{"id":"https://openalex.org/W7225465864","doi":"https://doi.org/10.1051/mmnp/2026025","title":"Predicting Outcomes in Acetaminophen Overdose Using Real Patient Data: The Role of Protein Adducts in Determining Survival and Mortality","display_name":"Predicting Outcomes in Acetaminophen Overdose Using Real Patient Data: The Role of Protein Adducts in Determining Survival and Mortality","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225465864","doi":"https://doi.org/10.1051/mmnp/2026025"},"language":"en","primary_location":{"id":"doi:10.1051/mmnp/2026025","doi":"https://doi.org/10.1051/mmnp/2026025","is_oa":false,"landing_page_url":"https://doi.org/10.1051/mmnp/2026025","pdf_url":null,"source":{"id":"https://openalex.org/S15090102","display_name":"Mathematical Modelling of Natural Phenomena","issn_l":"0973-5348","issn":["0973-5348","1760-6101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mathematical Modelling of Natural Phenomena","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035250029","display_name":"Christine Brasic","orcid":"https://orcid.org/0000-0002-8589-0393","observed_orcids":["https://orcid.org/0000-0002-8589-0393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Brasic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091107545","display_name":"Samiran Ghosh","orcid":"https://orcid.org/0000-0002-1151-4539","observed_orcids":["https://orcid.org/0000-0002-1151-4539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samiran Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161195251","display_name":"Christopher Remien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Remien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161157105","display_name":"William Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161228110","display_name":"Malay Banerjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malay Banerjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010879040","display_name":"Aditi Ghosh","orcid":"https://orcid.org/0000-0003-4239-0038","observed_orcids":["https://orcid.org/0000-0003-4239-0038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditi Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetaminophen-overdose","display_name":"acetaminophen overdose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/protein-adducts","display_name":"protein adducts","score":0.8700000047683716},{"id":"https://openalex.org/keywords/king-s-college-criteria","display_name":"King's College criteria","score":0.9169999957084656},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.6600000262260437},{"id":"https://openalex.org/keywords/differential-equation-model","display_name":"differential equation model","score":0.5180000066757202},{"id":"https://openalex.org/keywords/sensitivity-analysis","display_name":"sensitivity analysis","score":0.6320000290870667},{"id":"https://openalex.org/keywords/asymptotic-behavior","display_name":"asymptotic behavior","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.744700014591217},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.7242000102996826},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.4918000102043152},{"id":"https://openalex.org/C2776877392","wikidata":"https://www.wikidata.org/wiki/Q2572879","display_name":"acetaminophen overdose","level":4,"score":0.4779999852180481},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4765999913215637},{"id":"https://openalex.org/C2776315796","wikidata":"https://www.wikidata.org/wiki/Q3505252","display_name":"Drug overdose","level":3,"score":0.4661000072956085},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.42750000953674316},{"id":"https://openalex.org/C2994427840","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Liver failure","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3427000045776367},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.31060001254081726},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.296099990606308},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C2991799789","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Orthotopic liver transplantation","level":4,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1051/mmnp/2026025","doi":"https://doi.org/10.1051/mmnp/2026025","is_oa":false,"landing_page_url":"https://doi.org/10.1051/mmnp/2026025","pdf_url":null,"source":{"id":"https://openalex.org/S15090102","display_name":"Mathematical Modelling of Natural Phenomena","issn_l":"0973-5348","issn":["0973-5348","1760-6101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mathematical Modelling of Natural Phenomena","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965215481","https://openalex.org/W2166114182","https://openalex.org/W2292470222","https://openalex.org/W2122578591","https://openalex.org/W7160868307","https://openalex.org/W2802042400","https://openalex.org/W2965126369","https://openalex.org/W1991079684","https://openalex.org/W4237157934","https://openalex.org/W2624684789"],"abstract_inverted_index":{"In":[0],"the":[1,8,19,97,109,131,135],"United":[2],"States,":[3],"acetaminophen":[4],"(APAP)":[5],"overdose":[6,29,58,175],"is":[7,69],"leading":[9],"cause":[10],"of":[11,46,105,134],"acute":[12],"liver":[13,163],"injury.":[14],"Current":[15],"assessment":[16],"tools":[17],"like":[18,169],"King\u2019s":[20],"College":[21],"Criteria":[22],"(KCC)":[23],"cannot":[24],"predict":[25],"APAP":[26,78],"dosage":[27],"or":[28,66],"timing,":[30],"crucial":[31],"for":[32,38,161],"guiding":[33],"treatment":[34,159],"decisions.":[35],"The":[36,103],"Model":[37],"APAP-Induced":[39],"Liver":[40,99],"Damage":[41],"(MALD)":[42],"employs":[43],"a":[44,86],"system":[45],"differential":[47],"equations":[48],"using":[49],"biomarkers":[50,73],"namely":[51],"AST,":[52],"ALT,":[53],"and":[54,60,138,158,177],"INR,":[55],"to":[56,77,146,154],"estimate":[57],"parameters":[59],"determine":[61],"whether":[62],"NAC":[63],"therapy":[64],"suffices":[65],"if":[67],"transplantation":[68],"needed.":[70],"However,":[71],"these":[72],"are":[74,126],"not":[75],"specific":[76],"toxicity.":[79],"Our":[80],"work":[81],"enhances":[82],"MALD":[83],"by":[84,171],"incorporating":[85],"fourth":[87],"biomarker,":[88],"APAP-protein":[89],"adducts,":[90],"validated":[91],"with":[92,123],"real":[93],"patient":[94],"data":[95],"from":[96],"Acute":[98],"Failure":[100],"Study":[101],"Group.":[102],"inclusion":[104],"Adducts":[106],"significantly":[107],"improves":[108],"model\u2019s":[110],"predictive":[111,148],"accuracy,":[112],"reflected":[113],"in":[114],"higher":[115],"ROC":[116],"curve":[117],"performance,":[118],"further":[119],"enhanced":[120],"when":[121],"patients":[122],"alcohol":[124],"use":[125],"excluded.":[127],"We":[128],"also":[129],"analyze":[130],"asymptotic":[132],"behavior":[133],"extended":[136],"model":[137],"conduct":[139],"sensitivity":[140],"analyses":[141],"on":[142],"key":[143],"parameters,":[144],"aiming":[145],"refine":[147],"capabilities.":[149],"Ultimately,":[150],"this":[151],"extension":[152],"aims":[153],"improve":[155],"early":[156],"diagnosis":[157],"decisions":[160],"APAP-induced":[162],"injury,":[164],"advancing":[165],"beyond":[166],"existing":[167],"models":[168],"KCC":[170],"providing":[172],"more":[173],"precise":[174],"estimation":[176],"prognosis.":[178]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}
