{"id":"https://openalex.org/W7225595144","doi":"https://doi.org/10.12669/pjms.42.11.21158","title":"Outcomes of mechanical thrombectomy following the Tenecteplase bridge therapy in acute large vessel occlusion stroke","display_name":"Outcomes of mechanical thrombectomy following the Tenecteplase bridge therapy in acute large vessel occlusion stroke","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225595144","doi":"https://doi.org/10.12669/pjms.42.11.21158"},"language":"en","primary_location":{"id":"doi:10.12669/pjms.42.11.21158","doi":"https://doi.org/10.12669/pjms.42.11.21158","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.11.21158","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/21158/11774","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pjms.org.pk/index.php/pjms/article/download/21158/11774","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020170203","display_name":"Muhammad Naveed Majeed","orcid":"https://orcid.org/0000-0003-4438-8417","observed_orcids":["https://orcid.org/0000-0003-4438-8417"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Naveed Majeed","raw_affiliation_strings":["Fellow, Dept. of Neuro Endovascular Surgery, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-4438-8417","affiliations":[{"raw_affiliation_string":"Fellow, Dept. of Neuro Endovascular Surgery, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108599394","display_name":"Farid Ahmad Khan","orcid":"https://orcid.org/0009-0001-1213-0238","observed_orcids":["https://orcid.org/0009-0001-1213-0238"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faiqa Ijaz Khan","raw_affiliation_strings":["Resident Trainee, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0009-0001-1213-0238","affiliations":[{"raw_affiliation_string":"Resident Trainee, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050732302","display_name":"Haseeb Mehmood Qadri","orcid":"https://orcid.org/0000-0003-0675-9934","observed_orcids":["https://orcid.org/0000-0003-0675-9934"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Haseeb Mehmood Qadri","raw_affiliation_strings":["Resident Trainee and Clinical Research Fellow, Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-0675-9934","affiliations":[{"raw_affiliation_string":"Resident Trainee and Clinical Research Fellow, Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072752297","display_name":"Qasim Bashir","orcid":"https://orcid.org/0000-0002-2012-9579","observed_orcids":["https://orcid.org/0000-0002-2012-9579","https://orcid.org/0009-0001-9032-9314"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qasim Bashir","raw_affiliation_strings":["Professor, Dept. of Neuro Endovascular Surgery, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-2012-9579","affiliations":[{"raw_affiliation_string":"Professor, Dept. of Neuro Endovascular Surgery, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405254933"],"apc_list":{"value":400,"currency":"USD","value_usd":400},"apc_paid":{"value":400,"currency":"USD","value_usd":400},"fwci":3.1664,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84712935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"42","issue":"11","first_page":"3275","last_page":"3279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanical-thrombectomy","display_name":"mechanical thrombectomy","score":0.902999997138977},{"id":"https://openalex.org/keywords/tenecteplase","display_name":"tenecteplase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bridge-therapy","display_name":"bridge therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.5870000123977661},{"id":"https://openalex.org/keywords/nihss-score","display_name":"NIHSS score","score":0.7279999852180481},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.7990000247955322},{"id":"https://openalex.org/keywords/recanalization","display_name":"recanalization","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.628000020980835},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.824999988079071},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.878000020980835},{"id":"https://openalex.org/keywords/tandem-occlusion","display_name":"tandem occlusion","score":0.828000009059906},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endovascular-stroke-treatment","display_name":"endovascular stroke treatment","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9799000024795532},{"id":"https://openalex.org/C2779095551","wikidata":"https://www.wikidata.org/wiki/Q1644947","display_name":"Tenecteplase","level":4,"score":0.8468999862670898},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.717199981212616},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5544999837875366},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.551800012588501},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.49480000138282776},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.46799999475479126},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.4611999988555908},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4388999938964844},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4122999906539917},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.38359999656677246},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.3725999891757965},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3677000105381012},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3449000120162964},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.32739999890327454},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C100776233","wikidata":"https://www.wikidata.org/wiki/Q2532492","display_name":"Bridge (graph theory)","level":2,"score":0.31610000133514404},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.287200003862381}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12669/pjms.42.11.21158","doi":"https://doi.org/10.12669/pjms.42.11.21158","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.11.21158","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/21158/11774","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12669/pjms.42.11.21158","doi":"https://doi.org/10.12669/pjms.42.11.21158","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.11.21158","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/21158/11774","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225595144.pdf","grobid_xml":"https://content.openalex.org/works/W7225595144.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1966674141","https://openalex.org/W1969661146","https://openalex.org/W2050880768","https://openalex.org/W2080504768","https://openalex.org/W2767776410","https://openalex.org/W2787867590","https://openalex.org/W3209439707","https://openalex.org/W4388368851","https://openalex.org/W4396532948","https://openalex.org/W4404612053","https://openalex.org/W4407592728","https://openalex.org/W4407939079","https://openalex.org/W4410050142","https://openalex.org/W4416672801","https://openalex.org/W4417280421","https://openalex.org/W7123343717","https://openalex.org/W7125688844"],"related_works":["https://openalex.org/W4413312495","https://openalex.org/W4391836220","https://openalex.org/W3205262398","https://openalex.org/W3184559174","https://openalex.org/W7126033966","https://openalex.org/W4391438895","https://openalex.org/W4415902448","https://openalex.org/W4409227003","https://openalex.org/W4415792748","https://openalex.org/W4389404743"],"abstract_inverted_index":{"Background":[0],"&":[1],"Objective:":[2],"Growing":[3],"evidence":[4],"suggests":[5],"that":[6],"intravenous":[7],"(IV)":[8],"Tenecteplase":[9,79],"(TNK)":[10,80],"as":[11,239],"bridging":[12],"therapy":[13,49,82,260],"before":[14],"mechanical":[15],"thrombectomy":[16],"(MT)":[17],"may":[18],"facilitate":[19],"recanalization":[20,191],"and":[21,36,188,266],"improve":[22],"outcomes":[23,35,42,220],"in":[24,43,50,160,177,194,202,232],"acute":[25,51],"large-vessel":[26],"occlusion":[27],"stroke":[28],"(LVOS).":[29],"This":[30,54],"study":[31,60],"evaluated":[32],"the":[33,38,63,97,109,116,150,167],"functional":[34,112,246,267,277],"identified":[37],"predictors":[39,110],"of":[40,65,70,111,130,138,166,205,244,276],"favorable":[41,245],"patients":[44,76],"undergoing":[45],"MT":[46],"following":[47],"TNK-bridge":[48],"LVOS.":[52],"Methodology:":[53],"was":[55,91,105,121,140,149,169,175,186,192,211,216],"a":[56,127,240,273],"retrospective":[57],"observational":[58],"cohort":[59],"conducted":[61],"at":[62,221,270],"Department":[64],"Neuro-Endovascular":[66],"Surgery,":[67],"Punjab":[68],"Institute":[69],"Neurosciences,":[71],"Lahore,":[72],"Pakistan,":[73],"including":[74],"all":[75],"who":[77],"underwent":[78],"bridge":[81,259],"from":[83,136],"November":[84],"2025":[85],"to":[86,107],"April":[87],"2026.":[88],"Data":[89],"analysis":[90],"done":[92],"using":[93],"Statistical":[94],"Package":[95],"for":[96,264],"Social":[98],"Sciences":[99],"(SPSS)":[100],"version":[101],"27.0.":[102],"Logistic":[103],"regression":[104],"used":[106],"assess":[108],"outcome.":[113,278],"Results:":[114],"Of":[115],"total":[117],"30":[118],"patients,":[119],"there":[120],"male":[122],"predominance":[123],"(76.70%,":[124],"23),":[125],"with":[126],"mean":[128,164],"age":[129],"54.23\u00b113.71":[131],"years.":[132],"The":[133,144,163,181,198],"median":[134,200],"duration":[135,165],"onset":[137],"symptoms":[139],"3.37":[141],"(2.91-4.00)":[142],"hours.":[143],"most":[145],"commonly":[146],"affected":[147],"vessel":[148],"middle":[151],"cerebral":[152],"artery":[153],"(MCA)":[154],"(66.60%).":[155],"Tandem":[156],"occlusions":[157],"were":[158,230],"observed":[159],"20.00%":[161],"(6).":[162],"procedure":[168],"75.63\u00b117.11":[170],"minutes.":[171],"Post-procedural":[172],"intracranial":[173],"hemorrhage":[174],"seen":[176],"6.67%":[178],"(2)":[179],"cases.":[180],"overall":[182,199],"first-pass":[183],"effect":[184],"(FPE)":[185],"53.30%,":[187],"final":[189],"successful":[190],"achieved":[193,231],"90.00%":[195],"(27)":[196],"patients.":[197],"reduction":[201],"National":[203],"Institutes":[204],"Health":[206],"Stroke":[207],"Scale":[208,226],"(NIHSS)":[209],"score":[210,237],"7.00":[212],"(IQR:":[213],"3.75-12.0),":[214],"which":[215],"significant":[217,241],"(p<0.001).":[218],"Favorable":[219],"one":[222],"month":[223],"(modified":[224],"Rankin":[225],"(mRS)":[227],"=":[228,255],"0-2)":[229],"36.70%":[233],"(11).":[234],"Low":[235],"NIHSS":[236,269],"emerged":[238],"independent":[242],"predictor":[243,275],"outcome":[247],"(adjusted":[248],"OR:":[249],"0.705,":[250],"95%":[251],"CI:":[252],"0.514-0.967,":[253],"p-value":[254],"0.030).":[256],"Conclusion:":[257],"TNK":[258],"offers":[261],"potential":[262],"benefits":[263],"neurological":[265],"outcomes.":[268],"admission":[271],"remained":[272],"powerful":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}