{"id":"https://openalex.org/W7225612489","doi":"https://doi.org/10.3389/fmolb.2026.1971794","title":"Molecular architecture of surface-active ionic liquids governs protein structural integrity and drug recognition at engineered carbon quantum dot nano\u2013bio interfaces","display_name":"Molecular architecture of surface-active ionic liquids governs protein structural integrity and drug recognition at engineered carbon quantum dot nano\u2013bio interfaces","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225612489","doi":"https://doi.org/10.3389/fmolb.2026.1971794"},"language":"en","primary_location":{"id":"doi:10.3389/fmolb.2026.1971794","doi":"https://doi.org/10.3389/fmolb.2026.1971794","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2026.1971794","pdf_url":"https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2026.1971794/pdf","source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2026.1971794/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120823007","display_name":"Iaimanda Nonglamin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197465736","display_name":"North Eastern Hill University","ror":"https://ror.org/055m2tx54","country_code":"IN","type":"education","lineage":["https://openalex.org/I197465736"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Iaimanda Nonglamin","raw_affiliation_strings":["Department of Chemistry, North-Eastern Hill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, North-Eastern Hill University","institution_ids":["https://openalex.org/I197465736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161315161","display_name":"Sugam Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1329621470","display_name":"Bhabha Atomic Research Centre","ror":"https://ror.org/05w6wfp17","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1329621470","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]},{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sugam Kumar","raw_affiliation_strings":["Homi Bhabha National Institute","Solid State Physics Division, Bhabha Atomic Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homi Bhabha National Institute","institution_ids":["https://openalex.org/I200207707"]},{"raw_affiliation_string":"Solid State Physics Division, Bhabha Atomic Research Centre","institution_ids":["https://openalex.org/I1329621470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020471765","display_name":"Sivaprasad Mitra","orcid":"https://orcid.org/0000-0002-5746-0070","observed_orcids":["https://orcid.org/0000-0002-5746-0070"]},"institutions":[{"id":"https://openalex.org/I197465736","display_name":"North Eastern Hill University","ror":"https://ror.org/055m2tx54","country_code":"IN","type":"education","lineage":["https://openalex.org/I197465736"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sivaprasad Mitra","raw_affiliation_strings":["Department of Chemistry, North-Eastern Hill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, North-Eastern Hill University","institution_ids":["https://openalex.org/I197465736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020471765"],"corresponding_institution_ids":["https://openalex.org/I197465736"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.22020000219345093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surface-active-ionic-liquids","display_name":"surface-active ionic liquids","score":0.9869999885559082},{"id":"https://openalex.org/keywords/carbon-quantum-dots","display_name":"carbon quantum dots","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9649999737739563},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.9470000267028809},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.8230000138282776},{"id":"https://openalex.org/keywords/molecular-architecture","display_name":"molecular architecture","score":0.5529999732971191},{"id":"https://openalex.org/keywords/alkyl-chain-length","display_name":"alkyl chain length","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.8040000200271606},{"id":"https://openalex.org/keywords/nano-bio-interface","display_name":"nano-bio interface","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-identification","display_name":"drug identification","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C154881586","wikidata":"https://www.wikidata.org/wiki/Q898579","display_name":"Ionic liquid","level":3,"score":0.6944000124931335},{"id":"https://openalex.org/C2777221202","wikidata":"https://www.wikidata.org/wiki/Q2518436","display_name":"Pyridinium","level":2,"score":0.6708999872207642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6100000143051147},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5993000268936157},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5138000249862671},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.49410000443458557},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.4936000108718872},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.47519999742507935},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.44130000472068787},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3984000086784363},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.39010000228881836},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.375},{"id":"https://openalex.org/C104015590","wikidata":"https://www.wikidata.org/wiki/Q1451740","display_name":"Neutron scattering","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C2777735830","wikidata":"https://www.wikidata.org/wiki/Q6507061","display_name":"Molecular binding","level":3,"score":0.35899999737739563},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.34450000524520874},{"id":"https://openalex.org/C116306529","wikidata":"https://www.wikidata.org/wiki/Q7269495","display_name":"Quasielastic neutron scattering","level":5,"score":0.33880001306533813},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C65604355","wikidata":"https://www.wikidata.org/wiki/Q3523861","display_name":"Molecular engineering","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.3188999891281128},{"id":"https://openalex.org/C2778150588","wikidata":"https://www.wikidata.org/wiki/Q8884513","display_name":"Azobenzene","level":3,"score":0.3179999887943268},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.31130000948905945},{"id":"https://openalex.org/C132841051","wikidata":"https://www.wikidata.org/wiki/Q4165337","display_name":"Small-angle neutron scattering","level":4,"score":0.30959999561309814},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2957000136375427},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2825999855995178},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2761000096797943},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.26510000228881836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fmolb.2026.1971794","doi":"https://doi.org/10.3389/fmolb.2026.1971794","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2026.1971794","pdf_url":"https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2026.1971794/pdf","source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fmolb.2026.1971794","doi":"https://doi.org/10.3389/fmolb.2026.1971794","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2026.1971794","pdf_url":"https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2026.1971794/pdf","source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335491","display_name":"UGC-DAE\u00a0Consortium for Scientific Research, University Grants Commission","ror":"https://ror.org/047g7f905"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225612489.pdf","grobid_xml":"https://content.openalex.org/works/W7225612489.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1968385312","https://openalex.org/W1998567038","https://openalex.org/W2005400049","https://openalex.org/W2010614626","https://openalex.org/W2016771203","https://openalex.org/W2024027867","https://openalex.org/W2041597718","https://openalex.org/W2045683699","https://openalex.org/W2048331339","https://openalex.org/W2048822589","https://openalex.org/W2053536761","https://openalex.org/W2060079863","https://openalex.org/W2066962978","https://openalex.org/W2067574991","https://openalex.org/W2079257101","https://openalex.org/W2092277696","https://openalex.org/W2094795801","https://openalex.org/W2118233996","https://openalex.org/W2136470366","https://openalex.org/W2147993766","https://openalex.org/W2164276034","https://openalex.org/W2221701072","https://openalex.org/W2318276496","https://openalex.org/W2320165883","https://openalex.org/W2331304475","https://openalex.org/W2331460309","https://openalex.org/W2345883187","https://openalex.org/W2491458126","https://openalex.org/W2530653483","https://openalex.org/W2565021045","https://openalex.org/W2594837678","https://openalex.org/W2618269370","https://openalex.org/W2911671710","https://openalex.org/W2920087172","https://openalex.org/W2924317848","https://openalex.org/W2937999906","https://openalex.org/W2950598100","https://openalex.org/W2954667328","https://openalex.org/W2974002825","https://openalex.org/W3016456929","https://openalex.org/W3111003051","https://openalex.org/W3131194489","https://openalex.org/W3149895850","https://openalex.org/W3153810920","https://openalex.org/W3176156053","https://openalex.org/W4226018147","https://openalex.org/W4296203623","https://openalex.org/W4311674079","https://openalex.org/W4313013638","https://openalex.org/W4360849792","https://openalex.org/W4362666564","https://openalex.org/W4376643325","https://openalex.org/W4379209614","https://openalex.org/W4387617747","https://openalex.org/W4387941019","https://openalex.org/W4388038700","https://openalex.org/W4388561229","https://openalex.org/W4392193585","https://openalex.org/W4392296321","https://openalex.org/W4400129591","https://openalex.org/W4400555124","https://openalex.org/W4400786552","https://openalex.org/W4406393576","https://openalex.org/W4407584339","https://openalex.org/W4407770667","https://openalex.org/W4408624903","https://openalex.org/W4409177588","https://openalex.org/W7128791740","https://openalex.org/W7164308015","https://openalex.org/W7170081710","https://openalex.org/W7204438335"],"related_works":["https://openalex.org/W7170081710","https://openalex.org/W4296203623","https://openalex.org/W2999353736","https://openalex.org/W2887534835","https://openalex.org/W7164308015","https://openalex.org/W2996549536","https://openalex.org/W4416126927","https://openalex.org/W4383879193","https://openalex.org/W2046530763","https://openalex.org/W7152657731"],"abstract_inverted_index":{"Introduction":[0],"Protein\u2013nanomaterial":[1],"interfaces":[2,257],"are":[3],"increasingly":[4],"exploited":[5],"in":[6],"biomedicine,":[7],"yet":[8],"the":[9,29,46,123,144,153,160,165,187,196,230,235],"influence":[10],"of":[11,31,49,155,164,190,234,244,251],"ionic":[12,36],"liquid":[13],"(IL)":[14],"molecular":[15,102,175,246],"architecture":[16,247],"on":[17],"protein":[18,260],"structure":[19,189],"and":[20,45,55,80,101,107,116,178,271],"ligand":[21,146,193,226],"recognition":[22,147,227,253],"remains":[23],"poorly":[24],"understood.":[25],"Here,":[26],"we":[27],"investigate":[28],"interactions":[30],"lysozyme":[32],"(LYZ)":[33],"with":[34,67,130,152,195,207,214,224],"surface-active":[35],"liquids":[37],"(SAILs),":[38],"SAIL":[39,183,245],"functionalized":[40],"carbon":[41],"quantum":[42],"dots":[43],"(CQD-ILs),":[44],"subsequent":[47],"binding":[48,110,124,171,205],"donepezil":[50],"(DON)":[51],"to":[52,140],"native":[53,141],"LYZ":[54,191],"LYZ\u2013CQD/CQD-IL":[56],"conjugates.":[57],"Methods":[58],"SAILs":[59],"bearing":[60],"imidazolium":[61],"(IB)":[62],"or":[63,70],"pyridinium":[64,132],"(PB)":[65],"headgroups":[66],"dodecyl":[68],"(DD)":[69],"tetradecyl":[71,131],"(TD)":[72],"alkyl":[73],"chains":[74],"were":[75],"systematically":[76],"examined":[77],"using":[78],"steady-state":[79],"time-resolved":[81],"fluorescence":[82],"spectroscopy,":[83,91],"circular":[84],"dichroism":[85],"(CD),":[86],"Fourier":[87],"transform":[88],"infrared":[89],"(FTIR)":[90],"small":[92],"angle":[93],"neutron":[94],"scattering":[95,99],"(SANS),":[96],"dynamic":[97],"light":[98],"(DLS),":[100],"dynamics":[103],"(MD)":[104],"simulations.":[105],"Results":[106],"Discussion":[108],"DON":[109,204],"proceeded":[111],"predominantly":[112],"through":[113],"a":[114,135],"static":[115],"spontaneous":[117],"mechanism,":[118],"while":[119,258],"CQD":[120],"association":[121],"enhanced":[122,145,225],"affinity":[125],"by":[126],"approximately":[127],"1.3-fold.":[128],"Functionalization":[129],"(TDPB)":[133],"produced":[134],"further":[136],"\u223c4.7-fold":[137],"increase":[138],"relative":[139],"LYZ.":[142],"Notably,":[143],"did":[148],"not":[149],"correlate":[150],"directly":[151],"strength":[154,172],"LYZ\u2013CQD/SAIL":[156],"association,":[157],"indicating":[158],"that":[159,182,241,262],"local":[161],"physicochemical":[162],"organization":[163],"IL-modified":[166],"nano\u2013bio":[167],"interface,":[168],"rather":[169],"than":[170],"alone,":[173],"governs":[174],"recognition.":[176],"CD":[177],"FTIR":[179],"analyses":[180],"showed":[181],"functionalization":[184],"substantially":[185],"preserved":[186],"secondary":[188],"during":[192],"binding,":[194],"LYZ\u2013CQD\u2013TDPB":[197],"conjugate":[198],"retaining":[199],"43.5%":[200],"\u03b1-helical":[201],"content":[202],"after":[203],"compared":[206],"only":[208],"12.2%":[209],"for":[210,268],"pristine":[211],"LYZ\u2013CQD.":[212],"Consistent":[213],"these":[215,238],"observations,":[216],"MD":[217],"simulations":[218],"revealed":[219],"localized":[220],"interfacial":[221],"rearrangements":[222],"consistent":[223],"without":[228],"compromising":[229],"overall":[231],"structural":[232],"stability":[233],"protein.":[236],"Collectively,":[237],"findings":[239],"demonstrate":[240],"rational":[242],"tuning":[243],"enables":[248],"controlled":[249],"modulation":[250],"protein\u2013ligand":[252],"at":[254],"engineered":[255],"nano-bio":[256],"preserving":[259],"integrity,":[261],"may":[263],"provide":[264],"molecular-level":[265],"design":[266],"principles":[267],"biofunctional":[269],"nanomaterials":[270],"protein-based":[272],"nanotherapeutic":[273],"platforms.":[274]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}