{"id":"https://openalex.org/W7225468482","doi":"https://doi.org/10.1038/s41420-026-03449-5","title":"Microbial genetic variation drives host social traits via agmatine and NO-mediated cGMP-PKG pathways","display_name":"Microbial genetic variation drives host social traits via agmatine and NO-mediated cGMP-PKG pathways","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225468482","doi":"https://doi.org/10.1038/s41420-026-03449-5"},"language":"en","primary_location":{"id":"doi:10.1038/s41420-026-03449-5","doi":"https://doi.org/10.1038/s41420-026-03449-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-026-03449-5","pdf_url":"https://www.nature.com/articles/s41420-026-03449-5_reference.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41420-026-03449-5_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100414252","display_name":"Ying Li","orcid":"https://orcid.org/0000-0002-5372-1974","observed_orcids":["https://orcid.org/0000-0002-5372-1974"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Medical Technology College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology College, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108661462","display_name":"Tao Wang","orcid":"https://orcid.org/0009-0009-8230-5249","observed_orcids":["https://orcid.org/0009-0009-8230-5249"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139377630","display_name":"Ruijie Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruijie Bai","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161235556","display_name":"Simin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Simin Xu","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122987221","display_name":"Jingxuan Zhang","orcid":"https://orcid.org/0009-0005-4235-7459","observed_orcids":["https://orcid.org/0009-0005-4235-7459"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxuan Zhang","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161219226","display_name":"Yao Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Zhu","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079561501","display_name":"Dianshuang Zhou","orcid":"https://orcid.org/0000-0002-9205-4641","observed_orcids":["https://orcid.org/0000-0002-9205-4641"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dianshuang Zhou","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108678589","display_name":"Xinrong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinrong Zhang","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135572413","display_name":"Tao Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhu","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161244454","display_name":"Peng Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Shi","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050095618","display_name":"Rongrong Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongrong Gu","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139342531","display_name":"Yawei Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yawei Cai","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161204795","display_name":"Juntao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juntao Chen","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Xuzhou First Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161215185","display_name":"Xiangming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangming Wang","raw_affiliation_strings":["Department of Cell Biology, School of Basic Medical Sciences, Laboratory for Clinical Medicine, Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Basic Medical Sciences, Laboratory for Clinical Medicine, Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015011842","display_name":"Zuobin Zhu","orcid":"https://orcid.org/0000-0003-1022-5943","observed_orcids":["https://orcid.org/0000-0003-1022-5943"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zuobin Zhu","raw_affiliation_strings":["Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-1022-5943","affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015011842"],"corresponding_institution_ids":["https://openalex.org/I177388780"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9940000176429749},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.8450000286102295},{"id":"https://openalex.org/keywords/aggregation","display_name":"aggregation","score":0.4300000071525574},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.859000027179718},{"id":"https://openalex.org/keywords/agmatine","display_name":"agmatine","score":0.7730000019073486},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cgmp-pkg-signaling-pathway","display_name":"cGMP-PKG signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/speb","display_name":"SpeB","score":0.777999997138977},{"id":"https://openalex.org/keywords/narg","display_name":"narG","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9210000038146973},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.8930000066757202},{"id":"https://openalex.org/keywords/microbiota-gut-brain-axis","display_name":"microbiota-gut-brain axis","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8169000148773193},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7121000289916992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5913000106811523},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5360999703407288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5322999954223633},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.4878000020980835},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.46549999713897705},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45260000228881836},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4343999922275543},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.4081999957561493},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.3328999876976013},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C2781448169","wikidata":"https://www.wikidata.org/wiki/Q394317","display_name":"Agmatine","level":4,"score":0.3160000145435333},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3125999867916107},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.30649998784065247},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C21204594","wikidata":"https://www.wikidata.org/wiki/Q921513","display_name":"Social behavior","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41420-026-03449-5","doi":"https://doi.org/10.1038/s41420-026-03449-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-026-03449-5","pdf_url":"https://www.nature.com/articles/s41420-026-03449-5_reference.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41420-026-03449-5","doi":"https://doi.org/10.1038/s41420-026-03449-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-026-03449-5","pdf_url":"https://www.nature.com/articles/s41420-026-03449-5_reference.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7502563222","display_name":null,"funder_award_id":"BK20241953","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G8017782072","display_name":null,"funder_award_id":"82572594","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225468482.pdf","grobid_xml":"https://content.openalex.org/works/W7225468482.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412643970","https://openalex.org/W4409435808","https://openalex.org/W3048675463","https://openalex.org/W2782570775","https://openalex.org/W3176205589","https://openalex.org/W1498830788","https://openalex.org/W3014849405","https://openalex.org/W2625708948","https://openalex.org/W2792824696","https://openalex.org/W6903817849"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"gut":[2,25,135],"microbiota":[3,26],"plays":[4],"a":[5,48],"vital":[6],"role":[7],"in":[8,93],"regulating":[9,72],"host":[10,29],"physiology":[11],"and":[12,33,65,81,103,124],"behavior":[13],"through":[14],"its":[15],"influence":[16],"on":[17],"the":[18,31,79,118,129],"microbiota-gut-brain":[19],"axis.":[20],"Despite":[21],"extensive":[22],"research":[23],"linking":[24],"diversity":[27],"to":[28],"behaviors,":[30],"genetic":[32],"molecular":[34,119],"mechanisms":[35],"underlying":[36],"microbial":[37],"regulation":[38,130],"of":[39,60,83,117,121,131],"social":[40,58,132],"behaviors":[41,59,133],"remain":[42],"poorly":[43],"understood.":[44],"In":[45],"this":[46,98],"study,":[47],"screening":[49],"for":[50],"E.":[51,69,88],"coli":[52,70,89],"single-gene":[53],"knockout":[54],"mutants":[55],"that":[56,101],"increased":[57,78],"C.":[61,73,94,106],"elegans":[62,74,95,107],"identified":[63],"speB":[64,76],"narG":[66,86],"as":[67],"key":[68],"genes":[71],"aggregation.":[75],"mutant":[77,87],"production":[80],"secretion":[82],"agmatine,":[84],"while":[85],"reduced":[90],"NO":[91,104],"levels":[92],".":[96],"Mechanistically,":[97],"study":[99],"found":[100],"agmatine":[102],"regulated":[105],"aggregation":[108],"via":[109],"cGMP-PKG":[110],"pathway.":[111],"These":[112],"findings":[113],"deepen":[114],"our":[115],"understanding":[116],"basis":[120],"host-microbe":[122],"interactions":[123],"provide":[125],"new":[126],"insights":[127],"into":[128],"by":[134],"microbiota.":[136]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-08T00:00:00"}
