{"id":"https://openalex.org/W7225587485","doi":"https://doi.org/10.1002/adhm.71966","title":"Synergistic Sulfur\u2010Atom Positioning and Acceptor Engineering Enable Preferential Type\u2010I Photodynamic Therapy","display_name":"Synergistic Sulfur\u2010Atom Positioning and Acceptor Engineering Enable Preferential Type\u2010I Photodynamic Therapy","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225587485","doi":"https://doi.org/10.1002/adhm.71966","pmid":"https://pubmed.ncbi.nlm.nih.gov/43000199"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.71966","doi":"https://doi.org/10.1002/adhm.71966","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71966","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71966","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71966","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161265515","display_name":"Junhui Liu","orcid":"https://orcid.org/0009-0001-7548-4199","observed_orcids":["https://orcid.org/0009-0001-7548-4199"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhui Liu","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":"https://orcid.org/0009-0001-7548-4199","affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156637660","display_name":"Mengna Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengna Xie","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869311","display_name":"Tianxin Yang","orcid":"https://orcid.org/0000-0002-5224-4360","observed_orcids":["https://orcid.org/0000-0002-5224-4360"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianxin Yang","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161294676","display_name":"Tenghui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tenghui Wang","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091984318","display_name":"Xinyu Zhang","orcid":"https://orcid.org/0000-0002-3685-0563","observed_orcids":["https://orcid.org/0000-0002-3685-0563"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhang","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126924695","display_name":"Qinhong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinhong Jiang","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034350214","display_name":"Panfei Xing","orcid":"https://orcid.org/0009-0004-3738-7226","observed_orcids":["https://orcid.org/0009-0004-3738-7226","https://orcid.org/0000-0003-4877-0533"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Panfei Xing","raw_affiliation_strings":["Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China"],"raw_orcid":"https://orcid.org/0009-0004-3738-7226","affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034350214"],"corresponding_institution_ids":["https://openalex.org/I173899330"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/photosensitizer-design","display_name":"photosensitizer design","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sulfur-substitution","display_name":"sulfur substitution","score":0.7860000133514404},{"id":"https://openalex.org/keywords/twisted-intramolecular-charge-transfer","display_name":"twisted intramolecular charge transfer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/intersystem-crossing","display_name":"intersystem crossing","score":0.9750000238418579},{"id":"https://openalex.org/keywords/near-infrared-photosensitizer","display_name":"near-infrared photosensitizer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nanoparticle-self-assembly","display_name":"nanoparticle self-assembly","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.8680999875068665},{"id":"https://openalex.org/C73978554","wikidata":"https://www.wikidata.org/wiki/Q772919","display_name":"Intersystem crossing","level":4,"score":0.8246999979019165},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8082000017166138},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.6657999753952026},{"id":"https://openalex.org/C2779892579","wikidata":"https://www.wikidata.org/wiki/Q912138","display_name":"Acceptor","level":2,"score":0.6309000253677368},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5088000297546387},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48190000653266907},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.4756999909877777},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4722000062465668},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.44699999690055847},{"id":"https://openalex.org/C2900893","wikidata":"https://www.wikidata.org/wiki/Q1231592","display_name":"Electron acceptor","level":2,"score":0.3862999975681305},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38609999418258667},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.38089999556541443},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.36039999127388},{"id":"https://openalex.org/C106447425","wikidata":"https://www.wikidata.org/wiki/Q11379","display_name":"Energy transfer","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34290000796318054},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3352999985218048},{"id":"https://openalex.org/C65604355","wikidata":"https://www.wikidata.org/wiki/Q3523861","display_name":"Molecular engineering","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C123669783","wikidata":"https://www.wikidata.org/wiki/Q902898","display_name":"Electron transfer","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.25859999656677246}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.71966","doi":"https://doi.org/10.1002/adhm.71966","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71966","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71966","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:43000199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43000199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/adhm.71966","doi":"https://doi.org/10.1002/adhm.71966","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71966","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71966","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6832353010","display_name":null,"funder_award_id":"2023M730970","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322878","display_name":"Henan University","ror":"https://ror.org/003xyzq10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225587485.pdf","grobid_xml":"https://content.openalex.org/works/W7225587485.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1986951817","https://openalex.org/W2105957140","https://openalex.org/W2168036745","https://openalex.org/W2269445948","https://openalex.org/W2559588549","https://openalex.org/W2968636445","https://openalex.org/W2969282776","https://openalex.org/W2972196262","https://openalex.org/W3013928507","https://openalex.org/W3017229881","https://openalex.org/W3085615338","https://openalex.org/W3113788789","https://openalex.org/W3181830375","https://openalex.org/W3184517075","https://openalex.org/W3205818211","https://openalex.org/W3205940877","https://openalex.org/W3211630912","https://openalex.org/W4205830412","https://openalex.org/W4283067182","https://openalex.org/W4285240000","https://openalex.org/W4287455687","https://openalex.org/W4294847136","https://openalex.org/W4321167021","https://openalex.org/W4323352726","https://openalex.org/W4362594708","https://openalex.org/W4391174475","https://openalex.org/W4393388803","https://openalex.org/W4400585494","https://openalex.org/W4401534526","https://openalex.org/W4402269962","https://openalex.org/W4402309573","https://openalex.org/W4402391579","https://openalex.org/W4403203862","https://openalex.org/W4403339150","https://openalex.org/W4404246451","https://openalex.org/W4404850213","https://openalex.org/W4405355897","https://openalex.org/W4405776609","https://openalex.org/W4406666071","https://openalex.org/W4407358569","https://openalex.org/W4407989541","https://openalex.org/W4409395505","https://openalex.org/W4409831980","https://openalex.org/W4410235933","https://openalex.org/W4412595025","https://openalex.org/W4412834474","https://openalex.org/W4413637696","https://openalex.org/W4413660618","https://openalex.org/W4415388292","https://openalex.org/W4416344753","https://openalex.org/W7168145729"],"related_works":["https://openalex.org/W4404910492","https://openalex.org/W4400571129","https://openalex.org/W4405868422","https://openalex.org/W7139972884","https://openalex.org/W4389720468","https://openalex.org/W4291567132","https://openalex.org/W4401845020","https://openalex.org/W4381988222","https://openalex.org/W3165504457","https://openalex.org/W7117150367"],"abstract_inverted_index":{"ABSTRACT":[0],"Less":[1],"oxygen\u2010independent":[2],"Type\u2010I":[3,54,62,119,138,181],"reactive":[4],"oxygen":[5],"species":[6],"(ROS)":[7],"generated":[8],"by":[9],"photosensitizers":[10,22,182],"offer":[11],"distinct":[12],"advantages":[13],"for":[14,175],"tumor":[15,147,162],"photodynamic":[16],"therapy":[17],"(PDT).":[18],"However,":[19],"most":[20],"conventional":[21],"activate":[23],"nonselective":[24],"mixed":[25],"ROS":[26,55,139],"pathways,":[27],"significantly":[28,160],"hindering":[29],"the":[30,77,99,102,108,115,176,185],"advancement":[31],"of":[32,101,118,137,158,179,188],"PDT.":[33,189],"In":[34,150],"this":[35],"study,":[36],"we":[37],"propose":[38],"a":[39,59,88,155],"synergistic":[40],"molecular":[41],"design":[42,178],"strategy":[43],"that":[44,73,154],"integrates":[45],"sulfur\u2010atom":[46],"positioning":[47],"and":[48,69,106,125,131,172,183],"acceptor":[49,85],"engineering":[50,86],"to":[51],"achieve":[52],"preferential":[53,116],"generation.":[56],"We":[57],"identified":[58],"novel":[60],"near\u2010infrared":[61],"photosensitizer":[63],"NS4":[64,123,130],".":[65],"Combined":[66],"theoretical":[67,171],"calculations":[68],"experimental":[70],"characterizations":[71],"demonstrate":[72],"sulfur":[74],"substitution":[75],"enhances":[76],"S":[78,103],"1":[79,81,104,110],"\u2010T":[80],"intersystem":[82],"crossing,":[83],"while":[84],"promotes":[87],"pronounced":[89],"twisted":[90],"intramolecular":[91],"charge":[92],"transfer":[93],"(TICT).":[94],"This":[95,168],"TICT":[96],"effect":[97],"lowers":[98],"energy":[100],"state":[105],"stabilizes":[107],"T":[109],"state,":[111],"thereby":[112],"synergistically":[113],"enabling":[114],"production":[117],"ROS.":[120],"Both":[121],"free":[122],"derivative":[124],"NS\u2010NPs":[126,159],",":[127],"self\u2010assembled":[128],"from":[129],"F\u2010127,":[132],"can":[133],"generate":[134],"substantial":[135],"amounts":[136],"under":[140],"660":[141],"nm":[142],"laser":[143],"irradiation,":[144],"effectively":[145],"triggering":[146],"cell":[148],"apoptosis.":[149],"vivo":[151],"assessments":[152],"confirm":[153],"single":[156],"dose":[157],"suppresses":[161],"growth":[163],"with":[164],"negligible":[165],"systemic":[166],"toxicity.":[167],"work":[169],"establishes":[170],"structural":[173],"guidelines":[174],"rational":[177],"high\u2010performance":[180],"facilitates":[184],"further":[186],"translation":[187]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-09T00:00:00"}
