{"id":"https://openalex.org/W7225585388","doi":"https://doi.org/10.3389/fgene.2026.1855056","title":"Anthropometric traits, intraocular pressure, and glaucoma in the Canadian Longitudinal Study on Aging: a sex-specific Mendelian randomization study","display_name":"Anthropometric traits, intraocular pressure, and glaucoma in the Canadian Longitudinal Study on Aging: a sex-specific Mendelian randomization study","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225585388","doi":"https://doi.org/10.3389/fgene.2026.1855056"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2026.1855056","doi":"https://doi.org/10.3389/fgene.2026.1855056","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1855056","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1855056/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1855056/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081746787","display_name":"Joseph Bastasic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joseph Bastasic","raw_affiliation_strings":["School of Epidemiology and Public Health, University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Epidemiology and Public Health, University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109387434","display_name":"Mohan Rakesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mohan Rakesh","raw_affiliation_strings":["School of Epidemiology and Public Health, University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Epidemiology and Public Health, University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012001147","display_name":"Ellen E. Freeman","orcid":"https://orcid.org/0000-0002-1403-8427","observed_orcids":["https://orcid.org/0000-0002-1403-8427"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ellen E. Freeman","raw_affiliation_strings":["School of Epidemiology and Public Health, University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Epidemiology and Public Health, University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011428472","display_name":"Meng\u2010Che Tsai","orcid":"https://orcid.org/0000-0003-1057-3315","observed_orcids":["https://orcid.org/0000-0003-1057-3315"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Meng-Che Tsai","raw_affiliation_strings":["Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073764742","display_name":"Julian Little","orcid":"https://orcid.org/0000-0001-5026-5531","observed_orcids":["https://orcid.org/0000-0001-5026-5531"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julian Little","raw_affiliation_strings":["School of Epidemiology and Public Health, University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Epidemiology and Public Health, University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016454136","display_name":"Pirro G. Hysi","orcid":"https://orcid.org/0000-0001-5752-2510","observed_orcids":["https://orcid.org/0000-0001-5752-2510"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pirro G. Hysi","raw_affiliation_strings":["Section of Ophthalmology, School of Life Course Sciences, King\u2019s College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Ophthalmology, School of Life Course Sciences, King\u2019s College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041258568","display_name":"Kelly M. Burkett","orcid":"https://orcid.org/0000-0002-9488-5588","observed_orcids":["https://orcid.org/0000-0002-9488-5588"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kelly M. Burkett","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070692469","display_name":"Marie\u2010H\u00e9l\u00e8ne Roy\u2010Gagnon","orcid":"https://orcid.org/0000-0001-8747-0846","observed_orcids":["https://orcid.org/0000-0001-8747-0846","https://orcid.org/0000-0003-1381-5180"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marie-H\u00e9l\u00e8ne Roy-Gagnon","raw_affiliation_strings":["School of Epidemiology and Public Health, University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Epidemiology and Public Health, University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070692469"],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9409999847412109},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anthropometric-traits","display_name":"anthropometric traits","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7089999914169312},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.4729999899864197},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.47699999809265137},{"id":"https://openalex.org/keywords/canadian-longitudinal-study-on-aging","display_name":"Canadian Longitudinal Study on Aging","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8374000191688538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8202000260353088},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.795799970626831},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7577000260353088},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.7450000047683716},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.7032999992370605},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.565500020980835},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.5565000176429749},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5357000231742859},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.47999998927116394},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.47380000352859497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43700000643730164},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.41839998960494995},{"id":"https://openalex.org/C33997684","wikidata":"https://www.wikidata.org/wiki/Q876152","display_name":"Waist\u2013hip ratio","level":4,"score":0.40950000286102295},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.28040000796318054},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.27619999647140503}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fgene.2026.1855056","doi":"https://doi.org/10.3389/fgene.2026.1855056","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1855056","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1855056/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6ec0a7e4e46a4a4d8d82a7f6bf6019ce","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6ec0a7e4e46a4a4d8d82a7f6bf6019ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2026.1855056","doi":"https://doi.org/10.3389/fgene.2026.1855056","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2026.1855056","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1855056/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1551914075","display_name":null,"funder_award_id":"LSA 94,473","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6227940160","display_name":null,"funder_award_id":"94473","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8059889987","display_name":null,"funder_award_id":"LSA 94473","funder_id":"https://openalex.org/F4320319880","funder_display_name":"Government of Canada"}],"funders":[{"id":"https://openalex.org/F4320319880","display_name":"Government of Canada","ror":"https://ror.org/010q4q527"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225585388.pdf","grobid_xml":"https://content.openalex.org/works/W7225585388.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W84625781","https://openalex.org/W1770429057","https://openalex.org/W1905058580","https://openalex.org/W1975414559","https://openalex.org/W1984461274","https://openalex.org/W1991983928","https://openalex.org/W1992326094","https://openalex.org/W1993722458","https://openalex.org/W1994667259","https://openalex.org/W1998783498","https://openalex.org/W2039153962","https://openalex.org/W2047783882","https://openalex.org/W2057266151","https://openalex.org/W2087631881","https://openalex.org/W2092328292","https://openalex.org/W2099085143","https://openalex.org/W2103783427","https://openalex.org/W2106036991","https://openalex.org/W2113699335","https://openalex.org/W2118008714","https://openalex.org/W2124994858","https://openalex.org/W2126238538","https://openalex.org/W2127767012","https://openalex.org/W2127768736","https://openalex.org/W2129062364","https://openalex.org/W2135987452","https://openalex.org/W2152885121","https://openalex.org/W2157253302","https://openalex.org/W2157752701","https://openalex.org/W2157940561","https://openalex.org/W2160605010","https://openalex.org/W2161633633","https://openalex.org/W2162204400","https://openalex.org/W2224938005","https://openalex.org/W2324862792","https://openalex.org/W2330340796","https://openalex.org/W2507815726","https://openalex.org/W2510973425","https://openalex.org/W2520048741","https://openalex.org/W2528302205","https://openalex.org/W2529681800","https://openalex.org/W2575018533","https://openalex.org/W2597850678","https://openalex.org/W2613603864","https://openalex.org/W2614566443","https://openalex.org/W2625091963","https://openalex.org/W2731900457","https://openalex.org/W2735376054","https://openalex.org/W2770598799","https://openalex.org/W2780560743","https://openalex.org/W2797906093","https://openalex.org/W2798750837","https://openalex.org/W2803072880","https://openalex.org/W2803323905","https://openalex.org/W2805983714","https://openalex.org/W2818417770","https://openalex.org/W2921747719","https://openalex.org/W2947891141","https://openalex.org/W2952686929","https://openalex.org/W2972265869","https://openalex.org/W3000547714","https://openalex.org/W3018876644","https://openalex.org/W3084608394","https://openalex.org/W3119287118","https://openalex.org/W3126160703","https://openalex.org/W3131963404","https://openalex.org/W3157424511","https://openalex.org/W3159102563","https://openalex.org/W3210570897","https://openalex.org/W3216913398","https://openalex.org/W4214741146","https://openalex.org/W4220691247","https://openalex.org/W4224312444","https://openalex.org/W4280541700","https://openalex.org/W4291110437","https://openalex.org/W4296998664","https://openalex.org/W4313828812","https://openalex.org/W4318684535","https://openalex.org/W4362692254","https://openalex.org/W4381334612","https://openalex.org/W4383599236","https://openalex.org/W4385577954","https://openalex.org/W4388653216","https://openalex.org/W7126189270"],"related_works":["https://openalex.org/W4296998664","https://openalex.org/W4224312444","https://openalex.org/W2330340796","https://openalex.org/W2113804192","https://openalex.org/W2224938005","https://openalex.org/W4283657959","https://openalex.org/W4214741146","https://openalex.org/W2404202271","https://openalex.org/W2931877324","https://openalex.org/W7166561490"],"abstract_inverted_index":{"Purpose":[0],"Investigate":[1],"potential":[2,77],"causal":[3],"relationships":[4],"of":[5,47,161,193],"body":[6,48],"mass":[7,49],"index":[8,50],"(BMI)":[9],"and":[10,18,51,57,64,68,102,139],"waist-to-hip":[11],"ratio":[12],"(WHR)":[13],"with":[14,53,84,117,145,199],"intraocular":[15,55],"pressure":[16,56],"(IOP)":[17],"glaucoma":[19,58,146],"using":[20,30,61],"sex-specific":[21],"Mendelian":[22,70],"randomization":[23,71],"(MR).":[24],"Methods":[25],"Cross-sectional":[26],"analyses":[27,72,190],"were":[28,59,73,141,220],"performed":[29],"baseline":[31],"data":[32],"on":[33,42,165],"22,902":[34],"study":[35],"participants":[36],"from":[37],"the":[38,155,159],"Canadian":[39],"Longitudinal":[40],"Study":[41],"Aging":[43],"(CLSA).":[44],"Sex-specific":[45,230],"associations":[46],"WHR":[52,113,140,224],"corneal-compensated":[54],"examined":[60],"multivariable":[62],"linear":[63],"logistic":[65],"regression.":[66],"One-sample":[67],"two-sample":[69,188],"conducted":[74],"to":[75,243],"assess":[76],"causality.":[78],"Results":[79],"BMI":[80,138,164,196,236],"was":[81,114,169],"positively":[82],"associated":[83,116,144,198],"IOP":[85,118,166,200],"for":[86,119,147,223],"both":[87],"males":[88,132,168],"(\u03b2":[89,104,121,172],"=":[90,105,122,136,173,185,206,216],"0.125":[91],"per":[92,107,124,175,208],"standard":[93],"deviation":[94],"(SD),":[95],"95%":[96,109,126,177,210],"confidence":[97,178],"interval":[98,179],"(CI)":[99,180],"[0.049,":[100],"0.200])":[101],"females":[103,120,202],"0.235":[106],"SD,":[108,125,176,209],"CI":[110,127,211],"[0.164,":[111],"0.307]).":[112],"significantly":[115,143],"0.098":[123],"[0.025,":[128],"0.170]),":[129],"but":[130],"not":[131,142,221],"(":[133,150,225],"P":[134,151,183,214,226],"-value":[135,152,184,215,227],"0.463).":[137],"either":[148],"sex":[149],"\u22650.2).":[153],"For":[154],"one-sample":[156],"MR":[157,189,218,231],"analyses,":[158],"effect":[160],"genetically":[162,194],"predicted":[163,195],"in":[167,201],"borderline":[170],"significant":[171,222],"0.434":[174],"[0.005,":[181],"0.874],":[182],"0.053).":[186],"The":[187],"found":[191,232],"evidence":[192,234],"being":[197],"(Weighted":[203],"Median:":[204],"\u03b2":[205],"0.694":[207],"[0.127,":[212],"1.260],":[213],"0.016).":[217],"results":[219],">0.05).":[228],"Conclusion":[229],"suggestive":[233],"that":[235],"(general":[237],"adiposity)":[238],"might":[239],"be":[240],"causally":[241],"linked":[242],"IOP.":[244]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-09T00:00:00"}
