"self/non-self recognition","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bivalvia","display_name":"Bivalvia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histocompatibility-loci","display_name":"histocompatibility loci","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hemocytes","display_name":"hemocytes","score":0.6809999942779541},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.777999997138977},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pathogen-recognition","display_name":"pathogen recognition","score":0.8230000138282776},{"id":"https://openalex.org/keywords/viral-mimic","display_name":"viral mimic","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C200315206","wikidata":"https://www.wikidata.org/wiki/Q4733146","display_name":"Allorecognition","level":4,"score":0.9970999956130981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8022000193595886},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7053999900817871},{"id":"https://openalex.org/C2778712684","wikidata":"https://www.wikidata.org/wiki/Q10915","display_name":"Chordate","level":4,"score":0.5627999901771545},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4291999936103821},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42899999022483826},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39239999651908875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38040000200271606},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3752000033855438},{"id":"https://openalex.org/C202965653","wikidata":"https://www.wikidata.org/wiki/Q2664028","display_name":"Histocompatibility","level":4,"score":0.3698999881744385},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2786000072956085},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.27489998936653137},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.2687000036239624},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.2646999955177307}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/33799","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/33799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"doi:10.17630/sta/1767","doi":"https://doi.org/10.17630/sta/1767","is_oa":true,"landing_page_url":"https://doi.org/10.17630/sta/1767","pdf_url":null,"source":{"id":"https://openalex.org/S7407050793","display_name":"University of St Andrews","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/33799","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/33799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7147668999","https://openalex.org/W2053175583","https://openalex.org/W1967009664","https://openalex.org/W3036354458","https://openalex.org/W2117186687","https://openalex.org/W1992571169","https://openalex.org/W2167096807","https://openalex.org/W1593865038","https://openalex.org/W2017915780","https://openalex.org/W2073516812"],"abstract_inverted_index":{"Allorecognition":[0,12],"is":[1,13,56,262],"the":[2,43,49,86,134,154,186,205],"ability":[3],"to":[4,112,176,179,188,204],"distinguish":[5],"between":[6,78],"self":[7],"and":[8,17,26,48,75,81,95,97,115,121,124,153,172,181,194,200,214,231,272,284],"nonself":[9],"in":[10,15,54,65,93,118,129,133,147,170,191,198,219,241,256,264,282,292],"conspecifics.":[11],"described":[14],"vertebrates":[16],"several":[18],"species":[19],"of":[20,45,51,62,88,156,161,185,196,208,212,237,253,270,279,295],"colonial":[21],"invertebrates,":[22],"including":[23],"Chordata,":[24],"Cnidaria,":[25],"Porifera.":[27],"Responses":[28],"involve":[29],"highly":[30],"polymorphic":[31],"histocompatibility":[32],"loci":[33],"that":[34,197],"encode":[35],"allodeterminants":[36],"governing":[37],"fusion":[38,117,127],"or":[39],"rejection,":[40],"depending":[41],"on":[42,139],"degree":[44],"shared":[46],"alleles,":[47],"presence":[50],"this":[52,79,140,293],"system":[53],"bivalves":[55,283],"unknown.":[57],"This":[58,267],"thesis":[59],"provided":[60],"evidence":[61,184,252],"allogeneic":[63,130,171,199,213,242,246,257,271],"response":[64,80,274],"bivalves.":[66],"It":[67],"observed":[68],"xenorecognition":[69],"across":[70],"classes":[71],"(bivalve":[72],"vs.":[73],"gastropod)":[74],"found":[76,125,250,263],"similarities":[77],"pathogen":[82,229],"recognition.":[83],"By":[84],"combining":[85],"outcomes":[87],"explant":[89,110],"cultures,":[90],"molecular":[91,145],"responses":[92,100,146],"mantle":[94],"haemocytes,":[96],"caspase-mediated":[98,254,260],"apoptosis,":[99],"were":[101,163,168,217],"explored.":[102],"Specifically,":[103],"chapter":[104,142,220],"two":[105,136,165],"developed":[106],"novel":[107],"methods":[108],"using":[109,151],"cultures":[111],"explore":[113],"allorecognition":[114],"observe":[116],"auto-,":[119],"allo-,":[120],"xenogeneic":[122,173,201,215,265,273],"treatments,":[123,174],"lower":[126],"levels":[128,160,207],"treatment":[131,193,243],"than":[132],"other":[135],"treatments.":[137],"Based":[138],"finding,":[141],"three":[143,149],"investigated":[144],"these":[148],"treatments":[150],"transcriptomics":[152],"identification":[155],"DEGs.":[157],"Although":[158],"low":[159,206],"DEGs":[162,209],"observed,":[164],"paralogous":[166],"genes":[167],"downregulated":[169,238],"thought":[175],"be":[177],"related":[178],"biomineralization":[180],"are":[182],"possible":[183],"return":[187],"normal":[189],"processes":[190,240],"autogeneic":[192],"limitations":[195],"treatment.":[202,266],"Due":[203],"identified,":[210],"injections":[211],"haemocytes":[216],"analysed":[218],"four,":[221],"comparing":[222],"results":[223],"from":[224],"a":[225,286],"viral":[226],"mimic":[227],"(for":[228],"recognition)":[230],"an":[232,245],"assumed":[233],"apoptosis":[234,255,261],"inducer.":[235],"Findings":[236],"enriched":[239],"indicated":[244],"response.":[247],"Chapter":[248],"five":[249],"no":[251],"challenge,":[258],"however":[259],"foundational":[268],"knowledge":[269],"has":[275],"advanced":[276],"our":[277],"understanding":[278],"self/nonself":[280],"recognition":[281],"provides":[285],"clear":[287],"direction":[288],"for":[289],"future":[290],"studies":[291],"area":[294],"bivalve":[296],"innate":[297],"immunity.":[298]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}