{"id":"https://openalex.org/W7225466527","doi":"https://doi.org/10.1016/j.reth.2026.101200","title":"Contamination spread within biosafety cabinets during wiping and its transfer to gloves: Quantitative assessment of cleaning risks","display_name":"Contamination spread within biosafety cabinets during wiping and its transfer to gloves: Quantitative assessment of cleaning risks","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225466527","doi":"https://doi.org/10.1016/j.reth.2026.101200"},"language":"en","primary_location":{"id":"doi:10.1016/j.reth.2026.101200","doi":"https://doi.org/10.1016/j.reth.2026.101200","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reth.2026.101200","pdf_url":null,"source":{"id":"https://openalex.org/S2898509233","display_name":"Regenerative Therapy","issn_l":"2352-3204","issn":["2352-3204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.reth.2026.101200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068969088","display_name":"Mitsuru Mizuno","orcid":"https://orcid.org/0000-0002-4410-3621","observed_orcids":["https://orcid.org/0000-0002-4410-3621"]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsuru Mizuno","raw_affiliation_strings":["Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","Future Intelligence Visionary Initiative, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4400009020"]},{"raw_affiliation_string":"Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4210161548"]},{"raw_affiliation_string":"Future Intelligence Visionary Initiative, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139316028","display_name":"Tomoko Oono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Oono","raw_affiliation_strings":["Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102760372","display_name":"Hisako Katano","orcid":"https://orcid.org/0000-0002-6952-895X","observed_orcids":["https://orcid.org/0000-0002-6952-895X"]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisako Katano","raw_affiliation_strings":["Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6952-895X","affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4400009020"]},{"raw_affiliation_string":"Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039180718","display_name":"Ichiro Sekiya","orcid":"https://orcid.org/0000-0002-6331-722X","observed_orcids":["https://orcid.org/0000-0002-6331-722X"]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Sekiya","raw_affiliation_strings":["Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4400009020"]},{"raw_affiliation_string":"Center for Transfusion Medicine and Cell Therapy, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan","institution_ids":["https://openalex.org/I4210161548"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068969088"],"corresponding_institution_ids":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"101200","last_page":"101200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13279","display_name":"Safe Handling of Antineoplastic Drugs","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11957","display_name":"Food Safety and Hygiene","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosafety-cabinet","display_name":"biological safety cabinet","score":0.9900000095367432},{"id":"https://openalex.org/keywords/wiping","display_name":"wiping","score":0.38999998569488525},{"id":"https://openalex.org/keywords/surface-decontamination","display_name":"surface decontamination","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bacillus-subtilis-endospores","display_name":"Bacillus subtilis endospores","score":0.8130000233650208},{"id":"https://openalex.org/keywords/stainless-steel-surfaces","display_name":"stainless steel surfaces","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C112570922","wikidata":"https://www.wikidata.org/wiki/Q60528603","display_name":"Contamination","level":2,"score":0.8745999932289124},{"id":"https://openalex.org/C2984588014","wikidata":"https://www.wikidata.org/wiki/Q730675","display_name":"Quantitative assessment","level":2,"score":0.6704000234603882},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.5242000222206116},{"id":"https://openalex.org/C107211472","wikidata":"https://www.wikidata.org/wiki/Q284486","display_name":"Human decontamination","level":2,"score":0.48969998955726624},{"id":"https://openalex.org/C2780017307","wikidata":"https://www.wikidata.org/wiki/Q145863","display_name":"Polyethylene terephthalate","level":2,"score":0.38029998540878296},{"id":"https://openalex.org/C65764964","wikidata":"https://www.wikidata.org/wiki/Q828761","display_name":"Endospore","level":3,"score":0.3646000027656555},{"id":"https://openalex.org/C528095902","wikidata":"https://www.wikidata.org/wiki/Q2283886","display_name":"Pulp and paper industry","level":1,"score":0.35929998755455017},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3582000136375427},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.34940001368522644},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C2776023875","wikidata":"https://www.wikidata.org/wiki/Q637703","display_name":"Debris","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C3017814627","wikidata":"https://www.wikidata.org/wiki/Q864713","display_name":"Biological safety","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29679998755455017},{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.2700999975204468},{"id":"https://openalex.org/C82085835","wikidata":"https://www.wikidata.org/wiki/Q16142045","display_name":"Aerosolization","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C139149728","wikidata":"https://www.wikidata.org/wiki/Q335201","display_name":"Laboratory flask","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.reth.2026.101200","doi":"https://doi.org/10.1016/j.reth.2026.101200","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reth.2026.101200","pdf_url":null,"source":{"id":"https://openalex.org/S2898509233","display_name":"Regenerative Therapy","issn_l":"2352-3204","issn":["2352-3204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3d1643372f2c4f6fa177d0cd0bff2c76","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3d1643372f2c4f6fa177d0cd0bff2c76","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regenerative Therapy, Vol 33, Iss , Pp 101200- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.reth.2026.101200","doi":"https://doi.org/10.1016/j.reth.2026.101200","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reth.2026.101200","pdf_url":null,"source":{"id":"https://openalex.org/S2898509233","display_name":"Regenerative Therapy","issn_l":"2352-3204","issn":["2352-3204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regenerative Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1597959609","https://openalex.org/W1970394313","https://openalex.org/W2003083472","https://openalex.org/W2026279856","https://openalex.org/W2035938144","https://openalex.org/W2048834190","https://openalex.org/W2140775467","https://openalex.org/W2155950200","https://openalex.org/W2262111172","https://openalex.org/W2471151681","https://openalex.org/W2623038514","https://openalex.org/W2794293123","https://openalex.org/W2940647023","https://openalex.org/W2972872824","https://openalex.org/W3004878604","https://openalex.org/W3012112729","https://openalex.org/W3047351870","https://openalex.org/W3164025555","https://openalex.org/W4308344693","https://openalex.org/W4313479035","https://openalex.org/W4319660314","https://openalex.org/W4386096369","https://openalex.org/W4387996263","https://openalex.org/W4391032349","https://openalex.org/W4400748864","https://openalex.org/W4404955818","https://openalex.org/W4406921699","https://openalex.org/W4409392316","https://openalex.org/W4415757171"],"related_works":["https://openalex.org/W4319660314","https://openalex.org/W4400748864","https://openalex.org/W4404955818","https://openalex.org/W3111702967","https://openalex.org/W4320032526","https://openalex.org/W7169833544","https://openalex.org/W4416957651","https://openalex.org/W1591429219","https://openalex.org/W1597165735","https://openalex.org/W7164551279"],"abstract_inverted_index":{"Introduction":[0],"Cell":[1],"processing":[2,326],"facilities":[3],"commonly":[4],"employ":[5],"manual":[6],"wiping":[7,20,46,73,113,118,125,189,228,268,308],"to":[8,23,37,181,214,237,259],"decontaminate":[9],"biosafety":[10],"cabinet":[11],"(BSC)":[12],"surfaces":[13,33,99],"during":[14,72,241,254],"changeovers":[15],"between":[16],"manufacturing":[17],"lots.":[18],"Although":[19],"is":[21],"intended":[22],"remove":[24],"contaminants,":[25],"it":[26],"may":[27],"also":[28],"inadvertently":[29],"redistribute":[30],"them":[31,36],"across":[32,185],"or":[34,138],"transfer":[35,56,180,213,258],"operators\u2019":[38],"gloves.":[39],"Quantitative":[40],"data":[41],"on":[42,52,78,92,150],"the":[43,53,68,120,131,205,222,238,248,311],"impact":[44],"of":[45,57,70,90,188,267,313],"techniques,":[47],"repetition,":[48],"and":[49,55,84,96,105,123,155,199,294,316],"surface":[50,167],"materials":[51],"dispersion":[54],"biological":[58],"contaminants":[59,91],"within":[60,287],"BSCs":[61,288],"remain":[62],"limited.":[63],"This":[64],"study":[65],"systematically":[66],"evaluated":[67,101,184],"spread":[69],"contamination":[71,168,298],"operations":[74,286],"in":[75,204,221,247],"BSCs,":[76],"focusing":[77],"three":[79],"representative":[80],"indicators:":[81],"DNA,":[82,103],"protein,":[83,104],"viable":[85,232],"bacteria.":[86],"Methods":[87],"The":[88],"redistribution":[89],"stainless":[93],"steel":[94],"(SUS304)":[95],"polyethylene":[97],"terephthalate":[98],"was":[100,169,183,251],"using":[102],"Bacillus":[106],"subtilis":[107],"endospores":[108],"as":[109,291],"model":[110],"indicators.":[111],"Two":[112],"protocols":[114],"were":[115,157,234],"evaluated:":[116],"multi-pass":[117,242],"(reusing":[119],"same":[121],"sheet)":[122],"replacement":[124,255,307],"(using":[126],"a":[127],"new":[128],"sheet":[129,314],"after":[130,226],"source":[132,206,223],"area),":[133],"each":[134],"performed":[135],"either":[136],"once":[137],"four":[139,227],"times":[140],"with":[141,211,263],"ethanol-moistened":[142],"nonwoven":[143],"sheets":[144,190,269],"under":[145,208],"standardized":[146],"mechanical":[147],"conditions":[148],"based":[149],"EN":[151],"16615:2015.":[152],"Residual":[153],"DNA":[154,198],"protein":[156,200],"quantified":[158],"fluorometrically":[159],"(n":[160,174,191],"=":[161,175,192,272,278],"6":[162],"per":[163,177,194],"condition),":[164],"whereas":[165,244],"bacterial":[166,245],"measured":[170],"by":[171],"contact":[172],"culture":[173],"12":[176],"condition).":[178,196],"Bacterial":[179,257],"gloves":[182,260],"increasing":[186,265,310],"numbers":[187],"16":[193],"sheet-number":[195],"Results":[197],"residues":[201,219],"predominantly":[202],"persisted":[203,220],"area":[207,224,240,250],"all":[209],"conditions,":[210],"minimal":[212],"adjacent":[215],"areas.":[216],"However,":[217],"measurable":[218],"even":[225],"cycles.":[229],"By":[230],"contrast,":[231],"bacteria":[233],"readily":[235],"redistributed":[236],"affected":[239,249],"wiping,":[243],"detection":[246],"less":[252],"frequent":[253],"wiping.":[256],"decreased":[261],"monotonically":[262],"an":[264],"number":[266],"(Cram\u00e9r's":[270],"V":[271],"0.82;":[273],"Cochran\u2013Armitage":[274],"trend":[275],"test,":[276],"p":[277],"1.7":[279],"\u00d7":[280],"10":[281],"\u221214":[282],").":[283],"Conclusions":[284],"Wiping":[285],"serve":[289],"both":[290],"decontamination":[292],"steps":[293],"potential":[295],"vehicles":[296],"for":[297,305,324],"redistribution.":[299],"These":[300],"findings":[301],"provide":[302],"quantitative":[303],"evidence":[304],"implementing":[306],"strategies,":[309],"frequency":[312],"changes,":[315],"incorporating":[317],"nonmicrobial":[318],"residue":[319],"indicators":[320],"into":[321],"changeover":[322],"validation":[323],"cell":[325],"facilities.":[327]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-08T00:00:00"}
