{"id":"https://openalex.org/W7225613162","doi":"https://doi.org/10.21203/rs.3.rs-11207616/v1","title":"Surface coating biomaterials shape morphology, transcriptomic identity, and excitability of human iPSC-derived nociceptors","display_name":"Surface coating biomaterials shape morphology, transcriptomic identity, and excitability of human iPSC-derived nociceptors","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225613162","doi":"https://doi.org/10.21203/rs.3.rs-11207616/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11207616/v1","doi":"https://doi.org/10.21203/rs.3.rs-11207616/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11207616/v1","pdf_url":"https://www.researchsquare.com/article/rs-11207616/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11207616/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102929040","display_name":"Buket U\u00e7ar","orcid":"https://orcid.org/0000-0001-8924-1932","observed_orcids":["https://orcid.org/0000-0001-8924-1932"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Buket Ucar","raw_affiliation_strings":["Medical University Innsbruck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Innsbruck","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081394430","display_name":"David Zimmermann","orcid":"https://orcid.org/0009-0008-0183-7298","observed_orcids":["https://orcid.org/0009-0008-0183-7298"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"David Zimmermann","raw_affiliation_strings":["Medical University Innsbruck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Innsbruck","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000506463","display_name":"Ferenc T\u00f6r\u00f6k","orcid":"https://orcid.org/0009-0006-8133-5778","observed_orcids":["https://orcid.org/0009-0006-8133-5778"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ferenc T\u00f6r\u00f6k","raw_affiliation_strings":["Medical University Innsbruck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Innsbruck","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040730141","display_name":"Georg Kern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Georg Kern","raw_affiliation_strings":["Medical University Innsbruck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Innsbruck","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036753916","display_name":"Kai K. Kummer","orcid":"https://orcid.org/0000-0002-5854-6503","observed_orcids":["https://orcid.org/0000-0002-5854-6503"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kai K. Kummer","raw_affiliation_strings":["Medical University Innsbruck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Innsbruck","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059294774","display_name":"Karolina Pircs","orcid":"https://orcid.org/0000-0001-8281-4785","observed_orcids":["https://orcid.org/0000-0001-8281-4785"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Karolina Pircs","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128204599","display_name":"Attila Szucs","orcid":"https://orcid.org/0000-0003-2803-7123","observed_orcids":["https://orcid.org/0000-0003-2803-7123"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Sz\u00fccs","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047821411","display_name":"Michaela Kress","orcid":"https://orcid.org/0000-0002-8921-7470","observed_orcids":["https://orcid.org/0000-0002-8921-7470"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michaela Kress","raw_affiliation_strings":["Medical University Innsbruck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University Innsbruck","institution_ids":["https://openalex.org/I143397708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nociceptor-excitability","display_name":"nociceptor excitability","score":0.7879999876022339},{"id":"https://openalex.org/keywords/spontaneous-firing","display_name":"spontaneous firing","score":0.6129999756813049},{"id":"https://openalex.org/keywords/pain-models","display_name":"pain models","score":0.5199999809265137},{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"neuronal morphology","score":0.47600001096725464},{"id":"https://openalex.org/keywords/single-cell-electrophysiology","display_name":"single-cell electrophysiology","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6682999730110168},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6611999869346619},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6514999866485596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6238999962806702},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.582099974155426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5619000196456909},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.439300000667572},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.40790000557899475},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.39820000529289246},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.38339999318122864},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.36800000071525574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3499999940395355},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.3321000039577484},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3285999894142151},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2676999866962433},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C2910924664","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Human Induced Pluripotent Stem Cells","level":5,"score":0.2635999917984009},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.25589999556541443},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25119999051094055},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11207616/v1","doi":"https://doi.org/10.21203/rs.3.rs-11207616/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11207616/v1","pdf_url":"https://www.researchsquare.com/article/rs-11207616/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11207616/v1","doi":"https://doi.org/10.21203/rs.3.rs-11207616/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11207616/v1","pdf_url":"https://www.researchsquare.com/article/rs-11207616/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320326164","display_name":"Medizinische Universit\u00e4t Innsbruck","ror":"https://ror.org/03pt86f80"},{"id":"https://openalex.org/F4320328081","display_name":"Stiftung Aktion \u00d6sterreich-Ungarn","ror":"https://ror.org/04vqvwv40"},{"id":"https://openalex.org/F4320335908","display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225613162.pdf","grobid_xml":"https://content.openalex.org/works/W7225613162.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1568440737","https://openalex.org/W1985180469","https://openalex.org/W2000765473","https://openalex.org/W2003554016","https://openalex.org/W2019962736","https://openalex.org/W2033072655","https://openalex.org/W2043216372","https://openalex.org/W2051507702","https://openalex.org/W2053457382","https://openalex.org/W2056229778","https://openalex.org/W2062168681","https://openalex.org/W2077247278","https://openalex.org/W2082682623","https://openalex.org/W2082833517","https://openalex.org/W2086434606","https://openalex.org/W2093629630","https://openalex.org/W2102338390","https://openalex.org/W2110119922","https://openalex.org/W2148128847","https://openalex.org/W2179438025","https://openalex.org/W2211603551","https://openalex.org/W2376305620","https://openalex.org/W2546592055","https://openalex.org/W2616972228","https://openalex.org/W2759267903","https://openalex.org/W2762851710","https://openalex.org/W2923498555","https://openalex.org/W2948487620","https://openalex.org/W2952675533","https://openalex.org/W3007644775","https://openalex.org/W3033979265","https://openalex.org/W3134557264","https://openalex.org/W3135813546","https://openalex.org/W3173018522","https://openalex.org/W3198611391","https://openalex.org/W3201760514","https://openalex.org/W3215181486","https://openalex.org/W4211169528","https://openalex.org/W4212921021","https://openalex.org/W4213110813","https://openalex.org/W4213124878","https://openalex.org/W4220980437","https://openalex.org/W4225106291","https://openalex.org/W4281635772","https://openalex.org/W4315705320","https://openalex.org/W4385985710","https://openalex.org/W4388911664","https://openalex.org/W4388923900","https://openalex.org/W4393992416","https://openalex.org/W4394741196","https://openalex.org/W4399671596","https://openalex.org/W4405853111","https://openalex.org/W4406638937","https://openalex.org/W4410315980","https://openalex.org/W7147061573","https://openalex.org/W7155200568"],"related_works":["https://openalex.org/W4405920811","https://openalex.org/W4318934620","https://openalex.org/W3198611391","https://openalex.org/W4403891732","https://openalex.org/W7203825306","https://openalex.org/W4243548223","https://openalex.org/W4225562610","https://openalex.org/W7212870742","https://openalex.org/W7105767475","https://openalex.org/W3010764945"],"abstract_inverted_index":{"Abstract":[0],"Human":[1],"induced":[2],"pluripotent":[3],"stem":[4],"cell":[5,143],"(iPSC)-derived":[6],"nociceptors":[7],"(iNocs)":[8],"are":[9],"valuable":[10],"tools":[11],"for":[12],"modelling":[13],"sensory":[14],"neurobiology":[15],"and":[16,21,57,65,81,97,111,119,122,157,192],"pain,":[17],"while":[18],"achieving":[19],"maturation":[20,193],"reproducibility":[22],"remains":[23],"challenging.":[24],"Currently":[25],"available":[26],"differentiation":[27],"protocols":[28],"focus":[29],"on":[30,135,153],"soluble":[31],"factors,":[32],"but":[33],"the":[34,37,61,92,138,189],"role":[35],"of":[36,68,94,150,161,176,194],"extracellular":[38,169],"matrix":[39,109,170],"is":[40],"insufficiently":[41],"understood.":[42],"In":[43],"this":[44],"study":[45],"we":[46],"investigated":[47],"how":[48],"widely":[49],"used":[50],"plastic":[51],"surface":[52,180],"coatings":[53],"including":[54],"laminin,":[55],"poly-L-lysine/laminin":[56,136],"Matrigel":[58,100],"\u2122":[59],"influenced":[60],"morphology,":[62,91],"transcriptional":[63],"identity,":[64],"functional":[66],"activity":[67,129],"human":[69,196],"iNocs":[70,90,133],"combining":[71],"indirect":[72],"immune":[73],"fluorescence":[74],"microscopy,":[75],"RNA":[76],"sequencing,":[77],"multi-electrode":[78],"array":[79],"recordings":[80,146],"single-cell":[82],"patch-clamp":[83],"techniques.":[84],"Significant":[85],"differences":[86],"were":[87],"obtained":[88],"in":[89,132],"size":[93],"cellular":[95],"clusters,":[96],"transcriptomic":[98],"signatures.":[99],"coating":[101,116,151,167,181],"promoted":[102],"biological":[103],"gene":[104,125],"ontologies":[105],"related":[106],"to":[107,187],"\u201cextracellular":[108],"remodelling\u201d":[110],"\u201cmesenchymal":[112],"pathways\u201d":[113],"whereas":[114],"laminin":[115],"enhanced":[117],"neuronal":[118],"synaptic":[120],"processes":[121],"enriched":[123],"proliferative":[124],"sets.":[126],"Spontaneous":[127],"discharge":[128],"was":[130],"increased":[131],"cultured":[134],"exhibiting":[137],"highest":[139],"firing":[140],"rates.":[141],"Single":[142],"patch":[144],"clamp":[145],"revealed":[147],"minor":[148],"effects":[149],"materials":[152],"passive":[154],"membrane":[155],"properties":[156],"basic":[158],"electrophysiological":[159],"parameters":[160],"individual":[162],"iNocs.":[163],"These":[164],"findings":[165],"introduce":[166],"specific":[168],"compositions":[171],"as":[172],"a":[173,184],"critical":[174],"regulator":[175],"iNoc":[177],"phenotypes.":[178],"Optimizing":[179],"substrates":[182],"offers":[183],"powerful":[185],"strategy":[186],"improve":[188],"physiological":[190],"relevance":[191],"translational":[195],"pain":[197],"models.":[198]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
