{"id":"https://openalex.org/W7225598366","doi":"https://doi.org/10.1161/circ.154.suppl_1.5412","title":"Abstract 5412: Trigger Phenotype, Sex, and Clinical Outcomes in Intensive Care Unit Takotsubo Cardiomyopathy: A MIMIC-IV Analysis","display_name":"Abstract 5412: Trigger Phenotype, Sex, and Clinical Outcomes in Intensive Care Unit Takotsubo Cardiomyopathy: A MIMIC-IV Analysis","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225598366","doi":"https://doi.org/10.1161/circ.154.suppl_1.5412"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.5412","doi":"https://doi.org/10.1161/circ.154.suppl_1.5412","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.5412","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048284090","display_name":"Toluwalase Awoyemi","orcid":"https://orcid.org/0000-0003-1542-9435","observed_orcids":["https://orcid.org/0000-0003-1542-9435"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toluwalase Awoyemi","raw_affiliation_strings":["Mass General Brigham, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013963376","display_name":"Oluwaremilekun Zeth Tolu-Akinnawo","orcid":"https://orcid.org/0009-0007-2871-6878","observed_orcids":["https://orcid.org/0009-0007-2871-6878"]},"institutions":[{"id":"https://openalex.org/I1319743688","display_name":"Abbott Northwestern Hospital","ror":"https://ror.org/01fzm0693","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1319743688","https://openalex.org/I1326929380"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwaremilekun Z Tolu-Akinnawo","raw_affiliation_strings":["Abbott Northwestern Hosp, Dallas, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Northwestern Hosp, Dallas, GA","institution_ids":["https://openalex.org/I1319743688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072762399","display_name":"CHINENYE CYNTHIA ODO","orcid":"https://orcid.org/0009-0005-4580-5800","observed_orcids":["https://orcid.org/0009-0005-4580-5800"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinenye Odo","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124864999","display_name":"Abdullah Ayyoub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802603828","display_name":"Kent Hospital","ror":"https://ror.org/01kcq3761","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802603828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah Ayyoub","raw_affiliation_strings":["Brown Univ - Kent Hosp, West Warwick, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Univ - Kent Hosp, West Warwick, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802603828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092420526","display_name":"Ahmad Abdelkhalek","orcid":"https://orcid.org/0009-0008-6194-2057","observed_orcids":["https://orcid.org/0009-0008-6194-2057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmad Abdelkhalek","raw_affiliation_strings":["RFU- Northwestern McHenry Hosp, McHenry, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RFU- Northwestern McHenry Hosp, McHenry, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065968771","display_name":"Olufemi Philip Odugbemi","orcid":"https://orcid.org/0009-0003-6025-6374","observed_orcids":["https://orcid.org/0009-0003-6025-6374"]},"institutions":[{"id":"https://openalex.org/I1281027232","display_name":"Lincoln Medical Center","ror":"https://ror.org/035a72598","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281027232","https://openalex.org/I1283621791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"OLUFEMI P ODUGBEMI","raw_affiliation_strings":["Lincoln Med and Mental Cntr, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lincoln Med and Mental Cntr, Bronx, NY","institution_ids":["https://openalex.org/I1281027232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114110376","display_name":"Yoana Ara\u00fajo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoana Palatianos de Araujo","raw_affiliation_strings":["Northwestern Medicine McHenry Hosp, McHenry, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Medicine McHenry Hosp, McHenry, IL","institution_ids":["https://openalex.org/I4210147348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025295838","display_name":"Ruth Eshikotse Pius","orcid":"https://orcid.org/0000-0001-9069-5747","observed_orcids":["https://orcid.org/0000-0001-9069-5747"]},"institutions":[{"id":"https://openalex.org/I1281027232","display_name":"Lincoln Medical Center","ror":"https://ror.org/035a72598","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281027232","https://openalex.org/I1283621791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Pius","raw_affiliation_strings":["Lincoln Med and Mental Cntr, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lincoln Med and Mental Cntr, Bronx, NY","institution_ids":["https://openalex.org/I1281027232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098994977","display_name":"Francis Ezekwueme","orcid":"https://orcid.org/0009-0003-9765-0930","observed_orcids":["https://orcid.org/0009-0003-9765-0930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis Ezekwueme","raw_affiliation_strings":["UPMC, Monroeville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC, Monroeville, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160993273","display_name":"Aigin Heydari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aigin Heydari","raw_affiliation_strings":["Northwestern McHenry, McHenry, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern McHenry, McHenry, IL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5095085724","display_name":"Dania Jaamour","orcid":"https://orcid.org/0009-0006-1100-7066","observed_orcids":["https://orcid.org/0009-0006-1100-7066"]},"institutions":[{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dania Jaamour","raw_affiliation_strings":["Northwestern Memorial Hosp, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Memorial Hosp, Chicago, IL","institution_ids":["https://openalex.org/I4210089162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/takotsubo-cardiomyopathy","display_name":"takotsubo cardiomyopathy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.7590000033378601},{"id":"https://openalex.org/keywords/psychological-triggers","display_name":"psychological triggers","score":0.6269999742507935},{"id":"https://openalex.org/keywords/physical-triggers","display_name":"physical triggers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cardiogenic-shock","display_name":"cardiogenic shock","score":0.8550000190734863},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mimic-iv","display_name":"MIMIC-IV","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.9549999833106995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9523000121116638},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.6733999848365784},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6330999732017517},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.51910001039505},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4950000047683716},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.48829999566078186},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.459199994802475},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C2777260377","wikidata":"https://www.wikidata.org/wiki/Q2604639","display_name":"Coronary care unit","level":3,"score":0.40470001101493835},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36250001192092896},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3336000144481659},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3296999931335449},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2578999996185303},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.5412","doi":"https://doi.org/10.1161/circ.154.suppl_1.5412","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.5412","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2590634037","https://openalex.org/W7128094074","https://openalex.org/W2346581161","https://openalex.org/W2110733697","https://openalex.org/W3023443629","https://openalex.org/W4378234534","https://openalex.org/W2514418393","https://openalex.org/W3001159475","https://openalex.org/W7204849313","https://openalex.org/W1999233867"],"abstract_inverted_index":{"INTRODUCTION":[0],"/":[1,40,71,137],"BACKGROUND:":[2],"Takotsubo":[3,80,265],"cardiomyopathy":[4,81],"carries":[5],"substantially":[6,147],"lower":[7],"mortality":[8,57,144,163,182,197,202,242,276,303],"in":[9,156],"general":[10,149],"populations,":[11],"yet":[12],"neurological":[13,47,232,267,287],"and":[14,46,55,61,114,121,164,199,268],"physical":[15,45,269],"triggers":[16,48,159,171,192,220,254,270,281,288],"carry":[17,50,271],"markedly":[18],"higher":[19,51,240],"complication":[20],"rates":[21,54,206],"than":[22,58,243],"emotional":[23],"triggers.":[24,279],"Intensive":[25],"care":[26],"unit":[27],"characterisation":[28],"of":[29,187,277],"trigger-stratified":[30],"outcomes":[31],"has":[32],"not":[33],"been":[34],"reported":[35],"at":[36],"scale.":[37],"Research":[38],"QUESTIONS":[39],"HYPOTHESIS:":[41],"We":[42],"hypothesised":[43],"that":[44,62],"would":[49,65],"cardiogenic":[52,153],"shock":[53,113,154],"30-day":[56,143,275],"psychological":[59,253,278],"triggers,":[60],"catecholamine":[63,115,176,285],"exposure":[64,116,177,205],"differ":[66],"by":[67,209],"trigger":[68,189,210,225,302],"type.":[69,190],"MethodS":[70],"APPROACH:":[72],"From":[73],"MIMIC-IV":[74],"v3.1,":[75],"340":[76],"ICU":[77,264],"admissions":[78],"with":[79,126],"(ICD-10":[82],"I51.81":[83],"or":[84,103],"ICD-9":[85],"429.83)":[86],"were":[87,109,117,227],"identified,":[88],"excluding":[89],"confirmed":[90],"obstructive":[91],"coronary":[92],"artery":[93],"disease.":[94],"Trigger":[95],"phenotype":[96],"was":[97,130,145,178,183,250],"classified":[98],"as":[99,132],"psychological,":[100],"physical,":[101],"neurological,":[102],"unclassified":[104],"using":[105],"ICD":[106],"codes;":[107],"categories":[108],"non-mutually":[110,228],"exclusive.":[111,229],"Cardiogenic":[112],"ascertained":[118],"from":[119],"diagnosis":[120],"prescription":[122],"records.":[123],"Logistic":[124],"regression":[125],"sex-by-trigger":[127],"interaction":[128],"terms":[129],"performed":[131],"an":[133],"exploratory":[134],"analysis.":[135],"ResultS":[136],"DATA:":[138],"Women":[139],"comprised":[140,221],"75.9%;":[141],"overall":[142],"22.9%,":[146],"exceeding":[148],"registry":[150],"rates;":[151],"in-hospital":[152],"occurred":[155],"19.7%.":[157],"Physical":[158,280],"(36.2%)":[160],"carried":[161,173],"28.5%":[162],"27.6%":[165],"shock;":[166],"85.4%":[167],"received":[168],"catecholamines.":[169],"Neurological":[170],"(14.7%)":[172],"30.0%":[174],"mortality;":[175],"60.0%":[179],"but":[180],"catecholamine-exposed":[181,201,292],"36.7%,":[184],"the":[185,195,231,248,274,283,290],"highest":[186,284,291],"any":[188],"Psychological":[191],"(27.4%)":[193],"had":[194,239],"lowest":[196,200],"(15.1%)":[198],"(18.0%).":[203],"Catecholamine":[204],"differed":[207],"significantly":[208],"type":[211],"(46.0%":[212],"to":[213],"85.4%;":[214],"chi-squared(3)":[215],"=":[216],"44.25,":[217],"p<0.001).":[218],"Unclassified":[219],"40.3%":[222],"(mortality":[223],"18.2%);":[224],"codes":[226],"In":[230,263],"subgroup":[233],"(n=50;":[234],"approximately":[235,272],"12":[236],"men),":[237],"men":[238],"observed":[241,251],"women":[244],"(46.2%":[245],"vs":[246,256],"24.3%);":[247],"reverse":[249],"for":[252],"(16.0%":[255],"11.1%).":[257],"These":[258],"are":[259],"hypothesis-generating":[260],"only.":[261],"Conclusion(S):":[262],"cardiomyopathy,":[266],"twice":[273],"show":[282,289],"need;":[286],"mortality,":[293],"suggesting":[294],"haemodynamic":[295],"vulnerability":[296],"beyond":[297],"vasopressor":[298],"burden.":[299],"The":[300],"sex-neurological":[301],"difference":[304],"is":[305],"exploratory.":[306]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}