{"id":"https://openalex.org/W7225611422","doi":"https://doi.org/10.5281/zenodo.24045471","title":"Expanding the Therapeutic Window of PLK1 Inhibition Through hTERT Promoter\u2013Restricted RNA Interference and Reduced-Dose Pharmacotherapy","display_name":"Expanding the Therapeutic Window of PLK1 Inhibition Through hTERT Promoter\u2013Restricted RNA Interference and Reduced-Dose Pharmacotherapy","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225611422","doi":"https://doi.org/10.5281/zenodo.24045471"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24045471","doi":"https://doi.org/10.5281/zenodo.24045471","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24045471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24045471","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161218338","display_name":"Georg Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wolf, Georg","raw_affiliation_strings":["Independent Researcher, CODON4 Scientific Editions, Berlin-Wannsee, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent Researcher, CODON4 Scientific Editions, Berlin-Wannsee, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161218338"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/plk1-inhibition","display_name":"PLK1 inhibition","score":0.9929999709129333},{"id":"https://openalex.org/keywords/htert-promoter","display_name":"hTERT promoter","score":0.8709999918937683},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.800000011920929},{"id":"https://openalex.org/keywords/artificial-microrna","display_name":"artificial microRNA","score":0.9229999780654907},{"id":"https://openalex.org/keywords/volasertib","display_name":"volasertib","score":0.7480000257492065},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.6340000033378601},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.5149999856948853},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.4300000071525574},{"id":"https://openalex.org/keywords/vector-delivery","display_name":"vector delivery","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.8003000020980835},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6449000239372253},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5812000036239624},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4796000123023987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4496000111103058},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44269999861717224},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.44209998846054077},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4348999857902527},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.4124000072479248},{"id":"https://openalex.org/C84815855","wikidata":"https://www.wikidata.org/wiki/Q7225885","display_name":"Polo-like kinase","level":4,"score":0.3971000015735626},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.3544999957084656},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.352400004863739},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.34880000352859497},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3206999897956848},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3188000023365021},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.30059999227523804},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.2922999858856201},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.2851000130176544},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C46622094","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic window","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.27390000224113464},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C143141573","wikidata":"https://www.wikidata.org/wiki/Q7450971","display_name":"Sense (electronics)","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.25920000672340393},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24045471","doi":"https://doi.org/10.5281/zenodo.24045471","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24045471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.24045472","doi":"https://doi.org/10.5281/zenodo.24045472","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24045472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24045471","doi":"https://doi.org/10.5281/zenodo.24045471","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24045471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2110864471","https://openalex.org/W7161572974","https://openalex.org/W2467902526","https://openalex.org/W2106391705","https://openalex.org/W2161761124","https://openalex.org/W4285264963","https://openalex.org/W7038024188","https://openalex.org/W2028483887","https://openalex.org/W4287654898","https://openalex.org/W2364839770"],"abstract_inverted_index":{"Abstract":[0],"Polo-like":[1],"kinase":[2],"1":[3],"(PLK1)":[4],"has":[5,80],"long":[6],"been":[7],"recognized":[8],"as":[9,196],"a":[10,16,88,96,119,134,168],"key":[11],"regulator":[12],"of":[13,74,95,140,145],"mitosis":[14],"and":[15,23,31,44,55,71,77,84,167,175,191],"potential":[17],"target":[18,107],"in":[19,34,109,136,154,193],"oncology.":[20],"Early":[21],"molecular":[22],"clinicopathological":[24],"investigations":[25],"established":[26],"its":[27],"association":[28],"with":[29,184],"proliferation":[30],"adverse":[32],"outcomes":[33],"several":[35],"tumor":[36,132],"entities.":[37],"Subsequent":[38],"studies":[39],"demonstrated":[40],"that":[41],"antisense":[42],"oligonucleotides":[43],"RNA":[45],"interference":[46],"(RNAi)":[47],"can":[48],"suppress":[49],"PLK1":[50,173],"expression,":[51],"disturb":[52],"mitotic":[53],"progression,":[54],"increase":[56],"sensitivity":[57],"to":[58,118],"certain":[59],"anticancer":[60],"agents.":[61],"Yet":[62],"systemic":[63,116],"PLK":[64,120],"inhibition":[65],"remains":[66],"limited":[67],"by":[68],"hematological":[69],"toxicity,":[70],"clinical":[72],"development":[73],"both":[75],"volasertib":[76],"PLK1-directed":[78],"siRNA":[79],"encountered":[81],"important":[82],"efficacy":[83],"safety":[85],"constraints.":[86],"Here,":[87],"dual-level":[89],"therapeutic":[90,157],"hypothesis":[91,127],"is":[92,151,182],"advanced:":[93],"expression":[94],"PLK1-targeting":[97],"artificial":[98],"microRNA":[99],"under":[100],"an":[101,152],"hTERT-responsive":[102],"promoter":[103,162],"could":[104],"preferentially":[105],"reduce":[106],"abundance":[108],"selected":[110],"malignant":[111],"cells,":[112],"potentially":[113],"lowering":[114],"the":[115,137,143,155],"exposure":[117],"inhibitor":[121],"required":[122],"for":[123],"antitumor":[124],"efficacy.":[125],"This":[126],"does":[128],"not":[129],"imply":[130],"absolute":[131],"specificity,":[133],"change":[135],"biochemical":[138],"potency":[139],"volasertib,":[141],"or":[142],"elimination":[144],"bone-marrow":[146],"toxicity.":[147],"Its":[148],"central":[149],"prediction":[150],"improvement":[153],"tumor-to-normal-tissue":[156],"differential,":[158],"contingent":[159],"on":[160],"functional":[161],"selectivity,":[163],"efficient":[164],"vector":[165],"delivery,":[166],"favorable":[169],"relationship":[170],"between":[171],"residual":[172],"activity":[174],"cellular":[176],"sensitivity.":[177],"A":[178],"staged":[179],"validation":[180],"strategy":[181],"proposed,":[183],"primary":[185],"hematopoietic":[186],"progenitors,":[187],"pharmacodynamic":[188],"interaction":[189],"studies,":[190],"exposure-matched":[192],"vivo":[194],"comparisons":[195],"essential":[197],"decision":[198],"points.":[199]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}