{"id":"https://openalex.org/W7225596808","doi":"https://doi.org/10.5281/zenodo.23850941","title":"SSRIs Are Drugs, Too","display_name":"SSRIs Are Drugs, Too","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225596808","doi":"https://doi.org/10.5281/zenodo.23850941"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23850941","doi":"https://doi.org/10.5281/zenodo.23850941","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23850941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23850941","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161067538","display_name":"Dale Farley","orcid":"https://orcid.org/0009-0001-9184-5732","observed_orcids":["https://orcid.org/0009-0001-9184-5732"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Farley, Dale","raw_affiliation_strings":["Independent Researcher"],"raw_orcid":"https://orcid.org/0009-0001-9184-5732","affiliations":[{"raw_affiliation_string":"Independent Researcher","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161067538"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/antidepressant-treatment","display_name":"antidepressant treatment","score":0.5370000004768372},{"id":"https://openalex.org/keywords/thiamine","display_name":"thiamine","score":0.6779999732971191},{"id":"https://openalex.org/keywords/metabolic-reserves","display_name":"metabolic reserves","score":0.6140000224113464},{"id":"https://openalex.org/keywords/antidepressant-discontinuation","display_name":"antidepressant discontinuation","score":0.609000027179718},{"id":"https://openalex.org/keywords/maintenance-effects","display_name":"maintenance effects","score":0.42899999022483826},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.6359999775886536},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.4830000102519989},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.3630000054836273},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tremor","display_name":"tremor","score":0.9599999785423279},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.35600000619888306},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/thiamine-transporter","display_name":"thiamine transporter","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.6510000228881836},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.48500001430511475},{"id":"https://openalex.org/keywords/multisystem-symptoms","display_name":"multisystem symptoms","score":0.49799999594688416},{"id":"https://openalex.org/keywords/long-term-prescribing","display_name":"long-term prescribing","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.5591999888420105},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.47130000591278076},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.46709999442100525},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46650001406669617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4535999894142151},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.43380001187324524},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3711000084877014},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3165000081062317},{"id":"https://openalex.org/C116222747","wikidata":"https://www.wikidata.org/wiki/Q220888","display_name":"Falsifiability","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23850941","doi":"https://doi.org/10.5281/zenodo.23850941","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23850941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23850942","doi":"https://doi.org/10.5281/zenodo.23850942","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23850942","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23850941","doi":"https://doi.org/10.5281/zenodo.23850941","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23850941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3116525408","https://openalex.org/W2947837392","https://openalex.org/W1965526627","https://openalex.org/W6885179421","https://openalex.org/W2160599403","https://openalex.org/W4388641323","https://openalex.org/W2269744771","https://openalex.org/W2949652491","https://openalex.org/W2006895116","https://openalex.org/W1967559575"],"abstract_inverted_index":{"Antidepressant":[0],"treatment":[1,24],"should":[2],"be":[3],"judged":[4],"by":[5],"durable":[6],"improvement":[7],"in":[8,58,86,110],"the":[9,20,42,161,169],"patient\u2019s":[10],"life,":[11],"including":[12],"function,":[13],"independence,":[14],"emotional":[15],"responsiveness,":[16],"sexual":[17],"health,":[18],"and":[19,41,63,82,102,118,121,129,150,177],"ability":[21],"to":[22,48],"leave":[23],"when":[25,126],"appropriate.":[26],"This":[27],"Perspective":[28],"reviews":[29],"evidence":[30],"for":[31],"acute":[32],"SSRI":[33,73],"benefit,":[34],"maintenance":[35],"effects,":[36],"withdrawal,":[37],"persistent":[38],"adverse":[39],"outcomes,":[40],"limits":[43],"of":[44,50,98,136,141,181],"short-duration":[45],"trials":[46],"relative":[47],"years":[49],"prescribing.":[51],"It":[52],"advances":[53],"a":[54,59,174],"falsifiable":[55],"Dynamic-Reserve":[56],"hypothesis:":[57],"susceptible":[60],"subgroup,":[61],"depressive":[62],"multisystem":[64],"symptoms":[65],"arise":[66],"from":[67,173],"constrained":[68],"thiamine-dependent":[69],"cerebral":[70],"capacity;":[71],"an":[72],"may":[74,83],"restore":[75],"selected":[76,111],"functions":[77],"without":[78],"correcting":[79],"that":[80],"constraint":[81],"accelerate":[84],"decline":[85],"effective":[87],"metabolic":[88],"reserve":[89,171],"during":[90],"sustained":[91],"exposure.":[92],"The":[93,166],"model":[94],"predicts":[95],"early":[96],"clustering":[97],"insomnia,":[99],"anxiety,":[100],"irritability,":[101],"tremor;":[103],"additional":[104],"autonomic,":[105],"peripheral,":[106],"or":[107],"ocular":[108],"signs":[109],"patients;":[112],"treatment-related":[113],"divergence":[114],"between":[115],"symptom":[116],"scores":[117],"whole-person":[119],"recovery;":[120],"increased":[122],"difficulty":[123],"discontinuing":[124],"medication":[125],"Borrowed":[127],"Function":[128],"physiological":[130],"adaptation":[131],"coexist.":[132],"An":[133],"operational":[134],"definition":[135],"addiction":[137],"based":[138],"on":[139],"loss":[140],"practical":[142],"exit":[143],"control":[144],"is":[145],"proposed.":[146],"Experimental":[147],"thiamine-transporter":[148],"interactions":[149],"mitochondrial":[151],"findings":[152],"provide":[153],"partial":[154],"biological":[155],"rationale":[156],"but":[157],"do":[158],"not":[159],"demonstrate":[160],"proposed":[162],"patient-level":[163],"causal":[164],"chain.":[165],"manuscript":[167],"distinguishes":[168],"broad":[170],"hypothesis":[172],"thiamine-specific":[175],"mechanism":[176],"specifies":[178],"observations":[179],"capable":[180],"falsifying":[182],"both.":[183]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}
