{"id":"https://openalex.org/W7225613787","doi":"https://doi.org/10.1002/jum.70538","title":"Multiparametric Transperineal Ultrasound Features of Perianal Fistulas in Pediatric Crohn's Disease","display_name":"Multiparametric Transperineal Ultrasound Features of Perianal Fistulas in Pediatric Crohn's Disease","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225613787","doi":"https://doi.org/10.1002/jum.70538","pmid":"https://pubmed.ncbi.nlm.nih.gov/43000915"},"language":"en","primary_location":{"id":"doi:10.1002/jum.70538","doi":"https://doi.org/10.1002/jum.70538","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jum.70538","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jum.70538","source":{"id":"https://openalex.org/S111362775","display_name":"Journal of Ultrasound in Medicine","issn_l":"0278-4297","issn":["0278-4297","1550-9613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ultrasound in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jum.70538","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055361239","display_name":"Suhyeon Kim","orcid":"https://orcid.org/0000-0001-7618-1854","observed_orcids":["https://orcid.org/0000-0001-7618-1854","https://orcid.org/0009-0003-1048-2242"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suhyeon Kim","raw_affiliation_strings":["Department of Radiology Seoul National University Bundang Hospital  Seongnam Korea"],"raw_orcid":"https://orcid.org/0009-0003-1048-2242","affiliations":[{"raw_affiliation_string":"Department of Radiology Seoul National University Bundang Hospital  Seongnam Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001518775","display_name":"Young Jin Ryu","orcid":"https://orcid.org/0000-0001-5222-3749","observed_orcids":["https://orcid.org/0000-0001-5222-3749","https://orcid.org/0009-0001-4862-7270"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young Jin Ryu","raw_affiliation_strings":["Department of Radiology Seoul National University Bundang Hospital  Seongnam Korea","Department of Radiology Seoul National University College of Medicine  Seoul Korea"],"raw_orcid":"https://orcid.org/0000-0001-5222-3749","affiliations":[{"raw_affiliation_string":"Department of Radiology Seoul National University Bundang Hospital  Seongnam Korea","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Radiology Seoul National University College of Medicine  Seoul Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420169","display_name":"Ji Young Kim","orcid":"https://orcid.org/0000-0003-1466-2112","observed_orcids":["https://orcid.org/0000-0003-1466-2112","https://orcid.org/0000-0003-0695-0712"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Young Kim","raw_affiliation_strings":["Department of Radiology Seoul National University Bundang Hospital  Seongnam Korea","Department of Radiology Seoul National University College of Medicine  Seoul Korea"],"raw_orcid":"https://orcid.org/0000-0003-1466-2112","affiliations":[{"raw_affiliation_string":"Department of Radiology Seoul National University Bundang Hospital  Seongnam Korea","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Radiology Seoul National University College of Medicine  Seoul Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077680652","display_name":"Jong Woo Hahn","orcid":"https://orcid.org/0000-0001-6331-1314","observed_orcids":["https://orcid.org/0000-0001-6331-1314","https://orcid.org/0000-0002-3563-835X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Woo Hahn","raw_affiliation_strings":["Department of Pediatrics Seoul National University Bundang Hospital  Seongnam Korea","Department of Pediatrics Seoul National University College of Medicine  Seoul Korea"],"raw_orcid":"https://orcid.org/0000-0001-6331-1314","affiliations":[{"raw_affiliation_string":"Department of Pediatrics Seoul National University Bundang Hospital  Seongnam Korea","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Pediatrics Seoul National University College of Medicine  Seoul Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100734569","display_name":"Hye Ran Yang","orcid":"https://orcid.org/0000-0002-3423-6922","observed_orcids":["https://orcid.org/0000-0002-3423-6922","https://orcid.org/0000-0001-9744-6735"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Ran Yang","raw_affiliation_strings":["Department of Pediatrics Seoul National University Bundang Hospital  Seongnam Korea","Department of Pediatrics Seoul National University College of Medicine  Seoul Korea"],"raw_orcid":"https://orcid.org/0000-0002-3423-6922","affiliations":[{"raw_affiliation_string":"Department of Pediatrics Seoul National University Bundang Hospital  Seongnam Korea","institution_ids":["https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Pediatrics Seoul National University College of Medicine  Seoul Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001518775"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.1906999945640564,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anal-fistula","display_name":"anal fistula","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pediatric-crohn-s-disease","display_name":"pediatric Crohn's disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/transperineal-ultrasound","display_name":"transperineal ultrasound","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anisotropy","display_name":"anisotropy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9769999980926514},{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.7813000082969666},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.651199996471405},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5734999775886536},{"id":"https://openalex.org/C206111553","wikidata":"https://www.wikidata.org/wiki/Q3501532","display_name":"Echogenicity","level":3,"score":0.49790000915527344},{"id":"https://openalex.org/C2781163205","wikidata":"https://www.wikidata.org/wiki/Q105499","display_name":"Perineum","level":2,"score":0.48190000653266907},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.4388999938964844},{"id":"https://openalex.org/C2778357063","wikidata":"https://www.wikidata.org/wiki/Q713102","display_name":"Pelvis","level":2,"score":0.415800005197525},{"id":"https://openalex.org/C2780139565","wikidata":"https://www.wikidata.org/wiki/Q5376217","display_name":"Endoanal ultrasound","level":4,"score":0.388700008392334},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C2780035688","wikidata":"https://www.wikidata.org/wiki/Q2465231","display_name":"Anal canal","level":3,"score":0.35600000619888306},{"id":"https://openalex.org/C2776341189","wikidata":"https://www.wikidata.org/wiki/Q189470","display_name":"Fistula","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C2992200296","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn disease","level":4,"score":0.29980000853538513},{"id":"https://openalex.org/C2781102422","wikidata":"https://www.wikidata.org/wiki/Q2601133","display_name":"Internal anal sphincter","level":4,"score":0.2874000072479248},{"id":"https://openalex.org/C2780877482","wikidata":"https://www.wikidata.org/wiki/Q746416","display_name":"Sphincter","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C186282968","wikidata":"https://www.wikidata.org/wiki/Q1434261","display_name":"McNemar's test","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2808000147342682}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jum.70538","doi":"https://doi.org/10.1002/jum.70538","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jum.70538","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jum.70538","source":{"id":"https://openalex.org/S111362775","display_name":"Journal of Ultrasound in Medicine","issn_l":"0278-4297","issn":["0278-4297","1550-9613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ultrasound in Medicine","raw_type":"journal-article"},{"id":"pmid:43000915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43000915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jum.70538","doi":"https://doi.org/10.1002/jum.70538","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jum.70538","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jum.70538","source":{"id":"https://openalex.org/S111362775","display_name":"Journal of Ultrasound in Medicine","issn_l":"0278-4297","issn":["0278-4297","1550-9613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ultrasound in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225613787.pdf","grobid_xml":"https://content.openalex.org/works/W7225613787.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1949794726","https://openalex.org/W1979815300","https://openalex.org/W1984522473","https://openalex.org/W2007528354","https://openalex.org/W2023331831","https://openalex.org/W2032533938","https://openalex.org/W2075566237","https://openalex.org/W2093958459","https://openalex.org/W2105423417","https://openalex.org/W2114492079","https://openalex.org/W2168132096","https://openalex.org/W2314644132","https://openalex.org/W2409908904","https://openalex.org/W2519813109","https://openalex.org/W2585236953","https://openalex.org/W2606394434","https://openalex.org/W2759840705","https://openalex.org/W2885617448","https://openalex.org/W2906229755","https://openalex.org/W2962803899","https://openalex.org/W3168246272","https://openalex.org/W4283794470","https://openalex.org/W4409255942","https://openalex.org/W4412780968","https://openalex.org/W7140222013"],"related_works":["https://openalex.org/W7203740657","https://openalex.org/W2759840705","https://openalex.org/W2075566237","https://openalex.org/W1979815300","https://openalex.org/W2083500526","https://openalex.org/W2104937946","https://openalex.org/W4283794470","https://openalex.org/W3031255032","https://openalex.org/W4322719891","https://openalex.org/W2058138693"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"evaluate":[2],"and":[3,16,38,57,70,74,83,120,132,157,161,166,233,240,271,304],"compare":[4],"the":[5,102,149,183,190,200,217,289],"multiparametric":[6,206,258],"transperineal":[7],"ultrasound":[8],"(TPUS)":[9],"features":[10],"of":[11,115,148,185,216,235,265,269,273,293],"perianal":[12,51,176,251],"fistulas":[13,52,63,142,177,193,203,294],"at":[14,66],"baseline":[15,137],"upon":[17],"achieving":[18,171],"magnetic":[19],"resonance":[20],"imaging":[21],"(MRI)-confirmed":[22],"radiologic":[23,174],"healing":[24,77,248,297],"in":[25,89,124,182,210,249,301],"pediatric":[26,250],"Crohn":[27,252],"disease.":[28],"METHODS:":[29],"This":[30],"retrospective":[31],"study":[32],"included":[33],"24":[34],"children":[35],"(22":[36],"boys":[37],"2":[39,68,92],"girls;":[40],"mean":[41],"age,":[42],"13.0":[43],"\u00b1":[44],"2.3":[45],"years":[46],"[range,":[47],"9-19])":[48],"with":[49,62],"45":[50],"evaluated":[53,88],"between":[54],"January":[55],"2019":[56],"July":[58],"2025.":[59],"All":[60],"patients":[61],"who":[64],"underwent":[65],"least":[67],"TPUS":[69,85,181,259,277],"pelvic":[71],"MRI":[72,79,284],"assessments":[73],"achieved":[75],"complete":[76,172],"on":[78],"were":[80,87,127,195],"enrolled.":[81],"Baseline":[82],"follow-up":[84,306],"images":[86],"consensus":[90],"by":[91,180,256],"radiologists":[93],"for":[94,285],"multiple":[95],"parameters,":[96],"including":[97,208,261],"diameter,":[98],"echogenicity":[99,145],"relative":[100],"to":[101,283],"internal":[103,108,158],"anal":[104],"sphincter":[105],"(IAS),":[106],"vascularity,":[107],"pattern":[109,155,219],"(layered":[110],"versus":[111],"homogeneous),":[112],"anisotropy,":[113,270],"presence":[114],"pus,":[116],"air":[117],"bubbles,":[118],"abscesses,":[119],"adjacent":[121,167,241],"inflammation.":[122],"Changes":[123],"these":[125],"findings":[126],"compared":[128],"using":[129],"paired":[130],"t-tests":[131],"McNemar":[133],"tests.":[134],"RESULTS:":[135],"At":[136],"(n":[138],"=":[139,231,238],"45),":[140],"most":[141],"demonstrated":[143,204],"higher":[144],"than":[146],"that":[147],"IAS":[150],"(73%),":[151],"exhibited":[152],"a":[153,280],"layered":[154,218,266],"(80%)":[156],"vascularity":[159,229],"(94%)":[160],"frequently":[162],"showed":[163],"pus":[164,236],"(40%)":[165,194],"inflammation":[168,242],"(78%).":[169],"Despite":[170],"MRI-defined":[173,296],"healing,":[175],"remained":[178],"detectable":[179],"majority":[184],"cases":[186],"(60%,":[187],"27/45),":[188],"while":[189],"other":[191],"18":[192],"no":[196],"longer":[197],"detectable.":[198],"However,":[199],"27":[201],"persisting":[202],"significant":[205],"evolution,":[207],"reductions":[209],"diameter":[211,262],"(p":[212,220,225,230,237,243],"<":[213,221,226,244],".001),":[214,222,227],"loss":[215,264],"increased":[223],"anisotropy":[224],"decreased":[228],".002),":[232],"resolution":[234,272],".001)":[239],".001).":[245],"CONCLUSION:":[246],"Radiologic":[247],"disease":[253],"is":[254],"characterized":[255],"distinct":[257],"changes,":[260],"reduction,":[263],"pattern,":[267],"emergence":[268],"inflammatory":[274],"markers.":[275],"While":[276],"serves":[278],"as":[279],"valuable":[281],"adjunct":[282],"assessing":[286],"treatment":[287],"response,":[288],"persistent":[290],"sonographic":[291],"detectability":[292],"despite":[295],"warrants":[298],"further":[299],"validation":[300],"larger":[302],"cohorts":[303],"long-term":[305],"studies.":[307]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}