{"id":"https://openalex.org/W7225575639","doi":"https://doi.org/10.64898/2026.11.05.26367397","title":"Investigating the potential effect of topiramate on anorexia nervosa and binge eating behaviour using drug-target Mendelian randomization","display_name":"Investigating the potential effect of topiramate on anorexia nervosa and binge eating behaviour using drug-target Mendelian randomization","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225575639","doi":"https://doi.org/10.64898/2026.11.05.26367397"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.26367397","doi":"https://doi.org/10.64898/2026.11.05.26367397","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.26367397","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/08/2026.11.05.26367397.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/08/2026.11.05.26367397.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125169766","display_name":"Kym-Mai Nguyen","orcid":"https://orcid.org/0000-0002-2592-9372","observed_orcids":["https://orcid.org/0000-0002-2592-9372","https://orcid.org/0009-0003-5344-3841"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kym-Mai Nguyen","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161265945","display_name":"Eva Yi-Hsien Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Eva Yi-Hsien Chang","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082797644","display_name":"Brain Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brain Kim","raw_affiliation_strings":["School of Environment, The University of Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environment, The University of Queensland","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066766341","display_name":"Paul Ebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul Ebert","raw_affiliation_strings":["School of Environment, The University of Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environment, The University of Queensland","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161266983","display_name":"Jiayue-Clara Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jiayue-Clara Chiang","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010693078","display_name":"Liang\u2010Dar Hwang","orcid":"https://orcid.org/0000-0002-5535-2199","observed_orcids":["https://orcid.org/0000-0002-5535-2199"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Liang-Dar Hwang","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland;"],"raw_orcid":"https://orcid.org/0000-0002-5535-2199","affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010693078"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topiramate","display_name":"topiramate","score":1.0},{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/binge-eating","display_name":"binge eating","score":0.878000020980835},{"id":"https://openalex.org/keywords/eating-disorders","display_name":"eating disorders","score":0.9049999713897705},{"id":"https://openalex.org/keywords/drug-target-mendelian-randomization","display_name":"drug-target Mendelian randomization","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ca4","display_name":"CA4","score":0.6759999990463257},{"id":"https://openalex.org/keywords/grik1","display_name":"GRIK1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/grik3","display_name":"GRIK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/appetite-suppression","display_name":"appetite suppression","score":0.6209999918937683},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9259999990463257},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.8709999918937683},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8240000009536743},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8363999724388123},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.8346999883651733},{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.5005999803543091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4350000023841858},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4343999922275543},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42660000920295715},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.42010000348091125},{"id":"https://openalex.org/C2778202721","wikidata":"https://www.wikidata.org/wiki/Q209522","display_name":"Binge-eating disorder","level":4,"score":0.4153999984264374},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.3668000102043152},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C2780319597","wikidata":"https://www.wikidata.org/wiki/Q1549918","display_name":"Impulsivity","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.33730000257492065},{"id":"https://openalex.org/C2777529043","wikidata":"https://www.wikidata.org/wiki/Q741713","display_name":"Panic disorder","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C2781426410","wikidata":"https://www.wikidata.org/wiki/Q2303219","display_name":"Binge eating","level":3,"score":0.2953999936580658},{"id":"https://openalex.org/C2780740339","wikidata":"https://www.wikidata.org/wiki/Q416930","display_name":"Ethyl glucuronide","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.26089999079704285},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2581999897956848}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.26367397","doi":"https://doi.org/10.64898/2026.11.05.26367397","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.26367397","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/08/2026.11.05.26367397.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.26367397","doi":"https://doi.org/10.64898/2026.11.05.26367397","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.26367397","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/08/2026.11.05.26367397.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225575639.pdf","grobid_xml":"https://content.openalex.org/works/W7225575639.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1540876114","https://openalex.org/W1892078977","https://openalex.org/W1983540132","https://openalex.org/W1985043270","https://openalex.org/W1985966440","https://openalex.org/W1990076778","https://openalex.org/W1995592495","https://openalex.org/W2008291984","https://openalex.org/W2021155136","https://openalex.org/W2030085291","https://openalex.org/W2032132493","https://openalex.org/W2032159952","https://openalex.org/W2046895642","https://openalex.org/W2049157137","https://openalex.org/W2053264640","https://openalex.org/W2060894123","https://openalex.org/W2061645338","https://openalex.org/W2073509001","https://openalex.org/W2073836327","https://openalex.org/W2075415732","https://openalex.org/W2078318317","https://openalex.org/W2078429444","https://openalex.org/W2084857211","https://openalex.org/W2086064342","https://openalex.org/W2097510503","https://openalex.org/W2103264791","https://openalex.org/W2104062458","https://openalex.org/W2104196389","https://openalex.org/W2104549677","https://openalex.org/W2106036991","https://openalex.org/W2118008714","https://openalex.org/W2120445941","https://openalex.org/W2127767012","https://openalex.org/W2142232389","https://openalex.org/W2153815587","https://openalex.org/W2161554615","https://openalex.org/W2165630646","https://openalex.org/W2170146596","https://openalex.org/W2264357185","https://openalex.org/W2328393125","https://openalex.org/W2340761255","https://openalex.org/W2497603175","https://openalex.org/W2514447495","https://openalex.org/W2515404667","https://openalex.org/W2783804473","https://openalex.org/W2788609121","https://openalex.org/W2794415265","https://openalex.org/W2805712258","https://openalex.org/W2835221766","https://openalex.org/W2911487850","https://openalex.org/W2919004480","https://openalex.org/W2936051680","https://openalex.org/W2979994192","https://openalex.org/W2983423072","https://openalex.org/W3025047014","https://openalex.org/W3037039951","https://openalex.org/W3039237517","https://openalex.org/W3114181907","https://openalex.org/W3121173001","https://openalex.org/W3128936277","https://openalex.org/W3162259891","https://openalex.org/W3197364483","https://openalex.org/W3209466757","https://openalex.org/W4200155235","https://openalex.org/W4223520055","https://openalex.org/W4223999250","https://openalex.org/W4225677162","https://openalex.org/W4281249924","https://openalex.org/W4293068541","https://openalex.org/W4296843460","https://openalex.org/W4307843054","https://openalex.org/W4382139061","https://openalex.org/W4386308158","https://openalex.org/W4386332807","https://openalex.org/W4389262449","https://openalex.org/W4389440080","https://openalex.org/W4391545301","https://openalex.org/W4391841654","https://openalex.org/W4392446652","https://openalex.org/W4396662959","https://openalex.org/W4400524230","https://openalex.org/W4401932529","https://openalex.org/W4404599053","https://openalex.org/W4404628441","https://openalex.org/W4404672125","https://openalex.org/W4414824234","https://openalex.org/W6910641848","https://openalex.org/W7127282211","https://openalex.org/W7155580110","https://openalex.org/W7204237749"],"related_works":["https://openalex.org/W1984881398","https://openalex.org/W3189424004","https://openalex.org/W4233643609","https://openalex.org/W2103264791","https://openalex.org/W3041220001","https://openalex.org/W2138797587","https://openalex.org/W7106705032","https://openalex.org/W1983540132","https://openalex.org/W1994119157","https://openalex.org/W2032132493"],"abstract_inverted_index":{"Topiramate":[0],"is":[1,12],"an":[2],"antiseizure":[3],"medication":[4],"used":[5,92],"to":[6,38,97,245],"treat":[7],"epilepsy":[8],"and":[9,11,18,54,57,63,89,107,130,136,139,154,186,206,230,239,242],"migraine":[10],"commonly":[13],"prescribed":[14],"for":[15,113,198,216],"appetite":[16,237],"suppression":[17,238],"weight":[19,240],"loss.":[20],"However,":[21],"whether":[22],"its":[23,116],"pharmacological":[24,101],"actions":[25,102],"influence":[26],"eating":[27],"disorder":[28],"risk":[29,47,173],"remains":[30],"unclear.":[31],"We":[32,91],"applied":[33],"drug-target":[34],"Mendelian":[35,94],"randomization":[36,95],"(MR)":[37],"investigate":[39,98],"potential":[40],"causal":[41,201],"effects":[42],"of":[43,48,103,146,163],"topiramate":[44,104],"on":[45],"the":[46,134,143,147,219],"anorexia":[49],"nervosa":[50],"(AN;":[51],"24,223":[52],"cases":[53,62],"1,243,971":[55],"controls)":[56,65],"binge-eating":[58],"behaviour":[59],"(BE;":[60],"39,279":[61],"1,227,436":[64],"and,":[66],"exploratorily,":[67],"eight":[68,220],"other":[69],"psychiatric":[70,222],"disorders:":[71],"attention-deficit/hyperactivity":[72],"disorder,":[73,78,80,83,85,88],"anxiety":[74],"disorders,":[75],"alcohol":[76],"use":[77],"bipolar":[79],"major":[81],"depressive":[82],"panic":[84],"post-traumatic":[86],"stress":[87],"schizophrenia.":[90],"summary-data-based":[93],"(SMR)":[96],"genetically":[99,160],"predicted":[100,161],"using":[105,151],"brain-":[106],"blood-derived":[108],"cis-expression":[109],"quantitative":[110],"trait":[111],"loci":[112],"genes":[114],"encoding":[115],"molecular":[117],"targets.":[118],"Five":[119],"genetic":[120],"instruments":[121],"consistent":[122],"with":[123,170],"topiramate's":[124],"antiepileptic":[125],"action":[126],"were":[127],"validated:":[128],"CA4":[129,164,204],"CACNB3":[131],"expression":[132,141,165,205],"in":[133,142,166,189],"brain":[135],"CA4,":[137],"GRIK1,":[138],"GRIK3":[140],"blood.":[144],"Robustness":[145],"findings":[148,226],"was":[149,168,214],"assessed":[150],"SMR-multi,":[152],"HEIDI,":[153],"colocalization":[155],"analyses.":[156],"After":[157],"multiple-testing":[158],"correction,":[159],"inhibition":[162],"blood":[167],"associated":[169],"decreased":[171],"BE":[172,207],"(OR":[174],"=":[175,179,184,192,209],"0.867,":[176],"95%":[177],"CI":[178],"0.792":[180],"-":[181],"0.950,":[182],"p":[183],"0.002)":[185],"remained":[187],"significant":[188],"SMR-multi":[190],"(p":[191],"0.0049).":[193],"Colocalization":[194],"provided":[195],"moderate":[196],"support":[197],"a":[199],"shared":[200],"variant":[202],"underlying":[203,235],"(PPH4":[208],"0.58).":[210],"No":[211],"robust":[212],"evidence":[213],"identified":[215],"AN":[217],"or":[218],"exploratory":[221],"outcomes.":[223],"Overall,":[224],"our":[225],"warrant":[227],"further":[228],"clinical":[229],"functional":[231],"investigations":[232],"into":[233],"mechanisms":[234],"topiramate-associated":[236],"loss":[241],"their":[243],"relevance":[244],"eating-disorder":[246],"risk.":[247]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}