{"id":"https://openalex.org/W7225596071","doi":"https://doi.org/10.1161/circ.154.suppl_1.7424","title":"Abstract 7424: Early Hormone Replacement Therapy and Cognitive Outcomes in Postmenopausal Women","display_name":"Abstract 7424: Early Hormone Replacement Therapy and Cognitive Outcomes in Postmenopausal Women","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225596071","doi":"https://doi.org/10.1161/circ.154.suppl_1.7424"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.7424","doi":"https://doi.org/10.1161/circ.154.suppl_1.7424","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.7424","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130811749","display_name":"Armin Nouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armin Nouri","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161295538","display_name":"Caroline Hoeft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Hoeft","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071138301","display_name":"Raiza Rossi","orcid":"https://orcid.org/0000-0001-6898-2192","observed_orcids":["https://orcid.org/0000-0001-6898-2192"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raiza Rossi","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120816363","display_name":"Shefa Arya Nezhad","orcid":"https://orcid.org/0000-0002-0935-1806","observed_orcids":["https://orcid.org/0000-0002-0935-1806"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shefa Arya Nezhad","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139864277","display_name":"Parvaneh Rastgou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvaneh Rastgou","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046504734","display_name":"Laura Tycon Moreines","orcid":"https://orcid.org/0009-0003-5827-5429","observed_orcids":["https://orcid.org/0009-0003-5827-5429"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Moreines","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106702347","display_name":"Kuan Yu Chi","orcid":"https://orcid.org/0000-0003-0763-8157","observed_orcids":["https://orcid.org/0000-0003-0763-8157"]},"institutions":[{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuan Yu Chi","raw_affiliation_strings":["Jacobi Med Cntr, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobi Med Cntr, Bronx, NY","institution_ids":["https://openalex.org/I2800364127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161030654","display_name":"Yu Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu Chang","raw_affiliation_strings":["National Cheng Kung Univ, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cheng Kung Univ, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052978037","display_name":"Abdulla A. Damluji","orcid":"https://orcid.org/0000-0002-8774-6416","observed_orcids":["https://orcid.org/0000-0002-8774-6416"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdulla Damluji","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046257512","display_name":"Michael G. Nanna","orcid":"https://orcid.org/0000-0001-5745-1636","observed_orcids":["https://orcid.org/0000-0001-5745-1636"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Nanna","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048761120","display_name":"Norrisa Haynes","orcid":"https://orcid.org/0000-0001-8028-7133","observed_orcids":["https://orcid.org/0000-0001-8028-7133"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norrisa Haynes","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/early-postmenopausal-women","display_name":"early postmenopausal women","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.953000009059906},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.871999979019165},{"id":"https://openalex.org/keywords/stroke-and-transient-ischemic-attack","display_name":"stroke and transient ischemic attack","score":0.875},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.875},{"id":"https://openalex.org/keywords/estrogen-and-progesterone","display_name":"estrogen and progesterone","score":0.7720000147819519},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.5740000009536743},{"id":"https://openalex.org/keywords/neurovascular-protection","display_name":"neurovascular protection","score":0.5609999895095825},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cerebrovascular-health","display_name":"cerebrovascular health","score":0.7699999809265137},{"id":"https://openalex.org/keywords/dementia-subtypes","display_name":"dementia subtypes","score":0.335999995470047},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9663000106811523},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.7128999829292297},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.7069000005722046},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6784999966621399},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4458000063896179},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.4307999908924103},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.42800000309944153},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.3880000114440918},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.382099986076355},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3734000027179718},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.35839998722076416},{"id":"https://openalex.org/C2778525166","wikidata":"https://www.wikidata.org/wiki/Q7353974","display_name":"Rochester Epidemiology Project","level":4,"score":0.3578999936580658},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.351500004529953},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.3449999988079071},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.31130000948905945},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3012999892234802},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.29420000314712524},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2874000072479248},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.27379998564720154},{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.25380000472068787},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2529999911785126},{"id":"https://openalex.org/C2910557164","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Surgical Menopause","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.7424","doi":"https://doi.org/10.1161/circ.154.suppl_1.7424","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.7424","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2897001748","https://openalex.org/W1571167586","https://openalex.org/W7117766936","https://openalex.org/W2033584587","https://openalex.org/W4294335519","https://openalex.org/W4294335580","https://openalex.org/W3111120246","https://openalex.org/W6999323235","https://openalex.org/W2000233246","https://openalex.org/W1706937218"],"abstract_inverted_index":{"Background:":[0],"Hormone":[1],"replacement":[2],"therapy":[3],"(HRT)":[4],"initiated":[5,66],"during":[6],"the":[7,28,52,216,313,370],"early":[8,31],"postmenopausal":[9,39,75,340],"period":[10],"has":[11],"been":[12],"hypothesized":[13],"to":[14,368],"exert":[15],"neurovascular":[16],"protective":[17],"effects":[18],"through":[19],"modulation":[20],"of":[21,70,175,209,215,219,246,343,348,356,372],"endothelial":[22],"function":[23],"and":[24,34,102,121,131,149,159,186,257,330,376],"cerebrovascular":[25],"health.":[26],"However,":[27],"relationship":[29],"between":[30,336],"HRT":[32,61,78,185,190,205,227,240,295,314,344,373],"initiation":[33,342],"long-term":[35,379],"dementia":[36,98,103,153,166,221,275,358],"risk":[37,176,214,355],"in":[38,198,312],"women":[40,58,76,183,188,203,224,293],"remains":[41],"incompletely":[42],"understood.":[43],"Methods:":[44],"We":[45],"conducted":[46],"a":[47,212],"retrospective":[48],"cohort":[49],"study":[50],"using":[51,140],"TriNetX":[53],"Global":[54],"Collaborative":[55],"Network.":[56],"Postmenopausal":[57],"receiving":[59,184,226,294],"estrogen-containing":[60],"with":[62,74,99,105,173,223,243,352],"or":[63],"without":[64,77,189],"progesterone":[65],"within":[67,206,345],"10":[68,207,346],"years":[69,208,347],"menopause":[71,210,349],"were":[72,168,191,332],"compared":[73,222],"exposure.":[79],"The":[80],"primary":[81,217],"outcome":[82],"was":[83,138,241,271,289,309,350],"incident":[84,357],"overall":[85,220],"dementia,":[86,90,92,97,120],"defined":[87],"as":[88,170],"vascular":[89,119,274],"unspecified":[91],"Alzheimer":[93],"disease":[94,164],"(AD),":[95],"frontotemporal":[96],"Lewy":[100],"bodies,":[101],"associated":[104,242,351],"other":[106],"neurologic":[107],"diseases.":[108],"Secondary":[109],"outcomes":[110,167,172],"included":[111,128],"cognitive":[112,287,380],"impairment,":[113],"stroke/transient":[114],"ischemic":[115],"attack":[116],"(TIA),":[117],"AD,":[118],"venous":[122],"thromboembolic":[123],"events":[124],"(VTE).":[125],"Falsification":[126,325],"endpoints":[127],"acute":[129,328],"cholecystitis":[130,329],"nephrolithiasis.":[132],"1:1":[133],"propensity":[134],"score":[135],"matching":[136],"(PSM)":[137],"performed":[139],"53":[141],"variables,":[142],"including":[143,327],"demographic":[144],"characteristics,":[145],"medications,":[146],"laboratory":[147],"parameters,":[148],"comorbidities.":[150],"Since":[151],"ICD-based":[152],"diagnoses":[154],"often":[155],"reflect":[156],"delayed":[157],"recognition":[158],"coding":[160],"rather":[161],"than":[162],"true":[163],"onset,":[165],"modeled":[169],"binary":[171],"estimation":[174],"ratios":[177],"(RRs).":[178],"Results:":[179],"Before":[180],"matching,":[181,202],"27,351":[182],"229,671":[187],"identified.":[192],"After":[193],"PSM,":[194],"27,347":[195],"patients":[196],"remained":[197],"each":[199],"cohort.":[200],"Following":[201],"initiating":[204],"had":[211],"lower":[213,244,353],"endpoint":[218],"not":[225,333],"(4.0%":[228],"vs":[229,249,260,277,297,317],"4.6%;":[230],"RR":[231,251,262,279,299,319],"0.87,":[232],"95%":[233,253,264,281,301,321],"CI":[234,254,265,282,302,322],"0.80-0.94;":[235],"p=0.001).":[236,304],"Among":[237,339],"secondary":[238],"endpoints,":[239,326],"risks":[245],"stroke/TIA":[247],"(6.4%":[248],"7.5%;":[250],"0.86,":[252,280],"0.81-0.91;":[255],"p<0.001)":[256],"AD":[258],"(1.4%":[259],"1.7%;":[261],"0.81,":[263],"0.70-0.92;":[266],"p=0.002).":[267],"No":[268],"significant":[269],"difference":[270],"observed":[272],"for":[273],"(0.9%":[276],"1.0%;":[278],"0.73-1.02;":[283],"p=0.086).":[284],"In":[285],"contrast,":[286],"impairment":[288],"more":[290],"frequent":[291],"among":[292],"(5.4%":[296],"4.8%;":[298],"1.13,":[300],"1.05-1.21;":[303],"For":[305],"safety":[306],"outcomes,":[307],"VTE":[308,361],"significantly":[310,334],"increased":[311],"group":[315],"(7.2%":[316],"5.2%;":[318],"1.38,":[320],"1.29-1.47;":[323],"p<0.001).":[324],"nephrolithiasis,":[331],"different":[335],"groups.":[337],"Conclusions:":[338],"women,":[341],"cumulative":[354],"but":[359],"higher":[360],"risk.":[362],"Further":[363],"prospective":[364],"studies":[365],"are":[366],"needed":[367],"clarify":[369],"impact":[371],"timing,":[374],"formulation,":[375],"duration":[377],"on":[378],"outcomes.":[381]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}