{"id":"https://openalex.org/W7225613613","doi":"https://doi.org/10.3389/fphys.2026.1951859","title":"Association of preoperative frailty, inflammatory markers and CT radiomics with complications after esophagectomy in older adults: a five-year retrospective analysis and online dynamic nomogram development","display_name":"Association of preoperative frailty, inflammatory markers and CT radiomics with complications after esophagectomy in older adults: a five-year retrospective analysis and online dynamic nomogram development","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225613613","doi":"https://doi.org/10.3389/fphys.2026.1951859"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2026.1951859","doi":"https://doi.org/10.3389/fphys.2026.1951859","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1951859","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1951859/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1951859/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115595338","display_name":"Qing Liu","orcid":"https://orcid.org/0009-0008-9320-450X","observed_orcids":["https://orcid.org/0009-0008-9320-450X","https://orcid.org/0000-0003-0120-7102","https://orcid.org/0009-0007-4918-0232"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Liu","raw_affiliation_strings":["Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103048108","display_name":"Da Qin","orcid":"https://orcid.org/0000-0001-9725-2244","observed_orcids":["https://orcid.org/0000-0001-9725-2244"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da Qin","raw_affiliation_strings":["Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110848623","display_name":"Ze Tang","orcid":"https://orcid.org/0000-0003-2412-5871","observed_orcids":["https://orcid.org/0000-0003-2412-5871"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze Tang","raw_affiliation_strings":["Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431358","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0003-1130-8214","observed_orcids":["https://orcid.org/0000-0003-1130-8214"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069757344","display_name":"Tianyu Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Lu","raw_affiliation_strings":["Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021660454","display_name":"\u5d14\u6709\u658c","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Youbin Cui","raw_affiliation_strings":["Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery II, Organ Transplantation Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037991020","display_name":"Yanbo Zhu","orcid":"https://orcid.org/0000-0003-4108-2025","observed_orcids":["https://orcid.org/0000-0003-4108-2025"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanbo Zhu","raw_affiliation_strings":["Stem Cell and Cancer Center, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Cancer Center, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021660454","https://openalex.org/A5037991020"],"corresponding_institution_ids":["https://openalex.org/I4210125137"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.44190001487731934,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.44190001487731934,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophagectomy","display_name":"esophagectomy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8259999752044678},{"id":"https://openalex.org/keywords/preoperative-frailty","display_name":"preoperative frailty","score":0.8999999761581421},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-index","display_name":"systemic inflammation response index","score":0.7599999904632568},{"id":"https://openalex.org/keywords/systemic-immune-inflammation-index","display_name":"systemic immune-inflammation index","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ct-radiomics","display_name":"CT radiomics","score":0.7979999780654907},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.9810000061988831},{"id":"https://openalex.org/keywords/risk-prediction-nomogram","display_name":"risk prediction nomogram","score":0.800000011920929},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9160000085830688},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":0.902999997138977},{"id":"https://openalex.org/keywords/monocyte-to-lymphocyte-ratio","display_name":"monocyte-to-lymphocyte ratio","score":0.949999988079071},{"id":"https://openalex.org/keywords/frailty-phenotype","display_name":"Fried frailty phenotype","score":0.7590000033378601},{"id":"https://openalex.org/keywords/shap","display_name":"SHAP","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.9351999759674072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9222000241279602},{"id":"https://openalex.org/C2777297899","wikidata":"https://www.wikidata.org/wiki/Q298191","display_name":"Esophagectomy","level":4,"score":0.7461000084877014},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7034000158309937},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6772000193595886},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5960000157356262},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5414999723434448},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4422000050544739},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4334999918937683},{"id":"https://openalex.org/C2776667177","wikidata":"https://www.wikidata.org/wiki/Q1779148","display_name":"Colectomy","level":4,"score":0.4189000129699707},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.4138000011444092},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4108000099658966},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.3621000051498413},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3546000123023987},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C207386681","wikidata":"https://www.wikidata.org/wiki/Q451323","display_name":"Derivation","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fphys.2026.1951859","doi":"https://doi.org/10.3389/fphys.2026.1951859","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1951859","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1951859/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2026.1951859","doi":"https://doi.org/10.3389/fphys.2026.1951859","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1951859","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1951859/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225613613.pdf","grobid_xml":"https://content.openalex.org/works/W7225613613.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W2107640783","https://openalex.org/W2118278569","https://openalex.org/W2160345528","https://openalex.org/W2164059021","https://openalex.org/W2345885627","https://openalex.org/W2463800533","https://openalex.org/W2618303047","https://openalex.org/W2763355946","https://openalex.org/W2959497269","https://openalex.org/W3022298391","https://openalex.org/W3086268209","https://openalex.org/W4220700321","https://openalex.org/W4221008887","https://openalex.org/W4225709745","https://openalex.org/W4226059677","https://openalex.org/W4226292555","https://openalex.org/W4229082992","https://openalex.org/W4285389869","https://openalex.org/W4292623292","https://openalex.org/W4295234846","https://openalex.org/W4317718157","https://openalex.org/W4367461136","https://openalex.org/W4388946879","https://openalex.org/W4391042733","https://openalex.org/W4400513622","https://openalex.org/W4402243136","https://openalex.org/W4404926645","https://openalex.org/W4406156217","https://openalex.org/W4407743314","https://openalex.org/W4416445386","https://openalex.org/W7117292906","https://openalex.org/W7133221072"],"related_works":["https://openalex.org/W7131784386","https://openalex.org/W4401636567","https://openalex.org/W7203976620","https://openalex.org/W4415208812","https://openalex.org/W2170459715","https://openalex.org/W7161154445","https://openalex.org/W4385147098","https://openalex.org/W7203855926","https://openalex.org/W4385187510","https://openalex.org/W7225332646"],"abstract_inverted_index":{"Objective":[0],"Older":[1],"adults":[2],"with":[3,68,134,226,258,288],"esophageal":[4],"cancer":[5],"have":[6],"poor":[7],"physiological":[8],"tolerance":[9],"and":[10,26,34,63,81,105,114,119,121,139,146,154,182,196,209,220,249,255,261,265,278,301],"a":[11,36,142,270],"high":[12],"risk":[13,42,300],"of":[14,162,189,243,285],"postoperative":[15,286],"complications.":[16],"This":[17,45],"study":[18,48],"examined":[19],"whether":[20],"preoperative":[21,78],"frailty,":[22,275],"hematologic":[23],"inflammatory":[24,73,168,276],"indices":[25,74,94,107,169,208,277],"CT":[27,82,211,279],"radiomic":[28,83,212,280],"features":[29,84,213,281],"independently":[30,188],"predict":[31],"these":[32],"complications":[33],"built":[35],"validated":[37,295],"web-based":[38],"nomogram":[39,234,297],"for":[40],"personalized":[41],"prediction.":[43],"Methods":[44],"five-year":[46],"retrospective":[47],"included":[49],"526":[50,163],"patients":[51,164],"aged":[52],"at":[53],"least":[54],"60":[55],"years":[56],"who":[57],"underwent":[58],"radical":[59],"esophagectomy":[60],"between":[61],"2019":[62],"2023.":[64],"Frailty":[65],"was":[66,103,267],"assessed":[67],"the":[69,92,96,106,177,193,204,229,238,253],"Fried":[70],"phenotype,":[71],"five":[72,93,167],"were":[75,85,108,126,150,170,186,223],"calculated":[76],"from":[77,87],"blood":[79],"counts,":[80,100],"extracted":[86],"contrast-enhanced":[88],"chest":[89],"CT.":[90],"Because":[91],"share":[95],"same":[97],"four":[98],"cell":[99],"their":[101],"collinearity":[102],"diagnosed":[104],"compared":[109],"through":[110],"sequential":[111],"selection,":[112],"single-index":[113],"alternative-model":[115],"discrimination,":[116,144],"reclassification":[117],"metrics,":[118],"order-reversed":[120],"bootstrap":[122],"validation.":[123],"Independent":[124],"predictors":[125,284],"identified":[127],"by":[128,292],"two-stage":[129],"multivariable":[130],"logistic":[131],"regression,":[132],"ranked":[133],"SHapley":[135],"Additive":[136],"exPlanations":[137],"(SHAP),":[138],"assembled":[140],"into":[141],"nomogram;":[143],"calibration":[145,260],"net":[147,262],"clinical":[148,263],"benefit":[149],"evaluated":[151],"in":[152,160,252],"training":[153,254],"validation":[155,256],"cohorts.":[156],"Results":[157],"Complications":[158],"occurred":[159],"187":[161],"(35.55%).":[165],"The":[166,233,294],"strongly":[171],"collinear;":[172],"across":[173],"all":[174],"sensitivity":[175],"analyses":[176],"systemic":[178,183],"inflammation":[179],"response":[180],"index":[181,185],"immune-inflammation":[184],"retained":[187,206],"entry":[190],"order,":[191],"whereas":[192],"neutrophil-,":[194],"platelet-":[195],"monocyte-to-lymphocyte":[197],"ratios":[198],"added":[199],"no":[200],"incremental":[201],"information.":[202],"Frailty,":[203],"two":[205],"composite":[207],"three":[210],"(lesion":[214],"texture":[215],"heterogeneity,":[216],"gray-level":[217],"mean":[218],"value":[219],"shape":[221],"irregularity)":[222],"independent":[224,283],"predictors,":[225],"frailty":[227],"carrying":[228],"greatest":[230],"SHAP":[231],"weight.":[232],"achieved":[235],"areas":[236],"under":[237],"receiver":[239],"operating":[240],"characteristic":[241],"curve":[242],"0.824":[244],"(95%":[245],"confidence":[246],"interval":[247],"0.780-0.868)":[248],"0.807":[250],"(0.746-0.868)":[251],"cohorts,":[257],"good":[259],"benefit,":[264],"it":[266],"implemented":[268],"as":[269],"web":[271,296],"tool.":[272],"Conclusion":[273],"Preoperative":[274],"are":[282],"complications,":[287],"distinct":[289],"contributions":[290],"revealed":[291],"SHAP.":[293],"reliably":[298],"stratifies":[299],"supports":[302],"individualized":[303],"perioperative":[304],"management.":[305]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}