{"id":"https://openalex.org/W7225566874","doi":"https://doi.org/10.22159/ijap.2026v18i6.59072","title":"Oral Biosurfactant-Stabilized, ROS-Responsive Nanocarriers Demonstrate Targeted Anti-Arthritic Efficacy and Cytokine Modulation in Collagen-Induced Arthritis Models","display_name":"Oral Biosurfactant-Stabilized, ROS-Responsive Nanocarriers Demonstrate Targeted Anti-Arthritic Efficacy and Cytokine Modulation in Collagen-Induced Arthritis Models","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225566874","doi":"https://doi.org/10.22159/ijap.2026v18i6.59072"},"language":"en","primary_location":{"id":"doi:10.22159/ijap.2026v18i6.59072","doi":"https://doi.org/10.22159/ijap.2026v18i6.59072","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2026v18i6.59072","pdf_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/59072/34577","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/59072/34577","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125230390","display_name":"T. PRADEEPA","orcid":"https://orcid.org/0009-0005-3840-6158","observed_orcids":["https://orcid.org/0009-0005-3840-6158"]},"institutions":[{"id":"https://openalex.org/I860813019","display_name":"Bharath University","ror":"https://ror.org/04yazpn06","country_code":"IN","type":"education","lineage":["https://openalex.org/I860813019"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"PRADEEPA T.","raw_affiliation_strings":["Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, Tamil Nadu, India"],"raw_orcid":"https://orcid.org/0009-0005-3840-6158","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, Tamil Nadu, India","institution_ids":["https://openalex.org/I860813019"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006919661","display_name":"Rajaganapathy Kaliyaperumal","orcid":"https://orcid.org/0000-0001-7788-4623","observed_orcids":["https://orcid.org/0000-0001-7788-4623"]},"institutions":[{"id":"https://openalex.org/I860813019","display_name":"Bharath University","ror":"https://ror.org/04yazpn06","country_code":"IN","type":"education","lineage":["https://openalex.org/I860813019"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"RAJAGANAPATHY KALIYAPERUMAL","raw_affiliation_strings":["Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, Tamil Nadu, India"],"raw_orcid":"https://orcid.org/0000-0001-7788-4623","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, Tamil Nadu, India","institution_ids":["https://openalex.org/I860813019"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I860813019"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"365","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.2287999987602234,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":0.9679999947547913},{"id":"https://openalex.org/keywords/reactive-oxygen-species-responsive-release","display_name":"reactive oxygen species-responsive release","score":0.7680000066757202},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.9049999713897705},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8600000143051147},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytokine-modulation","display_name":"cytokine modulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/mucus-penetration","display_name":"mucus penetration","score":0.6579999923706055},{"id":"https://openalex.org/keywords/caco-2-permeability","display_name":"Caco-2 permeability","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.8199999928474426},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.683899998664856},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6126000285148621},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5922999978065491},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5863000154495239},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5679000020027161},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5392000079154968},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4912000000476837},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.48809999227523804},{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.4796999990940094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4399000108242035},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4284999966621399},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4212999939918518},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.34779998660087585},{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.32170000672340393},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C2776167589","wikidata":"https://www.wikidata.org/wiki/Q10354103","display_name":"Probucol","level":3,"score":0.31209999322891235},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.26420000195503235},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22159/ijap.2026v18i6.59072","doi":"https://doi.org/10.22159/ijap.2026v18i6.59072","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2026v18i6.59072","pdf_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/59072/34577","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22159/ijap.2026v18i6.59072","doi":"https://doi.org/10.22159/ijap.2026v18i6.59072","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2026v18i6.59072","pdf_url":"https://journals.innovareacademics.in/index.php/ijap/article/download/59072/34577","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320331604","display_name":"Bharath Institute of Higher Education and Research","ror":"https://ror.org/04yazpn06"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225566874.pdf","grobid_xml":"https://content.openalex.org/works/W7225566874.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2623617647","https://openalex.org/W2993958552","https://openalex.org/W2998115905","https://openalex.org/W2999034797","https://openalex.org/W3004450518","https://openalex.org/W3021323304","https://openalex.org/W3027465441","https://openalex.org/W3038019749","https://openalex.org/W3046068155","https://openalex.org/W3074216478","https://openalex.org/W3084416421","https://openalex.org/W3086213972","https://openalex.org/W3092199218","https://openalex.org/W3102983191","https://openalex.org/W3117518012","https://openalex.org/W3137336075","https://openalex.org/W3154370106","https://openalex.org/W3162717528","https://openalex.org/W3176273582","https://openalex.org/W3185376334","https://openalex.org/W3202037473","https://openalex.org/W4200073297","https://openalex.org/W4200212020","https://openalex.org/W4206997324","https://openalex.org/W4211111012","https://openalex.org/W4398762717","https://openalex.org/W7118162790","https://openalex.org/W7127933807","https://openalex.org/W7140090634","https://openalex.org/W7141255759","https://openalex.org/W7162305643"],"related_works":["https://openalex.org/W7127933807","https://openalex.org/W7123339941","https://openalex.org/W2888348642","https://openalex.org/W1956074928","https://openalex.org/W2612533609","https://openalex.org/W2949156773","https://openalex.org/W7211934600","https://openalex.org/W2904819041","https://openalex.org/W2229779148","https://openalex.org/W4407055419"],"abstract_inverted_index":{"Objective:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,52,114],"develop":[5],"and":[6,28,60,74,94,104,129,141,156,163,178,186],"evaluate":[7],"sophorolipid-stabilized,":[8],"thioketal-gated":[9,168],"nanostructured":[10],"lipid":[11],"carriers":[12],"(SL-NLCs)":[13],"for":[14,190],"oral":[15,122,172],"delivery":[16],"of":[17,124,150],"celecoxib":[18,125],"with":[19,67,148],"reactive":[20],"oxygen":[21],"species":[22],"(ROS)-responsive":[23],"drug":[24,97,176],"release,":[25,177],"improved":[26,121],"bioavailability,":[27,173],"joint-targeted":[29],"therapeutic":[30,77],"efficacy":[31],"in":[32,68,75,79,133,138],"collagen-induced":[33],"arthritis":[34,192],"(CIA)":[35],"models.":[36],"Methods:":[37],"SL-NLCs":[38,85],"were":[39,64,111,145,159],"formulated":[40],"using":[41],"a":[42,48,184],"microfluidic":[43],"ethanol":[44],"injection":[45],"method":[46],"incorporating":[47],"thioketal":[49],"(TK-PEG-Chol)":[50],"linker":[51],"achieve":[53],"ROS":[54],"sensitivity.":[55],"Physicochemical":[56],"characterization,":[57],"mucus":[58],"penetration,":[59],"Caco-2":[61],"transport":[62],"studies":[63],"performed,":[65],"along":[66,147],"vitro":[69],"anti-inflammatory":[70],"evaluation,":[71],"pharmacokinetic":[72],"analysis,":[73],"vivo":[76],"assessment":[78],"CIA":[80],"rats.":[81],"Results:":[82],"The":[83,118],"optimized":[84],"exhibited":[86],"uniform":[87],"spherical":[88],"morphology,":[89],"high":[90],"encapsulation":[91],"efficiency":[92],"(>91%),":[93],"ROS-triggered":[95],"accelerated":[96],"release.":[98],"Enhanced":[99],"mucosal":[100],"diffusivity":[101],"(0.85":[102],"\u00b5m\u00b2/s)":[103],"approximately":[105,127],"5.2-fold":[106],"higher":[107],"epithelial":[108],"permeability":[109],"(Papp)":[110],"observed":[112],"compared":[113],"the":[115],"free":[116],"drug.":[117],"SL-NLC(TK)":[119],"formulation":[120],"bioavailability":[123],"by":[126],"3.5-fold":[128],"demonstrated":[130],"preferential":[131],"accumulation":[132],"synovial":[134],"tissue.":[135],"Significant":[136],"reductions":[137],"TNF-\u03b1,":[139],"IL-6,":[140],"oxidative":[142],"stress":[143],"markers":[144],"observed,":[146],"restoration":[149],"antioxidant":[151],"enzyme":[152],"levels.":[153],"Joint":[154],"protection":[155],"tissue":[157],"recovery":[158],"confirmed":[160],"through":[161],"micro-CT":[162],"histological":[164],"analysis.":[165],"Conclusion:":[166],"Sophorolipid-stabilized,":[167],"nanocarriers":[169],"significantly":[170],"enhance":[171],"enable":[174],"ROS-responsive":[175],"provide":[179],"targeted":[180],"anti-arthritic":[181],"effects,":[182],"demonstrating":[183],"sustainable":[185],"translational":[187],"nanomedicine":[188],"platform":[189],"rheumatoid":[191],"therapy.":[193]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}
