{"id":"https://openalex.org/W7225591802","doi":"https://doi.org/10.13107/jocr.2026.v16.i11.8546","title":"Beyond Weight Loss: Effects of Semaglutide on Knee Pain, Physical Function, and Thigh Skeletal Muscle Volume in Obesity-Associated Knee Osteoarthritis.","display_name":"Beyond Weight Loss: Effects of Semaglutide on Knee Pain, Physical Function, and Thigh Skeletal Muscle Volume in Obesity-Associated Knee Osteoarthritis.","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225591802","doi":"https://doi.org/10.13107/jocr.2026.v16.i11.8546","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997011","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740860"},"language":"en","primary_location":{"id":"pmid:42997011","doi":"https://doi.org/10.13107/jocr.2026.v16.i11.8546","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic case reports","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740860/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084634451","display_name":"Bodla Arvind Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139669409","display_name":"Nizam's Institute of Medical Sciences","ror":"https://ror.org/01wjz9118","country_code":"IN","type":"education","lineage":["https://openalex.org/I139669409"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bodla Arvind Kumar","raw_affiliation_strings":["Department of Orthopaedics, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I139669409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079312650","display_name":"Nithin Sundaresan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nithin Sundaresan","raw_affiliation_strings":["Department of Orthopaedics, Arunai Medical College, Tiruvannamalai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Arunai Medical College, Tiruvannamalai, Tamil Nadu, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092194730","display_name":"Anuragdeep Syal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anuragdeep Syal","raw_affiliation_strings":["Department of Orthopaedics, AIIMS, Bathinda, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, AIIMS, Bathinda, Punjab, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093391157","display_name":"Mohammed Saleh AlSaifi","orcid":"https://orcid.org/0009-0002-8794-9982","observed_orcids":["https://orcid.org/0009-0002-8794-9982"]},"institutions":[{"id":"https://openalex.org/I4387156351","display_name":"21 September University for Medical and Applied Sciences","ror":"https://ror.org/05b8hjk91","country_code":"YE","type":"education","lineage":["https://openalex.org/I4387156351"]}],"countries":["YE"],"is_corresponding":false,"raw_author_name":"Mohammed Saleh AlSaifi","raw_affiliation_strings":["Department of Orthopaedics, 21 September University for Medical and Applied Sciences, Sanaa, Yemen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, 21 September University for Medical and Applied Sciences, Sanaa, Yemen","institution_ids":["https://openalex.org/I4387156351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161272224","display_name":"B Gokula Krishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799707979","display_name":"Swami Vivekanand Subharti University","ror":"https://ror.org/053h7gw81","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799707979"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B Gokula Krishnan","raw_affiliation_strings":["Department of Naturopathy and Yoga, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Naturopathy and Yoga, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India","institution_ids":["https://openalex.org/I2799707979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161262631","display_name":"B Mohanakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799707979","display_name":"Swami Vivekanand Subharti University","ror":"https://ror.org/053h7gw81","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799707979"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B Mohanakrishnan","raw_affiliation_strings":["Department of Naturopathy and Yoga, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Naturopathy and Yoga, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India","institution_ids":["https://openalex.org/I2799707979"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86439243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"541","last_page":"546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.904699981212616},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7950999736785889},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.6644999980926514},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6606000065803528},{"id":"https://openalex.org/C2909862629","wikidata":"https://www.wikidata.org/wiki/Q27261089","display_name":"Semaglutide","level":5,"score":0.6043999791145325},{"id":"https://openalex.org/C2779018429","wikidata":"https://www.wikidata.org/wiki/Q129757","display_name":"Thigh","level":2,"score":0.5752999782562256},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.39910000562667847},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C2779279471","wikidata":"https://www.wikidata.org/wiki/Q6421876","display_name":"Knee pain","level":4,"score":0.35350000858306885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3409999907016754},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.31630000472068787},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.25699999928474426},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2506999969482422},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:42997011","doi":"https://doi.org/10.13107/jocr.2026.v16.i11.8546","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic case reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740860","doi":"https://doi.org/10.13107/jocr.2026.v16.i11.8546","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740860/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Orthop Case Rep","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13740860","doi":"https://doi.org/10.13107/jocr.2026.v16.i11.8546","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740860/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Orthop Case Rep","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W4300905579"],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Obesity":[1],"is":[2],"an":[3],"important":[4],"modifiable":[5],"risk":[6],"factor":[7],"for":[8,95],"knee":[9,36,57,72,87,105,271,295],"osteoarthritis,":[10],"contributing":[11],"to":[12,47,153,169,189,205,222,238,250],"pain,":[13,58],"functional":[14,32],"limitation,":[15],"and":[16,31,65,75,92,121,134,197,267,273],"systemic":[17,280],"inflammation.":[18],"Semaglutide":[19],"may":[20],"provide":[21],"benefits":[22,287],"beyond":[23,290],"weight":[24,147,265,291],"reduction,":[25],"but":[26],"its":[27],"effects":[28,50],"on":[29,55],"clinical":[30],"outcomes":[33],"in":[34,68,99,270,279,293],"obesity-associated":[35,71,86,294],"osteoarthritis":[37,88],"remain":[38],"insufficiently":[39],"characterized.":[40],"Against":[41],"this":[42,44],"background,":[43],"study":[45,81],"sought":[46],"evaluate":[48],"the":[49,109,118,143],"of":[51,258,288],"6-month":[52,144],"semaglutide":[53,91,259,289],"treatment":[54,260],"weight,":[56,100],"physical":[59,114,274],"function,":[60,275],"thigh":[61,127],"skeletal":[62,128,214],"muscle":[63,129,215],"volume,":[64,130],"inflammatory":[66,281],"markers":[67],"patients":[69,84],"with":[70,85,263,300],"osteoarthritis.":[73,296],"Materials":[74],"Methods:":[76],"This":[77],"prospective,":[78],"observational,":[79],"single-arm":[80],"included":[82],"75":[83],"who":[89],"received":[90],"were":[93,139],"followed":[94],"6":[96,256],"months.":[97],"Changes":[98],"body":[101,146],"mass":[102],"index":[103],"(BMI),":[104],"pain":[106,182,272],"assessed":[107,116],"by":[108,277],"Visual":[110],"Analogue":[111],"Scale":[112],"(VAS),":[113],"function":[115],"using":[117],"Western":[119],"Ontario":[120],"McMaster":[122],"Universities":[123],"Osteoarthritis":[124],"Index":[125],"(WOMAC),":[126],"C-reactive":[131],"protein":[132],"(CRP),":[133],"erythrocyte":[135],"sedimentation":[136],"rate":[137],"(ESR)":[138],"evaluated.":[140],"Results:":[141],"At":[142],"follow-up,":[145],"decreased":[148,164,184,233,245],"from":[149,165,185,201,218,234,246],"101.23":[150],"\u00b1":[151,155,167,171,187,191,203,207,220,224,236,240,248,252],"15.45":[152],"91.47":[154],"9.67":[156],"kg":[157],"(mean":[158],"change":[159],"-9.76":[160],"kg),":[161],"while":[162,243],"BMI":[163],"34.49":[166],"3.67":[168],"31.89":[170],"5.78":[172],"kg/m2":[173],"(-2.60":[174],"kg/":[175],"m2;":[176],"both":[177],"P":[178,194,210,229],"<":[179,195,211,230],"0.001).":[180,212,231],"VAS":[181],"scores":[183,199],"6.90":[186],"2.10":[188],"4.89":[190],"0.73":[192,237],"(-2.01;":[193],"0.001),":[196],"WOMAC":[198],"improved":[200],"59.67":[202],"6.47":[204],"44.60":[206],"6.12":[208],"(-15.07;":[209],"Thigh":[213],"volume":[216],"increased":[217],"10.6":[219],"2.3":[221],"11.1":[223],"1.8":[225],"L":[226],"(+0.50":[227],"L;":[228],"CRP":[232],"6.14":[235],"3.91":[239],"2.08":[241],"mg/L,":[242],"ESR":[244],"27.51":[247],"3.32":[249],"19.64":[251],"4.37":[253],"mm/h.":[254],"Conclusion:":[255],"months":[257],"was":[261],"associated":[262],"substantial":[264],"loss":[266],"significant":[268],"improvements":[269],"accompanied":[276],"reductions":[278],"markers.":[282],"These":[283],"findings":[284],"suggest":[285],"potential":[286],"reduction":[292],"Larger":[297],"controlled":[298],"studies":[299],"longer":[301],"follow-up":[302],"are":[303],"warranted.":[304]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-09T00:00:00"}
