{"id":"https://openalex.org/W7225567767","doi":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","title":"Regenerative effects of human placenta hydrolysate in an experimental model of accelerated aging","display_name":"Regenerative effects of human placenta hydrolysate in an experimental model of accelerated aging","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225567767","doi":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110"},"language":"en","primary_location":{"id":"doi:10.31146/1682-8658-ecg-247-3-98-110","doi":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","is_oa":true,"landing_page_url":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","pdf_url":"https://www.nogr.org/jour/article/download/3502/2911","source":{"id":"https://openalex.org/S4306540638","display_name":"\u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f","issn_l":"1682-8658","issn":["1682-8658"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nogr.org/jour/article/download/3502/2911","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020896556","display_name":"\u041e. \u0410. \u0413\u0440\u043e\u043c\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-7663-710X","observed_orcids":["https://orcid.org/0000-0002-7663-710X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4405258151","display_name":"Federal Research Center \u201cComputer Science and Control\u201d of the Russian Academy of Sciences","ror":"https://ror.org/006wm7015","country_code":"RU","type":"government","lineage":["https://openalex.org/I4405258151"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. A. Gromova","raw_affiliation_strings":["Federal Research Center \u201cInformatics and Control\u201d of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-7663-710X","affiliations":[{"raw_affiliation_string":"Federal Research Center \u201cInformatics and Control\u201d of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4405258151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075682516","display_name":"Tatiana E. Bogacheva","orcid":"https://orcid.org/0000-0002-5042-4886","observed_orcids":["https://orcid.org/0000-0002-5042-4886"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210126652","display_name":"Ivanovo State Medical Academy","ror":"https://ror.org/032sgfc78","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210126652"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. E. Bogacheva","raw_affiliation_strings":["Ivanovo State Medical University of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-5042-4886","affiliations":[{"raw_affiliation_string":"Ivanovo State Medical University of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210126652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157443882","display_name":"B. I. Belikov","orcid":"https://orcid.org/0009-0002-3538-7324","observed_orcids":["https://orcid.org/0009-0002-3538-7324"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210126652","display_name":"Ivanovo State Medical Academy","ror":"https://ror.org/032sgfc78","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210126652"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"B. I. Belikov","raw_affiliation_strings":["Ivanovo State Medical University of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0009-0002-3538-7324","affiliations":[{"raw_affiliation_string":"Ivanovo State Medical University of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210126652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054154429","display_name":"Vadim I. Demidov","orcid":"https://orcid.org/0000-0002-1064-8201","observed_orcids":["https://orcid.org/0000-0002-1064-8201"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210126652","display_name":"Ivanovo State Medical Academy","ror":"https://ror.org/032sgfc78","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210126652"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. I. Demidov","raw_affiliation_strings":["Ivanovo State Medical University of the Ministry of Health of the Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ivanovo State Medical University of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210126652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161290126","display_name":"A. A. Garanin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4405258151","display_name":"Federal Research Center \u201cComputer Science and Control\u201d of the Russian Academy of Sciences","ror":"https://ror.org/006wm7015","country_code":"RU","type":"government","lineage":["https://openalex.org/I4405258151"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Garanin","raw_affiliation_strings":["Federal Research Center \u201cInformatics and Control\u201d of the Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research Center \u201cInformatics and Control\u201d of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4405258151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080292376","display_name":"Ivan Yu. Torshin","orcid":"https://orcid.org/0000-0002-2659-7998","observed_orcids":["https://orcid.org/0000-0002-2659-7998"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4405258151","display_name":"Federal Research Center \u201cComputer Science and Control\u201d of the Russian Academy of Sciences","ror":"https://ror.org/006wm7015","country_code":"RU","type":"government","lineage":["https://openalex.org/I4405258151"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. Yu. Torshin","raw_affiliation_strings":["Federal Research Center \u201cInformatics and Control\u201d of the Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research Center \u201cInformatics and Control\u201d of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4405258151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037044147","display_name":"\u041a\u0430\u043b\u0430\u0447\u0435\u0432\u0430 \u0410\u043b\u043b\u0430 \u0413\u0435\u043d\u043d\u0430\u0434\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-6144-5781","observed_orcids":["https://orcid.org/0000-0001-6144-5781"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210126652","display_name":"Ivanovo State Medical Academy","ror":"https://ror.org/032sgfc78","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210126652"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. G. Kalacheva","raw_affiliation_strings":["Ivanovo State Medical University of the Ministry of Health of the Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ivanovo State Medical University of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210126652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112253495","display_name":"\u0422. \u0420. \u0413\u0440\u0438\u0448\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0002-1665-1188","observed_orcids":["https://orcid.org/0000-0002-1665-1188"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210126652","display_name":"Ivanovo State Medical Academy","ror":"https://ror.org/032sgfc78","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210126652"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. R. Grishina","raw_affiliation_strings":["Ivanovo State Medical University of the Ministry of Health of the Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ivanovo State Medical University of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210126652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"3","first_page":"98","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laennec","display_name":"Laennec","score":0.8220000267028809},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.5830000042915344},{"id":"https://openalex.org/keywords/d-galactose-induced-aging","display_name":"D-galactose-induced aging","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/lipofuscin","display_name":"lipofuscin","score":0.6119999885559082},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.843999981880188},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8360000252723694},{"id":"https://openalex.org/keywords/regenerative-effect","display_name":"regenerative effect","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.6930999755859375},{"id":"https://openalex.org/C118820876","wikidata":"https://www.wikidata.org/wiki/Q4672283","display_name":"Accelerated aging","level":2,"score":0.5559999942779541},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5482000112533569},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48660001158714294},{"id":"https://openalex.org/C186198217","wikidata":"https://www.wikidata.org/wiki/Q217740","display_name":"Lipofuscin","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4560999870300293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44040000438690186},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.439300000667572},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.4359999895095825},{"id":"https://openalex.org/C3018059006","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Human placenta","level":5,"score":0.4074000120162964},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3589000105857849},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3010999858379364},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.28529998660087585},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26170000433921814},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25839999318122864},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31146/1682-8658-ecg-247-3-98-110","doi":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","is_oa":true,"landing_page_url":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","pdf_url":"https://www.nogr.org/jour/article/download/3502/2911","source":{"id":"https://openalex.org/S4306540638","display_name":"\u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f","issn_l":"1682-8658","issn":["1682-8658"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Gastroenterology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31146/1682-8658-ecg-247-3-98-110","doi":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","is_oa":true,"landing_page_url":"https://doi.org/10.31146/1682-8658-ecg-247-3-98-110","pdf_url":"https://www.nogr.org/jour/article/download/3502/2911","source":{"id":"https://openalex.org/S4306540638","display_name":"\u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f","issn_l":"1682-8658","issn":["1682-8658"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225567767.pdf","grobid_xml":"https://content.openalex.org/works/W7225567767.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2117368376","https://openalex.org/W2143752451","https://openalex.org/W2600478555","https://openalex.org/W3004887173","https://openalex.org/W3096164888","https://openalex.org/W3124878850","https://openalex.org/W4220661592","https://openalex.org/W4224246466","https://openalex.org/W4295800732","https://openalex.org/W4391142716","https://openalex.org/W4391408431","https://openalex.org/W4392850892","https://openalex.org/W4401856617","https://openalex.org/W4407722221"],"related_works":["https://openalex.org/W2086798604","https://openalex.org/W4303615086","https://openalex.org/W2154099774","https://openalex.org/W3009784199","https://openalex.org/W2931480986","https://openalex.org/W7215112831","https://openalex.org/W3166483532","https://openalex.org/W7134199340","https://openalex.org/W4400282276","https://openalex.org/W4408844602"],"abstract_inverted_index":{"Standardized":[0],"human":[1],"placental":[2],"hydrolysates":[3],"(SHPs)":[4],"contain":[5],"peptides":[6,158],"exhibiting":[7],"regenerative,":[8],"hepatoprotective,":[9],"and":[10,48,61,82,92,138,147],"geroprotective":[11],"properties.":[12],"The":[13],"effects":[14],"of":[15,27,57,67,88,110,116,125,177,184],"SHP":[16],"\u201cLaennec\u201d":[17],"(Japan":[18],"Bioproducts,":[19],"Japan)":[20],"were":[21,169],"studied":[22],"in":[23,34,40,45,54,113,141,153,173,189],"a":[24,55,182],"rat":[25],"model":[26,52,74],"accelerated":[28,65,72,191],"aging":[29,73,192],"(n=30)":[30],"induced":[31],"by":[32],"D-galactose":[33],"combination":[35],"with":[36,181,186],"palm":[37],"oil,":[38],"L-methionine":[39],"the":[41,108,114,117,121,142,154,174],"diet,":[42],"sodium":[43],"chloride":[44],"drinking":[46],"water,":[47],"ferrous":[49],"sulfate.":[50],"This":[51,71],"resulted":[53,112],"complex":[56],"neurological,":[58],"somatic,":[59],"biochemical,":[60],"histological":[62],"abnormalities":[63],"indicating":[64],"development":[66],"multiple":[68],"organ":[69],"pathology.":[70],"negatively":[75],"impacts":[76],"hematopoiesis":[77],"(impaired":[78],"red":[79],"blood":[80,90],"cell":[81],"platelet":[83],"size":[84],"distribution,":[85],"abnormal":[86],"levels":[87],"other":[89],"cells)":[91],"increases":[93],"chronic":[94],"systemic":[95],"inflammation":[96],"(ESR,":[97],"leukocyte":[98],"levels,":[99],"including":[100],"neutrophils,":[101],"lymphocytes,":[102],"monocytes,":[103],"etc.).":[104],"For":[105],"most":[106],"parameters,":[107],"use":[109],"Laennec":[111,132,156,187],"return":[115],"corresponding":[118],"values":[119],"to":[120],"normal":[122],"ranges":[123],"characteristic":[124],"intact":[126],"animals.":[127],"Histological":[128],"analysis":[129],"showed":[130],"that":[131,159],"HPG":[133,157,188],"helped":[134],"eliminate":[135],"fatty":[136],"degeneration":[137],"iron":[139],"overload":[140],"liver,":[143],"kidneys,":[144],"brain,":[145],"myocardium,":[146],"skin,":[148],"also":[149],"reducing":[150],"lipofuscin":[151],"deposits":[152],"tissues.":[155],"may":[160],"promote":[161],"geroprotection":[162],"(JBP485,":[163],"HVLEFAL,":[164],"SENALVA,":[165],"YGGFM,":[166],"ELLQTG,":[167],"etc.)":[168],"identified.":[170],"An":[171],"improvement":[172],"clinical":[175],"condition":[176],"animals":[178],"was":[179],"observed":[180],"course":[183],"treatment":[185],"an":[190],"model.":[193]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}