{"id":"https://openalex.org/W7225464485","doi":"https://doi.org/10.1080/15384047.2026.2756150","title":"RBBP5 drives cancer stem cell-like characteristics by suppressing the hippo signaling pathway through WNT5A downregulation in breast cancer","display_name":"RBBP5 drives cancer stem cell-like characteristics by suppressing the hippo signaling pathway through WNT5A downregulation in breast cancer","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225464485","doi":"https://doi.org/10.1080/15384047.2026.2756150","pmid":"https://pubmed.ncbi.nlm.nih.gov/42998019"},"language":"en","primary_location":{"id":"doi:10.1080/15384047.2026.2756150","doi":"https://doi.org/10.1080/15384047.2026.2756150","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384047.2026.2756150","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2756150?needAccess=true","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2756150?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046358217","display_name":"Sojeong Moon","orcid":"https://orcid.org/0000-0002-6247-0855","observed_orcids":["https://orcid.org/0000-0002-6247-0855"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So-Jeong Moon","raw_affiliation_strings":["Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University"],"raw_orcid":"https://orcid.org/0000-0002-6247-0855","affiliations":[{"raw_affiliation_string":"Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014388450","display_name":"Young-Hyeon Kye","orcid":"https://orcid.org/0009-0009-1242-0807","observed_orcids":["https://orcid.org/0009-0009-1242-0807"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Hyeon Kye","raw_affiliation_strings":["Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University"],"raw_orcid":"https://orcid.org/0009-0009-1242-0807","affiliations":[{"raw_affiliation_string":"Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001681907","display_name":"Gu Kong","orcid":"https://orcid.org/0000-0001-9206-8210","observed_orcids":["https://orcid.org/0000-0001-9206-8210"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Gu Kong","raw_affiliation_strings":["Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University","Department of Pathology, College of Medicine, Hanyang University"],"raw_orcid":"https://orcid.org/0000-0001-9206-8210","affiliations":[{"raw_affiliation_string":"Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University","institution_ids":["https://openalex.org/I4575257"]},{"raw_affiliation_string":"Department of Pathology, College of Medicine, Hanyang University","institution_ids":["https://openalex.org/I4575257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001681907"],"corresponding_institution_ids":["https://openalex.org/I4575257"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":{"value":2710,"currency":"EUR","value_usd":2970},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"1","first_page":"2756150","last_page":"2756150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.1444000005722046,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rbbp5","display_name":"RBBP5","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.875},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.9769999980926514},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mst1-2","display_name":"MST1/2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-sphere-formation","display_name":"tumor sphere formation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/aldefluor-assay","display_name":"ALDEFLUOR assay","score":0.7839999794960022},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6809999942779541},{"id":"https://openalex.org/keywords/non-canonical-wnt-signaling","display_name":"non-canonical Wnt signaling","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.8034999966621399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7562000155448914},{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.7311000227928162},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7233999967575073},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6714000105857849},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6593999862670898},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6355000138282776},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5568000078201294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5516999959945679},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5259000062942505},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4909999966621399},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4433000087738037},{"id":"https://openalex.org/C170240278","wikidata":"https://www.wikidata.org/wiki/Q17928773","display_name":"FOXM1","level":4,"score":0.421099990606308},{"id":"https://openalex.org/C2780176071","wikidata":"https://www.wikidata.org/wiki/Q18032361","display_name":"WNT5A","level":4,"score":0.4004000127315521},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.3587000072002411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32760000228881836},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3249000012874603},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.31520000100135803},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.2946999967098236},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C2780546549","wikidata":"https://www.wikidata.org/wiki/Q7508338","display_name":"Side population","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25}],"mesh":[{"descriptor_ui":"D000071818","descriptor_name":"Wnt-5a Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071818","descriptor_name":"Wnt-5a Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000090683","descriptor_name":"Hippo Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/15384047.2026.2756150","doi":"https://doi.org/10.1080/15384047.2026.2756150","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384047.2026.2756150","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2756150?needAccess=true","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:42998019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42998019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d181d4cc05c84ee4908097763bd7c9df","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d181d4cc05c84ee4908097763bd7c9df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Biology & Therapy, Vol 27, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/15384047.2026.2756150","doi":"https://doi.org/10.1080/15384047.2026.2756150","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384047.2026.2756150","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2756150?needAccess=true","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1636475107","display_name":null,"funder_award_id":"HI19C0753","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G7236796675","display_name":null,"funder_award_id":"2019R1A2C3006305","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322091","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225464485.pdf","grobid_xml":"https://content.openalex.org/works/W7225464485.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1907833971","https://openalex.org/W1908864745","https://openalex.org/W1982255060","https://openalex.org/W1992662525","https://openalex.org/W2007494847","https://openalex.org/W2020651991","https://openalex.org/W2023316892","https://openalex.org/W2024099613","https://openalex.org/W2032028067","https://openalex.org/W2040430549","https://openalex.org/W2040467756","https://openalex.org/W2061472870","https://openalex.org/W2075439913","https://openalex.org/W2075905074","https://openalex.org/W2082335687","https://openalex.org/W2085329742","https://openalex.org/W2095785781","https://openalex.org/W2100502993","https://openalex.org/W2114301011","https://openalex.org/W2132264180","https://openalex.org/W2146337514","https://openalex.org/W2152875105","https://openalex.org/W2154041910","https://openalex.org/W2165238621","https://openalex.org/W2169562832","https://openalex.org/W2353708436","https://openalex.org/W2375577403","https://openalex.org/W2403874820","https://openalex.org/W2514155438","https://openalex.org/W2520146245","https://openalex.org/W2575704225","https://openalex.org/W2771794752","https://openalex.org/W2791923388","https://openalex.org/W2799702782","https://openalex.org/W2886127471","https://openalex.org/W2899576419","https://openalex.org/W2911380762","https://openalex.org/W2914644210","https://openalex.org/W3000663296","https://openalex.org/W3023686945","https://openalex.org/W3132957150","https://openalex.org/W3138120009","https://openalex.org/W3144131900","https://openalex.org/W3185354749","https://openalex.org/W3200010007","https://openalex.org/W4213434601","https://openalex.org/W4280505535","https://openalex.org/W4307805710","https://openalex.org/W4313877791","https://openalex.org/W4378745771","https://openalex.org/W4383878771","https://openalex.org/W4393235590","https://openalex.org/W4397009279","https://openalex.org/W4400325786","https://openalex.org/W4401370977","https://openalex.org/W4403008105","https://openalex.org/W7131269654"],"related_works":["https://openalex.org/W4414889517","https://openalex.org/W2998259914","https://openalex.org/W2221752800","https://openalex.org/W4414510250","https://openalex.org/W4200079590","https://openalex.org/W2912468274","https://openalex.org/W7168134780","https://openalex.org/W1586742424","https://openalex.org/W3127511066","https://openalex.org/W1735670763"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"stem":[2,123],"cells":[3,162],"(CSCs)":[4],"are":[5],"a":[6,133,190,208],"major":[7],"contributor":[8],"to":[9,138],"breast":[10,33,50,179],"cancer":[11,51,180],"recurrence":[12],"and":[13,40,56,73,76,102,122,142,166,196],"therapeutic":[14,210],"resistance.":[15],"This":[16],"study":[17],"investigates":[18],"the":[19,83,203],"oncogenic":[20],"role":[21],"of":[22,63,111,118,145,150,158],"Retinoblastoma":[23],"Binding":[24],"Protein":[25],"5":[26],"(RBBP5)":[27],"in":[28,32,38,77,126,160,178],"driving":[29],"CSC-like":[30,66,100,154,176],"properties":[31,177],"cancer.":[34],"METHODS:":[35],"Genetic":[36],"alterations":[37],"RBBP5":[39,64,95,129,174,188],"their":[41],"correlation":[42],"with":[43,115,214],"patient":[44],"survival":[45],"were":[46],"analyzed":[47],"using":[48],"multiple":[49],"cohorts,":[52],"including":[53],"METABRIC,":[54],"TCGA,":[55],"Kaplan-Meier":[57],"(KM)":[58],"plotter":[59],"datasets.":[60],"The":[61],"impact":[62],"on":[65],"traits":[67],"was":[68,90],"assessed":[69],"through":[70],"tumorsphere":[71],"formation":[72],"ALDEFLUOR":[74],"assays,":[75],"vivo":[78],"xenograft":[79],"models.":[80],"To":[81],"elucidate":[82],"underlying":[84],"molecular":[85],"mechanism,":[86],"RNA":[87],"sequencing":[88],"(RNA-seq)":[89],"performed.":[91],"RESULTS:":[92],"<":[93],"0.001).":[94],"overexpression":[96],"enhanced":[97],"tumorsphere-forming":[98],"capacity,":[99],"population":[101,125],"tumor-initiating":[103],"cell":[104,119,124],"frequency.":[105],"RNA-seq":[106],"results":[107],"revealed":[108],"an":[109],"enrichment":[110],"gene":[112],"sets":[113],"associated":[114],"negative":[116],"regulation":[117],"growth,":[120],"invasiveness,":[121],"RBBP5-knockdown":[127,161],"cells.":[128],"knockdown":[130],"upregulated":[131],"WNT5A,":[132],"non-canonical":[134],"Wnt":[135],"ligand,":[136],"leading":[137],"Hippo":[139,184,204],"pathway":[140,205],"activation":[141],"subsequent":[143],"suppression":[144,157],"YAP":[146,164,200],"signaling.":[147,185],"Pharmacological":[148],"inhibition":[149],"YAP1":[151],"abrogated":[152],"RBBP5-induced":[153],"properties,":[155],"while":[156],"MST1/2":[159],"restored":[163],"activity":[165],"CSC":[167],"traits.":[168],"CONCLUSIONS:":[169],"These":[170],"findings":[171],"indicate":[172],"that":[173,198],"promotes":[175],"by":[181],"repressing":[182],"WNT5A-mediated":[183],"We":[186],"suggest":[187],"as":[189],"potential":[191],"biomarker":[192],"for":[193,212],"poor":[194],"prognosis":[195],"propose":[197],"targeting":[199],"or":[201],"activating":[202],"could":[206],"represent":[207],"promising":[209],"approach":[211],"patients":[213],"RBBP5-overexpressing":[215],"tumors.":[216]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-08T00:00:00"}