{"id":"https://openalex.org/W7225560562","doi":"https://doi.org/10.1038/s41392-026-03088-3","title":"Mutant KRAS vaccination for pancreatic cancer interception: the G12D immunogenicity paradox","display_name":"Mutant KRAS vaccination for pancreatic cancer interception: the G12D immunogenicity paradox","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225560562","doi":"https://doi.org/10.1038/s41392-026-03088-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/43000508"},"language":"en","primary_location":{"id":"doi:10.1038/s41392-026-03088-3","doi":"https://doi.org/10.1038/s41392-026-03088-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-026-03088-3","pdf_url":"https://www.nature.com/articles/s41392-026-03088-3.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41392-026-03088-3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018937134","display_name":"Morten Orebo Holmstr\u00f6m","orcid":"https://orcid.org/0000-0002-3764-8578","observed_orcids":["https://orcid.org/0000-0002-3764-8578"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten Orebo Holmstr\u00f6m","raw_affiliation_strings":["Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark","Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-3764-8578","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010300392","display_name":"Mie Linder H\u00fcbbe","orcid":"https://orcid.org/0000-0002-0202-5784","observed_orcids":["https://orcid.org/0000-0002-0202-5784"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mie Linder H\u00fcbbe","raw_affiliation_strings":["Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071985590","display_name":"Inna  Markovna Chen","orcid":"https://orcid.org/0000-0003-2891-0762","observed_orcids":["https://orcid.org/0000-0003-2891-0762"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Inna Markovna Chen","raw_affiliation_strings":["Department of Oncology, Copenhagen University Hospital, Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2891-0762","affiliations":[{"raw_affiliation_string":"Department of Oncology, Copenhagen University Hospital, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026885591","display_name":"Mads Hald Andersen","orcid":"https://orcid.org/0000-0002-2914-9605","observed_orcids":["https://orcid.org/0000-0002-2914-9605"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Mads Hald Andersen","raw_affiliation_strings":["Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. mads.hald.andersen@regionh.dk","Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev, Denmark. mads.hald.andersen@regionh.dk"],"raw_orcid":"https://orcid.org/0000-0002-2914-9605","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. mads.hald.andersen@regionh.dk","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev, Denmark. mads.hald.andersen@regionh.dk","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026885591"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564","https://openalex.org/I2802567020"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cancer-immunoprevention","display_name":"cancer immunoprevention","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.5770000219345093},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.833299994468689},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.794700026512146},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.6697999835014343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6420000195503235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5493999719619751},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5370000004768372},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4383000135421753},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41830000281333923},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41429999470710754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3797000050544739},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3278000056743622},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.3046000003814697},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2750999927520752},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2522999942302704},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.2522999942302704},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41392-026-03088-3","doi":"https://doi.org/10.1038/s41392-026-03088-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-026-03088-3","pdf_url":"https://www.nature.com/articles/s41392-026-03088-3.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},{"id":"pmid:43000508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43000508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal transduction and targeted therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41392-026-03088-3","doi":"https://doi.org/10.1038/s41392-026-03088-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-026-03088-3","pdf_url":"https://www.nature.com/articles/s41392-026-03088-3.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313796","display_name":"Innovationsfonden","ror":"https://ror.org/00daj4111"},{"id":"https://openalex.org/F4320321590","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862"},{"id":"https://openalex.org/F4320321957","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225560562.pdf","grobid_xml":"https://content.openalex.org/works/W7225560562.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W4406034704","https://openalex.org/W7140896737","https://openalex.org/W7155058091","https://openalex.org/W7163002264","https://openalex.org/W7168696673"],"related_works":["https://openalex.org/W4233805752","https://openalex.org/W7125691770","https://openalex.org/W7203823143","https://openalex.org/W7128509330","https://openalex.org/W4310477927","https://openalex.org/W4409586974","https://openalex.org/W3206083669","https://openalex.org/W2092815945","https://openalex.org/W4309191431","https://openalex.org/W4315490698"],"abstract_inverted_index":{"In":[0],"a":[1,17,52],"recent":[2],"study":[3],"published":[4],"in":[5,29,48],"Cancer":[6],"Discovery":[7],",":[8],"Haldar":[9],"and":[10,42],"colleagues":[11],"report":[12],"the":[13],"first-in-human":[14],"evaluation":[15],"of":[16,34,54],"pooled":[18],"mutant":[19,44],"(Kirsten":[20],"rat":[21],"sarcoma":[22],"viral":[23],"oncogene":[24],"homolog)":[25],"KRAS":[26],"peptide":[27],"vaccine":[28],"individuals":[30],"at":[31],"high":[32],"risk":[33],"pancreatic":[35,63],"ductal":[36],"adenocarcinoma":[37],"(PDAC).":[38],"Vaccination":[39],"induced":[40],"broad":[41],"durable":[43],"KRAS-specific":[45],"T-cell":[46],"responses":[47],"most":[49],"participants,":[50],"providing":[51],"proof":[53],"concept":[55],"for":[56],"targeting":[57],"oncogenic":[58],"driver":[59],"mutations":[60],"before":[61],"invasive":[62],"cancer":[64],"develops.":[65],"1":[66]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-09T00:00:00"}