{"id":"https://openalex.org/W7225460932","doi":"https://doi.org/10.1016/j.tranon.2026.103106","title":"Fecal microbiota capsule transplantation plus immunotherapy as first-line maintenance therapy for patients with malignant solid tumors: A single-arm, dose-escalation, exploratory phase I study","display_name":"Fecal microbiota capsule transplantation plus immunotherapy as first-line maintenance therapy for patients with malignant solid tumors: A single-arm, dose-escalation, exploratory phase I study","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225460932","doi":"https://doi.org/10.1016/j.tranon.2026.103106","pmid":"https://pubmed.ncbi.nlm.nih.gov/42998537"},"language":"en","primary_location":{"id":"doi:10.1016/j.tranon.2026.103106","doi":"https://doi.org/10.1016/j.tranon.2026.103106","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2026.103106","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523326004420/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1936523326004420/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080298080","display_name":"Yunqian Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunqian Chu","raw_affiliation_strings":["Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161253451","display_name":"Yuling Qian","orcid":"https://orcid.org/0009-0003-4400-3924","observed_orcids":["https://orcid.org/0009-0003-4400-3924"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuling Qian","raw_affiliation_strings":["Nanjing Medical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0009-0003-4400-3924","affiliations":[{"raw_affiliation_string":"Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018562215","display_name":"Jing Shi","orcid":"https://orcid.org/0000-0002-9183-9631","observed_orcids":["https://orcid.org/0000-0002-9183-9631"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210105400","display_name":"The First People's Hospital of Changzhou","ror":"https://ror.org/01gaj0s81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Shi","raw_affiliation_strings":["The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210105400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161252898","display_name":"Muni Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muni Hu","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134996235","display_name":"Rui Ling","orcid":"https://orcid.org/0009-0002-5650-899X","observed_orcids":["https://orcid.org/0009-0002-5650-899X"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Ling","raw_affiliation_strings":["Nanjing Medical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0009-0002-5650-899X","affiliations":[{"raw_affiliation_string":"Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134979221","display_name":"Yuning Wu","orcid":"https://orcid.org/0009-0007-0876-3933","observed_orcids":["https://orcid.org/0009-0007-0876-3933"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuning Wu","raw_affiliation_strings":["Nanjing Medical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0009-0007-0876-3933","affiliations":[{"raw_affiliation_string":"Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060121252","display_name":"Hanjue Dai","orcid":"https://orcid.org/0000-0001-8597-6763","observed_orcids":["https://orcid.org/0000-0001-8597-6763"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanjue Dai","raw_affiliation_strings":["Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-8597-6763","affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088923961","display_name":"Feifei Wei","orcid":"https://orcid.org/0000-0001-6048-8894","observed_orcids":["https://orcid.org/0000-0001-6048-8894"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiying Yan","raw_affiliation_strings":["Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-6048-8894","affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075084209","display_name":"Qingying Xian","orcid":"https://orcid.org/0000-0001-9836-6163","observed_orcids":["https://orcid.org/0000-0001-9836-6163"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingying Xian","raw_affiliation_strings":["Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-9836-6163","affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161251104","display_name":"Haoyan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyan Chen","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104071697","display_name":"Hua Jiang","orcid":"https://orcid.org/0000-0002-7871-4818","observed_orcids":["https://orcid.org/0000-0002-7871-4818"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua Jiang","raw_affiliation_strings":["Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China. Electronic address: czeyjh@njmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-7871-4818","affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China. Electronic address: czeyjh@njmu.edu.cn","institution_ids":["https://openalex.org/I4210151861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108950479","display_name":"Wenyu Zhu","orcid":"https://orcid.org/0009-0001-3016-2559","observed_orcids":["https://orcid.org/0009-0001-3016-2559","https://orcid.org/0009-0001-1981-0906","https://orcid.org/0000-0002-2292-9553"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenyu Zhu","raw_affiliation_strings":["Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China. Electronic address: wenyu.zhu@njmu.edu.cn"],"raw_orcid":"https://orcid.org/0009-0001-1981-0906","affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China. Electronic address: wenyu.zhu@njmu.edu.cn","institution_ids":["https://openalex.org/I4210151861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5104071697","https://openalex.org/A5108950479"],"corresponding_institution_ids":["https://openalex.org/I4210151861"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":null,"first_page":"103106","last_page":"103106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.14720000326633453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7649999856948853},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.949999988079071},{"id":"https://openalex.org/keywords/blautia","display_name":"Blautia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/faecalibacterium","display_name":"Faecalibacterium","score":1.0},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.906000018119812},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.6769999861717224},{"id":"https://openalex.org/keywords/microbiota-diversity","display_name":"microbiome diversity","score":0.39800000190734863},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.840399980545044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6990000009536743},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.628000020980835},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.588699996471405},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.5817999839782715},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5295000076293945},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4884999990463257},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.462799996137619},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.39640000462532043},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39640000462532043},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.3582000136375427},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34689998626708984},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.3010999858379364},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tranon.2026.103106","doi":"https://doi.org/10.1016/j.tranon.2026.103106","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2026.103106","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523326004420/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},{"id":"pmid:42998537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42998537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:240df60118f44b679de970dbd2e4f705","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/240df60118f44b679de970dbd2e4f705","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Oncology, Vol 75, Iss , Pp 103106- (2027)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.tranon.2026.103106","doi":"https://doi.org/10.1016/j.tranon.2026.103106","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2026.103106","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523326004420/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1448417398","display_name":null,"funder_award_id":"82472886","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324176","display_name":"Changzhou Science and Technology Bureau","ror":"https://ror.org/00wgk5w17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225460932.pdf","grobid_xml":"https://content.openalex.org/works/W7225460932.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2563720483","https://openalex.org/W3111836013","https://openalex.org/W3126208996","https://openalex.org/W3171517418","https://openalex.org/W3215130312","https://openalex.org/W4200204256","https://openalex.org/W4213455992","https://openalex.org/W4324309747","https://openalex.org/W4386020321","https://openalex.org/W4387299443","https://openalex.org/W4388288933","https://openalex.org/W4388656357","https://openalex.org/W4389326921","https://openalex.org/W4391056041","https://openalex.org/W4391407963","https://openalex.org/W4394853505","https://openalex.org/W4394935641","https://openalex.org/W4400126503","https://openalex.org/W4400977720","https://openalex.org/W4401611324","https://openalex.org/W4401715267","https://openalex.org/W4404061126","https://openalex.org/W4406706810","https://openalex.org/W4409898680","https://openalex.org/W4412940298","https://openalex.org/W4415692485","https://openalex.org/W7133331386","https://openalex.org/W7162328794"],"related_works":["https://openalex.org/W4400408104","https://openalex.org/W4379284526","https://openalex.org/W4416087822","https://openalex.org/W4383341159","https://openalex.org/W4389393813","https://openalex.org/W4401327146","https://openalex.org/W7140119093","https://openalex.org/W4234293551","https://openalex.org/W3111836013","https://openalex.org/W4281665305"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chemotherapy":[1],"combined":[2,204],"with":[3,20,34,176,205,236],"programmed":[4],"cell":[5],"death":[6],"protein-1":[7],"(PD-1)":[8],"antibody":[9],"immunotherapy":[10,39,80,206],"has":[11],"become":[12],"the":[13,98,183,229,237],"standard":[14],"first-line":[15,35,68,208],"treatment":[16],"for":[17,116,211],"most":[18],"patients":[19,62,153,160],"malignant":[21],"solid":[22,212],"tumors.":[23],"However,":[24],"data":[25],"from":[26],"multiple":[27],"phase":[28,53,100],"III":[29],"trials":[30],"indicate":[31],"that":[32,193],"even":[33],"induction":[36],"followed":[37],"by":[38],"maintenance,":[40],"median":[41,131,136],"progression-free":[42,155],"survival":[43],"(PFS)":[44],"remains":[45],"less":[46],"than":[47],"one":[48],"year.":[49],"METHODS:":[50],"In":[51],"this":[52],"I":[54],"dose-escalation":[55],"trial":[56],"(3":[57],"+":[58,88,180],"3":[59],"design),":[60],"12":[61],"who":[63],"completed":[64],"six":[65],"cycles":[66],"of":[67,133,172],"chemoimmunotherapy":[69],"received":[70],"oral":[71],"fecal":[72],"microbiota":[73],"transplantation":[74],"(FMT)":[75],"capsules":[76],"plus":[77],"anti-PD-1":[78],"maintenance":[79,209],"at":[81],"escalating":[82],"dose":[83,102,177],"levels":[84,197],"(i":[85],"to":[86],"i":[87,179],"3).":[89],"The":[90],"primary":[91],"endpoint":[92],"was":[93,138,146,214,234],"safety;":[94],"secondary":[95],"endpoints":[96],"included":[97],"recommended":[99],"II":[101],"(RP2D),":[103],"PFS,":[104],"and":[105,111,119,174,187,216,223],"disease":[106],"control":[107],"rate":[108],"(DCR).":[109],"Fecal":[110],"blood":[112],"samples":[113],"were":[114],"collected":[115],"exploratory":[117],"microbiome":[118],"metabolomic":[120],"analyses.":[121],"RESULTS:":[122],"No":[123],"grade":[124,163],"\u22653":[125],"FMT-related":[126],"toxicities":[127],"occurred.":[128],"With":[129],"a":[130],"follow-up":[132],"36.9":[134],"months,":[135],"PFS":[137,145],"19.8":[139],"months":[140,148],"(95%":[141,149],"CI":[142,150],"11.2-28.4);":[143],"maintenance-phase":[144],"11.7":[147],"4.1-19.3).":[151],"4":[152],"remained":[154],"on":[156],"continued":[157],"immunotherapy.":[158],"Four":[159],"(33.3%)":[161],"experienced":[162],"1-2":[164],"gastrointestinal":[165],"events.":[166],"Microbiomic":[167],"analyses":[168],"showed":[169,192,219],"post-FMT":[170],"expansion":[171],"Blautia":[173],"Faecalibacterium,":[175],"level":[178],"1":[181],"demonstrating":[182],"greatest":[184],"\u03b1-diversity":[185],"shift":[186],"engraftment":[188],"rate.":[189],"Metabolomic":[190],"analysis":[191],"serum":[194],"arachidonic":[195],"acid":[196],"increased":[198],"after":[199],"FMT.":[200],"CONCLUSION:":[201],"Oral":[202],"FMT":[203],"as":[207],"therapy":[210],"tumors":[213],"safe":[215],"well":[217],"tolerated,":[218],"promising":[220],"preliminary":[221],"efficacy,":[222],"induced":[224],"favorable":[225],"compositional":[226],"changes":[227],"in":[228],"gut":[230],"microbiota.":[231],"This":[232],"study":[233],"registered":[235],"Chinese":[238],"Clinical":[239],"Trial":[240],"Registry":[241],"(Registration":[242],"No.:":[243],"ChiCTR2100054928).":[244]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-08T00:00:00"}