{"id":"https://openalex.org/W7225460264","doi":"https://doi.org/10.5281/zenodo.24040559","title":"The Architecture of the Observer: A Unified Physical Resolution of the Quantum Measurement Problem and the Missing Subject in Neuroscience","display_name":"The Architecture of the Observer: A Unified Physical Resolution of the Quantum Measurement Problem and the Missing Subject in Neuroscience","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225460264","doi":"https://doi.org/10.5281/zenodo.24040559"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24040559","doi":"https://doi.org/10.5281/zenodo.24040559","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24040559","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24040559","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161196394","display_name":"D. B. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mitchell, D. B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161196394"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10622","display_name":"Quantum Mechanics and Applications","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10622","display_name":"Quantum Mechanics and Applications","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10258","display_name":"Philosophy and Theoretical Science","score":0.3142000138759613,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy of Biology and Scientific Explanation","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantum-measurement-problem","display_name":"measurement problem","score":0.9710000157356262},{"id":"https://openalex.org/keywords/observer-problem","display_name":"observer problem","score":0.6890000104904175},{"id":"https://openalex.org/keywords/major-vault-protein","display_name":"major vault protein","score":0.8420000076293945},{"id":"https://openalex.org/keywords/free-energy-principle","display_name":"free energy principle","score":0.7739999890327454},{"id":"https://openalex.org/keywords/landauer-cost","display_name":"Landauer cost","score":0.8100000023841858},{"id":"https://openalex.org/keywords/time-reversal-symmetry","display_name":"time-reversal symmetry","score":0.6990000009536743},{"id":"https://openalex.org/keywords/acoustic-holography","display_name":"acoustic holography","score":0.7910000085830688},{"id":"https://openalex.org/keywords/consciousness","display_name":"consciousness","score":0.3840000033378601},{"id":"https://openalex.org/keywords/eliminative-materialism","display_name":"eliminativism","score":0.5419999957084656},{"id":"https://openalex.org/keywords/parp4","display_name":"PARP4","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nicotinamide-adenine-dinucleotide","display_name":"NAD+","score":0.6140000224113464},{"id":"https://openalex.org/keywords/phenomenal-field","display_name":"phenomenal field","score":0.375}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5683000087738037},{"id":"https://openalex.org/C80469333","wikidata":"https://www.wikidata.org/wiki/Q189088","display_name":"Von Neumann architecture","level":2,"score":0.49390000104904175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46160000562667847},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.45249998569488525},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3971000015735626},{"id":"https://openalex.org/C166689943","wikidata":"https://www.wikidata.org/wiki/Q850283","display_name":"Interferometry","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C173523689","wikidata":"https://www.wikidata.org/wiki/Q215589","display_name":"Dipole","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C183992945","wikidata":"https://www.wikidata.org/wiki/Q2495574","display_name":"Universality (dynamical systems)","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.32499998807907104},{"id":"https://openalex.org/C2780704645","wikidata":"https://www.wikidata.org/wiki/Q9251458","display_name":"Observer (physics)","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32089999318122864},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C116672817","wikidata":"https://www.wikidata.org/wiki/Q1454986","display_name":"Physical system","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.303600013256073},{"id":"https://openalex.org/C33332235","wikidata":"https://www.wikidata.org/wiki/Q18362","display_name":"Theoretical physics","level":1,"score":0.30230000615119934},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2780344732","wikidata":"https://www.wikidata.org/wiki/Q189771","display_name":"Vault (architecture)","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C182310444","wikidata":"https://www.wikidata.org/wiki/Q1332643","display_name":"Boundary value problem","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C177731217","wikidata":"https://www.wikidata.org/wiki/Q2622244","display_name":"Mesoscopic physics","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C179768478","wikidata":"https://www.wikidata.org/wiki/Q1120057","display_name":"Cyber-physical system","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C121040770","wikidata":"https://www.wikidata.org/wiki/Q215675","display_name":"Quantum entanglement","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C23576306","wikidata":"https://www.wikidata.org/wiki/Q17004698","display_name":"Astronomical interferometer","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24040559","doi":"https://doi.org/10.5281/zenodo.24040559","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24040559","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.24040560","doi":"https://doi.org/10.5281/zenodo.24040560","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24040560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24040559","doi":"https://doi.org/10.5281/zenodo.24040559","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24040559","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W147959756","https://openalex.org/W7133702676","https://openalex.org/W109691131","https://openalex.org/W7151100355","https://openalex.org/W7147025859","https://openalex.org/W314178381","https://openalex.org/W7201995369","https://openalex.org/W2717684278","https://openalex.org/W7164745618","https://openalex.org/W3089096860"],"abstract_inverted_index":{"The":[0],"foundational":[1],"crises":[2],"of":[3,20,42,252],"modern":[4],"physics":[5],"and":[6,73,91,119,166,180,199],"cognitive":[7],"neuroscience":[8,38],"originate":[9],"from":[10,204],"the":[11,17,21,32,40,56,60,66,103,109,115,138,154,164,169,176,181,186,192,197,205,209,249,253,260,263],"exact":[12],"same":[13],"unsolved":[14],"physical":[15,18,62,99,250,264],"problem:":[16],"definition":[19],"observer.":[22],"Quantum":[23],"mechanics":[24],"requires":[25],"an":[26,49],"irreversible":[27],"measurement":[28,145],"apparatus":[29],"to":[30,195,208,230,258],"terminate":[31,196],"von":[33,143],"Neumann":[34,144],"chain,":[35],"while":[36,108],"standard":[37],"denies":[39],"existence":[41],"a":[43,69,74,98,120,127,141,215,237,241,267],"central":[44],"observer":[45],"entirely,":[46],"resulting":[47],"in":[48,218],"eliminativist":[50],"paradox.":[51],"Here,":[52],"we":[53,213,246],"propose":[54],"that":[55,131,190,245],"cellular":[57],"vault":[58,67,139,148,171],"supplies":[59],"missing":[61],"apparatus.":[63],"We":[64],"model":[65],"as":[68,114,126,153,175,185,266],"dipolar":[70],"geometric":[71,161],"interferometer":[72],"nanoscale":[75],"spinning-disk":[76],"confocal":[77,128],"microscope.":[78],"Its":[79],"bilateral":[80],"architecture":[81,217],"establishes":[82],"opposing":[83],"boundary":[84],"conditions:":[85],"Cap":[86,92],"A":[87],"(the":[88,94],"Genetic":[89],"Pole)":[90,96],"B":[93],"Sensory":[95],"generate":[97],"interference":[100],"pattern":[101],"across":[102],"70":[104],"nm":[105],"barrel":[106],"cavity,":[107],"internal":[110],"TEP1":[111],"protein":[112,172],"acts":[113],"system's":[116],"firmware":[117],"(BIOS)":[118],"proposed":[121],"eight-fold":[122],"apical":[123],"aperture":[124],"serves":[125,152,184],"spatial":[129],"pinhole":[130],"rejects":[132],"thermodynamic":[133,270],"noise.":[134],"Within":[135],"this":[136],"architecture,":[137],"implements":[140],"three-step":[142],"chain:":[146],"dynamic":[147],"RNA":[149],"(vRNA)":[150],"geometry":[151],"superposed":[155],"state,":[156,179],"Free":[157],"Energy":[158],"Principle":[159],"(FEP)-driven":[160],"relaxation":[162],"selects":[163],"outcome":[165],"acoustically":[167],"rings":[168],"major":[170],"(MVP)":[173],"shell":[174],"mechanical":[177],"pointer":[178],"PARP4":[182],"enzyme":[183],"irreversible,":[187],"NAD\u207a-dependent":[188],"write-head":[189],"pays":[191],"Landauer":[193],"cost":[194],"chain":[198],"break":[200],"time-reversal":[201],"symmetry.":[202],"Scaling":[203],"single":[206],"cell":[207],"macroscopic":[210],"neural":[211],"network,":[212],"delineate":[214],"binding":[216],"which":[219],"cytoelectric":[220],"phase-locking":[221],"synchronizes":[222],"local":[223],"acoustic":[224,228],"phonon":[225],"fields":[226],"(phase-locked":[227],"holography)":[229],"integrate":[231],"these":[232],"discrete":[233],"micro-measurements,":[234],"each":[235],"carrying":[236],"proto-phenomenal":[238],"micro-quale,":[239],"into":[240],"continuous":[242],"phenomenal":[243],"field":[244],"identify":[247],"with":[248],"state":[251],"subject.":[254],"This":[255],"framework":[256],"proposes":[257],"reinstate":[259],"subject":[261],"within":[262],"universe":[265],"mathematically":[268],"tractable":[269],"mechanism.":[271]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}