{"id":"https://openalex.org/W7225565397","doi":"https://doi.org/10.5281/zenodo.24053241","title":"IN VITRO AND IN VIVO EVALUATION OF ANTI-ASTHMATIC ACTIVITY OF EUGENIA JAMBOLANA BARK","display_name":"IN VITRO AND IN VIVO EVALUATION OF ANTI-ASTHMATIC ACTIVITY OF EUGENIA JAMBOLANA BARK","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225565397","doi":"https://doi.org/10.5281/zenodo.24053241"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24053241","doi":"https://doi.org/10.5281/zenodo.24053241","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24053241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161298621","display_name":"Chichula Gouthami*, Dr. Neelam I, Dr. Nagaraj.M Kulkarni, G Vijaya Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chichula Gouthami*, Dr. Neelam I, Dr. Nagaraj.M Kulkarni, G Vijaya Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161298621"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syzygium-cumini","display_name":"Syzygium cumini","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-asthmatic-activity","display_name":"antiasthmatic activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7940000295639038},{"id":"https://openalex.org/keywords/bronchoconstriction","display_name":"bronchoconstriction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/acetylcholine-induced-contraction","display_name":"acetylcholine-induced contraction","score":0.9070000052452087},{"id":"https://openalex.org/keywords/histamine-induced-contraction","display_name":"histamine-induced contraction","score":0.8859999775886536},{"id":"https://openalex.org/keywords/guinea-pig-ileum","display_name":"guinea pig ileum","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.8069999814033508},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.9549999833106995},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/airway-smooth-muscle","display_name":"airway smooth muscle","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.8769999742507935},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.8248000144958496},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7573000192642212},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.710099995136261},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5491999983787537},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5378999710083008},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.41339999437332153},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.41290000081062317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41019999980926514},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3682999908924103},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32170000672340393},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C2777423695","wikidata":"https://www.wikidata.org/wiki/Q156563","display_name":"Myrtaceae","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.271699994802475},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.2515000104904175}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24053241","doi":"https://doi.org/10.5281/zenodo.24053241","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.24053242","doi":"https://doi.org/10.5281/zenodo.24053242","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24053241","doi":"https://doi.org/10.5281/zenodo.24053241","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24053241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405084710","https://openalex.org/W1991034834","https://openalex.org/W1966317290","https://openalex.org/W3013284355","https://openalex.org/W2791151681","https://openalex.org/W1778086490","https://openalex.org/W2188686108","https://openalex.org/W4291220461","https://openalex.org/W2948753977","https://openalex.org/W1984610666"],"abstract_inverted_index":{"Asthma":[0],"is":[1],"a":[2],"chronic":[3],"respiratory":[4],"disorder":[5],"associated":[6,159],"with":[7,107,160],"airway":[8],"hyperresponsiveness,":[9],"bronchoconstriction":[10],"and":[11,27,43,54,67,75,93,140,173,183],"inflammatory":[12],"changes":[13],"in":[14,25,28,119,165,170,191],"the":[15,24,65,83,97,120,131,161,166,180],"airways.":[16],"The":[17,37,61,134,155],"present":[18,164],"study":[19,121],"was":[20,39],"undertaken":[21],"to":[22,46,178],"evaluate":[23],"vitro":[26],"vivo":[29,171],"anti-asthmatic":[30,153],"activity":[31,156],"of":[32,50,57,64,85,186],"Eugenia":[33,51,58,146,187,194],"jambolana":[34,52,59,147,188],"bark":[35,38,148,189],"extracts.":[36,167],"extracted":[40],"using":[41],"aqueous":[42,48,66],"alcoholic":[44,68],"solvents":[45],"obtain":[47],"extract":[49,56],"(AQEEJ)":[53],"methanolic":[55],"(MEEJ).":[60],"percentage":[62],"yields":[63],"extracts":[69,103,149,190],"were":[70],"reported":[71,118],"as":[72],"20.48%":[73],"w/w":[74],"11.45%":[76],"w/w,":[77],"respectively.":[78],"Preliminary":[79],"phytochemical":[80],"screening":[81],"revealed":[82],"presence":[84],"alkaloids,":[86],"flavonoids,":[87],"saponins,":[88],"tannins,":[89],"steroids/terpenoids,":[90],"carbohydrates,":[91],"resins":[92],"other":[94],"phytoconstituents.":[95],"In":[96],"guinea":[98],"pig":[99,203],"ileum":[100],"preparation,":[101],"both":[102],"inhibited":[104],"acetylcholine-induced":[105,141],"contraction,":[106],"AQEEJ":[108],"producing":[109],"comparatively":[110],"greater":[111],"inhibition":[112],"than":[113],"MEEJ.The":[114],"acute":[115],"toxicity":[116],"observations":[117],"showed":[122],"no":[123],"significant":[124],"behavioural":[125],"or":[126],"morphological":[127],"toxic":[128],"manifestations":[129],"at":[130],"investigated":[132],"doses.":[133],"observed":[135],"inhibitory":[136],"effects":[137],"against":[138],"histamine-":[139],"smooth-muscle":[142],"responses":[143],"indicate":[144],"that":[145],"possess":[150],"promising":[151],"preliminary":[152],"activity.":[154],"may":[157],"be":[158],"bioactive":[162],"phytoconstituents":[163],"Further":[168],"well-controlled":[169],"studies":[172],"mechanistic":[174],"investigations":[175],"are":[176],"required":[177],"establish":[179],"efficacy,":[181],"safety":[182],"therapeutic":[184],"potential":[185],"asthma.":[192],"Keywords:":[193],"jambolana;":[195],"Bark":[196],"extract;":[197],"Anti-asthmatic":[198],"activity;":[199],"Histamine;":[200],"Acetylcholine;":[201],"Guinea":[202],"ileum;":[204],"Bronchoconstriction;":[205],"Phytochemical":[206],"screening.":[207]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-09T00:00:00"}