{"id":"https://openalex.org/W7225462019","doi":"https://doi.org/10.7860/jcdr/2026/91245.24789","title":"Prognostic Associations of MEDS Section Score, Procalcitonin, and Lactate with 28-day Mortality in Adults with Sepsis: A Prospective Observational Study","display_name":"Prognostic Associations of MEDS Section Score, Procalcitonin, and Lactate with 28-day Mortality in Adults with Sepsis: A Prospective Observational Study","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225462019","doi":"https://doi.org/10.7860/jcdr/2026/91245.24789"},"language":"en","primary_location":{"id":"doi:10.7860/jcdr/2026/91245.24789","doi":"https://doi.org/10.7860/jcdr/2026/91245.24789","is_oa":true,"landing_page_url":"https://doi.org/10.7860/jcdr/2026/91245.24789","pdf_url":null,"source":{"id":"https://openalex.org/S2737465529","display_name":"JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH","issn_l":"0973-709X","issn":["0973-709X","2249-782X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40"],"host_organization":"https://openalex.org/P4310318655","host_organization_name":"JCDR Research and Publications Private Limited","host_organization_lineage":["https://openalex.org/P4310318655"],"host_organization_lineage_names":["JCDR Research and Publications Private Limited"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7860/jcdr/2026/91245.24789","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161261089","display_name":"J Mithun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mithun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161153285","display_name":"R Prasanna Venkatesh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Prasanna Venkatesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159251086","display_name":"RM Anitha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RM Anitha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067532097","display_name":"Vignessh Raveekumaran","orcid":"https://orcid.org/0009-0006-6283-6542","observed_orcids":["https://orcid.org/0009-0006-6283-6542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vignessh Raveekumaran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":275,"currency":"USD","value_usd":275},"apc_paid":{"value":275,"currency":"USD","value_usd":275},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/28-day-mortality","display_name":"28-day mortality","score":0.9580000042915344},{"id":"https://openalex.org/keywords/meds-score","display_name":"MEDS score","score":0.8769999742507935},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sepsis-3-criteria","display_name":"Sepsis-3 criteria","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C10936531","wikidata":"https://www.wikidata.org/wiki/Q786600","display_name":"Procalcitonin","level":3,"score":0.8996999859809875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8629000186920166},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7972999811172485},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.680400013923645},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6425999999046326},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.5357000231742859},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5271000266075134},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5038999915122986},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4661000072956085},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.4593000113964081},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4507000148296356},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3163999915122986},{"id":"https://openalex.org/C2780347030","wikidata":"https://www.wikidata.org/wiki/Q344843","display_name":"APACHE II","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C2777120189","wikidata":"https://www.wikidata.org/wiki/Q780067","display_name":"Triage","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C2993277928","wikidata":"https://www.wikidata.org/wiki/Q7248370","display_name":"Prognostic model","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.2736999988555908},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.26829999685287476},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C2777984932","wikidata":"https://www.wikidata.org/wiki/Q7336293","display_name":"Risk of mortality","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2776914243","wikidata":"https://www.wikidata.org/wiki/Q7647235","display_name":"Surviving Sepsis Campaign","level":5,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7860/jcdr/2026/91245.24789","doi":"https://doi.org/10.7860/jcdr/2026/91245.24789","is_oa":true,"landing_page_url":"https://doi.org/10.7860/jcdr/2026/91245.24789","pdf_url":null,"source":{"id":"https://openalex.org/S2737465529","display_name":"JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH","issn_l":"0973-709X","issn":["0973-709X","2249-782X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40"],"host_organization":"https://openalex.org/P4310318655","host_organization_name":"JCDR Research and Publications Private Limited","host_organization_lineage":["https://openalex.org/P4310318655"],"host_organization_lineage_names":["JCDR Research and Publications Private Limited"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7860/jcdr/2026/91245.24789","doi":"https://doi.org/10.7860/jcdr/2026/91245.24789","is_oa":true,"landing_page_url":"https://doi.org/10.7860/jcdr/2026/91245.24789","pdf_url":null,"source":{"id":"https://openalex.org/S2737465529","display_name":"JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH","issn_l":"0973-709X","issn":["0973-709X","2249-782X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40"],"host_organization":"https://openalex.org/P4310318655","host_organization_name":"JCDR Research and Publications Private Limited","host_organization_lineage":["https://openalex.org/P4310318655"],"host_organization_lineage_names":["JCDR Research and Publications Private Limited"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010335090","https://openalex.org/W2021283420","https://openalex.org/W2020955970","https://openalex.org/W2373737276","https://openalex.org/W7224221779","https://openalex.org/W4404059051","https://openalex.org/W3129703854","https://openalex.org/W7218272887","https://openalex.org/W2354443393","https://openalex.org/W2068316060"],"abstract_inverted_index":{"Introduction:":[0],"Early":[1],"prognostic":[2,120],"stratification":[3],"in":[4,25,49,176,180,183,187],"sepsis":[5,74],"is":[6],"difficult":[7],"because":[8],"individual":[9,123],"biomarkers":[10],"and":[11,22,34,40,59,83,108,125,142,150,164,185,190,206],"clinical":[12,223],"scores":[13],"have":[14],"limited":[15],"accuracy.":[16],"Aim:":[17],"To":[18],"assess":[19],"procalcitonin,":[20],"lactate,":[21,82],"the":[23,50,119,132],"Mortality":[24,173],"Emergency":[26],"Department":[27,51],"Sepsis":[28],"(MEDS)":[29],"score":[30,85],"for":[31],"28-day":[32,98,211],"mortality":[33,102],"explore":[35],"combined":[36,214],"apparent":[37,215],"discrimination.":[38],"Materials":[39],"Methods:":[41],"This":[42],"hospital-based":[43],"prospective":[44],"observational":[45],"study":[46],"was":[47,96,115,135,174],"conducted":[48],"of":[52,89,122],"General":[53],"Medicine,":[54],"Mahatma":[55],"Gandhi":[56],"Medical":[57],"College":[58],"Research":[60],"Institute,":[61],"Pondicherry,":[62],"India":[63],"from":[64],"January":[65],"to":[66,76,117],"December":[67],"2025.":[68],"Adults":[69],"aged":[70],">18":[71],"years":[72],"with":[73,101,138,200,210],"according":[75],"Sepsis-3":[77],"criteria":[78],"were":[79,91,103,198,208],"eligible.":[80],"Procalcitonin,":[81],"MEDS":[84,193,203],"within":[86],"24":[87],"hours":[88],"presentation":[90],"recorded.":[92],"The":[93],"primary":[94],"outcome":[95],"all-cause":[97],"mortality.":[99,201,212],"Associations":[100],"assessed":[104],"using":[105],"logistic":[106],"regression,":[107],"Receiver":[109],"Operating":[110],"Characteristic":[111],"(ROC)":[112],"curve":[113],"analysis":[114],"performed":[116],"evaluate":[118],"discrimination":[121],"markers":[124,197],"their":[126],"combinations.":[127],"Results:":[128],"Among":[129],"67":[130],"participants,":[131],"mean":[133],"age":[134],"56.76\u00b113.78":[136],"years,":[137],"38":[139],"(56.7%)":[140],"females":[141],"29":[143],"(43.3%)":[144],"males.":[145],"Fifty":[146],"participants":[147],"(74.6%)":[148],"survived":[149],"17":[151],"(25.4%)":[152],"died.":[153],"Non":[154],"survivors":[155],"had":[156],"higher":[157],"procalcitonin":[158,205],"(11.13\u00b18.46":[159],"vs":[160,167],"2.58\u00b12.08":[161],"ng/":[162],"mL)":[163],"lactate":[165,207],"(5.17\u00b11.82":[166],"1.88\u00b10.64":[168],"mmol/L;":[169],"both":[170],"p-value":[171],"<0.001).":[172],"0/8":[175],"very":[177,191],"low-risk,":[178,181],"0/22":[179],"5/25":[182],"moderate-risk,":[184],"6/6":[186],"each":[188],"high-risk":[189],"highrisk":[192],"category.":[194],"All":[195],"three":[196],"associated":[199,209],"Conclusion:":[202],"score,":[204],"Their":[213],"performance":[216],"requires":[217],"adequately":[218],"powered":[219],"external":[220],"validation":[221],"before":[222],"use.":[224]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}
