{"id":"https://openalex.org/W7225614181","doi":"https://doi.org/10.3390/ijms272110051","title":"Ribonucleases of Very Stable Multi-Protein Complexes from Different Organs of Sea Cucumber Paracaudina chilensis","display_name":"Ribonucleases of Very Stable Multi-Protein Complexes from Different Organs of Sea Cucumber Paracaudina chilensis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225614181","doi":"https://doi.org/10.3390/ijms272110051"},"language":"en","primary_location":{"id":"doi:10.3390/ijms272110051","doi":"https://doi.org/10.3390/ijms272110051","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272110051","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms272110051","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057914677","display_name":"Svetlana E. Soboleva","orcid":"https://orcid.org/0000-0002-7430-3683","observed_orcids":["https://orcid.org/0000-0002-7430-3683"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Svetlana E. Soboleva","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, pr. Akademika Lavrentieva, 8, Novosibirsk 630090, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7430-3683","affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, pr. Akademika Lavrentieva, 8, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036757787","display_name":"Irina A. Kostrikina","orcid":"https://orcid.org/0000-0002-0987-7066","observed_orcids":["https://orcid.org/0000-0002-0987-7066"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina A. Kostrikina","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, pr. Akademika Lavrentieva, 8, Novosibirsk 630090, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0987-7066","affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, pr. Akademika Lavrentieva, 8, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018933806","display_name":"Pavel S. Dmitrenok","orcid":"https://orcid.org/0000-0002-4416-7844","observed_orcids":["https://orcid.org/0000-0002-4416-7844"]},"institutions":[{"id":"https://openalex.org/I4210120806","display_name":"Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/02x9fc857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210120806","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210148470","display_name":"Far Eastern Branch of the Russian Academy of Sciences","ror":"https://ror.org/05t43vz03","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210148470"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Pavel S. Dmitrenok","raw_affiliation_strings":["G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Pr. 100 let Vladivostoku, Vladivostok 690022, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4416-7844","affiliations":[{"raw_affiliation_string":"G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Pr. 100 let Vladivostoku, Vladivostok 690022, Russia","institution_ids":["https://openalex.org/I4210120806","https://openalex.org/I4210148470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081504559","display_name":"Georgy A. Nevinsky","orcid":"https://orcid.org/0000-0002-4988-8923","observed_orcids":["https://orcid.org/0000-0002-4988-8923"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Georgy A. Nevinsky","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, pr. Akademika Lavrentieva, 8, Novosibirsk 630090, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4988-8923","affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, pr. Akademika Lavrentieva, 8, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"21","first_page":"10051","last_page":"10051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12841","display_name":"Echinoderm biology and ecology","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12841","display_name":"Echinoderm biology and ecology","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.19689999520778656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.839900016784668},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.8269000053405762},{"id":"https://openalex.org/C2776093933","wikidata":"https://www.wikidata.org/wiki/Q127470","display_name":"Sea cucumber","level":2,"score":0.7071999907493591},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5819000005722046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5620999932289124},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5130000114440918},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48980000615119934},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.4607999920845032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37869998812675476},{"id":"https://openalex.org/C3019440265","wikidata":"https://www.wikidata.org/wiki/Q238156","display_name":"Complex formation","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C199164860","wikidata":"https://www.wikidata.org/wiki/Q6822745","display_name":"Metal ions in aqueous solution","level":3,"score":0.2992999851703644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29420000314712524},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.2750000059604645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms272110051","doi":"https://doi.org/10.3390/ijms272110051","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272110051","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms272110051","doi":"https://doi.org/10.3390/ijms272110051","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272110051","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Ribonuclease":[0],"(RNase)":[1],"activity,":[2],"which":[3,102],"mediates":[4],"RNA":[5,268],"degradation,":[6],"plays":[7],"a":[8,28,165,213],"critical":[9],"role":[10,302],"in":[11,76,138,173,261,284,307],"the":[12,24,45,121,139,145,153,177,183,240,250,257,262,274,300,312],"development":[13],"and":[14,55,73,150,157,195,205,256,267,289,310],"survival":[15],"of":[16,31,44,115,134,167,179,185,229,236,254,259,264,277,303,317],"various":[17],"organisms.":[18],"In":[19],"this":[20],"study,":[21],"we":[22,82],"for":[23,244,298,314],"first":[25],"time":[26],"performed":[27],"comprehensive":[29],"analysis":[30],"ribonuclease":[32],"activity":[33,105],"within":[34,99],"highly":[35],"stable":[36,230,304],"multi-protein":[37],"complexes":[38,60,146,232,306],"isolated":[39],"from":[40,68,93,109,141,147],"five":[41],"different":[42],"organs":[43],"holothurian":[46],"Paracaudina":[47],"chilensis":[48],"(coelomic":[49],"fluid,":[50,143],"body":[51,148],"wall,":[52],"gut,":[53],"gonads,":[54],"respiratory":[56],"trees).":[57],"Previously,":[58],"these":[59,100,245],"were":[61,210],"shown":[62],"to":[63,70,74,96,111,193,197,220],"have":[64],"molecular":[65,90],"masses":[66,91],"ranging":[67,92],"1.2":[69],"1.8":[71],"MDa":[72],"differ":[75],"their":[77,318],"protein\u2013peptide":[78],"composition.":[79],"Using":[80],"zymography,":[81],"identified":[83],"enzymatically":[84],"active":[85],"protein":[86],"bands":[87],"with":[88],"apparent":[89,186],"approximately":[94],"10":[95],"180":[97],"kDa":[98],"complexes,":[101],"exhibited":[103],"RNase":[104,168,208,278],"at":[106,130],"pH":[107,175,187],"values":[108],"3.5":[110],"9.5.":[112],"The":[113,223],"number":[114,184],"detectable":[116],"activities":[117,127,170,209,246,279],"differed":[118,172],"among":[119],"organs:":[120],"greatest":[122],"diversity":[123],"(13":[124],"distinct":[125],"RNA-hydrolyzing":[126,237],"detected":[128,275],"under":[129],"least":[131],"one":[132,192],"set":[133,166],"conditions)":[135],"was":[136,162],"observed":[137],"complex":[140,161],"coelomic":[142],"whereas":[144],"wall":[149],"gut":[151],"contained":[152],"lowest":[154],"numbers":[155],"(5":[156],"6,":[158],"respectively).":[159],"Each":[160],"characterized":[163],"by":[164,212],"catalytic":[169,319],"that":[171,227,273],"optimal":[174],"(in":[176],"presence":[178],"5":[180],"mM":[181],"MgCl2),":[182],"optima":[188],"per":[189],"band":[190],"(from":[191],"four),":[194],"sensitivity":[196],"metal":[198,215],"ions":[199],"(Mg2+,":[200],"Mn2+,":[201],"Zn2+,":[202],"Co2+,":[203],"Ca2+,":[204],"Ni2+).":[206],"Some":[207],"activated":[211],"single":[214],"ion,":[216],"while":[217],"others":[218],"responded":[219],"multiple":[221],"ions.":[222],"obtained":[224],"data":[225],"demonstrate":[226],"preparations":[228],"multiprotein":[231,305],"contain":[233],"diverse":[234],"sets":[235,276],"activities,":[238],"but":[239],"individual":[241],"enzymes":[242],"responsible":[243],"remain":[247],"unidentified.":[248],"Given":[249],"outstanding":[251],"regenerative":[252],"capacity":[253],"holothurians":[255],"involvement":[258],"RNases":[260],"regulation":[263],"gene":[265],"expression":[266],"processing,":[269],"it":[270],"is":[271],"suggested":[272],"may":[280],"play":[281],"important":[282],"roles":[283],"tissue":[285],"regeneration,":[286],"immune":[287],"defense,":[288],"other":[290],"physiological":[291],"processes.":[292],"This":[293],"work":[294],"opens":[295],"new":[296],"perspectives":[297],"studying":[299],"functional":[301],"marine":[308],"invertebrates":[309],"highlights":[311],"need":[313],"further":[315],"investigation":[316],"potential.":[320]},"counts_by_year":[],"updated_date":"2026-11-10T13:44:29.811591","created_date":"2026-11-10T00:00:00"}
