{"id":"https://openalex.org/W7225573181","doi":"https://doi.org/10.1161/circulationaha.126.084009","title":"Iron Repletion in Heart Failure With Preserved Ejection Fraction: The IRONMET-HFpEF Randomized Trial","display_name":"Iron Repletion in Heart Failure With Preserved Ejection Fraction: The IRONMET-HFpEF Randomized Trial","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225573181","doi":"https://doi.org/10.1161/circulationaha.126.084009","pmid":"https://pubmed.ncbi.nlm.nih.gov/42999950"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.126.084009","doi":"https://doi.org/10.1161/circulationaha.126.084009","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.126.084009","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1161/circulationaha.126.084009","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028473973","display_name":"Gregory D. Lewis","orcid":"https://orcid.org/0000-0001-8108-8240","observed_orcids":["https://orcid.org/0000-0001-8108-8240","https://orcid.org/0000-0002-3673-0182"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Lewis","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0001-8108-8240","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073757407","display_name":"Nora Horick","orcid":"https://orcid.org/0000-0002-4355-5853","observed_orcids":["https://orcid.org/0000-0002-4355-5853"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora K. Horick","raw_affiliation_strings":["Department of Biostatistics, Massachusetts General Hospital, Boston (N.K.H.)"],"raw_orcid":"https://orcid.org/0000-0002-4355-5853","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Massachusetts General Hospital, Boston (N.K.H.)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161055185","display_name":"Fabely Moreno","orcid":"https://orcid.org/0009-0007-7360-0719","observed_orcids":["https://orcid.org/0009-0007-7360-0719"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabely Moreno","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0009-0007-7360-0719","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161113641","display_name":"Kenneth Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Lim","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012595809","display_name":"Diane Cocca-Spofford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Cocca-Spofford","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016609222","display_name":"Takenori Ikoma","orcid":"https://orcid.org/0000-0001-5521-5189","observed_orcids":["https://orcid.org/0000-0001-5521-5189"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takenori Ikoma","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0001-5521-5189","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136689596","display_name":"Paridhi Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paridhi Gupta","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160999007","display_name":"Carly Camphausen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly Camphausen","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057334949","display_name":"Laura Caccamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Caccamo","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058716824","display_name":"Charounipha Soydara","orcid":"https://orcid.org/0009-0004-1949-2460","observed_orcids":["https://orcid.org/0009-0004-1949-2460"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charounipha Soydara","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0009-0004-1949-2460","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057990095","display_name":"Shaina McGinnis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaina McGinnis","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113391638","display_name":"Chloe Newlands","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chloe Newlands","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130792510","display_name":"Skyler Williams","orcid":"https://orcid.org/0009-0000-6248-7844","observed_orcids":["https://orcid.org/0009-0000-6248-7844"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skyler Williams","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0009-0000-6248-7844","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011269030","display_name":"Alexandra Minasian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Minasian","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120228954","display_name":"Nicholas Iskenderian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Iskenderian","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161277338","display_name":"Isabela Landsteiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabela Landsteiner","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056724069","display_name":"Bhavani Iyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavani Iyer","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161299350","display_name":"Justin Joseph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Joseph","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014216258","display_name":"Alvaro Delgado","orcid":"https://orcid.org/0000-0003-0865-2153","observed_orcids":["https://orcid.org/0000-0003-0865-2153"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvaro Delgado","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0003-0865-2153","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118176308","display_name":"Helena Tattersfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helena Tattersfield","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159953285","display_name":"Elizabeth Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Moore","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016749409","display_name":"Veronica Platt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Platt","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383386","display_name":"Sujin Lee","orcid":"https://orcid.org/0000-0002-6692-6880","observed_orcids":["https://orcid.org/0000-0002-6692-6880","https://orcid.org/0000-0003-3345-2073"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujin Lee","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","Vascular Surgery Division (S.L.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0002-6692-6880","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]},{"raw_affiliation_string":"Vascular Surgery Division (S.L.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088991562","display_name":"Rajeev Kumar Malhotra","orcid":"https://orcid.org/0000-0003-0120-4630","observed_orcids":["https://orcid.org/0000-0003-0120-4630"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeev Malhotra","raw_affiliation_strings":["Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0003-0120-4630","affiliations":[{"raw_affiliation_string":"Cardiology Division (G.D.L., F.M., K.L., D.C.-S., T.I., P.G., C.C., L.C., C.S., S.M., C.N., S.W., A.M., N.I., I.L., B.I., J.J., A.D., H.T., E.M., V.P., S.L., R.M.), Mass General Brigham Heart and Vascular Institute, Boston, MA","institution_ids":["https://openalex.org/I48633490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.4311999976634979,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.4311999976634979,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.09350000321865082,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9679999947547913},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.9729999899864197},{"id":"https://openalex.org/keywords/iron-repletion","display_name":"iron repletion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ferric-derisomaltose","display_name":"ferric derisomaltose","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peak-oxygen-uptake","display_name":"peak oxygen uptake","score":0.7900000214576721},{"id":"https://openalex.org/keywords/exercise-capacity","display_name":"exercise capacity","score":0.984000027179718},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.8450000286102295},{"id":"https://openalex.org/keywords/anaerobic-threshold","display_name":"anaerobic threshold","score":0.7590000033378601},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.878000020980835},{"id":"https://openalex.org/keywords/nyha-functional-class","display_name":"NYHA functional class","score":0.7480000257492065},{"id":"https://openalex.org/keywords/kansas-city-cardiomyopathy-questionnaire","display_name":"Kansas City Cardiomyopathy Questionnaire","score":0.9200000166893005},{"id":"https://openalex.org/keywords/iron-status-biomarkers","display_name":"iron status biomarkers","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/transferrin-saturation","display_name":"transferrin saturation","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9063000082969666},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8345000147819519},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7821000218391418},{"id":"https://openalex.org/C153852466","wikidata":"https://www.wikidata.org/wiki/Q907072","display_name":"Transferrin saturation","level":4,"score":0.6499000191688538},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.646399974822998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.60589998960495},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5706999897956848},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.5087000131607056},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.46869999170303345},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4593000113964081},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.4343000054359436},{"id":"https://openalex.org/C2777321227","wikidata":"https://www.wikidata.org/wiki/Q5420062","display_name":"Exercise intolerance","level":3,"score":0.41819998621940613},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.4020000100135803},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.38350000977516174},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3828999996185303},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.36160001158714294},{"id":"https://openalex.org/C196310339","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"VO2 max","level":4,"score":0.3206999897956848},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.25380000472068787}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1161/circulationaha.126.084009","doi":"https://doi.org/10.1161/circulationaha.126.084009","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.126.084009","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:42999950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42999950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.126.084009","doi":"https://doi.org/10.1161/circulationaha.126.084009","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.126.084009","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W162181629","https://openalex.org/W2002946832","https://openalex.org/W2020198029","https://openalex.org/W2028265881","https://openalex.org/W2113829060","https://openalex.org/W2125597090","https://openalex.org/W2139605571","https://openalex.org/W2145965840","https://openalex.org/W2148669301","https://openalex.org/W2414785804","https://openalex.org/W3002868624","https://openalex.org/W3011986409","https://openalex.org/W3115628228","https://openalex.org/W3193598686","https://openalex.org/W4221124850","https://openalex.org/W4308001766","https://openalex.org/W4308249260","https://openalex.org/W4367609068","https://openalex.org/W4386194065","https://openalex.org/W4401895982","https://openalex.org/W4406624157","https://openalex.org/W4411174251","https://openalex.org/W4411216908","https://openalex.org/W4411983984","https://openalex.org/W7133753336","https://openalex.org/W7154473530","https://openalex.org/W7161572166","https://openalex.org/W7204544709","https://openalex.org/W7206161301"],"related_works":["https://openalex.org/W4390756651","https://openalex.org/W2614710189","https://openalex.org/W7161572166","https://openalex.org/W3195066835","https://openalex.org/W2346372518","https://openalex.org/W3188257855","https://openalex.org/W7160881525","https://openalex.org/W2734960411","https://openalex.org/W4403155624","https://openalex.org/W4401895982"],"abstract_inverted_index":{"BACKGROUND:":[0],"Iron":[1,49],"deficiency":[2],"is":[3,17,41],"present":[4],"in":[5,56,73,145,178,236],">50%":[6],"of":[7,47,53,92,158,233,250],"patients":[8,93],"with":[9,12,19,66,76,80,94,97,112,155,239,243],"heart":[10,74,95,237],"failure":[11,75,96,238],"preserved":[13,77,98,240],"ejection":[14,78,99,241],"fraction":[15,79,100,242],"and":[16,23,101,122,171,206],"associated":[18],"reduced":[20],"exercise":[21,29,251],"capacity":[22,30],"survival.":[24],"Whether":[25],"iron":[26,81,102,207,234,244],"repletion":[27,235],"improves":[28,68],"as":[31,105],"objectively":[32],"measured":[33],"by":[34,198],"peak":[35,69,146,167],"oxygen":[36],"uptake":[37],"([Formula:":[38],"see":[39,71,148,169,180],"text])":[40],"unknown.":[42],"The":[43,138],"IRONMET-HFpEF":[44],"trial":[45,91,230],"(Impact":[46],"Intravenous":[48],"Repletion":[50],"on":[51],"Mechanisms":[52],"Exercise":[54],"Intolerance":[55],"HFpEF)":[57],"sought":[58],"to":[59,152,223,231],"determine":[60],"whether":[61],"ferric":[62,126],"derisomaltose":[63,127],"(FDI)":[64],"compared":[65],"placebo":[67,132],"[Formula:":[70,147,168,179],"text]":[72,149,181],"deficiency.":[82],"METHODS:":[83],"This":[84],"was":[85,134,142],"a":[86],"double-blind,":[87],"placebo-controlled":[88],"randomized":[89],"clinical":[90],"deficiency,":[103,245],"defined":[104],"ferritin":[106],"<100":[107],"ng/mL":[108,111],"or":[109,131],"<300":[110],"transferrin":[113],"saturation":[114],"<20%.":[115],"Participants":[116],"were":[117,217],"enrolled":[118],"between":[119],"December":[120],"2021":[121],"April":[123],"2026.":[124],"Single-dose":[125],"(1000":[128],"mg;":[129],"n=44)":[130],"(n=21)":[133],"administered":[135],"once":[136],"intravenously.":[137],"primary":[139],"end":[140,174],"point":[141],"the":[143,183,199,228],"change":[144],"from":[150],"baseline":[151,166],"12":[153,210],"weeks":[154],"an":[156],"analysis":[157],"covariance":[159],"model":[160],"including":[161],"terms":[162],"for":[163,214],"treatment":[164],"group,":[165],"text],":[170],"sex.":[172],"Secondary":[173],"points":[175],"included":[176],"changes":[177],"at":[182,209],"anaerobic":[184],"threshold,":[185],"6-minute":[186],"walk":[187],"test":[188],"distance,":[189],"New":[190],"York":[191],"Heart":[192],"Association":[193],"class,":[194],"health":[195],"status":[196],"assessed":[197],"Kansas":[200],"City":[201],"Cardiomyopathy":[202],"Questionnaire-Overall":[203],"Summary":[204],"Score,":[205],"biomarkers":[208],"weeks.":[211],"RESULTS:":[212],"<0.001":[213],"both).":[215],"There":[216],"no":[218],"serious":[219],"adverse":[220],"events":[221],"related":[222],"FDI":[224,246],"administration.":[225],"CONCLUSIONS:":[226],"In":[227],"largest":[229],"date":[232],"improved":[247],"multiple":[248],"measures":[249],"capacity.":[252],"REGISTRATION:":[253],"URL:":[254],"https://www.clinicaltrials.gov;":[255],"Unique":[256],"identifier:":[257],"NCT04945707.":[258]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}