{"id":"https://openalex.org/W7225468280","doi":"https://doi.org/10.1038/s41598-026-79356-7","title":"Clinical and imaging characteristics of difficult-to-treat patients with rheumatoid arthritis and peripheral psoriatic arthritis with ultrasound-confirmed inflammation","display_name":"Clinical and imaging characteristics of difficult-to-treat patients with rheumatoid arthritis and peripheral psoriatic arthritis with ultrasound-confirmed inflammation","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225468280","doi":"https://doi.org/10.1038/s41598-026-79356-7"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-79356-7","doi":"https://doi.org/10.1038/s41598-026-79356-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79356-7","pdf_url":"https://www.nature.com/articles/s41598-026-79356-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-79356-7_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093643564","display_name":"Oriana Oma\u00f1a-Iglesias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Oriana Oma\u00f1a-Iglesias","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118390292","display_name":"Georgina Novell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Georgina Novell","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049822392","display_name":"A. Azuaga","orcid":"https://orcid.org/0000-0002-8058-5154","observed_orcids":["https://orcid.org/0000-0002-8058-5154"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Bel\u00e9n Azuaga","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089728477","display_name":"Beatriz Frade\u2010Sosa","orcid":"https://orcid.org/0000-0002-5867-8434","observed_orcids":["https://orcid.org/0000-0002-5867-8434"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Frade-Sosa","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056224396","display_name":"Juan Camilo Sarmiento-Monroy","orcid":"https://orcid.org/0000-0002-8426-7268","observed_orcids":["https://orcid.org/0000-0002-8426-7268"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Camilo Sarmiento-Monroy","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046043759","display_name":"Andrea Mireya Cuervo","orcid":"https://orcid.org/0000-0002-2730-3525","observed_orcids":["https://orcid.org/0000-0002-2730-3525"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andrea Cuervo","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028232743","display_name":"Andr\u00e9s Ponce","orcid":"https://orcid.org/0000-0003-3068-5752","observed_orcids":["https://orcid.org/0000-0003-3068-5752"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andr\u00e9s Ponce","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058590711","display_name":"Patricia Corzo","orcid":"https://orcid.org/0000-0002-0970-0631","observed_orcids":["https://orcid.org/0000-0002-0970-0631"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Corzo","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161194242","display_name":"Sandra Farietta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra Farietta","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031598739","display_name":"Virginia Ru\u00edz-Esquide","orcid":"https://orcid.org/0000-0002-2657-6601","observed_orcids":["https://orcid.org/0000-0002-2657-6601"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I4403928279","display_name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","ror":"https://ror.org/041gvmd67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Virginia Ruiz-Esquide","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain","institution_ids":["https://openalex.org/I4210160192","https://openalex.org/I4403928279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008861132","display_name":"Jos\u00e9 Alfredo G\u00f3mez-Puerta","orcid":"https://orcid.org/0000-0001-8177-702X","observed_orcids":["https://orcid.org/0000-0001-8177-702X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I4403928279","display_name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","ror":"https://ror.org/041gvmd67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. G\u00f3mez-Puerta","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain","institution_ids":["https://openalex.org/I4210160192","https://openalex.org/I4403928279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005788294","display_name":"Juan de Dios Ca\u00f1ete","orcid":"https://orcid.org/0000-0003-2606-0573","observed_orcids":["https://orcid.org/0000-0003-2606-0573","https://orcid.org/0000-0001-7932-2632"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I4403928279","display_name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","ror":"https://ror.org/041gvmd67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan D. Ca\u00f1ete","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain","institution_ids":["https://openalex.org/I4210160192","https://openalex.org/I4403928279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016122411","display_name":"Julio Ram\u00edrez","orcid":"https://orcid.org/0000-0002-7047-8056","observed_orcids":["https://orcid.org/0000-0002-7047-8056"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I4403928279","display_name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","ror":"https://ror.org/041gvmd67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Julio Ram\u00edrez","raw_affiliation_strings":["Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7047-8056","affiliations":[{"raw_affiliation_string":"Arthritis Unit, Rheumatology Department, Hospital Clinic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, (IDIBAPS), 170 Villarroel street, Barcelona, 08036, Spain","institution_ids":["https://openalex.org/I4210160192","https://openalex.org/I4403928279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016122411"],"corresponding_institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4403928279"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/peripheral-psoriatic-arthritis","display_name":"peripheral psoriatic arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/difficult-to-treat-diseases","display_name":"difficult-to-treat diseases","score":0.8360000252723694},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.7689999938011169},{"id":"https://openalex.org/keywords/erosive-disease","display_name":"erosive disease","score":0.5860000252723694},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.781000018119812},{"id":"https://openalex.org/keywords/cardiovascular-comorbidity","display_name":"cardiovascular comorbidity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nail-involvement","display_name":"nail involvement","score":0.8259999752044678},{"id":"https://openalex.org/keywords/csdmards","display_name":"csDMARDs","score":0.4970000088214874},{"id":"https://openalex.org/keywords/biologic-and-targeted-synthetic-dmards","display_name":"biologic and targeted synthetic DMARDs","score":0.7570000290870667},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.5329999923706055},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.3659999966621399},{"id":"https://openalex.org/keywords/structural-damage","display_name":"structural damage","score":0.47699999809265137},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.963100016117096},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7811999917030334},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.7368000149726868},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6668999791145325},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5974000096321106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5367000102996826},{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.5256999731063843},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4586000144481659},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4440999925136566},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4438999891281128},{"id":"https://openalex.org/C2776821229","wikidata":"https://www.wikidata.org/wiki/Q16965166","display_name":"Inflammatory arthritis","level":3,"score":0.38940000534057617},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36309999227523804},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3529999852180481},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.33340001106262207},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.289000004529953},{"id":"https://openalex.org/C2909063479","wikidata":"https://www.wikidata.org/wiki/Q810254","display_name":"Antirheumatic Agents","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-79356-7","doi":"https://doi.org/10.1038/s41598-026-79356-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79356-7","pdf_url":"https://www.nature.com/articles/s41598-026-79356-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-79356-7","doi":"https://doi.org/10.1038/s41598-026-79356-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79356-7","pdf_url":"https://www.nature.com/articles/s41598-026-79356-7_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225468280.pdf","grobid_xml":"https://content.openalex.org/works/W7225468280.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414438255","https://openalex.org/W4379649307","https://openalex.org/W4387369085","https://openalex.org/W4412708029","https://openalex.org/W4411428526","https://openalex.org/W4411410783","https://openalex.org/W4411428232","https://openalex.org/W4391937291","https://openalex.org/W7143434008","https://openalex.org/W4403638178"],"abstract_inverted_index":{"To":[0,6],"evaluate":[1],"the":[2,144,149,154],"proportion":[3],"of":[4,18,87,111,136],"Difficult":[5],"Treat":[7],"(D2T)":[8],"disease":[9,59,160,174,194,217,250,264,271,297,305,328],"according":[10,62],"to":[11,32,63,76,96,123],"three":[12,64],"operational":[13,67],"definitions":[14],"in":[15,164,221,254],"a":[16,90,109,117,299],"population":[17],"Rheumatoid":[19],"Arthritis":[20,25],"(RA)":[21],"and":[22,31,37,55,80,100,116,127,152,170,208,224,240,260,289,310,317,330],"peripheral":[23,45],"Psoriatic":[24],"(PsA)":[26],"with":[27,84,105,131,172,227,262],"ultrasound":[28],"(US)-confirmed":[29],"inflammation,":[30],"characterize":[33],"its":[34],"clinical,":[35],"structural,":[36],"therapeutic":[38],"features.":[39],"Cross-sectional":[40],"study":[41],"involving":[42],"RA":[43,165,223,255],"or":[44,74,102],"PsA":[46],"who":[47],"had":[48],"active":[49],"disease,":[50,314],"established":[51],"through":[52],"both":[53,222],"clinical":[54],"US":[56,186,276],"examination.":[57],"D2T":[58,69,146,159,216,249,296],"was":[60,161,218,251],"categorized":[61],"criteria:":[65],"an":[66],"treatment-failure-based":[68,145],"definition,":[70,147,151],"requiring":[71,121],"inadequate":[72],"response":[73],"failure":[75,95,122],"\u2265":[77,81,97,124],"1":[78,98,125],"csDMARD":[79,99,126],"2":[82],"b/tsDMARDs":[83,104,130],"different":[85,106,132],"mechanisms":[86],"action":[88],"(MOAs);":[89],"time-dependent":[91],"criterion,":[92,120],"defined":[93],"by":[94,303],"two":[101],"more":[103,162,252],"MOAs":[107],"over":[108],"period":[110],"less":[112],"than":[113],"12":[114],"months":[115],"very":[118,155],"refractory":[119,156,248],"\u2265\u200b":[128],"3":[129],"MOAs.":[133],"A":[134],"total":[135],"148":[137],"patients":[138],"were":[139],"included.":[140],"Overall,":[141],"31.7%":[142],"fulfilled":[143],"12.1%":[148],"time-based":[150],"18.2%":[153],"one.":[157],"Treatment-failure-based":[158],"frequent":[163],"(":[166,176,182,189,195,204,211,230,236,243,256,266,272,279,285,292],"p":[167,177,183,190,196,205,212,231,237,244,257,267,273,280,286,293],"=":[168,184,191,232,238,245,258,268,281,287],"0.033)":[169],"associated":[171,226,261,322],"longer":[173,263],"duration":[175,265],"<":[178,197,206,213,274,294],"0.001),":[179,198,207,275],"cardiovascular":[180],"comorbidity":[181],"0.037),":[185],"proliferative":[187,277],"synovitis":[188,278],"0.034),":[192],"erosive":[193,270],"combined":[199,228,283,315],"therapy":[200,229,284],"(csDMARD":[201],"+":[202],"b/tsDMARD)":[203],"prior":[209],"tsDMARD":[210,234,290,318],"0.001).":[214,295],"Time-based":[215],"equally":[219],"present":[220],"PsA,":[225],"0.008),":[233],"use":[235],"0.002),":[239],"nail":[241],"involvement":[242],"0.019).":[246],"Very":[247],"prevalent":[253],"0.029)":[259],"0.014),":[269],"0.046),":[282],"0.003),":[288],"exposure":[291,319],"defines":[298],"severe":[300],"phenotype":[301],"characterized":[302],"cumulative":[304],"burden,":[306],"structural":[307],"damage,":[308],"comorbidities,":[309],"treatment":[311],"refractoriness.":[312],"Erosive":[313],"therapy,":[316],"emerged":[320],"as":[321],"factors":[323],"across":[324],"definitions,":[325],"emphasizing":[326],"early":[327],"control":[329],"comprehensive":[331],"management.":[332]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}
