{"id":"https://openalex.org/W7225576166","doi":"https://doi.org/10.1161/circ.154.suppl_1.9161","title":"Abstract 9161: Latent Biomarker Phenotypes in Older Adults Identify Distinct Patterns of Frailty, Cardiovascular Disease, and Mortality Risk","display_name":"Abstract 9161: Latent Biomarker Phenotypes in Older Adults Identify Distinct Patterns of Frailty, Cardiovascular Disease, and Mortality Risk","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225576166","doi":"https://doi.org/10.1161/circ.154.suppl_1.9161"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.9161","doi":"https://doi.org/10.1161/circ.154.suppl_1.9161","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.9161","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120816363","display_name":"Shefa Arya Nezhad","orcid":"https://orcid.org/0000-0002-0935-1806","observed_orcids":["https://orcid.org/0000-0002-0935-1806"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shefa Arya Nezhad","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032552563","display_name":"Sridhar Mangalesh","orcid":"https://orcid.org/0000-0002-2645-3994","observed_orcids":["https://orcid.org/0000-0002-2645-3994"]},"institutions":[{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Mangalesh","raw_affiliation_strings":["Jacobi Med Cntr, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobi Med Cntr, Bronx, NY","institution_ids":["https://openalex.org/I2800364127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071138301","display_name":"Raiza Rossi","orcid":"https://orcid.org/0000-0001-6898-2192","observed_orcids":["https://orcid.org/0000-0001-6898-2192"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raiza Rossi","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130811749","display_name":"Armin Nouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armin Nouri","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139864277","display_name":"Parvaneh Rastgou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvaneh Rastgou","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029190750","display_name":"Zafer Akman","orcid":"https://orcid.org/0000-0002-6317-4417","observed_orcids":["https://orcid.org/0000-0002-6317-4417"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zafer Akman","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046504734","display_name":"Laura Tycon Moreines","orcid":"https://orcid.org/0009-0003-5827-5429","observed_orcids":["https://orcid.org/0009-0003-5827-5429"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Moreines","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052978037","display_name":"Abdulla A. Damluji","orcid":"https://orcid.org/0000-0002-8774-6416","observed_orcids":["https://orcid.org/0000-0002-8774-6416"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdulla Damluji","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046257512","display_name":"Michael G. Nanna","orcid":"https://orcid.org/0000-0001-5745-1636","observed_orcids":["https://orcid.org/0000-0001-5745-1636"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Nanna","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7089999914169312},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9860000014305115},{"id":"https://openalex.org/keywords/latent-class-analysis","display_name":"latent class analysis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.7049999833106995},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hypoalbuminemia","display_name":"hypoalbuminemia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.7770000100135803},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5400000214576721},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8389999866485596},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.718999981880188},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.7289999723434448},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.921999990940094},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.6480000019073486},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8902999758720398},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6577000021934509},{"id":"https://openalex.org/C70727504","wikidata":"https://www.wikidata.org/wiki/Q1806878","display_name":"Latent class model","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5690000057220459},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5424000024795532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5389000177383423},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.42809998989105225},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3483999967575073},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3206999897956848},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2754000127315521},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.27059999108314514},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.25589999556541443},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.9161","doi":"https://doi.org/10.1161/circ.154.suppl_1.9161","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.9161","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3163353277","https://openalex.org/W4400120542","https://openalex.org/W7127456050","https://openalex.org/W1554335923","https://openalex.org/W4280609140","https://openalex.org/W3181538448","https://openalex.org/W7162790199","https://openalex.org/W4200288261","https://openalex.org/W4392792767","https://openalex.org/W4389508984"],"abstract_inverted_index":{"Background:":[0],"Frailty,":[1],"cardiovascular":[2,46,73,160,250,282,313,328],"disease,":[3,47,74,314,329],"and":[4,40,48,66,75,95,126,149,163,212,226,228,257,281,315,330],"mortality":[5,164,275,283,296],"in":[6,22,37],"older":[7,38,53,172,301,342],"adults":[8,39,80,173,343],"arise":[9],"from":[10,84],"multiple":[11],"interacting":[12],"biologic":[13,28],"processes.":[14],"However,":[15],"most":[16],"studies":[17],"have":[18],"evaluated":[19,153],"individual":[20],"biomarkers":[21,59,88],"isolation,":[23],"potentially":[24],"overlooking":[25],"clinically":[26,63,196],"meaningful":[27,64],"phenotypes.":[29,146],"We":[30,78],"sought":[31],"to":[32,143],"identify":[33,144,339],"latent":[34,156,181,304],"biomarker":[35,234,305,335],"phenotypes":[36,69,198,306],"evaluate":[41],"their":[42],"associations":[43,154],"with":[44,71,237,244,272,292,322],"frailty,":[45,72,158,312,327],"mortality.":[49,316],"Research":[50],"Question:":[51],"Among":[52,179,300],"adults,":[54,303],"do":[55],"routinely":[56],"available":[57],"laboratory":[58],"cluster":[60],"into":[61],"distinct,":[62],"phenotypes,":[65],"are":[67],"these":[68],"associated":[70,243,271,291,321],"mortality?":[76],"Methods:":[77],"analyzed":[79],"aged":[81],"\u226565":[82],"years":[83],"NHANES":[85],"2015-2018.":[86],"Nine":[87],"spanning":[89],"inflammatory,":[90],"glycemic,":[91],"renal,":[92],"hematologic,":[93],"lipid,":[94],"nutritional":[96],"domains":[97],"were":[98,177,199],"included:":[99],"high-sensitivity":[100],"C-reactive":[101],"protein":[102],"(hsCRP),":[103],"hemoglobin":[104,122],"A1c":[105],"(HbA1c),":[106],"urine":[107],"albumin-creatinine":[108],"ratio":[109,254,278],"(UACR),":[110],"estimated":[111],"glomerular":[112],"filtration":[113],"rate":[114],"(eGFR),":[115],"vitamin":[116],"D,":[117],"white":[118],"blood":[119],"cell":[120],"count,":[121],"(Hb),":[123],"HDL":[124],"cholesterol,":[125],"serum":[127],"albumin.":[128],"Frailty":[129],"was":[130,141,187,242,269,290,320],"defined":[131],"using":[132],"a":[133,217,231],"modified":[134],"Fried":[135],"phenotype.":[136,235],"Latent":[137],"class":[138,182],"analysis":[139],"(LCA)":[140],"used":[142],"biomarker-defined":[145],"Survey-weighted":[147],"logistic":[148],"Cox":[150,264],"regression":[151,265],"models":[152],"between":[155],"classes,":[157],"prevalent":[159,248],"disease":[161,251],"(CVD),":[162],"outcomes.":[165,349],"Results:":[166],"A":[167],"total":[168],"of":[169,247,311,326,347],"2,248":[170],"U.S.":[171,302],"(weighted,":[174],"41.5":[175],"million)":[176],"analyzed.":[178],"candidate":[180],"models,":[183,266],"the":[184],"3-class":[185],"solution":[186],"selected":[188],"based":[189],"on":[190],"fit":[191],"statistics":[192],"(Figure":[193,286],"1).":[194],"Three":[195],"interpretable":[197],"observed:":[200],"Class":[201,215,229,238,240,267,288],"1,":[202],"an":[203],"inflammatory-metabolic":[204],"phenotype":[205,219,319],"characterized":[206,220],"by":[207,221],"elevated":[208],"inflammatory":[209],"markers,":[210],"diabetes,":[211],"low":[213],"HDL-C;":[214],"2,":[216],"renal-proteinuric-anemia":[218,318],"albuminuria,":[222],"renal":[223],"dysfunction,":[224],"anemia,":[225],"hypoalbuminemia;":[227],"3,":[230,239],"relatively":[232],"preserved":[233],"Compared":[236],"2":[241,268],"higher":[245,324],"odds":[246,253],"clinical":[249],"(adjusted":[252,276],"1.98":[255],"[1.22-3.20])":[256],"frailty":[258,293],"(2.31":[259],"[1.69-3.16]).":[260],"In":[261],"fully":[262],"adjusted":[263],"also":[270],"increased":[273,345],"all-cause":[274],"hazard":[277],"2.34":[279],"[1.63-3.35])":[280],"(2.10":[284],"[1.10-4.03])":[285],"2).":[287],"1":[289],"but":[294],"not":[295],"after":[297],"adjustment.":[298],"Conclusions:":[299],"exhibited":[307],"markedly":[308],"different":[309],"profiles":[310],"The":[317],"substantially":[323],"risks":[325],"mortality,":[331],"suggesting":[332],"that":[333],"integrated":[334],"patterns":[336],"may":[337],"help":[338],"biologically":[340],"vulnerable":[341],"at":[344],"risk":[346],"adverse":[348]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}
