{"id":"https://openalex.org/W7225458380","doi":"https://doi.org/10.1093/cvr/cvag272","title":"Colchicine in chronic coronary artery disease: effects on vascular glucose uptake, inflammation, remodeling and blood pressure","display_name":"Colchicine in chronic coronary artery disease: effects on vascular glucose uptake, inflammation, remodeling and blood pressure","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225458380","doi":"https://doi.org/10.1093/cvr/cvag272","pmid":"https://pubmed.ncbi.nlm.nih.gov/42995452"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvag272","doi":"https://doi.org/10.1093/cvr/cvag272","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvag272","pdf_url":"https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvag272/73269031/cvag272.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvag272/73269031/cvag272.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083941657","display_name":"Samuel N. Baldwin","orcid":"https://orcid.org/0000-0002-3796-6090","observed_orcids":["https://orcid.org/0000-0002-3796-6090"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Samuel N Baldwin","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000621638","display_name":"Joakim Bastrup","orcid":"https://orcid.org/0000-0002-4292-5234","observed_orcids":["https://orcid.org/0000-0002-4292-5234"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Joakim A Bastrup","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074669572","display_name":"Valtteri Muroke","orcid":"https://orcid.org/0000-0003-0972-3873","observed_orcids":["https://orcid.org/0000-0003-0972-3873"]},"institutions":[{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Valtteri Muroke","raw_affiliation_strings":["Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0"],"raw_orcid":"https://orcid.org/0000-0003-0972-3873","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0","institution_ids":["https://openalex.org/I2800290161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057704732","display_name":"Jennifer van der Horst","orcid":"https://orcid.org/0000-0002-0167-8943","observed_orcids":["https://orcid.org/0000-0002-0167-8943"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jennifer van der Horst","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161238483","display_name":"\u00c9mile Rainville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"\u00c9mile Rainville","raw_affiliation_strings":["Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0","institution_ids":["https://openalex.org/I2800290161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002054287","display_name":"Magdalena Dubik","orcid":"https://orcid.org/0000-0002-4521-0410","observed_orcids":["https://orcid.org/0000-0002-4521-0410"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Magdalena Dubik","raw_affiliation_strings":["Department of Molecular Medicine, University of Southern Denmark , Odense ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Southern Denmark , Odense ,","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102115188","display_name":"Fran\u00e7ois Harel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Harel","raw_affiliation_strings":["Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0","institution_ids":["https://openalex.org/I2800290161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111825662","display_name":"Mari\u00e8ve Cossette","orcid":"https://orcid.org/0009-0001-1099-5502","observed_orcids":["https://orcid.org/0009-0001-1099-5502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mari\u00e8ve Cossette","raw_affiliation_strings":["Seriant , Montreal, Qu\u00e9bec ,"],"raw_orcid":"https://orcid.org/0009-0001-1099-5502","affiliations":[{"raw_affiliation_string":"Seriant , Montreal, Qu\u00e9bec ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010913589","display_name":"Marie\u2010Claude Guertin","orcid":"https://orcid.org/0000-0001-8523-5148","observed_orcids":["https://orcid.org/0000-0001-8523-5148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Claude Guertin","raw_affiliation_strings":["Seriant , Montreal, Qu\u00e9bec ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seriant , Montreal, Qu\u00e9bec ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103217544","display_name":"Olga Kudryavtseva","orcid":"https://orcid.org/0000-0003-3945-0159","observed_orcids":["https://orcid.org/0000-0003-3945-0159"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Olga S Kudryavtseva","raw_affiliation_strings":["Department of Molecular Medicine, University of Southern Denmark , Odense ,"],"raw_orcid":"https://orcid.org/0000-0003-3945-0159","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Southern Denmark , Odense ,","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050841709","display_name":"Arnela Saljic","orcid":"https://orcid.org/0000-0001-8910-0902","observed_orcids":["https://orcid.org/0000-0001-8910-0902"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Arnela Saljic","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":"https://orcid.org/0000-0001-8910-0902","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076044078","display_name":"Salom\u00e9 Rognant","orcid":"https://orcid.org/0000-0003-3276-5887","observed_orcids":["https://orcid.org/0000-0003-3276-5887"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Salom\u00e9 Rognant","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":"https://orcid.org/0000-0003-3276-5887","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065815774","display_name":"Johs Dannesboe","orcid":"https://orcid.org/0009-0009-7628-1287","observed_orcids":["https://orcid.org/0009-0009-7628-1287"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Johs Dannesboe","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083853279","display_name":"Anthony M. Mozzicato","orcid":"https://orcid.org/0000-0001-6711-5177","observed_orcids":["https://orcid.org/0000-0001-6711-5177"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anthony M Mozzicato","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010560388","display_name":"\u00c9ric Rh\u00e9aume","orcid":"https://orcid.org/0000-0002-0554-0984","observed_orcids":["https://orcid.org/0000-0002-0554-0984"]},"institutions":[{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"\u00c9ric Rh\u00e9aume","raw_affiliation_strings":["Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0","institution_ids":["https://openalex.org/I2800290161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057929880","display_name":"Jesper Bonnet Moeller","orcid":"https://orcid.org/0000-0001-8786-8037","observed_orcids":["https://orcid.org/0000-0001-8786-8037"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper B Moeller","raw_affiliation_strings":["Danish Institute for Advanced Study, University of Southern Denmark , Odense ,","Department of Molecular Medicine, University of Southern Denmark , Odense ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Institute for Advanced Study, University of Southern Denmark , Odense ,","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Molecular Medicine, University of Southern Denmark , Odense ,","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007281962","display_name":"Morten B\u00e6kgaard Thomsen","orcid":"https://orcid.org/0000-0002-2469-6458","observed_orcids":["https://orcid.org/0000-0002-2469-6458"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten B Thomsen","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107930477","display_name":"Jean\u2010Claude Tardif","orcid":"https://orcid.org/0000-0002-8200-8983","observed_orcids":["https://orcid.org/0000-0002-8200-8983"]},"institutions":[{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jean-Claude Tardif","raw_affiliation_strings":["Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0"],"raw_orcid":"https://orcid.org/0000-0002-8200-8983","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, Qu\u00e9bec ,","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Montreal Heart Institute , Montreal, Qu\u00e9bec \u00a0","institution_ids":["https://openalex.org/I2800290161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083523440","display_name":"Thomas A. Jepps","orcid":"https://orcid.org/0000-0002-9903-714X","observed_orcids":["https://orcid.org/0000-0002-9903-714X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Thomas A Jepps","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen ,"],"raw_orcid":"https://orcid.org/0000-0002-9903-714X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen ,","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083523440","https://openalex.org/A5107930477"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2800290161","https://openalex.org/I70931966"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":{"value":4715,"currency":"EUR","value_usd":5329},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9210000038146973},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9639999866485596},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8309999704360962},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.7279999852180481},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mesenteric-resistance-arteries","display_name":"mesenteric resistance arteries","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9054999947547913},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7085000276565552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7064999938011169},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.619700014591217},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5694000124931335},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5389000177383423},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5192999839782715},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5149000287055969},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.42730000615119934},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.39430001378059387},{"id":"https://openalex.org/C2781064879","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Common carotid artery","level":3,"score":0.38580000400543213},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.30959999561309814},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.30059999227523804},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C99322962","wikidata":"https://www.wikidata.org/wiki/Q17165464","display_name":"Vascular remodelling in the embryo","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.2858000099658966},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C1918360","wikidata":"https://www.wikidata.org/wiki/Q5357720","display_name":"Electrical impedance myography","level":3,"score":0.2581999897956848}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/cvr/cvag272","doi":"https://doi.org/10.1093/cvr/cvag272","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvag272","pdf_url":"https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvag272/73269031/cvag272.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:42995452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42995452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/cvr/cvag272","doi":"https://doi.org/10.1093/cvr/cvag272","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvag272","pdf_url":"https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvag272/73269031/cvag272.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225458380.pdf","grobid_xml":"https://content.openalex.org/works/W7225458380.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7172408593"],"related_works":["https://openalex.org/W7214977536","https://openalex.org/W3082047744","https://openalex.org/W4401235977","https://openalex.org/W3195900169","https://openalex.org/W2908842777","https://openalex.org/W2279593075","https://openalex.org/W4210935507","https://openalex.org/W3081761942","https://openalex.org/W4285490994","https://openalex.org/W4282970377"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,71],"mechanisms":[2],"underlying":[3],"colchicine's":[4],"cardiovascular":[5],"benefits":[6],"in":[7,77,174,204,247,256,265],"patients":[8,30],"with":[9,31,117,144,171],"coronary":[10,33,298],"artery":[11,34],"disease":[12,35],"remain":[13],"unclear":[14],"and":[15,36,86,95,125,135,165,200,215,240,243,260,295],"warrant":[16],"further":[17,301],"translational":[18],"investigation.":[19,302],"METHODS":[20],"AND":[21],"RESULTS:":[22],"In":[23,163,225],"a":[24,105,172,184],"randomized,":[25],"double-blind,":[26],"placebo-controlled":[27],"trial,":[28],"111":[29],"chronic":[32],"aortic":[37,140],"or":[38,51],"carotid":[39],"target-to-background":[40,80],"ratio":[41,81,176],"\u22651.6":[42],"were":[43,263],"assigned":[44],"to":[45,122,153,160,297],"colchicine":[46,118,131,168,227,272,284],"0.6":[47],"mg":[48],"daily":[49],"(n=55)":[50],"placebo":[52,145],"(n=56)":[53],"for":[54,119],"24":[55,83],"weeks.":[56,84],"Arterial":[57],"inflammation":[58,242],"was":[59,74,115,169],"assessed":[60],"using":[61,132],"18F-fluorodeoxyglucose":[62],"positron":[63],"emission":[64],"tomography":[65],"(FDG-PET)":[66],"of":[67,91,101,202,238,283],"the":[68,75,102,110,232,236,269,278,292],"ascending":[69],"aorta.":[70],"primary":[72],"endpoint":[73],"change":[76,148,179,195,208],"mean":[78,147,178,193,207],"maximum":[79],"over":[82],"Secondary":[85],"exploratory":[87,166],"objectives":[88],"included":[89],"evaluation":[90],"systemic":[92],"inflammatory":[93,126],"markers":[94],"blood":[96,223],"pressure.":[97,224],"To":[98],"support":[99,277],"interpretation":[100],"clinical":[103],"findings,":[104],"complementary":[106],"hypertensive":[107,112],"rodent":[108],"model,":[109],"spontaneously":[111],"rat":[113],"(SHR),":[114],"treated":[116],"4":[120],"weeks":[121],"explore":[123],"vascular":[124,281],"pathways":[127,294],"potentially":[128],"influenced":[129],"by":[130],"immunohistochemistry,":[133],"myography":[134],"proteomics.Colchicine":[136],"did":[137],"not":[138],"reduce":[139],"FDG":[141],"uptake":[142],"compared":[143],"(adjusted":[146,177,191,206],"0.05":[149],"[95%":[150,157],"CI":[151,158],"-0.02":[152],"0.12]":[154],"vs":[155,181,197],"0.01":[156],"-0.06":[159],"0.08];":[161],"p=0.38).":[162],"secondary":[164],"analyses,":[167],"associated":[170],"reduction":[173],"neutrophil-to-lymphocyte":[175],"-0.36":[180],"-0.08;":[182],"p=0.033),":[183],"trend":[185],"toward":[186],"lower":[187],"high-sensitivity":[188],"C-reactive":[189],"protein":[190],"geometric":[192],"percentage":[194],"-28.2%":[196],"-5.8%;":[198],"p=0.060)":[199],"attenuation":[201],"increases":[203],"systolic":[205],"0.88":[209],"mmHg":[210,218],"vs.":[211,219],"4.94":[212],"mmHg;":[213,221],"p=0.046)":[214],"diastolic":[216],"(1.41":[217],"4.35":[220],"p=0.048)":[222],"SHRs,":[226],"had":[228],"no":[229],"effect":[230],"on":[231],"aorta":[233],"but":[234],"attenuated":[235],"progression":[237],"hypertension":[239],"reduced":[241],"extracellular":[244],"matrix":[245],"remodelling":[246],"mesenteric":[248,266],"resistance":[249],"arteries,":[250,290],"while":[251,291],"enhancing":[252],"vasodilator":[253],"responses.":[254],"Reductions":[255],"CXCL10,":[257],"CXCL2,":[258],"NLRP3":[259],"IL-18":[261],"expression":[262],"observed":[264],"arteries":[267],"from":[268],"SHR":[270],"following":[271],"treatment.":[273],"CONCLUSIONS:":[274],"These":[275],"findings":[276],"hypothesis":[279],"that":[280],"effects":[282],"likely":[285],"extend":[286],"beyond":[287],"large":[288],"conduit":[289],"specific":[293],"relevance":[296],"atherosclerosis":[299],"require":[300]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-08T00:00:00"}