{"id":"https://openalex.org/W7225460717","doi":"https://doi.org/10.1186/s12885-026-17285-4","title":"Clinical efficacy of TACE combined with camrelizumab and apatinib in the treatment of elderly patients with intermediate-advanced hepatocellular carcinoma","display_name":"Clinical efficacy of TACE combined with camrelizumab and apatinib in the treatment of elderly patients with intermediate-advanced hepatocellular carcinoma","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225460717","doi":"https://doi.org/10.1186/s12885-026-17285-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-026-17285-4","doi":"https://doi.org/10.1186/s12885-026-17285-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-17285-4","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12885-026-17285-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024365048","display_name":"Qingkuang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingkuang Chen","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404331","display_name":"Shu Li","orcid":"https://orcid.org/0000-0003-0183-5459","observed_orcids":["https://orcid.org/0000-0003-0183-5459"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqin Li","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064567140","display_name":"Huasheng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huasheng Wu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161228895","display_name":"Shaonuan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaonuan Wu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161255855","display_name":"Peng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhao","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Sanming First Hospital Affiliated to Fujian Medical University\uffffDepartment of Rehabilitation Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Fujian, 365000, China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024365048"],"corresponding_institution_ids":["https://openalex.org/I129708740"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8420000076293945},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9580000042915344},{"id":"https://openalex.org/keywords/camrelizumab","display_name":"camrelizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apatinib","display_name":"apatinib","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6729999780654907},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7110000252723694},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.7590000033378601},{"id":"https://openalex.org/keywords/afp","display_name":"AFP","score":0.550000011920929},{"id":"https://openalex.org/keywords/hsp90alpha","display_name":"HSP90\u03b1","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9438999891281128},{"id":"https://openalex.org/C2780668389","wikidata":"https://www.wikidata.org/wiki/Q27262801","display_name":"Apatinib","level":3,"score":0.9229000210762024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7674000263214111},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7123000025749207},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.6205999851226807},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.5954999923706055},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5701000094413757},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5389999747276306},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.48649999499320984},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4528999924659729},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.421099990606308},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4185999929904938},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3917999863624573},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.3783000111579895},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.3783000111579895},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.364300012588501},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3059999942779541},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12885-026-17285-4","doi":"https://doi.org/10.1186/s12885-026-17285-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-17285-4","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12885-026-17285-4","doi":"https://doi.org/10.1186/s12885-026-17285-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-17285-4","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411991537","https://openalex.org/W3090436976","https://openalex.org/W2002048765","https://openalex.org/W4220945114","https://openalex.org/W2129214773","https://openalex.org/W4382181896","https://openalex.org/W2998348518","https://openalex.org/W2077141175","https://openalex.org/W2075693302","https://openalex.org/W2045598632"],"abstract_inverted_index":{"Transarterial":[0],"chemoembolization":[1],"(TACE)":[2],"combined":[3,39],"with":[4,40,47,59,149,284,296,304],"targeted":[5],"therapy":[6],"and":[7,35,42,66,84,120,140,162,179,182,238,242,250,290,317,321],"immunotherapy":[8],"has":[9],"emerged":[10],"as":[11],"a":[12,85,305],"promising":[13],"strategy":[14],"for":[15],"hepatocellular":[16],"carcinoma":[17],"(HCC).":[18],"However,":[19],"evidence":[20],"specific":[21],"to":[22,278],"elderly":[23,45,57,294],"patients":[24,46,58,295],"(\u2265":[25],"60":[26],"years)":[27],"remains":[28],"limited.":[29],"This":[30],"study":[31],"evaluated":[32],"the":[33,150,187,195,214,274,301,314],"efficacy":[34],"safety":[36,307],"of":[37,256,276],"TACE":[38,279],"camrelizumab":[41,78,277],"apatinib":[43,281],"in":[44,194,232,246,293,324],"intermediate-advanced":[48,60,297],"HCC.":[49],"A":[50],"retrospective":[51,315],"analysis":[52],"was":[53,218,259,282],"conducted":[54],"on":[55],"100":[56],"HCC":[61,298],"treated":[62],"between":[63,125,220,261],"June":[64,67],"2021":[65],"2024.":[68],"Patients":[69],"were":[70,123,172,190],"divided":[71],"into":[72],"an":[73],"observation":[74,128,196,226],"group":[75,87,129,197,227],"(TACE":[76,88],"+":[77,79,89,234,240],"apatinib,":[80,90],"n":[81,91],"=":[82,92,138,146,267],"50)":[83,93],"control":[86,106,151],"using":[94],"propensity":[95],"score":[96],"matching":[97],"(1:1,":[98],"caliper":[99],"0.02).":[100],"Objective":[101],"response":[102],"rate":[103,107,217],"(ORR),":[104],"disease":[105],"(DCR),":[108],"progression-free":[109],"survival":[110,113,291],"(PFS),":[111],"overall":[112,254],"(OS),":[114],"immune":[115,288],"function":[116],"markers,":[117,119],"tumor":[118],"adverse":[121,257],"events":[122,258],"compared":[124,148],"groups.":[126],"The":[127,177,225,253],"demonstrated":[130],"significantly":[131,173],"higher":[132,193],"ORR":[133],"(56.0%":[134],"vs.":[135,143,156,166,201,206,211,223,264],"32.0%,":[136],"P":[137,145,159,169,266],"0.016)":[139],"DCR":[141],"(86.0%":[142],"68.0%,":[144],"0.033)":[147],"group.":[152],"Median":[153],"PFS":[154,181],"(11.5":[155],"5.9":[157],"months,":[158,168],"<":[160,170],"0.001)":[161,171],"median":[163],"OS":[164,183,216],"(15.6":[165],"11.6":[167],"prolonged":[174],"(log-rank":[175],"test).":[176],"6-":[178],"12-month":[180,203,208],"rates":[184],"estimated":[185],"from":[186],"Kaplan\u2013Meier":[188],"curves":[189],"also":[191,228],"markedly":[192],"(6-month":[198],"PFS:":[199,204],"89.5%":[200],"46.1%;":[202],"45.9%":[205],"15.2%;":[207],"OS:":[209],"70.6%":[210],"44.8%),":[212],"whereas":[213],"6-month":[215],"comparable":[219,260],"groups":[221,262],"(98.0%":[222],"94.0%).":[224],"showed":[229],"greater":[230],"improvements":[231],"CD4":[233],"T":[235],"cell":[236],"proportion":[237],"CD4+/CD8":[239],"ratio,":[241],"more":[243],"pronounced":[244],"reductions":[245],"serum":[247],"AFP,":[248],"HSP90\u03b1,":[249],"CEA":[251],"levels.":[252],"incidence":[255],"(34.0%":[263],"26.0%,":[265],"0.382).":[268],"In":[269],"this":[270],"retrospective,":[271],"single-center":[272],"study,":[273],"addition":[275],"plus":[280],"associated":[283],"improved":[285],"treatment":[286],"response,":[287],"function,":[289],"outcomes":[292],"who":[299],"met":[300],"inclusion":[302],"criteria,":[303],"manageable":[306],"profile.":[308],"These":[309],"findings":[310],"are":[311],"limited":[312],"by":[313],"design":[316],"modest":[318],"sample":[319],"size,":[320],"require":[322],"confirmation":[323],"prospective":[325],"multicenter":[326],"studies.":[327]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}