{"id":"https://openalex.org/W7225462287","doi":"https://doi.org/10.29244/avi.14.3.295-301","title":"Phytochemical Screening, Antioxidant Activity, and Acute Toxicity Evaluation of Physalis angulata L. Leaf Infusion","display_name":"Phytochemical Screening, Antioxidant Activity, and Acute Toxicity Evaluation of Physalis angulata L. Leaf Infusion","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225462287","doi":"https://doi.org/10.29244/avi.14.3.295-301"},"language":"en","primary_location":{"id":"doi:10.29244/avi.14.3.295-301","doi":"https://doi.org/10.29244/avi.14.3.295-301","is_oa":true,"landing_page_url":"https://doi.org/10.29244/avi.14.3.295-301","pdf_url":"https://journal.ipb.ac.id/actavetindones/article/download/72959/34617","source":{"id":"https://openalex.org/S4210169897","display_name":"Acta Veterinaria Indonesiana","issn_l":"2337-3202","issn":["2337-3202","2337-4373"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314920","host_organization_name":"Bogor Institute of Agriculture","host_organization_lineage":["https://openalex.org/P4310314920"],"host_organization_lineage_names":["Bogor Institute of Agriculture"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Veterinaria Indonesiana","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal.ipb.ac.id/actavetindones/article/download/72959/34617","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135346538","display_name":"Arindina Mahendra","orcid":"https://orcid.org/0009-0001-2614-1499","observed_orcids":["https://orcid.org/0009-0001-2614-1499"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Arindina Mahendra","raw_affiliation_strings":["Graduate School of Veterinary Biomedical Science, School of Veterinary Medicine and Biomedical Science, IPB University, Indonesia"],"raw_orcid":"https://orcid.org/0009-0001-2614-1499","affiliations":[{"raw_affiliation_string":"Graduate School of Veterinary Biomedical Science, School of Veterinary Medicine and Biomedical Science, IPB University, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091812800","display_name":"Aryani Sismin Satyaningtijas","orcid":"https://orcid.org/0000-0002-3863-7555","observed_orcids":["https://orcid.org/0000-0002-3863-7555"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aryani Sismin Satyaningtijas","raw_affiliation_strings":["Division of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-3863-7555","affiliations":[{"raw_affiliation_string":"Division of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139530414","display_name":"Andriyanto Andriyanto","orcid":"https://orcid.org/0009-0000-4172-3916","observed_orcids":["https://orcid.org/0009-0000-4172-3916"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Andriyanto","raw_affiliation_strings":["Division of Pharmacology and Toxicology, School of Veterinary Medicine and Biomedical Sciences, IPB University"],"raw_orcid":"https://orcid.org/0009-0000-4172-3916","affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Toxicology, School of Veterinary Medicine and Biomedical Sciences, IPB University","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058285486","display_name":"Ronald Tarigan","orcid":"https://orcid.org/0000-0002-6058-0591","observed_orcids":["https://orcid.org/0000-0002-6058-0591"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ronald Tarigan","raw_affiliation_strings":["Division of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University"],"raw_orcid":"https://orcid.org/0000-0002-6058-0591","affiliations":[{"raw_affiliation_string":"Division of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University","institution_ids":["https://openalex.org/I21881038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I21881038"],"apc_list":{"value":150,"currency":"USD","value_usd":150},"apc_paid":{"value":150,"currency":"USD","value_usd":150},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"3","first_page":"295","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.3379000127315521,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/physalis-angulata","display_name":"Physalis angulata","score":1.0},{"id":"https://openalex.org/keywords/ciplukan","display_name":"ciplukan","score":0.8140000104904175},{"id":"https://openalex.org/keywords/leaf-infusion","display_name":"leaf infusion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.949999988079071},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.9850000143051147},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":1.0},{"id":"https://openalex.org/keywords/tannins","display_name":"tannins","score":1.0},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.7400000095367432},{"id":"https://openalex.org/keywords/herbal-tea","display_name":"herbal tea","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.8463000059127808},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.7825999855995178},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7008000016212463},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6549999713897705},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6470999717712402},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.6462000012397766},{"id":"https://openalex.org/C2777347573","wikidata":"https://www.wikidata.org/wiki/Q522244","display_name":"Secondary metabolite","level":3,"score":0.5164999961853027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41449999809265137},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.40639999508857727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3628000020980835},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.35179999470710754},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35109999775886536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3271999955177307},{"id":"https://openalex.org/C2776984453","wikidata":"https://www.wikidata.org/wiki/Q158663","display_name":"Physalis","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.273499995470047},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C523307889","wikidata":"https://www.wikidata.org/wiki/Q640068","display_name":"Phytochemistry","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2780309462","wikidata":"https://www.wikidata.org/wiki/Q187607","display_name":"Tannin","level":2,"score":0.25839999318122864},{"id":"https://openalex.org/C167552308","wikidata":"https://www.wikidata.org/wiki/Q711849","display_name":"Median lethal dose","level":3,"score":0.25279998779296875},{"id":"https://openalex.org/C2781380062","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Folk medicine","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29244/avi.14.3.295-301","doi":"https://doi.org/10.29244/avi.14.3.295-301","is_oa":true,"landing_page_url":"https://doi.org/10.29244/avi.14.3.295-301","pdf_url":"https://journal.ipb.ac.id/actavetindones/article/download/72959/34617","source":{"id":"https://openalex.org/S4210169897","display_name":"Acta Veterinaria Indonesiana","issn_l":"2337-3202","issn":["2337-3202","2337-4373"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314920","host_organization_name":"Bogor Institute of Agriculture","host_organization_lineage":["https://openalex.org/P4310314920"],"host_organization_lineage_names":["Bogor Institute of Agriculture"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Veterinaria Indonesiana","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29244/avi.14.3.295-301","doi":"https://doi.org/10.29244/avi.14.3.295-301","is_oa":true,"landing_page_url":"https://doi.org/10.29244/avi.14.3.295-301","pdf_url":"https://journal.ipb.ac.id/actavetindones/article/download/72959/34617","source":{"id":"https://openalex.org/S4210169897","display_name":"Acta Veterinaria Indonesiana","issn_l":"2337-3202","issn":["2337-3202","2337-4373"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314920","host_organization_name":"Bogor Institute of Agriculture","host_organization_lineage":["https://openalex.org/P4310314920"],"host_organization_lineage_names":["Bogor Institute of Agriculture"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Veterinaria Indonesiana","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225462287.pdf","grobid_xml":"https://content.openalex.org/works/W7225462287.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2055225004","https://openalex.org/W2794597140","https://openalex.org/W3036783797","https://openalex.org/W3088735385","https://openalex.org/W4200069990","https://openalex.org/W4214540193","https://openalex.org/W4316466076","https://openalex.org/W4319984800","https://openalex.org/W4367052783","https://openalex.org/W4386627590","https://openalex.org/W4389242029","https://openalex.org/W4400649248","https://openalex.org/W4407785716","https://openalex.org/W4415976694"],"related_works":["https://openalex.org/W2563544713","https://openalex.org/W2976154054","https://openalex.org/W4409413903","https://openalex.org/W4415976694","https://openalex.org/W4416442717","https://openalex.org/W2266443942","https://openalex.org/W2972790391","https://openalex.org/W4281670595","https://openalex.org/W2988787422","https://openalex.org/W7147274821"],"abstract_inverted_index":{"Background:":[0],"Physalis":[1],"angulata":[2],"L.":[3],"(ciplukan)":[4],"is":[5,22,178],"an":[6,52,170,200],"herbal":[7],"plant":[8,21,34],"rich":[9],"in":[10,144,195,199],"secondary":[11,81],"metabolites":[12,82],"and":[13,67,116,125,139,154,192,223],"has":[14,169],"antioxidant":[15,184,228],"activity.":[16,229],"Antioxidant":[17,88],"activity":[18,89],"of":[19,28,84,102,174,203],"this":[20,33],"commonly":[23],"the":[24,42,57,64,80,97,103,136],"reason":[25],"why":[26],"people":[27],"many":[29],"Asian":[30],"countries":[31],"use":[32],"as":[35,163,180,213],"traditional":[36],"medicine":[37],"or":[38],"a":[39,113,164,181,214],"supplement":[40],"through":[41],"infusion/tea":[43],"brewing":[44],"method.":[45],"Aims:":[46],"This":[47,167,230],"study":[48,54],"aims":[49],"to":[50,55,78,95,236],"be":[51],"exploratory":[53],"identify":[56,79],"metabolite":[58],"molecules":[59,220],"that":[60],"are":[61,76,157],"extracted":[62,160,218],"using":[63,90],"infusion":[65,119,150,212,231],"method":[66],"their":[68],"acute":[69],"toxicity.":[70],"Methods:":[71],"Simple":[72],"phytochemistry":[73],"screening":[74],"tests":[75],"conducted":[77,94],"composition":[83],"ciplukan":[85,117],"leaf":[86,118,149,211],"infusion.":[87],"DPPH":[91,172],"radicals":[92],"was":[93,130],"obtain":[96],"inhibitory":[98],"concentration":[99],"(IC50)":[100],"value":[101,173,202],"solution.":[104],"Twenty-five":[105],"female":[106],"mice":[107],"were":[108,142],"divided":[109],"into":[110],"5":[111],"groups:":[112],"control":[114],"group":[115],"with":[120],"doses":[121],"1,":[122],"5,":[123],"10,":[124],"15":[126,206,237],"g/kg":[127,207,238],"BW.":[128,208,239],"Infusion":[129],"administered":[131],"on":[132],"day":[133],"one,":[134],"while":[135],"mortality":[137,191,234],"rate":[138],"toxicity":[140,187,193],"symptoms":[141,194],"observed":[143],"14":[145],"days.":[146],"Results:":[147],"Ciplukan":[148,210],"contains":[151],"alkaloids,":[152],"flavonoids,":[153],"tannins,":[155],"which":[156,177,225],"all":[158],"successfully":[159,217],"by":[161],"water":[162],"polar":[165,215,219],"solvent.":[166],"solution":[168],"IC50":[171],"106.81":[175],"\u00b5g/ml,":[176],"categorized":[179],"moderately":[182],"active":[183],"extract.":[185],"Acute":[186],"test":[188],"showed":[189,232],"no":[190,233],"each":[196],"group,":[197],"resulting":[198],"LD50":[201],"more":[204],"than":[205],"Conclusion:":[209],"extract":[216],"alkaloid,":[221],"flavonoid,":[222],"tannin":[224],"have":[226],"moderate":[227],"up":[235]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}