{"id":"https://openalex.org/W7225611690","doi":"https://doi.org/10.21203/rs.3.rs-11474652/v1","title":"Predicting Persistent Creatinine Elevation After the First Recorded ICU Furosemide Event in Acute Heart Failure: A Retrospective Cohort Study","display_name":"Predicting Persistent Creatinine Elevation After the First Recorded ICU Furosemide Event in Acute Heart Failure: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225611690","doi":"https://doi.org/10.21203/rs.3.rs-11474652/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11474652/v1","doi":"https://doi.org/10.21203/rs.3.rs-11474652/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11474652/v1","pdf_url":"https://www.researchsquare.com/article/rs-11474652/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11474652/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112729040","display_name":"Shuting Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162045","display_name":"Jinhua Central Hospital","ror":"https://ror.org/04z13ha89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuting Kong","raw_affiliation_strings":["Jinhua Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinhua Central Hospital","institution_ids":["https://openalex.org/I4210162045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160293007","display_name":"Yibin Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162045","display_name":"Jinhua Central Hospital","ror":"https://ror.org/04z13ha89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibin Pan","raw_affiliation_strings":["Jinhua Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinhua Central Hospital","institution_ids":["https://openalex.org/I4210162045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162045"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-heart-failure","display_name":"acute heart failure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":0.9269999861717224},{"id":"https://openalex.org/keywords/creatinine-elevation","display_name":"creatinine elevation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.7680000066757202},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.4659999907016754},{"id":"https://openalex.org/keywords/diuretic-therapy","display_name":"diuretic therapy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mimic-iv","display_name":"MIMIC-IV","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ridge-logistic-regression","display_name":"ridge logistic regression","score":0.6039999723434448},{"id":"https://openalex.org/keywords/urine-output","display_name":"urine output","score":0.6230000257492065},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8041999936103821},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6923999786376953},{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.6301000118255615},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6266000270843506},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5601999759674072},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5054000020027161},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43389999866485596},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.42660000920295715},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.42250001430511475},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3702000081539154},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C2777260377","wikidata":"https://www.wikidata.org/wiki/Q2604639","display_name":"Coronary care unit","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C2779295919","wikidata":"https://www.wikidata.org/wiki/Q4677930","display_name":"Acute decompensated heart failure","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11474652/v1","doi":"https://doi.org/10.21203/rs.3.rs-11474652/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11474652/v1","pdf_url":"https://www.researchsquare.com/article/rs-11474652/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11474652/v1","doi":"https://doi.org/10.21203/rs.3.rs-11474652/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11474652/v1","pdf_url":"https://www.researchsquare.com/article/rs-11474652/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225611690.pdf","grobid_xml":"https://content.openalex.org/works/W7225611690.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2026274122","https://openalex.org/W2037181502","https://openalex.org/W2073115187","https://openalex.org/W2099724002","https://openalex.org/W2225109326","https://openalex.org/W2591419591","https://openalex.org/W2736301426","https://openalex.org/W2802154434","https://openalex.org/W2891400669","https://openalex.org/W2949823666","https://openalex.org/W2971645533","https://openalex.org/W3012413426","https://openalex.org/W3034467723","https://openalex.org/W3165045360","https://openalex.org/W3217620563","https://openalex.org/W4213295863","https://openalex.org/W4214940323","https://openalex.org/W4313439128","https://openalex.org/W4380489241","https://openalex.org/W4385770769","https://openalex.org/W4386150862","https://openalex.org/W4394857110","https://openalex.org/W4407895452","https://openalex.org/W4408806526","https://openalex.org/W4416971827","https://openalex.org/W6903442265","https://openalex.org/W6960102814","https://openalex.org/W7124440431","https://openalex.org/W7140405555"],"related_works":["https://openalex.org/W7166451583","https://openalex.org/W2754406177","https://openalex.org/W2796093199","https://openalex.org/W2085996436","https://openalex.org/W2012527164","https://openalex.org/W4403887257","https://openalex.org/W7123512713","https://openalex.org/W3107163210","https://openalex.org/W4412028119","https://openalex.org/W3198380099"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"During":[2],"decongestion":[3],"for":[4,87,291],"acute":[5,50],"heart":[6],"failure,":[7],"an":[8,18],"early":[9],"creatinine":[10,118,142,163,254],"rise":[11,33,66,231],"may":[12,275],"resolve":[13],"or":[14,42,296],"remain":[15],"elevated.":[16],"At":[17,165],"intensive":[19],"care":[20],"unit":[21],"(ICU)":[22],"reassessment,":[23,283],"clinicians":[24],"cannot":[25],"know":[26],"from":[27,147,264],"one":[28],"value":[29],"whether":[30],"a":[31,73,81,140,161,189,230],"first":[32,64,97,190],"will":[34],"later":[35,60],"persist.":[36],"Existing":[37],"furosemide-timed":[38],"models":[39,48,114,274],"address":[40,49],"death":[41],"organ":[43],"support,":[44],"and":[45,69,123,132,144,167,178,181,210,222,238],"broader":[46],"heart-failure":[47],"kidney":[51],"injury;":[52],"neither":[53],"directly":[54],"answers":[55],"this":[56],"question.":[57],"We":[58,79],"examined":[59,137],"confirmation":[61],"of":[62,107,183,236,267,280],"the":[63,96,145,151,170,198,258],"observed":[65],"at":[67],"12":[68,166],"24":[70,168],"hours":[71],"after":[72,216],"recorded":[74,152,233],"ICU":[75,148],"furosemide":[76,99,242],"event.":[77,153],"Methods":[78],"studied":[80],"single-center":[82],"retrospective":[83],"Medical":[84],"Information":[85],"Mart":[86],"Intensive":[88],"Care":[89],"IV":[90],"(MIMIC-IV)":[91],"cohort.":[92],"Time":[93],"zero":[94],"was":[95],"positive-dose":[98],"event":[100,184],"in":[101,297],"ICU-linked":[102],"records,":[103],"not":[104,245,288],"verified":[105],"initiation":[106],"hospital":[108],"diuretic":[109],"treatment.":[110],"Separate":[111],"ridge":[112],"logistic":[113],"used":[115],"baseline":[116],"creatinine,":[117],"change,":[119],"cumulative":[120,241],"urine":[121],"output,":[122],"mean":[124],"arterial":[125],"pressure.":[126],"Internal":[127],"validation":[128],"assessed":[129],"discrimination,":[130],"calibration,":[131],"prediction":[133],"error;":[134],"additional":[135],"analyses":[136],"initial-rise":[138],"status,":[139],"simple":[141,225],"rule,":[143],"interval":[146],"admission":[149],"to":[150,256],"Results":[154],"Of":[155],"784":[156],"patients,":[157],"481":[158],"(61.4%)":[159],"had":[160,186,234],"classifiable":[162,171,294],"course.":[164],"hours,":[169],"risk":[172,266],"sets":[173],"comprised":[174],"433":[175],"patients/63":[176],"events":[177],"383/57;":[179],"38.1%":[180],"57.9%":[182],"patients":[185,251,292],"already":[187,232],"shown":[188],"rise.":[191],"In":[192],"complete":[193],"cases,":[194],"optimism-corrected":[195],"areas":[196,215,235],"under":[197],"receiver":[199],"operating":[200],"characteristic":[201],"curve":[202],"were":[203,220],"0.783":[204],"(bootstrap":[205],"percentile":[206],"range":[207],"0.721\u20130.845;":[208],"368/52)":[209],"0.840":[211],"(0.791\u20130.900;":[212],"357/51).":[213],"Held-out":[214],"within-fold":[217],"predictor":[218],"imputation":[219],"0.790":[221],"0.846.":[223],"The":[224,273],"rule":[226],"based":[227],"only":[228],"on":[229],"0.650":[237],"0.728.":[239],"Adding":[240],"dose":[243],"did":[244],"consistently":[246],"improve":[247],"prediction.":[248],"Conclusions":[249],"Among":[250],"with":[252],"enough":[253],"follow-up":[255],"classify":[257],"outcome,":[259],"routine":[260],"measurements":[261],"separated":[262],"higher":[263],"lower":[265],"later-confirmed":[268],"persistent":[269],"worsening":[270],"renal":[271,282],"function.":[272],"help":[276],"frame":[277],"future":[278],"studies":[279],"scheduled":[281],"but":[284],"their":[285],"performance":[286],"has":[287],"been":[289],"established":[290],"without":[293],"outcomes":[295],"another":[298],"hospital.":[299]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}