{"id":"https://openalex.org/W7225612843","doi":"https://doi.org/10.1021/acsami.6c14968","title":"A Dual-Mode Fluorescence-Surface-Enhanced Raman Scattering Probe Integrated with Magnetic Separation and DSN Amplification for miR-10b Detection in Cancer Serum","display_name":"A Dual-Mode Fluorescence-Surface-Enhanced Raman Scattering Probe Integrated with Magnetic Separation and DSN Amplification for miR-10b Detection in Cancer Serum","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225612843","doi":"https://doi.org/10.1021/acsami.6c14968","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002666"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.6c14968","doi":"https://doi.org/10.1021/acsami.6c14968","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.6c14968","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100360815","display_name":"Yuping Li","orcid":"https://orcid.org/0000-0002-2506-1155","observed_orcids":["https://orcid.org/0000-0002-2506-1155"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuping Li","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124667932","display_name":"Lixuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixuan Wang","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161312044","display_name":"Zhenyu Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Wu","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161310965","display_name":"Xin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106035168","display_name":"Y ZHANG","orcid":"https://orcid.org/0009-0008-8596-3514","observed_orcids":["https://orcid.org/0009-0008-8596-3514","https://orcid.org/0000-0002-4941-8622"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Zhang","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":"https://orcid.org/0009-0008-8596-3514","affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456908","display_name":"Xiaoli Wang","orcid":"https://orcid.org/0000-0002-7198-273X","observed_orcids":["https://orcid.org/0000-0002-7198-273X"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoli Wang","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7198-273X","affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087356743","display_name":"Nandi Zhou","orcid":"https://orcid.org/0000-0002-2906-7781","observed_orcids":["https://orcid.org/0000-0002-2906-7781"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nandi Zhou","raw_affiliation_strings":["Jiangnan University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2906-7781","affiliations":[{"raw_affiliation_string":"Jiangnan University , , ,","institution_ids":["https://openalex.org/I111599522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111599522"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duplex-specific-nuclease","display_name":"duplex-specific nuclease","score":0.824999988079071},{"id":"https://openalex.org/keywords/magnetic-separation","display_name":"magnetic separation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/dna-hairpin","display_name":"DNA hairpins","score":0.7229999899864197},{"id":"https://openalex.org/keywords/fluorescence-resonance-energy-transfer","display_name":"fluorescence resonance energy transfer","score":0.8270000219345093},{"id":"https://openalex.org/keywords/localized-surface-plasmon-resonance","display_name":"localized surface plasmon resonance","score":0.9620000123977661},{"id":"https://openalex.org/keywords/target-recycling-amplification","display_name":"target recycling amplification","score":0.7549999952316284},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":1.0}],"concepts":[{"id":"https://openalex.org/C169573571","wikidata":"https://www.wikidata.org/wiki/Q466824","display_name":"Raman scattering","level":3,"score":0.7617999911308289},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7347999811172485},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.6534000039100647},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.618399977684021},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5806000232696533},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5543000102043152},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.4918999969959259},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.462799996137619},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.44350001215934753},{"id":"https://openalex.org/C10349863","wikidata":"https://www.wikidata.org/wiki/Q6553497","display_name":"Linear range","level":3,"score":0.4027999937534332},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.39719998836517334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.3910999894142151},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.38989999890327454},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.3671000003814697},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3652999997138977},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.3650999963283539},{"id":"https://openalex.org/C2983449737","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Clinical diagnosis","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C2779833257","wikidata":"https://www.wikidata.org/wiki/Q2663154","display_name":"Magnetic separation","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C120456961","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Light scattering","level":3,"score":0.27090001106262207},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2667999863624573},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C41858301","wikidata":"https://www.wikidata.org/wiki/Q2327870","display_name":"Nanosensor","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.6c14968","doi":"https://doi.org/10.1021/acsami.6c14968","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.6c14968","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},{"id":"pmid:43002666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W2048995007","https://openalex.org/W2059357290","https://openalex.org/W2086331407","https://openalex.org/W2117391818","https://openalex.org/W2945715267","https://openalex.org/W3043167881","https://openalex.org/W3109655646","https://openalex.org/W3203091089","https://openalex.org/W4303628262","https://openalex.org/W4392110371","https://openalex.org/W4396999821","https://openalex.org/W4399238726","https://openalex.org/W4404503682","https://openalex.org/W4405638402","https://openalex.org/W4406101456","https://openalex.org/W4406375717","https://openalex.org/W4408088840","https://openalex.org/W4409289836","https://openalex.org/W4409314857","https://openalex.org/W4409368075","https://openalex.org/W4410216785","https://openalex.org/W4411571716","https://openalex.org/W4412391233","https://openalex.org/W4412696462","https://openalex.org/W4413489874","https://openalex.org/W4415043879","https://openalex.org/W4415701547","https://openalex.org/W4417435980","https://openalex.org/W4417445045","https://openalex.org/W7083727031","https://openalex.org/W7135199781","https://openalex.org/W7138301344","https://openalex.org/W7141120247","https://openalex.org/W7154697060","https://openalex.org/W7154974603","https://openalex.org/W7155042575","https://openalex.org/W7159769461","https://openalex.org/W7164881836"],"related_works":["https://openalex.org/W4380291106","https://openalex.org/W2625532016","https://openalex.org/W2208877657","https://openalex.org/W2934856579","https://openalex.org/W2517707868","https://openalex.org/W4312810403","https://openalex.org/W4411957778","https://openalex.org/W2954260652","https://openalex.org/W4224294670","https://openalex.org/W2781622353"],"abstract_inverted_index":{"Developing":[0],"highly":[1],"sensitive":[2,209],"and":[3,20,37,83,94,102,107,140,155,183,190,210,221],"reliable":[4,211],"methods":[5],"for":[6,11,28,97,178,181,213],"microRNA":[7],"detection":[8,31,132],"is":[9,58],"crucial":[10],"early":[12,214],"cancer":[13,192,199,215],"diagnosis.":[14],"Herein,":[15],"a":[16,85,120,208],"dual-mode":[17,205],"fluorescence":[18,59],"(FL)":[19,139],"surface-enhanced":[21],"Raman":[22],"scattering":[23],"(SERS)":[24],"probe":[25,45,114,145,196],"was":[26,167],"constructed":[27],"the":[29,113,164,195],"ultrasensitive":[30],"of":[32,47,123,161,224],"miR-10b,":[33,56],"integrating":[34],"magnetic":[35],"separation":[36],"duplex-specific":[38],"nuclease":[39],"(DSN)-assisted":[40],"target":[41,79],"recycling":[42],"amplification.":[43],"The":[44,144],"consists":[46],"Fe3O4@AuNPs":[48],"modified":[49],"with":[50,131],"Cy5-labeled":[51],"hairpin":[52],"DNA":[53],"(H1).":[54],"Without":[55],"Cy5":[57,92],"resonance":[60,74],"energy":[61],"transfer":[62],"(FRET)-quenched":[63],"by":[64,70,169],"AuNPs":[65],"(low":[66],"FL)":[67],"but":[68],"SERS-enhanced":[69],"localized":[71],"surface":[72],"plasmon":[73],"(LSPR)":[75],"(strong":[76],"SERS).":[77],"Upon":[78],"recognition,":[80],"H1":[81],"opens":[82],"forms":[84],"DNA-RNA":[86],"duplex,":[87],"which":[88],"DSN":[89],"cleaves,":[90],"releasing":[91],"fragments":[93],"intact":[95],"miR-10b":[96,171],"recycling.":[98],"This":[99,204],"disrupts":[100],"FRET":[101],"LSPR,":[103],"causing":[104],"FL":[105],"recovery":[106],"SERS":[108],"decrease.":[109],"Under":[110],"optimized":[111],"conditions,":[112],"exhibited":[115],"excellent":[116,149],"linear":[117],"responses":[118],"over":[119,158],"concentration":[121],"range":[122],"101":[124],"to":[125],"105":[126],"pM":[127],"in":[128,172],"both":[129],"modes,":[130],"limits":[133],"as":[134,136],"low":[135],"18.20":[137],"fM":[138,142],"20.33":[141],"(SERS).":[143],"demonstrated":[146],"outstanding":[147],"selectivity,":[148],"reproducibility":[150],"(batch-to-batch":[151],"RSD":[152],"<":[153],"2.26%),":[154],"good":[156],"stability":[157],"28":[159],"days":[160],"storage.":[162],"Furthermore,":[163],"practical":[165],"applicability":[166],"validated":[168],"analyzing":[170],"spiked":[173],"human":[174],"serum":[175,185],"(recoveries:":[176],"99.50%-104.80%":[177],"FL;":[179],"101.30%-104.09%":[180],"SERS)":[182],"clinical":[184],"samples":[186],"from":[187,201],"lung,":[188],"breast,":[189],"thyroid":[191],"patients,":[193],"where":[194],"successfully":[197],"distinguished":[198],"patients":[200],"healthy":[202],"controls.":[203],"strategy":[206],"provides":[207],"platform":[212],"diagnosis":[216],"via":[217],"mutual":[218],"signal":[219],"cross-validation":[220],"effective":[222],"suppression":[223],"false":[225],"positives.":[226]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}