{"id":"https://openalex.org/W7225593173","doi":"https://doi.org/10.5281/zenodo.24053200","title":"FORMULATION AND CHARACTERIZATION OF METHIMAZOLE-LOADED TRANSDERMAL PATCHES FOR CONTROLLED SYSTEMIC DELIVERY","display_name":"FORMULATION AND CHARACTERIZATION OF METHIMAZOLE-LOADED TRANSDERMAL PATCHES FOR CONTROLLED SYSTEMIC DELIVERY","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225593173","doi":"https://doi.org/10.5281/zenodo.24053200"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24053200","doi":"https://doi.org/10.5281/zenodo.24053200","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24053200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161303315","display_name":"Bojja Prakarsha, I.Nagaraju, I., Dr.G.S.Valluri, G Vijaya Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bojja Prakarsha, I.Nagaraju, I., Dr.G.S.Valluri, G Vijaya Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161303315"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":1.0},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.9309999942779541},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/solvent-casting","display_name":"solvent casting","score":0.7289999723434448},{"id":"https://openalex.org/keywords/film-forming-polymers","display_name":"film-forming polymers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/plasticizers","display_name":"plasticizers","score":0.875},{"id":"https://openalex.org/keywords/penetration-enhancers","display_name":"penetration enhancers","score":0.9340000152587891},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ex-vivo-skin-permeation","display_name":"ex vivo skin permeation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/release-kinetics","display_name":"release kinetics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.38100001215934753},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.9277999997138977},{"id":"https://openalex.org/C2775842315","wikidata":"https://www.wikidata.org/wiki/Q1145270","display_name":"Transdermal patch","level":3,"score":0.6140999794006348},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5856999754905701},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5753999948501587},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.5072000026702881},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5034000277519226},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5006999969482422},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4300999939441681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3840999901294708},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.35589998960494995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3522000014781952},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C2777937549","wikidata":"https://www.wikidata.org/wiki/Q5464303","display_name":"Folding endurance","level":4,"score":0.3206999897956848},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3197000026702881},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C191168616","wikidata":"https://www.wikidata.org/wiki/Q5503337","display_name":"Friability","level":4,"score":0.28369998931884766},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2732999920845032},{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.266400009393692},{"id":"https://openalex.org/C201253974","wikidata":"https://www.wikidata.org/wiki/Q1330121","display_name":"First pass effect","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C3019451088","wikidata":"https://www.wikidata.org/wiki/Q67004728","display_name":"Patient compliance","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24053200","doi":"https://doi.org/10.5281/zenodo.24053200","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.24053201","doi":"https://doi.org/10.5281/zenodo.24053201","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24053200","doi":"https://doi.org/10.5281/zenodo.24053200","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7203760566","https://openalex.org/W3199048579","https://openalex.org/W2140850362","https://openalex.org/W7093096733","https://openalex.org/W3205023750","https://openalex.org/W7215200318","https://openalex.org/W7207684419","https://openalex.org/W4220874088","https://openalex.org/W7154451909","https://openalex.org/W3183471867"],"abstract_inverted_index":{"Methimazole":[0],"is":[1,16],"an":[2],"antithyroid":[3],"agent":[4],"widely":[5],"prescribed":[6],"for":[7,38,107,237],"the":[8,58,91,172,200,207,212,238],"management":[9,240],"of":[10,61,174,219,241],"hyperthyroidism;":[11],"however,":[12],"conventional":[13,234],"oral":[14,235],"administration":[15],"associated":[17],"with":[18,76],"frequent":[19],"dosing,":[20],"variable":[21],"bioavailability,":[22],"and":[23,33,46,74,99,110,132,196,224],"systemic":[24,40,217],"adverse":[25],"effects.":[26],"The":[27,85,102,177,203],"present":[28],"study":[29,201],"aimed":[30],"to":[31,42,50,56,158,170,214,233],"formulate":[32],"characterize":[34],"methimazole-loaded":[35],"transdermal":[36,86,160,180,209],"patches":[37,87,104],"controlled":[39,216],"delivery":[41,218],"improve":[43],"therapeutic":[44],"efficacy":[45],"patient":[47,226],"compliance.":[48],"Prior":[49],"formulation,":[51],"pre-formulation":[52],"studies":[53,138,151],"were":[54,88,105,139,152,165],"performed":[55,153],"evaluate":[57],"physicochemical":[59],"properties":[60],"methimazole,":[62,220],"including":[63,113],"organoleptic":[64],"characteristics,":[65,195],"solubility":[66],"profile,":[67],"melting":[68],"point,":[69],"partition":[70],"coefficient,":[71],"drug":[72,127,136,161,175,188,191],"identification,":[73],"compatibility":[75],"selected":[77],"polymers":[78],"using":[79,94,142,167],"Fourier":[80],"Transform":[81],"Infrared":[82],"(FTIR)":[83],"spectroscopy.":[84],"prepared":[89],"by":[90],"solvent-casting":[92],"technique":[93],"suitable":[95,144],"film-forming":[96],"polymers,":[97],"plasticizers,":[98],"permeation":[100,150,194],"enhancers.":[101],"formulated":[103],"characterized":[106],"Physio":[108],"chemical":[109,185],"pharmaceutical":[111],"properties,":[112,186],"appearance,":[114],"thickness,":[115],"weight":[116],"uniformity,":[117,129],"folding":[118],"endurance,":[119],"tensile":[120],"strength,":[121],"percentage":[122],"moisture":[123,125],"content,":[124],"uptake,":[126],"content":[128],"surface":[130],"pH,":[131],"flatness.":[133],"In":[134],"vitro":[135],"release":[137],"carried":[140],"out":[141],"a":[143,230],"diffusion":[145],"medium,":[146],"while":[147],"ex":[148],"vivo":[149],"across":[154],"biological":[155],"membrane":[156],"models":[157,169],"assess":[159],"transport.":[162],"Release":[163],"kinetics":[164],"analysed":[166],"mathematical":[168],"determine":[171],"mechanism":[173],"release.":[176],"optimized":[178],"methimazole":[179],"patch":[181],"demonstrated":[182],"acceptable":[183],"physio":[184],"uniform":[187],"distribution,":[189],"sustained":[190],"release,":[192],"satisfactory":[193],"good":[197],"stability":[198],"throughout":[199],"period.":[202],"findings":[204],"suggest":[205],"that":[206],"developed":[208],"system":[210],"has":[211],"potential":[213],"provide":[215],"reduce":[221],"dosing":[222],"frequency,":[223],"enhance":[225],"adherence,":[227],"making":[228],"it":[229],"promising":[231],"alternative":[232],"therapy":[236],"long-term":[239],"hyperthyroidism.":[242],"Keywords:":[243],"Methimazole,":[244],"Transdermal":[245],"Patch":[246]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}