{"id":"https://openalex.org/W7225458280","doi":"https://doi.org/10.1038/s42003-026-11293-7","title":"Allosteric network rewiring governs enzyme functional duality via a distal switch","display_name":"Allosteric network rewiring governs enzyme functional duality via a distal switch","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225458280","doi":"https://doi.org/10.1038/s42003-026-11293-7"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-026-11293-7","doi":"https://doi.org/10.1038/s42003-026-11293-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11293-7","pdf_url":"https://www.nature.com/articles/s42003-026-11293-7_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-026-11293-7_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001111098","display_name":"Yunju Zhang","orcid":"https://orcid.org/0000-0002-8258-0277","observed_orcids":["https://orcid.org/0000-0002-8258-0277"]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunju Zhang","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161254877","display_name":"Yongjun Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjun Cao","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161252623","display_name":"Wenjun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Zhao","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161186694","display_name":"Zhixin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixin Ma","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102863275","display_name":"Hongen Zhang","orcid":"https://orcid.org/0000-0001-6871-8463","observed_orcids":["https://orcid.org/0000-0001-6871-8463"]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongen Zhang","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161158396","display_name":"Yingnan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingnan Li","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161196578","display_name":"Tong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Zhang","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161160653","display_name":"Qinyuan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qinyuan Ma","raw_affiliation_strings":["Joint Institute of Synthetic Biology and Engineering Biotechnology, Shandong University of Technology and JINCHENG PHARMA, Zibo, China","School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Institute of Synthetic Biology and Engineering Biotechnology, Shandong University of Technology and JINCHENG PHARMA, Zibo, China","institution_ids":["https://openalex.org/I119203015"]},{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081600211","display_name":"Xiuzhen Gao","orcid":"https://orcid.org/0000-0002-9162-0509","observed_orcids":["https://orcid.org/0000-0002-9162-0509"]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuzhen Gao","raw_affiliation_strings":["School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China"],"raw_orcid":"https://orcid.org/0000-0002-9162-0509","affiliations":[{"raw_affiliation_string":"School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081600211","https://openalex.org/A5161160653"],"corresponding_institution_ids":["https://openalex.org/I119203015"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/symbiobacterium-thermophilum","display_name":"Symbiobacterium thermophilum","score":0.9739999771118164},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.48100000619888306},{"id":"https://openalex.org/keywords/enzyme-engineering","display_name":"enzyme engineering","score":0.44200000166893005},{"id":"https://openalex.org/keywords/active-site","display_name":"active site","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.63919997215271},{"id":"https://openalex.org/C2778023678","wikidata":"https://www.wikidata.org/wiki/Q554403","display_name":"Duality (order theory)","level":2,"score":0.5311999917030334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5281999707221985},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.350600004196167},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3386000096797943},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.31060001254081726},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2872999906539917},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42003-026-11293-7","doi":"https://doi.org/10.1038/s42003-026-11293-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11293-7","pdf_url":"https://www.nature.com/articles/s42003-026-11293-7_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s42003-026-11293-7","doi":"https://doi.org/10.1038/s42003-026-11293-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11293-7","pdf_url":"https://www.nature.com/articles/s42003-026-11293-7_reference.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5248352472","display_name":null,"funder_award_id":"ZR2023QB201","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225458280.pdf","grobid_xml":"https://content.openalex.org/works/W7225458280.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4413304628"],"related_works":["https://openalex.org/W4225318339","https://openalex.org/W4410765292","https://openalex.org/W7169639131","https://openalex.org/W6941194667","https://openalex.org/W6885099418","https://openalex.org/W2007139723","https://openalex.org/W7161296364","https://openalex.org/W578468378","https://openalex.org/W4230753903","https://openalex.org/W2588838678"],"abstract_inverted_index":{"How":[0],"specialist":[1],"enzymes":[2],"reconcile":[3],"the":[4,42,52,71,102,144],"fundamental":[5],"trade-off":[6],"between":[7],"catalytic":[8,87],"fidelity":[9],"and":[10,55,86,93,98,136],"functional":[11,94,103,110,129],"promiscuity":[12],"within":[13],"a":[14,19,25,47],"conserved":[15],"active":[16],"site":[17,64],"is":[18],"central":[20],"paradox":[21],"in":[22,131],"enzymology.":[23],"Using":[24],"representative":[26],"Type":[27,132],"II":[28,133],"meso":[29,134],"-DAPDH":[30,135],"enzyme":[31,148],"from":[32,117],"Symbiobacterium":[33],"thermophilum":[34],"(StDAPDH)":[35],"as":[36,46],"our":[37],"model":[38],"system,":[39],"we":[40],"identify":[41],"distal":[43,139],"residue":[44],"M176":[45],"switch":[48],"whose":[49],"substitutions":[50,61],"decouple":[51],"enzyme\u2019s":[53,72],"amination":[54],"deamination":[56],"activities.":[57,149],"We":[58],"find":[59],"that":[60,138],"at":[62],"this":[63],"are":[65,79],"associated":[66,108],"with":[67,109],"substrate-dependent":[68,147],"reorganization":[69],"of":[70,105,128,146],"intra-subunit":[73],"contact-correlation":[74],"network.":[75],"These":[76],"network":[77,140],"changes":[78],"accompanied":[80],"by":[81],"distinct":[82],"substrate-dissociation":[83],"free-energy":[84],"profiles":[85],"outcomes,":[88],"including":[89],"activity":[90],"retention,":[91],"inhibition,":[92],"decoupling.":[95],"Combined":[96],"simulations":[97],"mutational":[99],"analyses":[100],"support":[101],"importance":[104],"specific":[106],"residues":[107],"decoupling,":[111],"while":[112],"distinguishing":[113],"recurring":[114],"network-level":[115],"features":[116],"putative":[118],"residue-level":[119],"routes.":[120],"Together,":[121],"these":[122],"results":[123],"provide":[124],"an":[125],"ensemble-based":[126],"view":[127],"duality":[130],"suggest":[137],"modulation":[141],"may":[142],"aid":[143],"engineering":[145]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-08T00:00:00"}
