{"id":"https://openalex.org/W7225459674","doi":"https://doi.org/10.1016/j.lddd.2026.100662","title":"An endoplasmic reticulum stress-related four-gene tissue diagnostic signature associated with endometriosis and the immune microenvironment","display_name":"An endoplasmic reticulum stress-related four-gene tissue diagnostic signature associated with endometriosis and the immune microenvironment","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225459674","doi":"https://doi.org/10.1016/j.lddd.2026.100662"},"language":"en","primary_location":{"id":"doi:10.1016/j.lddd.2026.100662","doi":"https://doi.org/10.1016/j.lddd.2026.100662","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lddd.2026.100662","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design &amp; Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.lddd.2026.100662","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161229828","display_name":"Yiwen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081569566","display_name":"Yanbo Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbo Zhong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161228641","display_name":"Xiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161162525","display_name":"Ling Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Xu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161162525"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"100662","last_page":"100662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-microenvironment","display_name":"immune microenvironment","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pdia4","display_name":"PDIA4","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ip3r1","display_name":"IP3R1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7210000157356262},{"id":"https://openalex.org/keywords/immune-cell-abundance","display_name":"immune cell abundance","score":0.6259999871253967},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.7129999995231628},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/endometrial-lesions","display_name":"endometrial lesions","score":0.628000020980835},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6669999957084656},{"id":"https://openalex.org/keywords/gene-signature-validation","display_name":"gene signature validation","score":0.36500000953674316},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7182999849319458},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6234999895095825},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.51419997215271},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.49900001287460327},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.4781000018119812},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41999998688697815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4180999994277954},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.3928999900817871},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3921000063419342},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38370001316070557},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35280001163482666},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3077999949455261},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29330000281333923},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.2867000102996826},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26980000734329224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2639000117778778},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2621999979019165},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.25859999656677246},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.lddd.2026.100662","doi":"https://doi.org/10.1016/j.lddd.2026.100662","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lddd.2026.100662","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design &amp; Discovery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.lddd.2026.100662","doi":"https://doi.org/10.1016/j.lddd.2026.100662","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lddd.2026.100662","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design &amp; Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1985987855","https://openalex.org/W1991686022","https://openalex.org/W2006617902","https://openalex.org/W2010457001","https://openalex.org/W2011696346","https://openalex.org/W2035618305","https://openalex.org/W2056660087","https://openalex.org/W2100239923","https://openalex.org/W2118258530","https://openalex.org/W2120864426","https://openalex.org/W2130410032","https://openalex.org/W2146512944","https://openalex.org/W2158134092","https://openalex.org/W2159707944","https://openalex.org/W2169353806","https://openalex.org/W2474747771","https://openalex.org/W2767419625","https://openalex.org/W2890840903","https://openalex.org/W2900044275","https://openalex.org/W2921269376","https://openalex.org/W2949273159","https://openalex.org/W2969705573","https://openalex.org/W3035957926","https://openalex.org/W3194699388","https://openalex.org/W4294216483","https://openalex.org/W4306945746","https://openalex.org/W4317934433","https://openalex.org/W4395462802","https://openalex.org/W4398763602","https://openalex.org/W4400659227","https://openalex.org/W4400966150","https://openalex.org/W4404122228","https://openalex.org/W4408139159","https://openalex.org/W4409035483","https://openalex.org/W4410409352","https://openalex.org/W4411987170","https://openalex.org/W4414838952","https://openalex.org/W4415240259","https://openalex.org/W7135170277","https://openalex.org/W7153088882"],"related_works":["https://openalex.org/W4393155013","https://openalex.org/W4410409352","https://openalex.org/W4415883156","https://openalex.org/W4403471619","https://openalex.org/W4387939928","https://openalex.org/W4405927378","https://openalex.org/W4384497181","https://openalex.org/W4408238880","https://openalex.org/W4390585204","https://openalex.org/W4310989073"],"abstract_inverted_index":{"Background":[0],"Endoplasmic":[1],"reticulum":[2],"stress":[3],"(ERS)":[4],"has":[5],"been":[6],"implicated":[7],"in":[8,112,174,242,254,302,320,324],"endometrial":[9],"lesion":[10],"progression":[11],"and":[12,33,37,64,87,95,108,128,156,164,180,190,207,264,305,313,328],"immune":[13,318],"microenvironment":[14],"remodeling,":[15],"yet":[16],"ERS-related":[17,83,170],"molecular":[18],"signatures":[19],"for":[20,42],"endometriosis":[21],"(EM)":[22],"diagnosis":[23],"remain":[24],"poorly":[25],"defined.":[26],"Methods":[27],"Three":[28],"GEO":[29],"datasets":[30],"(GSE11691,":[31],"GSE7305,":[32],"GSE120103)":[34],"were":[35,51,91,98,158,172],"batch-corrected":[36],"integrated;":[38],"GSE25628":[39,243],"was":[40,118,136,202,215,314],"reserved":[41],"external":[43,256,311],"dataset-level":[44],"assessment.":[45],"The":[46,132,236],"resulting":[47],"74":[48],"tissue":[49,330],"samples":[50,331],"divided":[52],"at":[53],"the":[54,113,140,193,197,200,208,220,224,248,259,275,303],"patient":[55],"level":[56],"into":[57],"a":[58],"training":[59,114,134,198,304],"set":[60,68,143,227],"(N":[61,69],"=":[62,70],"57)":[63],"an":[65,229],"internal":[66,141,225,306],"validation":[67,142,226,307,323],"17).":[71],"Of":[72],"972":[73],"differentially":[74],"expressed":[75],"genes":[76,186,250],"(DEGs),":[77],"47":[78],"overlapped":[79],"with":[80,281,290,316],"357":[81],"unique":[82],"genes.":[84],"GO,":[85],"KEGG,":[86],"GSEA":[88],"enrichment":[89],"analyses":[90],"performed.":[92],"Random":[93],"forest":[94],"LASSO":[96],"regression":[97,111],"used":[99,159],"to":[100,139,160,223],"screen":[101],"candidate":[102],"genes,":[103],"followed":[104],"by":[105],"VIF":[106],"assessment":[107],"multivariable":[109],"logistic":[110],"set.":[115],"Model":[116],"performance":[117],"evaluated":[119,152],"using":[120],"ROC":[121],"analysis,":[122,127,261],"apparent":[123],"calibration,":[124],"decision":[125],"curve":[126],"bootstrap":[129,213],"optimism":[130],"correction.":[131],"fixed":[133,221,237],"model":[135,222,238],"directly":[137],"applied":[138],"without":[144],"re-estimating":[145],"its":[146],"coefficients.":[147],"A":[148],"GSE120103-only":[149,260],"sensitivity":[150],"analysis":[151],"differential-expression":[153],"consistency.":[154],"ssGSEA":[155],"CIBERSORT":[157],"estimate":[161],"immune-cell":[162],"abundance":[163],"assess":[165],"gene\u2013immune":[166],"correlations.":[167],"Results":[168],"Forty-seven":[169],"DEGs":[171],"enriched":[173],"ER":[175],"protein":[176],"processing,":[177],"apoptosis,":[178],"TNF,":[179],"IL-17":[181],"signaling":[182],"pathways.":[183],"Four":[184],"core":[185],"(PDIA4,":[187],"ITPR1,":[188,263],"CCL2,":[189],"PTGS2)":[191],"constituted":[192],"final":[194],"signature.":[195],"In":[196,258],"set,":[199],"AUC":[201,210,230],"0.985":[203],"(95%":[204,233],"CI:":[205,234],"0.955\u20131.000),":[206],"optimism-corrected":[209],"after":[211],"1000":[212],"resamples":[214],"0.966.":[216],"Direct":[217],"application":[218],"of":[219,231],"yielded":[228],"0.914":[232],"0.777\u20131.000).":[235],"showed":[239,251,299],"limited":[240,310],"discrimination":[241,253,301],"(AUC":[244],"<":[245],"0.6),":[246],"whereas":[247,270,286],"individual":[249],"low-to-moderate":[252],"this":[255],"dataset.":[257],"PDIA4,":[262],"PTGS2":[265],"retained":[266],"significant":[267],"differential":[268],"expression,":[269],"CCL2":[271,278],"did":[272],"not":[273],"meet":[274],"prespecified":[276],"threshold.":[277],"correlated":[279,288],"positively":[280],"inferred":[282,291],"M2":[283],"macrophage":[284],"abundance,":[285],"PDIA4":[287],"negatively":[289],"mast-cell":[292],"abundance.":[293],"Conclusion":[294],"This":[295],"ERS-based":[296],"four-gene":[297],"signature":[298],"preliminary":[300],"sets":[308],"but":[309],"transferability":[312],"associated":[315],"altered":[317],"infiltration":[319],"EM.":[321],"Further":[322],"larger":[325],"independent":[326],"cohorts":[327],"clinical":[329],"is":[332],"required.":[333]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}